Hacia el desarrollo de un framework para el diseño de Sistemas Infotainment Automotrices: Primeras aproximaciones contextuales

The objective of this article was to establish the first contextual approaches for the development of a framework focused on the design of automotive infotainment systems. Therefore, a method was developed to identify a group of characteristics of the infotainment system interfaces that ensure a good user experience by the user, according to previous studies. Besides, the establishment of usability is proposed as a basis for the development of the tool.El objetivo de este artículo fue establecer las primeras aproximaciones contextuales para el desarrollo de un framework enfocado en el diseño de sistemas Infotainment automotrices. Por lo cual, se desarrolló un método para la identificación de un grupo de características de las interfaces de sistemas Infotainment que aseguren una buena experiencia de uso por parte del usuario, de acuerdo con estudios previos. Además, se plantea la usabilidad como base para el desarrollo de la herramienta

Detection of traits in students with suicidal tendencies on Internet applying Web Mining

This article presents an Internet data analysis model based on Web Mining with the aim to find knowledge about large amounts of data in cyberspace. To test the proposed method, suicide web pages were analyzed as a study case to identify and detect traits in students with suicidal tendencies. The procedure considers a Web Scraper to locate and download information from the Internet, as well as Natural Language Processing techniques to retrieve the words. To explore the information, a dataset based on Dynamic Tables and Semantic Ontologies was constructed, specifying the predictive variables in young people with suicidal inclination. Finally, to evaluate the efficiency of the model, Machine Learning and Deep Learning algorithms were used. It should be noticed that the procedures for the construction of the dataset (using Genetic Algorithms) and obtaining the knowledge (using Parallel Computing and Acceleration with GPU) were optimized. The results reveal an accuracy of 96.28% on the detection of characteristics in adolescents with suicidal tendencies, reaching the best result through a Recurrent Neural Network with 98% accuracy. It is inferred that the model is viable to establish bases on mechanisms of action and prevention of suicidal behaviors, which can be implemented in educational institutions or different social actors

Geminivirus replication protein decreases PCNA sumoylation at two acceptor sites

Geminiviruses are plant viruses with circular, single-stranded DNA (ssDNA) genomes that infect a broad range of plants causing substantial crop diseases worldwide. They replicate in nuclei of infected cells by using host DNA replication machinery and an essential protein encoded in their genome designated Rep (replication-associated protein). This multifunctional protein induces the accumulation of the host factors involved in replication and it is capable of interacting with a lot of plant proteins including PCNA (Proliferating Cell Nuclear Antigen), a processivity factor that coordinates a wide range of processes involved in maintenance, duplication and transmission of the genome, and the sumoylation enzyme that conjugates SUMO to target proteins (SUMO-conjugating enzyme- SCE). PCNA modification by SUMO, and also ubiquitin, has long been known to be of key importance for determining how DNA damage is processed by the replisome and for maintenance of overall genome integrity. In yeast, PCNA sumoylation has been associated to DNA repair involving homologous recombination (HR). Previously, we reported that Rep ectopic expression does not result in broad changes in the sumoylation pattern of plant cells, but it modifies the sumoylation state of selected host proteins. In this work, we show, using a reconstituted sumoylation system in Escherichia coli, that tomato PCNA is sumoylated at two residues, K254 and K164, and that co-expression of the Rep protein suppresses PCNA sumoylation at these lysines. Finally, we confirm that PCNA is sumoylated and that Rep also interferes with PCNA sumoylation in planta.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

PCA and Parellel SVM to Optimize the Diagnostic of Breast Cancer Based on Raman Spectroscopy

Breast cancer is one of the most deadly diseases in the world; therefore, rapid automated detection of breast cancer in patients is a relevant step in initiating appropriate treatment. In this paper we present a method that optimizes the response time in the automated detection of breast cancer in which a Raman signal is classified as coming from a healthy tissue biopsy or a damaged tissue biopsy. To carry out the detection, we applied Multivariate Component Analysis (PCA) in conjunction with a Classifier (Vector Support Machine (SVM)) in Parallel and from this methods we obtained high correct detection rates, corroborated when comparing the results of the classifier against previous tissue classifications performed by an expert pathologist. We believe that our approach can be applied to other organs of the body where timely detection and classification of cancer can be difficult and of prognostic relevance, such as stomach and pancreas, among others

Diseño, modelado y construcción de la dirección de un vehículo tipo SAE mediante análisis vectoriales y geométricos

El objetivo de este artículo es diseñar la geometría del sistema de dirección de un vehículo SAE (Society of Automotive Engineers), para poder determinar el desplazamiento que debe recorrer la cremallera y que las ruedas del vehículo giren en un ángulo previamente establecido. Se utilizan vectores de posición para representar los elementos móviles del sistema de dirección en sus dos diferentes condiciones: sin ángulo de giro y con el ángulo máximo de giro. Los elementos usados para el diseño fueron los brazos de dirección, los tirantes y la cremallera, siendo esta última representada como un vector de desplazamiento en un solo eje. Los elementos restantes fueron representados con vectores de magnitud fija, después se procedió a determinar ecuaciones utilizando un lazo cerrado del mecanismo con base en las condiciones que se establecen (máximo ángulo de giro y geometría de la dirección), finalmente, se calcula el recorrido necesario en la cremallera, con esto se obtiene el diámetro de paso final del piñó

A Methodological Process for the Design of Frameworks Oriented to Infotainment User Interfaces

The objective of this paper was to propose a methodological process for the design of frameworks oriented to infotainment user interfaces. Four stages comprise the proposed process, conceptualization, structuring, documentation, and evaluation; in addition, these stages include activities, tasks, and deliverables to guide a work team during the design of a framework. To determine the stages and their components, an analysis of 42 papers was carried out through a systematic literature review in search of similarities during the design process of frameworks related to user interfaces. The evaluation method by a panel of experts was used to determine the validity of the proposal; the conceptual proposal was provided to a panel of 10 experts for their analysis and later a questionnaire in the form of a Likert scale was used to collect the information on the validation of the proposal. The results of the evaluation indicated that the methodological process is valid to meet the objective of designing a framework oriented to infotainment user interfaces

A Methodological Process for the Design of Frameworks Oriented to Infotainment User Interfaces

The objective of this paper was to propose a methodological process for the design of frameworks oriented to infotainment user interfaces. Four stages comprise the proposed process, conceptualization, structuring, documentation, and evaluation; in addition, these stages include activities, tasks, and deliverables to guide a work team during the design of a framework. To determine the stages and their components, an analysis of 42 papers was carried out through a systematic literature review in search of similarities during the design process of frameworks related to user interfaces. The evaluation method by a panel of experts was used to determine the validity of the proposal; the conceptual proposal was provided to a panel of 10 experts for their analysis and later a questionnaire in the form of a Likert scale was used to collect the information on the validation of the proposal. The results of the evaluation indicated that the methodological process is valid to meet the objective of designing a framework oriented to infotainment user interfaces

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group