Effects of perioperative blood transfusion in gastric cancer patients undergoing gastrectomy: A systematic review and meta-analysis

BackgroundThe short-term and long-term effects of perioperative blood transfusion (PBT) on patients with gastric cancer are still intriguing. This systematic review and meta-analysis aimed to investigate the effects of blood transfusion on clinical outcomes in patients with gastric cancer undergoing gastrectomy.MethodsWe searched PubMed, Web of Science, Embase, and The Cochrane Library on December 31th 2021. The main outcomes were overall survival (OS), disease-free survival (DFS), disease-specific survival (DFS), and postoperative complications. A fixed or random-effects model was used to calculate the hazard ratio (HR) with 95% confidence intervals (CIs).ResultsFifty-one studies with a total of 41,864 patients were included for this review and meta-analysis. Compared with patients who did not receive blood transfusions (NPBT), PBT was associated with worse 5-year OS (HR = 2.39 [95%CI: 2.00, 2.84]; p < 0.001; Multivariate HR = 1.43 [95%CI: 1.24, 1.63]; p < 0. 001), worse 5-year DFS (HR = 2.26 [95%CI: 1.68, 3.05]; p < 0.001; Multivariate HR = 1.45 [95%CI: 1.16, 1.82]; p < 0. 001), and worse 5-year DSS (HR = 2. 23 [95%CI: 1.35, 3.70]; p < 0.001; Multivariate HR = 1.24 [95%CI: 0.96, 1.60]; p < 0.001). Moreover, The PBT group showed a higher incidence of postoperative complications [OR = 2.30 (95%CI:1.78, 2. 97); p < 0.001] than that in the NPBT group, especially grade III-V complications, according to the Clavien-Dindo classification. [OR = 2.50 (95%CI:1.71, 3.63); p < 0.001].ConclusionIn patients who underwent gastrectomy, PBT was associated with negative survival effects (OS, DFS, DSS) and a higher incidence of perioperative complications. However, more research was expected to further explore the impact of PBT. Meanwhile, strict blood transfusion management should be implemented to minimize the use of PBT

Characterization of the Metabolic Fate of Datura metel Seed Extract and Its Main Constituents in Rats

Datura metel L. has been frequently used in Chinese traditional medicine. However, little is known on the chemical composition and in vivo metabolism of its seeds. In this study, using the strategy “chemical analysis, metabolism of single representative compounds, and metabolism of extract at clinical dosage” that we propose here, 42 constituents were characterized from D. metel seeds water extract. Furthermore, the metabolic pathways of 13 representative bioactive compounds of D. metel seeds were studied in rats after the oral administration of D. metel seeds water extract at a clinical dosage (0.15 g/kg). These included three withanolides, two withanolide glucosides, four amides, one indole, one triterpenoid, one steroid, and one sesquiterpenoid, and with regard to phase II metabolism, hydroxylation, (de)methylation, and dehydrogenation reactions were dominant. Furthermore, the metabolism of D. metel seeds water extract provided to rats at a clinical dosage was investigated by liquid chromatography-tandem mass spectrometry based on the above metabolic pathways. Sixty-one compounds were detected in plasma, 83 in urine, and 76 in fecal samples. Among them, withanolides exhibited higher plasma exposure than the other types. To our knowledge, this is the first systematic study on the chemical profiling and metabolite identification of D. metel seeds, including all compounds instead of single constituents

Evaluation of an identification method for the SARS-CoV-2 Delta variant based on the amplification-refractory mutation system

The Delta variant of SARS-CoV-2 dominated the COVID-19 pandemic due to its high viral replication capacity and immune evasion, causing massive outbreaks of cases, hospitalizations, and deaths. Currently, variant identification is performed mainly by sequencing. However, the high requirements for equipment and operators as well as its high cost have limited its application in underdeveloped regions. To achieve an economical and rapid method of variant identification suitable for undeveloped areas, we applied an amplification-refractory mutation system (ARMS) based on PCR for the detection of novel coronavirus variants. The results showed that this method could be finished in 90 min and detect as few as 500 copies/mL and not react with SARS-Coronavirus, influenza A H1N1(2009), and other cross-pathogens or be influenced by fresh human blood, α- interferon, and other interfering substances. In a set of double-blind trials, tests of 262 samples obtained from patients confirmed with Delta variant infection revealed that our method was able to accurately identify the Delta variant with high sensitivity and specificity. In conclusion, the ARMS-PCR method applied in Delta variant identification is rapid, sensitive, specific, economical, and suitable for undeveloped areas. In our future study, ARMS-PCR will be further applied in the identification of other variants, such as Omicron

Deciphering the origin of the Cenozoic intracontinental rifting and volcanism in eastern China using integrated evidence from the Jianghan Basin

Intracontinental rifting and low-volume volcanism are a globally common phenomenon, yet the underlying driving mechanisms and whether they can be explained through classic plate tectonic concepts, remain hotly debated. A prominent example is the Cenozoic rift and volcanic province in eastern China. Using an integration of geological, geophysical and geochemical data, we unravel the spatial and temporal variations of the rifting and volcanism in the Jianghan Basin. Both rifting and volcanism in the Jianghan Basin show two intense-to-weak cycles (65–50 Ma and 50–26 Ma, respectively) with significant enhancement in activity during the late rift phase. Moreover, rifting and depocentres progressively migrated eastward. The Jianghan basalts all share an asthenospheric origin while the source of the late phase basalts is slightly more enriched and heterogenous in Nd-Hf isotopes than that of the early phase basalts. The late phase basalts also display a smaller extent of partial melting even under a thinner lithosphere, likely indicating a significant decrease of volatile content in the mantle source. Based on regional tectonic correlations, the main stages of tectonic evolution of the Jianghan Basin and eastern China are not synchronous with changes in Pacific plate motion, while they are coincident with India-Asia collision processes. These observations lead us to propose that the asthenospheric flow driven by India-Asia collision rather than the rollback of the subducted Pacific slab has caused the widespread rifting and volcanism in eastern China. The variations of rifting and volcanism in the Jianghan Basin suggest a multiphase and eastward asthenospheric flow beneath eastern China driven by India-Asia collision, with an intense upwelling when passing through the North-South Gravity Lineament (NSGL). The much more intense rifting and volcanism during the late rift phase may indicate a much larger scale of volatile-poor asthenospheric flow than the early rift phase which could result in a more intense erosion of ancient enriched lithospheric mantle and the volatile content in the mantle source dropping sharply. This study provides an improved model based on our multidisciplinary observations for asthenospheric flow which may be an alternative driving mechanism for intracontinental rifting and low-volume volcanism in the regions where there are step changes in lithospheric thickness globally

A multimodal cell census and atlas of the mammalian primary motor cortex

ABSTRACT We report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties, and cellular resolution input-output mapping, integrated through cross-modal computational analysis. Together, our results advance the collective knowledge and understanding of brain cell type organization: First, our study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a unified taxonomy of transcriptomic types and their hierarchical organization that are conserved from mouse to marmoset and human. Third, cross-modal analysis provides compelling evidence for the epigenomic, transcriptomic, and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types and subtypes. Fourth, in situ single-cell transcriptomics provides a spatially-resolved cell type atlas of the motor cortex. Fifth, integrated transcriptomic, epigenomic and anatomical analyses reveal the correspondence between neural circuits and transcriptomic cell types. We further present an extensive genetic toolset for targeting and fate mapping glutamatergic projection neuron types toward linking their developmental trajectory to their circuit function. Together, our results establish a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties

3D Foot Reconstruction Based on Mobile Phone Photographing

Foot measurement is necessary for personalized customization. Nowadays, people usually obtain their foot size by using a ruler or foot scanner. However, there are some disadvantages to this, namely, large measurement error and variance when using rulers, and high price and poor convenience when using a foot scanner. To tackle these problems, we obtain foot parameters by 3D foot reconstruction based on mobile phone photography. Firstly, foot images are taken by a mobile phone. Secondly, the SFM (Structure-from-Motion) algorithm is used to acquire the corresponding parameters and then to calculate the camera position to construct the sparse model. Thirdly, the PMVS (Patch-based Multi View System) is adopted to build a dense model. Finally, the Meshlab is used to process and measure the foot model. The result shows that the experimental error of the 3D foot reconstruction method is around 1 mm, which is tolerable for applications such as shoe tree customization. The experiment proves that the method can construct the 3D foot model efficiently and easily. This technology has broad application prospects in the fields of shoe size recommendation, high-end customized shoes and medical correction

Research progress of artificial intelligence in the diagnosis of skin tumors

Dermatoses are highly intuitive, and disease information can be obtained from a large number of visual images. Artificial intelligence(AI) has made progress by leaps and bounds in the field of visual image processing in recent years. The application of AI has become a hot topic for dermatologists. The incidence rate of skin tumors is increasing, while the diagnosis of skin tumors is mainly through visual diagnosis, such as dermoscopy and pathological examination, which are difficult to make diagnosis in a timely manner. Based on skin imaging technology, AI does not only reduce doctors′ workload and improve the early detection rate, but also improves the diagnostic accuracy and sensitivity of skin diseases. This review summarizes the research status of AI in the auxiliary diagnosis of skin tumors in skin imaging and pathology, to provide reference for clinical application and future research of AI in dermatology

Modeling and Improvement Strategies for Safety Resilience in Maritime Hazardous Chemical Transportation System Based on Dissipative Structure Theory and System Dynamics

Maritime hazardous chemical transportation accidents have the characteristics of strong suddenness, wide influence, and great harm. To analyze the ability of a maritime hazardous chemical transportation system (MHCTS) to cope with sudden disturbance events, “resilience” is introduced into MHCTS safety research. The key to studying resilience is modeling its evolutionary process. Based on the dissipative structure theory, this study analyzes the entropy flow mechanism of MHCTS safety resilience evolution. Through a statistical analysis of 197 investigation reports on maritime hazardous chemical transportation accidents, the factors influencing the safety resilience of the MHCTS were determined. The entropy value and weight of each influencing factor were calculated using the entropy method and entropy weight method, respectively. Based on this, an entropy model of the safety resilience evolution of the MHCTS was established. The evolution process falls under four categories of disturbance strengths, which were simulated using the system dynamics method. The degree of contribution of absorptive, adaptive, and restorative capacities to the improvement of system safety resilience under four disturbance conditions and the sensitivity of each influencing factor to the absorptive, adaptive, and restorative capacities were analyzed. Based on the analyses, targeted resilience improvement strategies are proposed. The research results provide a theoretical reference for the study of safety resilience mechanisms and resilience management in the MHCTS

Wpływ absorbujących fale cząstek funkcyjnych na właściwości elektromagnetyczne i mechaniczne kompozytów powlekanych żywicą poliuretanową zawierającą proszek niklu

In this subject, a single-layer coated composite for nickel powders was prepared using PU2540 polyurethane as the matrix, nickel powder as the wave-absorbing functional particle, and coating technology on plain cotton fabric. The influence of wave-absorbing functional particles on the dielectric, shielding effectiveness and mechanical properties of the single-layer coated composite for nickel powders was mainly analysed and compared. Results showed that the real and imaginary parts and loss tangent of the dielectric constant were all the largest when the iron powder was mixed with the nickel powder, and its polarizing ability, loss ability and attenuation ability with respect to electromagnetic waves were all the maximum. When the graphene was mixed with the nickel powder, the shielding attenuation ability with respect to electromagnetic waves was the best.W ramach pracy przygotowano jednowarstwowy kompozyt powlekany żywicą poliuretanową zawierającą proszek niklu. Do przygotowania kompozytów użyto poliuretanu PU2540 jako matrycy i proszku niklu jako absorbującej fale cząstki funkcjonalnej oraz zastosowano technologię powlekania na gładkiej tkaninie bawełnianej. Przeanalizowano i porównano głównie wpływ absorbujących fale funkcjonalnych cząstek na dielektryk, skuteczność ekranowania i właściwości mechaniczne jednowarstwowego powlekanego kompozytu. Wyniki pokazały, że rzeczywiste i urojone części oraz styczna strat stałej dielektrycznej były największe, gdy proszek żelaza został zmieszany z proszkiem niklu, a jego zdolność polaryzacyjna, zdolność do strat i zdolność tłumienia fal elektromagnetycznych były maksymalne. Gdy grafen został zmieszany z proszkiem niklu, zdolność tłumienia ekranowania fal elektromagnetycznych była najlepsza

Impact of Treatment with Metformin on Adipocytokines in Patients with Polycystic Ovary Syndrome: A Meta-Analysis.

Metformin is effective for the treatment of polycystic ovary syndrome, but conflicting results regarding its effect on adipocytokine levels (adiponectin, resistin, visfatin, and leptin) in patients with polycystic ovary syndrome receiving metformin treatment have been reported. To provide high-quality evidence about the effect of metformin treatment on adipocytokines in patients with polycystic ovary syndrome, relevant studies that assessed the levels of adipocytokines (adiponectin, resistin, visfatin, and leptin) in patients with polycystic ovary syndrome receiving treatment with metformin administration were reviewed and analyzed.A literature search was conducted in the SCI, PUBMED, EMBASE, and Elsevier databases, and personal contact was made with the authors. Standard mean differences and 95% confidence intervals were calculated and combined appropriately. To ensure synthesis of the best available evidence, sensitivity analyses were performed.A total of 34 data sets were included in 4 different outcomes, involving 744 women with polycystic ovary syndrome and adipocytokine levels measured both before and after metformin administration. Metformin treatment was associated with significantly elevated serum adiponectin concentrations (standard mean differences [95% confidence interval], -0.43 [-0.75 to -0.11]) and decreased serum leptin concentrations (0.65 [0.26 to 1.04]), whereas no significant difference in resistin level (-0.01 [-0.49 to 0.45]) or visfatin level (-0.04 [-1.55 to 1.46]) was found.Metformin administration was associated with increased serum adiponectin concentrations and decreased serum leptin levels. Further study is needed to elucidate whether this apparent effect decreases the incidence of type 2 diabetes and other metabolic diseases in patients with polycystic ovary syndrome later in life