Impacto da pandemia COVID-19 no Pré-natal, Diabetes e consulta médica no Sistema Único de Saúde Brasileiro

Objectives: the purpose of this study was to describe the impact of the COVID-19 pandemic on Primary Health Care in Brazil. Methods: This retrospective ecological study was carried out using Brazilian municipality data obtained from the information systems of the National Public Health System. The outcomes were medical appointments, prenatal procedures and diabetes care. The exposure variable was the occurrence of the COVID-19 pandemic, based on the first case notified in Brazil. Multilevel mixed-effects negative binomial regression was used to analyze the association between the number of procedures per 10,000 inhabitants and COVID-19. Results: Data from 5,564 Brazilian municipalities were included in the present study. Regarding medical appointments, the largest reduction occasioned by the pandemic occurred in May (IRR = 0.27, CI 95% [0.24 – 0.30]). As far as prenatal procedures are concerned, the reduction was 65% (IRR= 0.35, CI 95% [0.32 – 0.38], also in May. In addition, diabetes care saw the biggest reductions in April 2020 (IRR = 0.24, CI 95% [0.11 – 0.53]) and May 2020 (IRR = 0.19, CI 95% [0.09 – 0.43]). From February to December 2020, the pandemic had a significant effect on the total number of procedures evaluated. Conclusion: The findings showed a reduction in prenatal procedures, diabetes and medical consultations performed in Brazil’s Primary Health Care, subsequent to the onset of the COVID-19 pandemic.Objetivos: o objetivo do estudo foi descrever o impacto da pandemia COVID-19 na Atenção Primária à Saúde Brasileira. Métodos: Estudo ecológico retrospectivo realizado com dados de municípios Brasileiros dos sistemas de informação do Sistema Único de Saúde. Os desfechos do estudo foram as consultas médicas, procedimentos de pré-natal e tratamento de diabetes. A exposição foi a ocorrência da pandemia de COVID-19, a partir do primeiro caso notificado no Brasil. Regressões binomiais negativas de efeitos mistos multinível foram utilizadas para analisar a associação entre o número de procedimentos por 10.000 habitantes e a pandemia de COVID-19. Resultados: Dados de 5.564 municípios brasileiros foram incluídos no presente estudo. Em relação à consulta médica, a maior redução devido à pandemia ocorreu em maio (IRR = 0,27, IC 95% [0,24 - 0,30]). Para os procedimentos de pré-natal, a redução foi de 65% (IRR= 0.35, IC 95% [0.32 – 0.38]) em maio. Ainda assim, os procedimentos de tratamento do diabetes tiveram maiores reduções em abril (IRR = 0,24, IC 95% [0,11 - 0,53]) e maio (IRR = 0,19, IC 95% [0,09 - 0,43]) de 2020. De fevereiro a dezembro de 2020 a pandemia impactou significantemente no total de procedimentos avaliados. Conclusão: Os achados mostraram uma redução de procedimentos de pré-natal, diabetes e consultas médicas realizadas na Atenção Primária à Saúde do Brasil, após o início da pandemia de COVID-19

Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review

The aim of presented systematic scoping review was to investigate the actual and future clinical possibilities of regenerative therapies and their ability to regenerate bone, periodontal and pulp with histological confirmation of the nature of formed tissue. Electronic search was conducted using a combination between Keywords and MeSH terms in PubMed, Scopus, ISI-Web of Science and Cochrane library databases up to January 2016. Two reviewers conducted independently the papers judgment. Screened studies were read following the predetermined inclusion criteria. The included studies were evaluated in accordance with Arksey and O’Malley’s modified framework. From 1349 papers, 168 completed inclusion criteria. Several characterized and uncharacterized cells used in Cell Therapy have provided bone regeneration, demonstrating bone gain in quantity and quality, even as accelerators for bone and periodontal regeneration. Synthetic and natural scaffolds presented good cell maintenance, however polyglycolid–polylactid presented faster resorption and consequently poor bone gain. The Growth Factor–Mediated Therapy was able to regenerate bone and all features of a periodontal tissue in bone defects. Teeth submitted to Revascularization presented an increase of length and width of root canal. However, formed tissues not seem able to deposit dentin, characterizing a repaired tissue. Both PRP and PRF presented benefits when applied in regenerative therapies as natural scaffolds. Therefore, most studies that applied regenerative therapies have provided promising results being possible to regenerate bone and periodontal tissue with histological confirmation. However, pulp regeneration was not reported. These results should be interpreted with caution due to the short follow-up periods

Triple-blinded randomized clinical trial comparing efficacy and tooth sensitivity of in-office and at-home bleaching techniques

Objective: Our study aims to compare the efficacy and tooth sensitivity following in-office (35% hydrogen peroxide) or at-home (10% carbamide peroxide) bleaching treatments both preceded by 2% potassium nitrate (2%KF) desensitizing gel. Methodology: 130 volunteers were randomly allocated to a) in-office bleaching and a placebo at-home protocol; or b) in-office placebo and at-home bleaching treatment. 2% KF was applied for 10 min before both treatments. Objective: color evaluation was performed (spectrophotometer CIEL*a*b* system and CIEDE2000) to calculate the color change (ΔE00). Subjective evaluation was performed using the VITA classical shade guide followed by shade variation (ΔSGU) at the beginning and end of bleaching treatment and 2 weeks post-bleaching. Tooth sensitivity was daily recorded using a Likert scale varying from 1 (no sensitivity) to 5 (severe sensitivity). Analysis was carried out using non-parametric tests. Results: Regarding the color change, at-home bleaching resulted in significant color improvement compared to in-office treatment for the parameters Δb* (p=0.003) and Δa* (p=0.014). Two weeks post-bleaching, the at-home treatment resulted in significant color improvement compared to in-office treatment for the parameters Δb* (p=0.037) and ΔE00 (p=0.033). No differences were observed in either ΔSGU parameters. Concerning sensitivity, patients treated with in-office bleaching reported more tooth sensitivity than the at-home group only on the first day after bleaching started, without significant differences in the other periods evaluated (p>0.05). Conclusions: At-home and in-office bleaching, preceded by a desensitizing agent, were effective for vital teeth bleaching and 10% carbamide peroxide produced a higher whitening effect than 35% hydrogen peroxide in the short time evaluation. Tooth sensitivity rates were similar for the two techniques tested

Does Cryopreservation Affect the Biological Properties of Stem Cells from Dental Tissues? A Systematic Review

This systematic review evaluated if different cryopreservation protocols could affect biological properties (Cell survival rate (CSR), proliferation, differentiation, maintenance of stem cell markers) of stem cells obtained from dental tissues (DSC) post-thaw. An electronic search was carried out within PubMed and ISI Web Science by using specific keyword. Two independent reviewers read the titles and abstracts of all reports respecting predetermined inclusion/exclusion criteria. Data were extracted considering the biological properties of previously cryopreserved DSCs and previously cryopreserved dental tissues. DSCs cryopreserved as soon as possible after their isolation presents a CSR quite similar to the non-cryopreserved DSC. Dimethyl sulfoxide (DMSO) [10%] showed good results related to cell recovery post-thaw to cryopreserve cells and tissues for periods of up to 2 years. The cryopreservation of DSC in a mechanical freezer (-80°C) allows the recovery of stem cells post-thaw. The facilities producing magnetic field (MF), demand a lower concentration of cryoprotectant, but their use is not dispensable. It is possible to isolate and cryopreserve dental pulp stem cell (DPSC) from healthy and diseased vital teeth. Cryopreservation of dental tissues for late DSC isolation, combined with MF dispensability, could be valuable to reduce costs and improve the logistics to develop teeth banks.This systematic review evaluated if different cryopreservation protocols could affect biological properties (Cell survival rate (CSR), proliferation, differentiation, maintenance of stem cell markers) of stem cells obtained from dental tissues (DSC) post-thaw. An electronic search was carried out within PubMed and ISI Web Science by using specific keyword. Two independent reviewers read the titles and abstracts of all reports respecting predetermined inclusion/exclusion criteria. Data were extracted considering the biological properties of previously cryopreserved DSCs and previously cryopreserved dental tissues. DSCs cryopreserved as soon as possible after their isolation presents a CSR quite similar to the non-cryopreserved DSC. Dimethyl sulfoxide (DMSO) [10%] showed good results related to cell recovery post-thaw to cryopreserve cells and tissues for periods of up to 2 years. The cryopreservation of DSC in a mechanical freezer (-80°C) allows the recovery of stem cells post-thaw. The facilities producing magnetic field (MF), demand a lower concentration of cryoprotectant, but their use is not dispensable. It is possible to isolate and cryopreserve dental pulp stem cell (DPSC) from healthy and diseased vital teeth. Cryopreservation of dental tissues for late DSC isolation, combined with MF dispensability, could be valuable to reduce costs and improve the logistics to develop teeth banks.This systematic review evaluated if different cryopreservation protocols could affect biological properties (Cell survival rate (CSR), proliferation, differentiation, maintenance of stem cell markers) of stem cells obtained from dental tissues (DSC) post-thaw. An electronic search was carried out within PubMed and ISI Web Science by using specific keyword. Two independent reviewers read the titles and abstracts of all reports respecting predetermined inclusion/exclusion criteria. Data were extracted considering the biological properties of previously cryopreserved DSCs and previously cryopreserved dental tissues. DSCs cryopreserved as soon as possible after their isolation presents a CSR quite similar to the non-cryopreserved DSC. Dimethyl sulfoxide (DMSO) [10%] showed good results related to cell recovery post-thaw to cryopreserve cells and tissues for periods of up to 2 years. The cryopreservation of DSC in a mechanical freezer (-80°C) allows the recovery of stem cells post-thaw. The facilities producing magnetic field (MF), demand a lower concentration of cryoprotectant, but their use is not dispensable. It is possible to isolate and cryopreserve dental pulp stem cell (DPSC) from healthy and diseased vital teeth. Cryopreservation of dental tissues for late DSC isolation, combined with MF dispensability, could be valuable to reduce costs and improve the logistics to develop teeth banks

A CULTURA DE PERIFERIA PARA O EMPODERAMENTO E O AUTOCUIDADO EM SAÚDE

CENTRO UNIVERSITÁRIO UNIVATE

Evaluation of factors that influencing amalgam restorations replacment by composite resins in posterior teeth in the life course: a study in a birth cohort.

Direct restorations are still the most frequently method used for the treatment of the sequelae of dental caries. Among the materials used for this purpose, the amalgam was the most used during the twentieth century and its use showed broad decline in recent decades mainly due to increase on esthetic demand and the absence of adhesion to tooth structure. With the improvement of adhesive systems, resin composites have become the materials of choice for professionals and patients, mainly due to high aesthetics provided by them. Replacement of amalgam for composite resin has been a common practice and this is due, in large part, to search for highly aesthetic patterns by patients. Thus, the aim of present study was to evaluate the occurrence and risk factors for replacement of amalgam posterior restorations for composite resins in individuals from 24 to 31 years old, in southern Brazil. A representative sample of all 5914 births in 1982 in Pelotas was prospectively investigated, and the posterior restorations were accessed at 24 (n=720) and 31 years of age (n=539). Individual-level variables (level 2) including demographic, socio-economic, oral health and dental service characteristics were collected from different waves of the cohort. Tooth-level variables (level 1) included dental group, estimated time in mouth and number of surfaces of restorations. A total of 246 individuals presented 718 amalgam restorations at 24 years. The occurrence of replacement in 7 years was 18.9%. Multilevel Poisson regression models showed that black people presented a lower risk for replacement of amalgam restorations for composite resin compared with white individuals (IRR – 0.39 (0.16 – 0.95)). The increase on educational level at age 31 was associated with increased risk for replacement of amalgam restorations. Individuals with 12 or more years of education presented more than four-fold risk to have their restorations replaced. Considering tooth-level variables, amalgam restorations with two or more surfaces at age 24 showed an IRR 2.80 times greater for replacement compared with those with only one surface. Both individual and tooth-related factors play a key role in choosing for replacement amalgam fillings by composite resin. Furthermore, substitution of amalgam restorations for composite resin in posterior teeth was a common procedure, even with a questionable aesthetic value.Sem bolsaAs restaurações diretas ainda são o método mais utilizado para o tratamento das sequelas da cárie dentária. Entre os materiais utilizados para esse fim, o amálgama foi o mais utilizado durante o século XX e seu uso mostrou grande declínio nas últimas décadas, principalmente devido ao aumento da demanda estética e à ausência de adesão à estrutura dentária. Com o avanço dos sistemas adesivos, as resinas compostas tornaram-se os materiais de escolha por profissionais e pacientes, principalmente devido à alta estética fornecida por eles. A substituição de amálgama por resina composta tem sido uma prática comum e isso se deve, em grande parte, à busca dos pacientes por padrões altamente estéticos. Assim, o objetivo do presente estudo foi avaliar a ocorrência e os fatores de risco para a substituição de restaurações posteriores de amálgama por resinas compostas em indivíduos do sul do Brasil, entre os 24 e 31 anos de idade. Uma amostra representativa de todos os 5914 nascimentos de 1982 em Pelotas foi investigada prospectivamente e as restaurações posteriores foram acessadas aos 24 (n=720) e aos 31 anos de idade (n=539). Foram coletadas variáveis de nível individual (nível 2), incluindo características demográficas, socioeconômicas, de saúde bucal e dentais de diferentes avaliações da coorte. As variáveis do nível dental (nível 1) incluíram o grupo dentário, o tempo estimado na boca e número de superfícies de restaurações. Um total de 246 indivíduos apresentaram 718 restaurações de amálgama aos 24 anos. A ocorrência de substituição em 7 anos foi de 18,9%. Os modelos de regressão de Poisson multinível mostraram que indivíduos negros apresentaram menor risco de substituição de restaurações de amálgama por resina composta em comparação com indivíduos brancos (IRR - 0,39 (0,16 - 0,95)). O aumento do nível educacional aos 31 anos foi associado ao aumento do risco de substituição de restaurações de amálgama. Indivíduos com 12 ou mais anos de educação apresentaram um risco maior que quatro vezes de ter suas restaurações substituídas. Considerando as variáveis de nível dental, as restaurações de amálgama com duas ou mais superfícies aos 24 anos mostraram um IRR 2,80 vezes maior para a substituição em comparação com aquelas com apenas uma superfície. Fatores individuais assim como os relacionados com os dentes desempenharam um papel fundamental na escolha da substituição de amálgama por resina composta. Além disso, a substituição de restaurações de amálgama por resina composta em dentes posteriores foi um procedimento comum, mesmo com um valor estético questionável

Influence and interactions (epistatic and geneenvironment) of SNPs on caries experience: evidence from systematic reviews and prospective studies

It is unquestionable - and the literature strongly supports - that the main factors for the development and progression of caries disease are related to biological, behavioral and socioeconomic factors. However, some individuals exposed to the same risk and/or protective factors may have a different pattern of caries occurrence. Thus, recent studies have investigated the possibility of genetic influence on the occurrence of dental caries, aiming to explain this part of the effect not explained by known risk factors. Therefore, the aim of the present study was to investigate the influence and interaction (epistatic and geneenvironment) of Single Nucluotide Polimorphysm (SNPs) on dental caries experience from systematic reviews and prospective studies in the 1982 Pelotas birth cohort. Systematic reviews and meta-analyzes were conducted to identify genetic polymorphisms and their effects on dental caries experience in adults and children. The search strategy was performed using relevant keywords and between MeSH terms considering the structure of each database (PubMed / MedLine, Scopus, ISI Web of Science, VHL - Virtual Health Library, Scielo). Only human studies were included with cross-sectional and/or longitudinal design. No language restrictions or period of publication were considered. Studies with literature review design, case reports and case series, conference abstracts, letters to the editor, and qualitative studies were excluded. After identifying SNPs and their estimated effects on dental caries experience in reviews, prospective studies were conducted to evaluate the impact and reproduction of the effects of these SNPs on the birth cohort. Thus, a representative sample of all 5,914 live births from the 1982 Pelotas cohort were prospectively investigated and the prevalence of caries was assessed at 15 years (n = 888), 24 (n = 720) and 31 years (n = 539). Group-Based trajectory modeling was used to identify groups with similar trajectories of CPO-D “decayed” component. Genetic material was collected, and SNPs related to genes (TUFT1, MMP20, MMP13, MMP2, DLX3, TIMP2, BMP7, TFIP11, TAS1R3, TAS1R2, CA6, MUC5B, AQP2, AQP5, LTF and MBL2) were genotyped. Genomic ancestry was evaluated using ADMIXTURE. Family income, sugar consumption and frequency and gingival bleeding were also investigated. We investigated epistatic interactions by the Generalized Multifactor Dimensionality Reduction (GMDR) software and gene-environment modification, inserting an interaction term between sugar consumption and genotype / allele. Parametric analysis by G-formula was used to analyze mediation effects. Results of the systematic reviews showed that the main SNPs associated with caries experience were: i) among the genes linked to dental mineral tissues the TFIP11, AMBN, VRD and AMELX ii) among the genes linked to the taste sensitivity genes TAS1R2, TAS1R3 and TAS2R38; iii) among the genes linked to salivary composition and salivary flow CA6, AQP5 and AQP2; iv) among the immune response genes MBL2 and MUC5B. Prospective studies found: i) an epistatic association involving rs243847 (MMP2), rs2303466 (DLX3) and rs388286 (BMP7) capable of increasing the dental caries trajectory (OR=2.51, 95%CI[1.54–4.09]); ii) SNP rs307355 (TAS1R3) was associated with high caries trajectory (OR=4.17, 95%CI[1.21– 14.42]) and showed an epistatic interaction with rs35874116 (TAS1R2) (OR=1.72, 95%CI [1.04-2.84]); iii) rs10875989 (AQP2) was associated with an elegant caries trajectory (OR=1.38, 95%CI [1.07–1.78]) and presented a three locus interaction with rs2274333 (CA6) and rs3759129 (AQP5) which increased the chances of being in the group of high caries trajectory (OR=2.31, 95%CI [1.53–3.47]); g-formula showed that the effect between rs10875989 (AQP2) and caries was mediated by gingival bleeding (p 0.05); iv) rs11716497 (LTF) was associated with high caries trajectory (OR=1.61, 95%CI [1.03–2.52]) and an epistatic interaction with rs4547741 (LTF) and rs11716497 (LTF) was also observed. G-formula showed that the association between rs11716497 (LTF) and caries trajectory had a direct effect and was not mediated by sugar intake (p <0.001). Thus, based on the results obtained from the systematic reviews and metaanalyzes added to the findings of prospective studies, we conclude that dental caries has an important genetic component capable of influence the caries experience and trajectory of individuals. In addition, epistatic interactions seem to play an important role in the genetic architecture of dental caries and environmental factors may modify the genetic effect on the phenotype.Sem bolsaÉ inquestionado – e a literatura suporta com forte evidência - que os principais fatores para o desenvolvimento e progressão da doença cárie são relacionados aos fatores biológicos, comportamentais e socioeconômicos. No entanto, alguns indivíduos expostos aos mesmos fatores de risco e/ou de proteção podem apresentar um padrão de ocorrência de cárie diferente. Desta forma, estudos recentes têm investigado a possibilidade de influência genética na ocorrência de cárie dental, objetivando explicar essa parte do efeito não explicada pelos fatores de risco já conhecidos. Desta forma, o objetivo do presente estudo foi investigar a influência e a interação (epistática e geneambiente) de Single Nucluotide Polimorphysm (SNPs) na experiência de cárie dental a partir de revisões sistemáticas e estudos prospectivos na coorte de nascimento de 1982 de Pelotas. Revisões sistemáticas e meta-análises foram conduzidas para identificar os polimorfismos genéticos e seus efeitos na experiência de cárie dental em adultos e crianças. A estratégia de pesquisa foi realizada utilizando palavras-chave relevantes e entre termos MeSH considerando a estrutura de cada base de dados (PubMed/MedLine, Scopus, ISI Web of Science, BVS - Biblioteca de saúde virtual, Scielo). Somente estudos em humanos foram incluídos com desenho transversal e/ou longitudinal. Não foram consideradas quaisquer restrições de idioma ou período de publicação. Estudos com desenho de revisões de literatura, relatos de casos e séries de casos, resumos de conferências, cartas para o editor e estudos qualitativos foram excluídos. Após a identificação dos SNPs e seus efeitos estimados sobre a experiência cárie dental nas revisões, conduziu-se estudos prospectivos para avaliar o impacto e a reprodução dos efeitos destes SNPs na coorte de nascimentos. Assim, uma amostra representativa de todos os 5,914 nascidos vivos da coorte de Pelotas de 1982 foram prospectivamente investigados e a prevalência de cárie foi acessada aos 15 anos (n=888), 24 (n=720) e 31 anos (n=539). Group-Based trajectory modeling foi utilizado para identificar grupos com trajetórias semelhantes do compodente “cariado” do CPO-D. O material genético foi coletado e SNPs relativos aos genes (TUFT1, MMP20, MMP13, MMP2, DLX3, TIMP2, BMP7, TFIP11, TAS1R3, TAS1R2, CA6, MUC5B, AQP2, AQP5, LTF e MBL2) foram genotipados. A ancestralidade genômica foi avaliada usando ADMIXTURE. Também foram investigadas renda familiar, consumo e frequência de açúcar e sangramento gengival. Investigamos interações epistáticas pelo software Generalized Multifactor Dimensionality Reduction (GMDR) e também modificação gene-ambiente, inserindo um termo de interação entre consumo de açúcar e genótipo / alelo. Análise paramétrica por G-fórmula foi utilizada para analisar efeitos de mediação. Resultados das revisões sistemáticas apresentaram que os principais SNPs associados com experiência de cárie foram: i) dentre os genes ligados aos tecidos minerais dentais o TFIP11, AMBN, VRD e AMELX ii) dentre os genes ligados aos genes da sensibilidade gustatória o TAS1R2, TAS1R3 e TAS2R38 ; iii) dentre os genes ligados à composição e fluxo salivar o CA6, AQP5 e AQP2; iv) dentre os genes da resposta imune o MBL2 e MUC5B. Estudos prospectivos encontraram: i) uma associação epistática envolvendo rs243847 (MMP2), rs2303466 (DLX3) e rs388286 (BMP7) capaz de aumentar a trajetória de cárie dental (OR=2.51, CI95%[1.54–4.09]); ii) O SNP rs307355 (TAS1R3) foi associado com elevada trajetória de cárie (OR=4.17, CI95%[1.21–14.42]) e apresentou uma interação epistática com rs35874116 (TAS1R2) (OR=1.72, CI95%[1.04-2.84]); iii) rs10875989 (AQP2) foi associado com elegada trajetória de cárie (OR=1.38 CI95%[1.07–1.78]) e apresentou uma interação de três locus com rs2274333 (CA6) e rs3759129 (AQP5) que elevou a chances de estar no grupo de elevada trajetória de cárie (OR=2.31, CI95%[1.53–3.47]); g-formula mostrou que o efeito entre rs10875989 (AQP2) e cárie foi mediada pelo sangramento gengival (p0.05). iv) rs11716497 (LTF) foi associada com elevada trajetória de cárie (OR=1.61, CI95% [1.03–2.52]) e uma interação epistática com rs4547741 (LTF) e rs11716497 (LTF) também foi observada. G-fórmula mostrou que a associação entre rs11716497 (LTF) e trajetória de cárie teve um efeito direto e não foi mediada pelo consumo de açúcar (p<0.001). Assim, baseado nos resultados obtidos a partir das revisões sistemáticas e meta-análises somado com os achados dos estudos prospectivos, concluímos que a cárie dental apresenta um componente genético importante capaz de influenciar a experiência e a trajetória de cárie dos indivíduos. Além disso, interações epistáticas parecem desempenhar um papel importante na arquitetura genética da cárie dental e fatores ambientais podem modificar o efeito genético no fenótipo

Therapeutic effect of cannabidiol in oral mucosa lesions: a scoping review

The forthcoming scoping review will be conducted with the question in mind: "Is there a therapeutic effect of the use of cannabidiol on lesions of the oral mucosa?"

Qual é a distribuição dos cursos de odontologia e de dentistas no Brasil?: um estudo ecológico descritivo

O objetivo deste estudo ecológico descritivo foi descrever a distribuição dos CO e de CDs nas distintas macrorregiões no Brasil, considerando dados acumulados até o ano de 2021

Influence of cannabis use on periodontal disease : a Scoping Review

Recientes publicaciones plantean la posible asociación del cannabis (Cannabis sativa) con el desarrollo de la periodontitis. Objetivo: Analizar la influencia del consumo de cannabis en la enfermedad periodontal, relevando la evidencia disponible e identificando las variables asociadas en los estudios. Material y método: se realizó una Scoping Review a partir de una búsqueda estructurada en PubMed/ MEDLINE, Science Direct, LILACS, SciELO hasta mayo de 2017 . Resultados: Estudios “In vivo” mostraron una mayor pérdida ósea en animales expuestos a Cannabis. Los casos clínicos muestran que el uso crónico de cannabis puede resultar en agrandamientos gingivales y periodontitis crónica severa localizada. Los estudios epidemiológicos demuestran una asociación estadística entre Cannabis y periodontitis. Conclusiones: El consumo del Cannabis parece estar asociado con una mayor presencia de periodontitis. Sin embargo, se desconoce el mecanismo específico por el cual actúa en los tejidos gingivales.Recent publications suggest the possible association between cannabis (Cannabis sativa) and periodontitis. Objective: To analyze the possible influence of cannabis use on periodontal disease, highlighting the available evidence and identifying the associated variables in the studies. Materials and methods: We conducted a scoping review applying a structured search method in PubMed/MEDLINE, Science Direct, LILACS, SciELO including publications until May 2017. Results: In vivo studies showed greater bone loss in animals exposed to cannabis. Clinical cases show that chronic cannabis use may result in gingival enlargement (with clinical features similar to phenytoin induced enlargement) and localized severe chronic periodontitis. Most of the epidemiological studies confirmed the possible association between cannabis and periodontitis. Conclusions: The specific mechanism by which cannabis acts in the gingival tissues is unknown