Method and apparatus for making aligned flake composite wood material including integral baffles

A method and apparatus for forming a loosely felted mat of elongated wood flakes mixed with a binder, the mat including a longitudinal axis and the wood flakes being aligned in mutually parallel relation and parallel to the longitudinal axis of the mat. The wood flakes are held in alignment in the mat by a plurality of closely spaced thin planar baffles, the baffles being comprised of a material which can form an integral part of the mat.https://digitalcommons.mtu.edu/patents/1120/thumbnail.jp

Apparatus for forming mat of aligned flake composite wood material with continuous baffles

An apparatus is provided for forming a continuous loosely felted mat of wood flakes, the wood flakes being elongated and being aligned in mutually parallel relation and parallel to the longitudinal axis of the mat. The apparatus includes a conveyor having an upper surface adapted to support a mat of wood flakes and formers for continuously depositing wood flakes on the conveyor as it moves under the former. Also included are continuous lengths of baffle material positioned between the formers and the conveyor, and oriented so as to define parallel adjacent vertical planes, the planes being parallel to the direction of movement of the upper surface. The lengths of baffle material are positioned in closely spaced side-by-side relation and move with the upper surface beneath the formers as the loosely felted mat is formed and are adapted to cause the flakes to become aligned and to be held in alignment during formation of the mat.https://digitalcommons.mtu.edu/patents/1129/thumbnail.jp

Static dropless flake aligner for producing composite wood material

Apparatus are provided for forming a loosely felted mat of elongated wood flakes, the wood flakes being supported on an elongated caul. The flakes are deposited between a plurality of closely spaced parallel baffles so as to be aligned in mutually parallel relation. The caul is supported adjacent the lower edges of the baffles and is support for vertical movement to facilitate buildup of the mat. Apparatus movable back and forth along the length of the caul is provided to deposit wood flakes in an evenly dispursed manner. At least one picker wheel also moves along the length of the baffles, the picker wheel including fingers extending downwardly between baffles and adapted to engage the flakes to cause them to fall between the baffles.https://digitalcommons.mtu.edu/patents/1107/thumbnail.jp

DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML

<b>Background</b>. Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are neoplastic disorders of hematopoietic stem cells. DNA methyltransferase inhibitors (DNMTi), 5-azacytidine (AzaC) and 5-aza-2’-deoxycytidine (Decitabine), benefit some MDS/AML patients. However, the role of DNMTi-induced DNA hypomethylation in regulation of gene expression in AML is unclear.<p></p> <b>Results. </b> We compared the effects of AzaC on DNA methylation and gene expression using whole-genome single-nucleotide bisulfite-sequencing (WGBS) and RNA-sequencing in OCI-AML3 (AML3) cells. For data analysis, we used an approach recently developed for discovery of differential patterns of DNA methylation associated with changes in gene expression, that is tailored to single-nucleotide bisulfite-sequencing data (Washington University Interpolated Methylation Signatures (WIMSi)). By this approach, a subset of genes upregulated by AzaC was found to be characterized by AzaC-induced signature methylation loss flanking the transcription start site. These genes are enriched for genes increased in methylation and decreased in expression in AML3 cells compared to normal hematopoietic stem and progenitor cells. Moreover, these genes are preferentially upregulated by Decitabine in human primary AML blasts, and control cell proliferation, death and development. <p></p> <b>Conclusions.</b> Our WGBS and WIMSi data analysis approach has identified a set of genes whose is methylation and silencing in AML is reversed by DNMTi. These genes are good candidates for direct regulation by DNMTi, and their reactivation by DNMTi may contribute to therapeutic activity. This study also demonstrates the ability of WIMSi to reveal relationships between DNA methylation and gene expression, based on single-nucleotide bisulfite-sequencing and RNA-seq data.<p></p&gt

Risk homeostasis theory - A study of intrinsic compensation

Risk homeostasis theory (RHT) suggests that changes made to the intrinsic risk of environments are negated in one of three ways: behavioural adjustments within the environment, mode migration, and avoidance of the physical risk. To date, this three-way model of RHT has little empirical support, whilst research findings on RHT have at times been diametrically opposed. A reconciliation of apparently opposing findings might be possible by suggesting that extrinsic compensation fails to restore previously existing levels of actual risk in cases where behavioural adjustments within the environment are incapable of negating intrinsic risk changes. This paper reports a study in which behavioural adjustments within the physical risk-taking environment are capable of reconciling target with actual risk. The results provide positive support for RHT in the form of overcompensation for the intrinsic risk change on specific driver behaviours

Apparatus for making continuous lengths of composite wood material, the apparatus including rotating circular baffles

Apparatus for forming an elongated loosely felted mat of thin elongated wood flakes with the flakes being aligned in mutually parallel relation and being aligned with the longitudinal direction of the elongated mat. The apparatus comprises a plurality of conveyor belts positioned in closely adjacent side-by-side relation and defining a mat supporting surface adapted to support the aligned wood flakes, the belts being supported on the surface of a cylinder. Wood flakes are deposited in loosely felted relation on the belts, and a plurality of closely spaced parallel planar baffles surround the cylinder, the baffles comprising plates positioned between the belts and functioning to cause alignment of the flakes as they are deposited on the belts. The mat is compressed against the supporting surface by a plurality of belts positioned in adjacent side-by-side relation, the belts being positionable between the baffles and engage- able against the mat.https://digitalcommons.mtu.edu/patents/1108/thumbnail.jp

Flake aligner including baffles supported on continuously moving conveyor

Apparatus for forming a continuous elongated loosely felted mat of thin elongated wood flakes with the flakes being aligned in mutually parallel interleaved relation. The apparatus includes a plurality of belts positioned in adjacent side-by-side relation and for continuous movement so as to define a supporting surface for the mat. A plurality of sets of thin planar baffle plates are provided, each set including a plurality of thin planar baffle plates supported in coplanar alignment and in edge-to-edge adjacent relation. The baffle plates are positioned between a hopper for depositing wood flakes and the supporting surface and function to align the wood flakes in substantially mutually parallel relation in substantially parallel relation to the direction of movement of the supporting surface and to maintain the wood flakes in substantially parallel alignment as the flakes fall from the hopper onto the supporting surface. Each of the sets of baffle plates are positioned between pairs of belts and are supported for movement with the belts, and the baffle plates of one set are parallel to and spaced closely adjacent to baffle plates of an adjacent set.https://digitalcommons.mtu.edu/patents/1119/thumbnail.jp

Positive and Negative Experiences With Supportive Services and Programming: Gaps and Recommendations From Youth Experiencing Homelessness

Services for youth experiencing homelessness (YEH) are designed with limited input from the youth themselves. This study explored the experiences and recommendations for services aimed at mitigating the negative effects of homelessness among youth. A total of 45 interviews were conducted with YEH (ages 15 to 24, M = 21.5 years) who experienced at least one night of homelessness. Transcripts were coded by using a modified constructivist grounded theory approach. YEH reported myriad challenges to navigating disjointed programming and misguided policies. Recommendations from YEH for policy and programmatic change include peacekeeping and diffusion training for program staff, trauma-informed approaches, and conflict resolution among agency staff; and integrate creative outlets and transitional services into existing programs. Programming supporting YEH must extend beyond meeting only basic needs to creating opportunities for safety, autonomy, and growth. Programs targeting youth homelessness need input from YEH in their design and implementation

Systematic review of the factors affecting cat and dog owner compliance with pharmaceutical treatment recommendations

© 2018 British Veterinary Association. The aim of this systematic review is to describe and assess the quality of the existing evidence base concerning factors that influence the compliance of cat and dog owners to pharmaceutical and specifically polypharmacy treatment recommendations. PubMed, CAB Abstracts and Google were searched to identify relevant literature and search results were filtered according to predetermined inclusion and exclusion criteria. Standardised data extraction and critical appraisal were carried out on each included study, and a Centre for Evidence-Based Medicine level of evidence grading was applied. Of the 8589 studies, eight studies were included in the review. Majority (five of eight) of the included studies were examining compliance with short-term antimicrobial therapies and none examined polypharmacy. Multiple definitions of compliance, methods of measurement and different factors potentially affecting compliance were used. Factors reported to have affected compliance in at least one study were dosing regimen, discussion of dosing regimen in light of owners' circumstances, consultation time, disease, month of consultation/treatment, physical risk, social risk and method of administration. The evidence available regarding factors affecting client compliance with pharmaceutical treatment recommendations in cats and dogs is scarce and of poor quality

Xenopus: An ideal system for chemical genetics

Chemical genetics, or chemical biology, has become an increasingly powerful method for studying biological processes. The main objective of chemical genetics is the identification and use of small molecules that act directly on proteins, allowing rapid and reversible control of activity. These compounds are extremely powerful tools for researchers, particularly in biological systems that are not amenable to genetic methods. In addition, identification of small molecule interactions is an important step in the drug discovery process. Increasingly, the African frog Xenopus is being used for chemical genetic approaches. Here, we highlight the advantages of Xenopus as a first-line in vivo model for chemical screening as well as for testing reverse engineering approaches. genesis 50:207–218, 2012. © 2012 Wiley Periodicals, Inc