Notulae to the Italian native vascular flora: 4

In this contribution new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, exclusion, extinction and confirmations to the Italian administrative regions for taxa in the genera Androsace, Artemisia, Fragaria, Melampyrum, Myosotis, Petrorhagia, Phillyrea, Rosa, Rumex, Spiranthes, Trifolium, and Vicia. Furthermore, a new combination in the genus Omalotheca is proposed

Notulae to the Italian native vascular flora: 1

In this contribution, new data concerning the Italian distribution of native vascular flora are presented. It includes new records, exclusions, and confirmations pertaining to the Italian administrative regions for taxa in the genera Arundo, Bromopsis, Cistus, Crocus, Festuca, Galeopsis, Genista, Lamium, Leucanthemum, Nerium, Orobanche, Peucedanum, Pilosella, Polycnemum, Stipa and Viola

Notulae to the Italian alien vascular flora: 1

In this contribution, new data concerning the Italian distribution of alien vascular flora are presented. It includes new records, exclusions, and confirmations for Italy or for Italian administrative regions for taxa in the genera Agave, Arctotheca, Berberis, Bidens, Cardamine, Catalpa, Cordyline, Cotoneaster, Dichondra, Elaeagnus, Eragrostis, Impatiens, Iris, Koelreuteria, Lamiastrum, Lantana, Ligustrum, Limnophila, Lonicera, Lycianthes, Maclura, Mazus, Paspalum, Pelargonium, Phyllanthus, Pyracantha, Ruellia, Sorghum, Symphyotrichum, Triticum, Tulbaghia and Youngia

Allium cyrilli Tenore 1827

Allium cyrilli Tenore (1827: 364). Type: — ITALY. Apulia: Foggia, s.d., Tenore s.n. (lectotype NAP!, here designated). Tenore's protologue consists of a diagnosis, referring also to " Allium fragrans ", an unpublished name and illustration by Domenico Cirillo (1739–1799). Unfortunately, Cirillo's collections were destroyed when he was murdered (Stafleu & Cowan 1976). Moreover, we have been unable to find the illustration cited by Tenore, but in his Herbarium in NAP we found a specimen collected in Foggia, Apulia, originally labelled as " Allium fragrans Cyrill. " and then as " Allium Cyrilli Nob. " (Fig. 1). In the protologue, the author quotes " né campi di Puglia, al Tavoliere " as locus classicus for this species. Foggia is a city within the "Tavoliere" area (a plain located in northern Apulia). Accordingly, this specimen can be considered as original material for the name and it is here selected as the lectotype.Published as part of Peruzzi, Lorenzo, Adorni, Michele, Dura, Teodoro, Ghillani, Luigi, Pasquali, Giancarlo, Rignanese, Luigi, Ronconi, Daniele & Teruzzi, Maurizio, 2012, Allium cyrilli (Amaryllidaceae): typification, taxonomy and update of the Italian distribution, pp. 53-58 in Phytotaxa 71 (1) on page 54, DOI: 10.11646/phytotaxa.71.1.11, http://zenodo.org/record/506640

Notulae to the Italian native vascular flora: 2

In this contribution new data concerning the Italian distribution of native vascular flora are presented. It includes new records, exclusions, and confirmations to the Italian administrative regions for taxa in the genera Arctostaphylos, Artemisia, Buglossoides, Convolvulus, Crocus, Damasonium, Epipogium, Ficaria, Filago, Genista, Heptaptera, Heracleum, Heteropogon, Hieracium, Myosotis, Ononis, Papaver, Pilosella, Polygonum, Pulmonaria, Scorzonera, Silene, Trifolium, Vicia and Viola

Notulae to the Italian native vascular flora: 15

In this contribution, new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, confirmations, and exclusions to the Italian administrative regions. New combinations in the genera Pilosella and Roemeria are proposed. Furthermore, the name Papaver siculum is lectotypified. Nomenclatural and distribution updates, published elsewhere, and corrigenda are provided as Suppl. material 1

Notulae to the Italian native vascular flora: 16

In this contribution, new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, confirmations, and exclusions to the Italian administrative regions. Nomenclatural and distribution updates, published elsewhere, and corrigenda are provided as supplementary material

Notulae to the Italian native vascular flora: 16

In this contribution, new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, confirmations, and exclusions to the Italian administrative regions. Nomenclatural and distribution updates, published elsewhere, and corrigenda are provided as supplementary material. © (2023) Fabrizio Bartolucci et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

: Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs)1,2, conferring a predisposition to life-threatening COVID-19 pneumonia3. Here we report that patients with autosomal recessive NIK or RELB deficiency, or a specific type of autosomal-dominant NF-κB2 deficiency, also have neutralizing autoantibodies against type I IFNs and are at higher risk of getting life-threatening COVID-19 pneumonia. In patients with autosomal-dominant NF-κB2 deficiency, these autoantibodies are found only in individuals who are heterozygous for variants associated with both transcription (p52 activity) loss of function (LOF) due to impaired p100 processing to generate p52, and regulatory (IκBδ activity) gain of function (GOF) due to the accumulation of unprocessed p100, therefore increasing the inhibitory activity of IκBδ (hereafter, p52LOF/IκBδGOF). By contrast, neutralizing autoantibodies against type I IFNs are not found in individuals who are heterozygous for NFKB2 variants causing haploinsufficiency of p100 and p52 (hereafter, p52LOF/IκBδLOF) or gain-of-function of p52 (hereafter, p52GOF/IκBδLOF). In contrast to patients with APS-1, patients with disorders of NIK, RELB or NF-κB2 have very few tissue-specific autoantibodies. However, their thymuses have an abnormal structure, with few AIRE-expressing medullary thymic epithelial cells. Human inborn errors of the alternative NF-κB pathway impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases