The INTEGRAL Core Observing Programme

The Core Programme of the INTEGRAL mission is defined as the portion of the scientific programme covering the guaranteed time observations for the INTEGRAL Science Working Team. This paper describes the current status of the Core Programme preparations and summarizes the key elements of the observing programme.Comment: Contributed paper, 3rd INTEGRAL Workshop, Taormina/Sicily, Sep 1998, to be published in Astrophys. Letters & Communications, 199

Registration of the First Thermonuclear X-ray Burst from AX J1754.2-2754

During the analysis of the INTEGRAL observatory archival data we found a powerful X-ray burst, registered by JEM-X and IBIS/ISGRI telescopes on April 16, 2005 from a weak and poorly known source AX J1754.2-2754. Analysis of the burst profiles and spectrum shows, that it was a type I burst, which result from thermonuclear explosion on the surface of nutron star. It means that we can consider AX J1754.2-2754 as an X-ray burster. Certain features of burst profile at its initial stage witness of a radiation presure driven strong expansion and a corresponding cooling of the nutron star photosphere. Assuming, that the luminosity of the source at this phase was close to the Eddington limit, we estimated the distance to the burst source d=6.6+/-0.3 kpc (for hidrogen atmosphere of the neutron star) and d=9.2+/-0.4 kpc (for helium atmosphere).Comment: 12 pages, 6 figure

Scattering of dislocated wavefronts by vertical vorticity and the Aharonov-Bohm effect II: Dispersive waves

Previous results on the scattering of surface waves by vertical vorticity on shallow water are generalized to the case of dispersive water waves. Dispersion effects are treated perturbatively around the shallow water limit, to first order in the ratio of depth to wavelength. The dislocation of the incident wavefront, analogous to the Aharonov-Bohm effect, is still observed. At short wavelengths the scattering is qualitatively similar to the nondispersive case. At moderate wavelengths, however, there are two markedly different scattering regimes according to wether the capillary length is smaller or larger than $\sqrt{3}$ times depth. The dislocation is characterized by a parameter that depends both on phase and group velocity. The validity range of the calculation is the same as in the shallow water case: wavelengths small compared to vortex radius, and low Mach number. The implications of these limitations are carefully considered.Comment: 30 pages, 11 figure

Scattering of second sound waves by quantum vorticity

A new method of detection and measurement of quantum vorticity by scattering second sound off quantized vortices in superfluid Helium is suggested. Theoretical calculations of the relative amplitude of the scattered second sound waves from a single quantum vortex, a vortex ring, and bulk vorticity are presented. The relevant estimates show that an experimental verification of the method is feasible. Moreover, it can even be used for the detection of a single quantum vortex.Comment: Latex file, 9 page

The Successful Operation of Hole-type Gaseous Detectors at Cryogenic Temperatures

We have demonstrated that hole-type gaseous detectors, GEMs and capillary plates, can operate up to 77 K. For example, a single capillary plate can operate at gains of above 10E3 in the entire temperature interval between 300 until 77 K. The same capillary plate combined with CsI photocathodes could operate perfectly well at gains (depending on gas mixtures) of 100-1000. Obtained results may open new fields of applications for capillary plates as detectors of UV light and charge particles at cryogenic temperatures: noble liquid TPCs, WIMP detectors or LXe scintillating calorimeters and cryogenic PETs.Comment: Presented at the IEEE Nuclear Science Symposium, Roma, 200

Elevated cerebral spinal fluid biomarkers in children with mucopolysaccharidosis I-H.

Mucopolysaccharidosis (MPS) type-IH is a lysosomal storage disease that results from mutations in the IDUA gene causing the accumulation of glycosaminoglycans (GAGs). Historically, children with the severe phenotype, MPS-IH (Hurler syndrome) develop progressive neurodegeneration with death in the first decade due to cardio-pulmonary complications. New data suggest that inflammation may play a role in MPS pathophysiology. To date there is almost no information on the pathophysiologic changes within the cerebral spinal fluid (CSF) of these patients. We evaluated the CSF of 25 consecutive patients with MPS-IH. While CSF glucose and total protein were within the normal range, we found a significantly mean elevated CSF opening pressure at 24 cm H2O (range 14-37 cm H2O). We observed a 3-fold elevation in CSF heparan sulfate and a 3-8 fold increase in MPS-IH specific non-reducing ends, I0S0 and I0S6. Cytokine analyses in CSF of children with MPS-IH showed significantly elevated inflammatory markers including: MCP-1 SDF-1a, IL-Ra, MIP-1b, IL-8, and VEGF in comparison to unaffected children. This is the largest report of CSF characteristics in children with MPS-IH. Identification of key biomarkers may provide further insight into the inflammatory-mediated mechanisms related to MPS diseases and perhaps lead to improved targeted therapies

New Approximability Results for the Robust k-Median Problem

We consider a robust variant of the classical $k$-median problem, introduced by Anthony et al. \cite{AnthonyGGN10}. In the \emph{Robust $k$-Median problem}, we are given an $n$-vertex metric space $(V,d)$ and $m$ client sets $\set{S_i \subseteq V}_{i=1}^m$. The objective is to open a set $F \subseteq V$ of $k$ facilities such that the worst case connection cost over all client sets is minimized; in other words, minimize $\max_{i} \sum_{v \in S_i} d(F,v)$. Anthony et al.\ showed an $O(\log m)$ approximation algorithm for any metric and APX-hardness even in the case of uniform metric. In this paper, we show that their algorithm is nearly tight by providing $\Omega(\log m/ \log \log m)$ approximation hardness, unless ${\sf NP} \subseteq \bigcap_{\delta >0} {\sf DTIME}(2^{n^{\delta}})$. This hardness result holds even for uniform and line metrics. To our knowledge, this is one of the rare cases in which a problem on a line metric is hard to approximate to within logarithmic factor. We complement the hardness result by an experimental evaluation of different heuristics that shows that very simple heuristics achieve good approximations for realistic classes of instances.Comment: 19 page

Financial conservatism, firm value and international business risk: Evidence from emerging economies around the global financial crisis

The increase in debt-free or under-levered firms (financial conservatism) is one of the most recent stylized puzzles that cannot be explained within the context of extant capital structure theories. In this paper, we exploit the 2008–09 contractions in credit supply in a quasi-natural experiment to examine whether financial conservatism affects firm value. Using a large sample of firms from seven African countries over the period 2003–2012, we find strong evidence that financial conservatism mitigates the adverse effect of contractions in credit supply on firm value for both local and international firms. Our results suggest that financial conservatism is an effective strategy for managing risks arising from contractions in credit supply and international business exposure. These findings provide novel empirical evidence on the value relevance of financial conservatism which shields firms from the adverse and far-reaching effects of contractions in credit supply

Socioeconomic predictors and consequences of depression among primary care attenders with non-communicable diseases in the Western Cape, South Africa:Cohort study within a randomised trial

Background: Socioeconomic predictors and consequences of depression and its treatment were investigated in 4393 adults with specified non-communicable diseases attending 38 public sector primary care clinics in the Eden and Overberg districts of the Western Cape, South Africa.   Methods: Participants were interviewed at baseline in 2011 and 14 months later, as part of a randomised controlled trial of a guideline-based intervention to improve diagnosis and management of chronic diseases. The 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) was used to assess depression symptoms, with higher scores representing more depressed mood. Results: Higher CESD-10 scores at baseline were independently associated with being less educated (p=0.004) and having lower income (p=0.003). CESD-10 scores at follow-up were higher in participants with less education (p=0.010) or receiving welfare grants (p=0.007) independent of their baseline scores. Participants with CESD-10 scores of 10 or more at baseline (56% of all participants) had 25% higher odds of being unemployed at follow-up (p=0.016), independently of baseline CESD-10 score and treatment status. Among participants with baseline CESD-10 scores of 10 or more, antidepressant medication at baseline was independently more likely in participants who had more education (p=0.002), higher income (p<0.001), or were unemployed (p=0.001). Antidepressant medication at follow up was independently more likely in participants with higher income (p=0.023), and in clinics with better access to pharmacists (p=0.053) and off-site drug delivery (p=0.013).  Conclusions: Socioeconomic disadvantage appears to be both a cause and consequence of depression, and may also be a barrier to treatment. There are opportunities for improving the prevention, diagnosis and treatment of depression in primary care in inequitable middle income countries like South Africa.  Trial registration: The trial is registered with Current Controlled Trials (ISRCTN20283604) and the Office for Human Research Protections Database (IRB00001938, FWA00001637)

The complex Sine-Gordon equation as a symmetry flow of the AKNS Hierarchy

It is shown how the complex sine-Gordon equation arises as a symmetry flow of the AKNS hierarchy. The AKNS hierarchy is extended by the ``negative'' symmetry flows forming the Borel loop algebra. The complex sine-Gordon and the vector Nonlinear Schrodinger equations appear as lowest negative and second positive flows within the extended hierarchy. This is fully analogous to the well-known connection between the sine-Gordon and mKdV equations within the extended mKdV hierarchy. A general formalism for a Toda-like symmetry occupying the ``negative'' sector of sl(N) constrained KP hierarchy and giving rise to the negative Borel sl(N) loop algebra is indicated.Comment: 8 pages, LaTeX, typos corrected, references update