High rate of viral identification and coinfections in infants with acute bronchiolitis

OBJECTIVES: To determine the viruses and risk factors associated with hospital and intensive care unit (ICU) admissions in infants with acute bronchiolitis. INTRODUCTION: Bronchiolitis is a major cause of morbidity in infants. Widespread use of molecular-based methods has yielded new insights about its etiology, but the impact of viral etiologies on early outcomes is still unclear. METHODS: Seventy-seven infants with bronchiolitis who were under two years of age and visited an emergency unit were included. Using molecular-based methods, samples were tested for 12 different respiratory viruses. Logistic regression models were used to identify clinical and virological variables associated with the main endpoints: hospital admission and ICU admission. RESULTS: We identified at least one virus in 93.5% of patients, and coinfections were found in nearly 40% of patients. RSV was the most common pathogen (63.6%), followed by rhinovirus (39%). Identification of RSV was only associated with an increased risk of hospital admission in the univariate model. Younger age and enterovirus infection were associated with an increased risk of hospital admission, while atopy of a first-degree relative showed a protective effect. Prematurity was associated with an increased risk of admission to the ICU. Coinfections were not associated with worse outcomes. CONCLUSIONS: Molecular-based methods resulted in high rates of viral identification but did not change the significant role of RSV in acute bronchiolitis. Younger age and enterovirus infection were risk factors for hospital admission, while prematurity appeared to be a significant risk factor for admission to the ICU in acute viral bronchiolitis.Sociedade Beneficiente Israelita Brasileira Hospital Israelita Albert Einstei

High Rate of Viral Identification and Coinfections in Infants with Acute Bronchiolitis

OBJECTIVES: To determine the viruses and risk factors associated with hospital and intensive care unit (ICU) admissions in infants with acute bronchiolitis.INTRODUCTION: Bronchiolitis is a major cause of morbidity in infants. Widespread use of molecular-based methods has yielded new insights about its etiology, but the impact of viral etiologies on early outcomes is still unclear.METHODS: Seventy-seven infants with bronchiolitis who were under two years of age and visited an emergency unit were included. Using molecular-based methods, samples were tested for 12 different respiratory viruses. Logistic regression models were used to identify clinical and virological variables associated with the main endpoints: hospital admission and ICU admission.RESULTS: We identified at least one virus in 93.5% of patients, and coinfections were found in nearly 40% of patients. RSV was the most common pathogen (63.6%), followed by rhinovirus (39%). Identification of RSV was only associated with an increased risk of hospital admission in the univariate model. Younger age and enterovirus infection were associated with an increased risk of hospital admission, while atopy of a first-degree relative showed a protective effect. Prematurity was associated with an increased risk of admission to the ICU. Coinfections were not associated with worse outcomes.CONCLUSIONS: Molecular-based methods resulted in high rates of viral identification but did not change the significant role of RSV in acute bronchiolitis. Younger age and enterovirus infection were risk factors for hospital admission, while prematurity appeared to be a significant risk factor for admission to the ICU in acute viral bronchiolitis.Sociedade Beneficiente Israelita Brasileira Hospital Israelita Albert EinsteinHosp Israelita Albert Einstein, Dept Saude Materno Infantil, São Paulo, BrazilHosp Israelita Albert Einstein, Ctr Pesquisa Expt, Inst Ensino & Pesquisa, São Paulo, BrazilHosp Israelita Albert Einstein, UPA, São Paulo, BrazilUniv São Paulo, Virol Lab, Inst Trop Med, São Paulo, BrazilUniversidade Federal de São Paulo, Fac Med, Hosp Clin, Inst Crianca, São Paulo, BrazilUniversidade Federal de São Paulo, Fac Med, Hosp Clin, Inst Crianca, São Paulo, BrazilWeb of Scienc

High rate of viral identification and coinfections in infants with acute bronchiolitis

OBJECTIVES: To determine the viruses and risk factors associated with hospital and intensive care unit (ICU) admissions in infants with acute bronchiolitis. INTRODUCTION: Bronchiolitis is a major cause of morbidity in infants. Widespread use of molecular-based methods has yielded new insights about its etiology, but the impact of viral etiologies on early outcomes is still unclear. METHODS: Seventy-seven infants with bronchiolitis who were under two years of age and visited an emergency unit were included. Using molecular-based methods, samples were tested for 12 different respiratory viruses. Logistic regression models were used to identify clinical and virological variables associated with the main endpoints: hospital admission and ICU admission. RESULTS: We identified at least one virus in 93.5% of patients, and coinfections were found in nearly 40% of patients. RSV was the most common pathogen (63.6%), followed by rhinovirus (39%). Identification of RSV was only associated with an increased risk of hospital admission in the univariate model. Younger age and enterovirus infection were associated with an increased risk of hospital admission, while atopy of a first-degree relative showed a protective effect. Prematurity was associated with an increased risk of admission to the ICU. Coinfections were not associated with worse outcomes. CONCLUSIONS: Molecular-based methods resulted in high rates of viral identification but did not change the significant role of RSV in acute bronchiolitis. Younger age and enterovirus infection were risk factors for hospital admission, while prematurity appeared to be a significant risk factor for admission to the ICU in acute viral bronchiolitis

ESTUDOS GEOMORFOLÓGICOS EM ÁREAS AMOSTRAIS DA BACIA DO RIO ARAGUARI – MG: DESTAQUE PARA A IMPORTÂNCIA DA CARTOGRAFIA GEOMORFOLÓGICA

This work there is the taxonomic propose for cartographic representation, which were done by Ross (1992). This propose start from a first taxon that represents the bigger relief forms (morphoestructural forms) and goes to the sixth one, which represents the shorter relief forms (gully, short channels, ravines, etc.). This study shows a geomorphologic classification in a sample five area of the Araguari River Basin, in scale of 1:50.000, proposing an analysis of de landscape organization differences.O trabalho em questão tem a proposta taxonômica de representação cartográfica do relevo de ROSS (1992), a qual parte de um primeiro táxon inicialmente maior, representado pela morfoestrutura e por outros cinco táxons menores representados pelas morfoesculturas e fatos geomórficos. Este estudo traz a classificação geomorfológica em cinco áreas de amostragens na Bacia do Rio Araguari na escala de 1:50.000, propondo uma análise dos diferentes padrões de organização da paisagem

CONTRATAÇÕES PÚBLICAS SUSTENTÁVEIS: UMA ANÁLISE DO PERFIL DAS LICITAÇÕES DE INSTITUIÇÕES PÚBLICAS BRASILEIRAS

This article, exploratory and descriptive, aims to examine scientific production about sustainable public hiring and to outline a profile of the “green” procurements processes used by Brazilian public administration. The research looked for data contained at the Government Procurement website – COMPRASNET, which comprises a total of 2.291 sustainable items bid by different Procurement Management Units. From items bid, an analysis was conducted to identify which Brazilian regions and states contributed the most for the sustainable public procurement policy and what kinds of good are more common in the bidding help by government agencies. Additionally, this study used descriptive statistics for analyzing data and aimed to contribute to the scientific production about a contemporary theme.Este artigo, de caráter exploratório e descritivo, tem o objetivo de mapear a produção acadêmica referente ao tema contratações públicas sustentáveis e de traçar um perfil das licitações “verdes” realizadas pela Administração Pública Brasileira. A pesquisa buscou dados constantes do Portal de Compras do Governo Federal – COMPRASNET, o qual é composto por um total de 2.291 itens sustentáveis licitados por diferentes Unidades Gestoras de Compras do Governo. A partir desses itens licitados, foi realizada uma análise para identificar quais as regiões e estados brasileiros mais contribuíram para a política de compras publicas sustentáveis e quais os tipos de objetos são mais comuns nas licitações realizadas pelos órgãos governamentais. Adicionalmente, o estudo utilizou a estatística descritiva para análise dos dados e visou contribuir com a produção acadêmica sobre um tema contemporâneo

A WEB-BASED RESOURCE FOR STRUCTURAL INFORMATION ON eIF5A AND ITS RELATED PROTEINS: NEW POTENTIAL THERAPEUTIC TARGETS IN MANY HUMAN DISORDERS

Objective: There is a considerable therapeutic interest in eIF5A as a potential target for drug development through inhibition of hypusination. In this regards, protein structural information is fundamental. Herein, we reported the developing of a web-based system, called eIF5ADB, which compiles all protein structural data on eIF5A and its related proteins.Methods: The eIF5ADB database was implemented as a MySQL relational database, using PHP scripting language. Web interfaces were developed using HTML, CSS and JavaScript. The data were collected from PDB, UniProt and Entrez databases. These data were filtered appropriately using specialized literature.Results: The database provides three modules that allow to search, acquisition of contents and access to statistical data, besides direct links to matching to external databases.Conclusion: The platform developed here is very useful for researchers interested in this content and can be accessed at http: //www. gurupi. uft. edu. br/btoxdb/eif5adb.Â

ACCELERATED CORROSION TEST FOR THE QUALITATIVE EVALUATION OF CORROSION IN CONCRETE

This paper is devoted to simulate the behavior of reinforced concrete in saline solution through the accelerated corrosion test. During this test, this method was evaluating the behavior of the steel bars that reinforce concrete for corrosion, according to the NACE 0775 standard. After the corrosion test, the steel bars were cleaned and dried according to the ASTM A380 standard and evaluated according to the NACE RP 0775, NACE SP0308, and NACE SP0187 standards. From the results obtained, the steel bars concrete showedhigh corrosion rates with structural impairment of the metal armor according to the NACE standards

Diminuição da cobertura vacinal e aumento da incidência de Sarampo em um estado da Amazônia brasileira no período de 2016 a 2021: Decrease in vaccination coverage and increase in Measles incidence in a state of the brazilian Amazon from 2016 to 2021

O presente estudo tem por objetivo contribuir com a análise de dados epidemiológicos relacionados ao sarampo no Amapá. Trata-se de um estudo transversal, de caráter descritivo, abordagem quantitativa, abrangendo uma análise da cobertura vacinal para tríplice e tetra viral do estado amapaense. Após a análise dos dados, observou-se o aumento da incidência do sarampo, e a notificação de novos casos a partir de 2018 no estado do Amapá, com a maior concentração dos casos na faixa etária menor que 1 ano. Tais dados devem-se a diminuição da cobertura vacinal das vacinais Tríplice viral D1, D2, e Tetra viral, com isso nenhum município dessa unidade federativa alcançou a meta de cobertura vacinal estabelecida pelo Ministério da Saúde, de 95%, desde 2016. Dessa forma, a queda das coberturas vacinais teve impacto direto na reemergência do Sarampo, doença infectocontagiosa e imunoprevenível, que já estava erradicada desde 2016, devido a informações com baixa evidência cientifica, disseminadas a partir do movimento antivacina, e pela pandemia da covid-19, que foi um empecilho às novas medidas adotadas pelo Ministério da Saúde para aumento das coberturas vacinais

The contribution of the participatory guarantee system in the revival of agroecological principles in southern Minas Gerais, Brazil

Market pressures generated by the demand for organic food have pushed farmers to turn away from agroecological principles, which leads to actions focused directly on the agricultural practices for production. The objective of this study was to analyze whether the methodology used by the Participatory Guarantee Systems (PGS) contributes to farmers' appropriation of agroecological principles, understood here in their environmental, sociocultural, economic, and political dimensions. We analyzed the PGS-Sul de Minas, which was the first PGS founded in the state of Minas Gerais, Brazil and includes 14 organizations and more than 200 families. Documentary analysis and participant observation were prioritized in data collection. The main results are the correlation between the practices used by the farmers in these organizations with the principles of agroecology. This is evident in aspects such as the encouragement of productive diversification, the construction of new marketing alternatives, the revival and use of heirloom seeds, the stimulation of women's leadership, and places and policies that support and strengthen agroecology. The study found that the procedures adopted by the PGSs help strengthen agroecology and bring direct benefits to the farmers through revival and encouragement of agroecological principles1117COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESsem informaçã

Performance of seeder-fertilizer using two furrow opening mechanism and three loads on soil firming mechanism

O objetivo deste trabalho foi estudar o efeito de diferentes mecanismos rompedores e níveis de pressões aplicadas pela roda compactadora sobre o desempenho de uma semeadora-adubadora na implantação da cultura de soja, em plantio direto sob três teores de água no solo. O experimento foi montado em esquema de parcelas subsubdivididas, em que as parcelas foram constituídas pelos três teores avaliados de água no solo (0,22, 0,24 e 0,26 kg kg-1), as subparcelas por dois mecanismos rompedores (facão e disco duplo) e as subsubparcelas por três níveis de pressões aplicadas pela roda compactadora (12,2, 18,5 e 24,1 kPa), com três repetições, em um delineamento de blocos ao acaso. Foram analisadas a distância entre sementes, a profundidade de deposição, a porosidade, o índice de velocidade de emergência, a emergência a campo e a resistência do solo à penetração. O mecanismo rompedor do tipo facão proporciona maior profundidade de plantio e porosidade do solo, menor distância entre sementes e menor resistência do solo à penetração. A pressão da roda compactadora influencia a emergência de plântulas a campo, quando é usado o rompedor do tipo facão. O teor de água influencia a profundidade de deposição e distância entre sementes, o índice de velocidade de emergência e a resistência do solo à penetração.The objective of this work was to study the effect of different furrow opening mechanism and levels of load applied to soil firming mechanism on the initial development of soybean, in no-till system under different soil moisture. A split-split-plot experiment was used, in which the main treatments were three soil water contents (0.22, 0.24 e 0.26 kg kg-1), split-plots were two types of furrow opening mechanisms (furrow plough and double disk), and split-split-plots were three levels of load applied to soil firming mechanism (12.2, 18.5 and 24.1 kPa), using a randomized block design, with three replications. Distance between seeds, depth of seed allocation, soil porosity around the seed, emergence speed index, seedling emergence on field and soil resistance to penetration were analyzed. The furrow plough type of soil opening mechanism resulted in deeper seed allocation, higher soil porosity around the seed, smaller distance between seeds and smaller soil resistance to penetration. The pressure on the soil firming mechanism influences seedling emergence on field, when the furrow plough is used. The soil moisture influences the seed allocation and distance between seeds, the emergence speed index and the soil resistance to penetration