The hippocampus as an indexing machine of episodic memory

Episodic memories refer to our ability to encode and reinstate experiences. By extension, these memories shape how we view ourselves and the world around us. Despite this, little is known about how neurons in the hippocampus encode and retrieve new episodes. Here, I will demonstrate evidence for single neurons in the human hippocampus that code specific episodic memories (hence called Episode Specific Neurons), both through a rate code and a temporal code. Importantly, these neurons cannot be construed as coding for specific timepoints or concepts. Next, I will extend these findings to population activity in the local field potential. I report evidence for a reinstatement in high frequency power during successful memory processing that mirrors earlier findings in single neurons. Again, these results cannot be explained by activity induced by a content-code. Despite the undisputed importance of theta activity in memory processing, we find no consistent evidence of an increase in theta power during memory processing. Likewise, we find no evidence that earlier identified Episode Specific Neurons or other hippocampal neurons fire preferentially at a particular theta phases or theta phase offsets between encoding or retrieval of episodic memories. Lastly, I embed these findings in the broader literature, identify future experiments, and discuss possible translational applications

Insight and Dissociation in Lucid Dreaming and Psychosis

Dreams and psychosis share several important features regarding symptoms and underlying neurobiology, which is helpful in constructing a testable model of, for example, schizophrenia and delirium. The purpose of the present communication is to discuss two major concepts in dreaming and psychosis that have received much attention in the recent literature: insight and dissociation. Both phenomena are considered functions of higher order consciousness because they involve metacognition in the form of reflective thought and attempted control of negative emotional impact. Insight in dreams is a core criterion for lucid dreams. Lucid dreams are usually accompanied by attempts to control the dream plot and dissociative elements akin to depersonalization and derealization. These concepts are also relevant in psychotic illness. Whereas insightfulness can be considered innocuous in lucid dreaming and even advantageous in psychosis, the concept of dissociation is still unresolved. The present review compares correlates and functions of insight and dissociation in lucid dreaming and psychosis. This is helpful in understanding the two concepts with regard to psychological function as well as neurophysiology

Hippocampal neurons code individual episodic memories in humans

The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations remains unknown. In particular, it is debated whether each hippocampal neuron represents an invariant element within an episode or whether single neurons bind together all the elements of a discrete episodic memory. Here we provide evidence for the latter hypothesis. Using single-neuron recordings from a total of 30 participants, we show that individual neurons, which we term episode-specific neurons, code discrete episodic memories using either a rate code or a temporal firing code. These neurons were observed exclusively in the hippocampus. Importantly, these episode-specific neurons do not reflect the coding of a particular element in the episode (that is, concept or time). Instead, they code for the conjunction of the different elements that make up the episode

Insight and dissociation in lucid dreaming and psychosis

Dreams and psychosis share several important features regarding symptoms and underlying neurobiology, which is helpful in constructing a testable model of, for example, schizophrenia and delirium. The purpose of the present communication is to discuss two major concepts in dreaming and psychosis that have received much attention in the recent literature: insight and dissociation. Both phenomena are considered functions of higher order consciousness because they involve metacognition in the form of reflective thought and attempted control of negative emotional impact. Insight in dreams is a core criterion for lucid dreams. Lucid dreams are usually accompanied by attempts to control the dream plot and dissociative elements akin to depersonalization and derealization. These concepts are also relevant in psychotic illness. Whereas insightfulness can be considered innocuous in lucid dreaming and even advantageous in psychosis, the concept of dissociation is still unresolved. The present review compares correlates and functions of insight and dissociation in lucid dreaming and psychosis. This is helpful in understanding the two concepts with regard to psychological function as well as neurophysiology

The Brain Time Toolbox, a software library to retune electrophysiology data to brain dynamics

Human thought is highly flexible, achieved by evolving patterns of brain activity across groups of cells. Neuroscience aims to understand cognition in the brain by analysing these intricate patterns. We argue that this goal is impeded by the time format of our data—clock time. The brain is a system with its own dynamics and regime of time, with no intrinsic concern for the human-invented second. Here, we present the Brain Time Toolbox, a software library that retunes electrophysiology data in line with oscillations that orchestrate neural patterns of cognition. These oscillations continually slow down, speed up and undergo abrupt changes, introducing a disharmony between the brain’s internal regime and clock time. The toolbox overcomes this disharmony by warping the data to the dynamics of coordinating oscillations, setting oscillatory cycles as the data’s new time axis. This enables the study of neural patterns as they unfold in the brain, aiding neuroscientific enquiry into dynamic cognition. In support of this, we demonstrate that the toolbox can reveal results that are absent in a default clock time format

Theta rhythmicity governs human behavior and hippocampal signals during memory-dependent tasks.

Memory formation and reinstatement are thought to lock to the hippocampal theta rhythm, predicting that encoding and retrieval processes appear rhythmic themselves. Here, we show that rhythmicity can be observed in behavioral responses from memory tasks, where participants indicate, using button presses, the timing of encoding and recall of cue-object associative memories. We find no evidence for rhythmicity in button presses for visual tasks using the same stimuli, or for questions about already retrieved objects. The oscillations for correctly remembered trials center in the slow theta frequency range (1-5 Hz). Using intracranial EEG recordings, we show that the memory task induces temporally extended phase consistency in hippocampal local field potentials at slow theta frequencies, but significantly more for remembered than forgotten trials, providing a potential mechanistic underpinning for the theta oscillations found in behavioral responses

Theta rhythmicity governs human behavior and hippocampal signals during memory-dependent tasks.

Memory formation and reinstatement are thought to lock to the hippocampal theta rhythm, predicting that encoding and retrieval processes appear rhythmic themselves. Here, we show that rhythmicity can be observed in behavioral responses from memory tasks, where participants indicate, using button presses, the timing of encoding and recall of cue-object associative memories. We find no evidence for rhythmicity in button presses for visual tasks using the same stimuli, or for questions about already retrieved objects. The oscillations for correctly remembered trials center in the slow theta frequency range (1-5 Hz). Using intracranial EEG recordings, we show that the memory task induces temporally extended phase consistency in hippocampal local field potentials at slow theta frequencies, but significantly more for remembered than forgotten trials, providing a potential mechanistic underpinning for the theta oscillations found in behavioral responses

Oscillations support short latency co-firing of neurons during human episodic memory formation

Theta and gamma oscillations in the medial temporal lobe are suggested to play a critical role for human memory formation via establishing synchrony in neural assemblies. Arguably, such synchrony facilitates efficient information transfer between neurons and enhances synaptic plasticity, both of which benefit episodic memory formation. However, to date little evidence exists from humans that would provide direct evidence for such a specific role of theta and gamma oscillations for episodic memory formation. Here, we investigate how oscillations shape the temporal structure of neural firing during memory formation in the medial temporal lobe. We measured neural firing and local field potentials in human epilepsy patients via micro-wire electrode recordings to analyze whether brain oscillations are related to co-incidences of firing between neurons during successful and unsuccessful encoding of episodic memories. The results show that phase-coupling of neurons to faster theta and gamma oscillations correlates with co-firing at short latencies (~20–30 ms) and occurs during successful memory formation. Phase-coupling at slower oscillations in these same frequency bands, in contrast, correlates with longer co-firing latencies and occurs during memory failure. Thus, our findings suggest that neural oscillations play a role for the synchronization of neural firing in the medial temporal lobe during the encoding of episodic memories

Lietuvos filosofijos topografinis žemėlapis

The article seeks to mark out the contours of the map of Lithuanian philosophy. The concentration is not on specific theories created by the philosophers in Lithuania, but on the conditions of philosophizing itself. While considering the conditions under which philosophy operates in Lithuania, its critical condition has been fixed during the post-Soviet period more than once. The crisis was considered to have been caused by two major factors. First, the discontinuity of time - lack of solid linear philosophical traditions resulting after the interruption of "organic" evolution of philosophy during the Soviet regime and under the intrusion of its thinking cliché. Second, the spatial discontinuity - transition of intellectual problems started in the West to Lithuanian situation, inevitably losing the relevance and contextuality of the themes being transferred. It is stated that in both cases, the Lithuanian philosophy was regarded from the notions of "backwardness", "delay", "lack", "slowdown" or even "stagnant development, "the need for catch-up" positions. The article argues that the thinking on the basis of these concepts, the situation of philosophy remains fundamentally untouched in Lithuania. Essential characteristic of philosophy in Lithuania is believed to be its "strategic" nature. Strategic and overall thinking which lays claims to the final answer denies an interactive or critical position in respect of its own is not able to respond to new challenges, and classifies and mummifies the history of philosophy. As an alternative to "strategic" position, the "tactical" philosophy is emphasized which does not lay claim to the universality but is open to the risk, alterity and critical re-thinking