Effect of level of dietary soluble fibre and threonine on digestion and growth performance in post-weaning rabbits

The aim of this work was to study the effect of soluble fibre and threonine deficiency on digestion and performance after weaning in rabbits. Four diets in a 2 x 2 factorial arrangement were used with two level of soluble fibre (89 vs.119 g/kg) and two level of threonine (5 vs. 6.4 g/kg). Two experiments were conducted with rabbits weaned at 25 (35/diet) and 35 (32/diet) d of age to determine apparent ileal (at 35 and 46 d) and faecal digestibility, intestinal mucin concentration, mucosa morphology and growth traits. The increase of soluble fibre improved intestinal mucosa integrity and mucin secretion leading to a better health status of the rabbits when the sanitary conditions worsened. Mucosa barrier traits were not affected by dietary threonine level although in poor sanitary conditions a low threonine level impaired rabbit health suggesting a limiting status of this amino acid

Psychoeducational intervention to improve oral assessment in people with autism spectrum disorder, BIO-BIO region, Chile

Lichen planus (LP) is a chronic autoimmune disease that affects the oral mucosa as well as the skin, genital mucosa and other sites. Objective: to evaluate the correlation between oral, genital and cutaneous lichen planus, in a sample of LP patients. This descriptive study reviewed 274 clinical histories of patients, who all presented histological confirmation of lichen planus verified by a pathologist, attending research centers in Barcelona. A total of 40 LP patients (14.59%) presented genital lesions. Of 131 patients with cutaneous LP (47.8%), the most commonly affected zones were the body?s flexor surfaces, representing 60.1% of cases. 24% of patients (n=55) related the start of the lesions with previous stress events. Of the 131 subjects with cutaneous lesions, 19% (n=25) also presented oral lichen planus (OLP). Of the total sample, 53.6% (n=147) of patients presented oral lesions. The systemic diseases most commonly associated with this patient sample were psychological problems such as stress, anxiety and depression (48%), hypertension (27%), gastric problems (12%), and diabetes (9.7%). A family history of lichen planus was found in only 2 cases (0,72%) out of the total of 274. Any patient with OLP should undergo a thorough history and examination to investigate potential extraoral manifestations. The fact that 37 patients with OLP in this series were identified with simultaneous involvement at more than one site highlights the need for exhaustive evaluation and multidisciplinary approaches to this disease

Near-infrared spectroscopy StO monitoring to assess the therapeutic effect of drotrecogin alfa (activated) on microcirculation in patients with severe sepsis or septic shock

Sepsis is a leading cause of death despite appropriate management. There is increasing evidence that microcirculatory alterations might persist independently from macrohemodynamic improvement and are related to clinical evolution. Future efforts need to be directed towards microperfusion monitoring and treatment. This study explored the utility of thenar muscle oxygen saturation (StO) and its changes during a transient vascular occlusion test (VOT) to measure the microcirculatory response to drotrecogin alfa (activated) (DrotAA) in septic patients. A prospective, observational study was performed in three general intensive care units at three university hospitals. We studied 58 patients with recent onset of severe sepsis or septic shock and at least two organ dysfunctions. Thirty-two patients were treated with DrotAA and 26 were not treated because of formal contraindication. StO was monitored using near-infrared spectroscopy (NIRS), and VOT was performed to obtain deoxygenation (DeOx) and reoxygenation (ReOx) slopes. Measurements were obtained before DrotAA was started and were repeated daily for a 96-hour period. Patients' characteristics, outcome, severity, and baseline values of StO, DeOx, and ReOx did not differ between groups. Treated patients significantly improved DeOx and ReOx values over time, whereas control patients did not. In treated patients, ReOx improvements were correlated to norepinephrine dose reductions. Early clinical response (SOFA improvement after 48 hours of treatment) was not associated to changes in VOT-derived slopes. In the treated group, the relative improvement of DeOx within 48 hours was able to predict mortality (AUC 0.91, p < 0.01). In patients with severe sepsis or septic shock, DrotAA infusion was associated with improvement in regional tissue oxygenation. The degree of DeOx amelioration after 2 days in treated patients predicted mortality with high sensitivity and specificity. Thus, StO derived variables might be useful to evaluate the microcirculatory response to treatment of septic shock

Near-infrared spectroscopy StO2 monitoring to assess the therapeutic effect of drotrecogin alfa (activated) on microcirculation in patients with severe sepsis or septic shock

BACKGROUND: Sepsis is a leading cause of death despite appropriate management. There is increasing evidence that microcirculatory alterations might persist independently from macrohemodynamic improvement and are related to clinical evolution. Future efforts need to be directed towards microperfusion monitoring and treatment. This study explored the utility of thenar muscle oxygen saturation (StO(2)) and its changes during a transient vascular occlusion test (VOT) to measure the microcirculatory response to drotrecogin alfa (activated) (DrotAA) in septic patients. METHODS: A prospective, observational study was performed in three general intensive care units at three university hospitals. We studied 58 patients with recent onset of severe sepsis or septic shock and at least two organ dysfunctions. Thirty-two patients were treated with DrotAA and 26 were not treated because of formal contraindication. StO(2) was monitored using near-infrared spectroscopy (NIRS), and VOT was performed to obtain deoxygenation (DeOx) and reoxygenation (ReOx) slopes. Measurements were obtained before DrotAA was started and were repeated daily for a 96-hour period. RESULTS: Patients’ characteristics, outcome, severity, and baseline values of StO(2), DeOx, and ReOx did not differ between groups. Treated patients significantly improved DeOx and ReOx values over time, whereas control patients did not. In treated patients, ReOx improvements were correlated to norepinephrine dose reductions. Early clinical response (SOFA improvement after 48 hours of treatment) was not associated to changes in VOT-derived slopes. In the treated group, the relative improvement of DeOx within 48 hours was able to predict mortality (AUC 0.91, p < 0.01). CONCLUSIONS: In patients with severe sepsis or septic shock, DrotAA infusion was associated with improvement in regional tissue oxygenation. The degree of DeOx amelioration after 2 days in treated patients predicted mortality with high sensitivity and specificity. Thus, StO(2) derived variables might be useful to evaluate the microcirculatory response to treatment of septic shock

Sites of interest in valle de Antinaco-Los Colorados, La Rioja province, Argentina

El Valle de Antinaco-Los Colorados, ubicado en el centro norte de la provincia de La Rioja, y su área de influencia, presentan una gran diversidad de sitios de interés geológico, arqueológico y turístico. Con el fin de destacar su valor natural, histórico y cultural, y utilizando como base la recopilación y análisis de la información bibliográfica, gráfica y de trabajos científicos, así como observaciones de campo, se procedió a realizar un análisis de ellos. Las características distintivas (geológicas, geomorfológicas y arqueológicas) de cada lugar, los convierten en sitios turísticos muy visitados, repercutiendo en el desarrollo socio-económico de la zona. El conocimiento de estas áreas de interés y su difusión, contribuyen a su puesta en valor y favorece la conservación y preservación por parte de la sociedad, siendo fundamental para no alterar el medioambiente en el que se encuentran y dar sustentabilidad a la actividad que generan.Antinaco-Los Colorados valley is located in the northern central part of La Rioja province. It and its area of influence have a great diversity of geological, archaeological and tourist sites of interest. In order to highlight its natural, historical and cultural value, they were analyzed through the collection and analysis of the bibliographic, graphic and scientific information together with field observations in the study area. The distinctive (geological, geomorphological and archaeological) characteristics of each place make them very popular tourist sites, influencing the socio-economic development of the area. Knowledge improvement of these areas of interest and its diffusion, contribute to value and promote their conservation and preservation by the society. This is essential not to alter their environment and make their activity sustainable.Facultad de Ciencias Naturales y Muse

Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1.

Anxiety and stress disorders are often characterized by an inability to extinguish learned fear responses. Orexins/ hypocretins are involved in the modulation of aversive memories, and dysregulation of this system may contribute to the aetiology of anxiety disorders characterized by pathological fear. The mechanisms by which orexins regulate fear are unknown. Here we investigated the role of the endogenous cannabinoid system in the impaired fear extinction induced by orexin-A (OXA) in male mice. The selective inhibitor of 2-arachidonoylglycerol (2-AG) biosynthesis O7460 abolished the fear extinction deficits induced by OXA. Accordingly, increased 2- AG levels were observed in the amygdala and hippocampus of mice treated with OXA that do not extinguish fear, suggesting that high levels of this endocannabinoid are related to poor extinction. Impairment of fear extinction induced by OXA was associated with increased expression of CB2 cannabinoid receptor (CB2R) in microglial cells of the basolateral amygdala. Consistently, the intra-amygdala infusion of the CB2R antagonist AM630 completely blocked the impaired extinction promoted by OXA. Microglial and CB2R expression depletion in the amygdala with PLX5622 chow also prevented these extinction deficits. These results show that overactivation of the orexin system leads to impaired fear extinction through 2-AG and amygdalar CB2R. This novel mechanism could be of relevance for the development of novel potential approaches to treat diseases associated with inappropriate retention of fear, such as post-traumatic stress disorder, panic anxiety and phobias.post-print3418 K

Robótica y fenotipado de alta capacidad con relevamiento de datos en campo : Aplicaciones en agricultura de precisión

En la UNNOBA se está trabajando en la aplicación combinada de diferentes desarrollos tecnológicos y Agricultura de Precisión. Ambas áreas de estudio constituyen una herramienta fundamental para lograr un manejo adecuado y preciso del suelo y sus cultivos en base a su variabilidad dentro de un lote, permitiendo adaptarse a las exigencias de la agricultura moderna en el manejo óptimo de grandes extensiones. El uso de herramientas tecnológicas orientadas al uso de imágenes y sensores (GPS, sensores, UAVs) en la agricultura de precisión, permite diferenciar variabilidad y características particulares de diferentes coberturas terrestres para mejorar la toma de decisiones en pos de obtener mayores rendimientos. En la actualidad se encuentran muchos trabajos de investigación que utilizan imágenes de sensado remoto (satélites, áreas). La presente línea de investigación pretende aportar desde otra perspectiva mediante el uso plataformas robóticas de sensado a campo y el uso de imágenes digitales capturadas con cámaras de luz visible, multi o hiper espectrales, térmicas, más la utilización de técnicas de procesamiento digital, con el fin de aportar un valor agregado a las tecnologías ya existentes en esta área. Esto permitirá mejorar el estudio de aspectos cualitativos y cuantitativos de diferentes tipos de cultivos en relación a su variabilidad fenológica, morfológica, fisiológica, temporal y espacial.Eje: Procesamiento de Señales y Sistemas de Tiempo RealRed de Universidades con Carreras en Informática (RedUNCI

Robótica y fenotipado de alta capacidad con relevamiento de datos en campo : Aplicaciones en agricultura de precisión

En la UNNOBA se está trabajando en la aplicación combinada de diferentes desarrollos tecnológicos y Agricultura de Precisión. Ambas áreas de estudio constituyen una herramienta fundamental para lograr un manejo adecuado y preciso del suelo y sus cultivos en base a su variabilidad dentro de un lote, permitiendo adaptarse a las exigencias de la agricultura moderna en el manejo óptimo de grandes extensiones. El uso de herramientas tecnológicas orientadas al uso de imágenes y sensores (GPS, sensores, UAVs) en la agricultura de precisión, permite diferenciar variabilidad y características particulares de diferentes coberturas terrestres para mejorar la toma de decisiones en pos de obtener mayores rendimientos. En la actualidad se encuentran muchos trabajos de investigación que utilizan imágenes de sensado remoto (satélites, áreas). La presente línea de investigación pretende aportar desde otra perspectiva mediante el uso plataformas robóticas de sensado a campo y el uso de imágenes digitales capturadas con cámaras de luz visible, multi o hiper espectrales, térmicas, más la utilización de técnicas de procesamiento digital, con el fin de aportar un valor agregado a las tecnologías ya existentes en esta área. Esto permitirá mejorar el estudio de aspectos cualitativos y cuantitativos de diferentes tipos de cultivos en relación a su variabilidad fenológica, morfológica, fisiológica, temporal y espacial.Eje: Procesamiento de Señales y Sistemas de Tiempo RealRed de Universidades con Carreras en Informática (RedUNCI

Robótica y fenotipado de alta capacidad con relevamiento de datos en campo : Aplicaciones en agricultura de precisión

En la UNNOBA se está trabajando en la aplicación combinada de diferentes desarrollos tecnológicos y Agricultura de Precisión. Ambas áreas de estudio constituyen una herramienta fundamental para lograr un manejo adecuado y preciso del suelo y sus cultivos en base a su variabilidad dentro de un lote, permitiendo adaptarse a las exigencias de la agricultura moderna en el manejo óptimo de grandes extensiones. El uso de herramientas tecnológicas orientadas al uso de imágenes y sensores (GPS, sensores, UAVs) en la agricultura de precisión, permite diferenciar variabilidad y características particulares de diferentes coberturas terrestres para mejorar la toma de decisiones en pos de obtener mayores rendimientos. En la actualidad se encuentran muchos trabajos de investigación que utilizan imágenes de sensado remoto (satélites, áreas). La presente línea de investigación pretende aportar desde otra perspectiva mediante el uso plataformas robóticas de sensado a campo y el uso de imágenes digitales capturadas con cámaras de luz visible, multi o hiper espectrales, térmicas, más la utilización de técnicas de procesamiento digital, con el fin de aportar un valor agregado a las tecnologías ya existentes en esta área. Esto permitirá mejorar el estudio de aspectos cualitativos y cuantitativos de diferentes tipos de cultivos en relación a su variabilidad fenológica, morfológica, fisiológica, temporal y espacial.Eje: Procesamiento de Señales y Sistemas de Tiempo RealRed de Universidades con Carreras en Informática (RedUNCI