Real-time Cosmology

In recent years the possibility of measuring the temporal change of radial and transverse position of sources in the sky in real time have become conceivable thanks to the thoroughly improved technique applied to new astrometric and spectroscopic experiments, leading to the research domain we call Real-time cosmology. We review for the first time great part of the work done in this field, analysing both the theoretical framework and some endeavor to foresee the observational strategies and their capability to constrain models. We firstly focus on real time measurements of the overall redshift drift and angular separation shift in distant source, able to trace background cosmic expansion and large scale anisotropy, respectively. We then examine the possibility of employing the same kind of observations to probe peculiar and proper acceleration in clustered systems and therefore the gravitational potential. The last two sections are devoted to the short time future change of the cosmic microwave background, as well as to the temporal shift of the temperature anisotropy power spectrum and maps. We conclude revisiting in this context the effort made to forecast the power of upcoming experiments like CODEX, GAIA and PLANCK in providing these new observational tools.Comment: 44 pages, 23 figures. References added; revised text, tables and plots. Accepted for publication in Physics Report

Cosmic Parallax as a probe of late time anisotropic expansion

Cosmic parallax is the change of angular separation between pair of sources at cosmological distances induced by an anisotropic expansion. An accurate astrometric experiment like Gaia could observe or put constraints on cosmic parallax. Examples of anisotropic cosmological models are Lemaitre-Tolman-Bondi void models for off-center observers (introduced to explain the observed acceleration without the need for dark energy) and Bianchi metrics. If dark energy has an anisotropic equation of state, as suggested recently, then a substantial anisotropy could arise at $z \lesssim 1$ and escape the stringent constraints from the cosmic microwave background. In this paper we show that such models could be constrained by the Gaia satellite or by an upgraded future mission.Comment: 9 pages, 7 figures, text extended, figures changed, accepted by PR

Relationship between the night shift work and thyroid disorders: A systematic review and meta-analysis

AbstractObjectives. The night shift workers were reported to have health consequences, ranging from mild, as cluster headache, to severe, as heart attacks and hormonal irregularities. This study is aimed to perform a systematic review and meta-analyze of the association between the night shift work and the thyroid disorders.Methods. We comprehensively searched eight databases, including PubMed and Google Scholar for the relevant articles. This systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement.Results. We finally included six papers involving 4074 participants. Four papers were eligible for meta-analysis involving 1864 night shift workers and 2017 day shift workers. We against found that thyroid stimulating hormone (TSH) is significantly higher in the night shift group compared to the day shift group.Conclusions. The higher TSH among the night shift workers is attributed to disruption of the circadian rhythm and sleep/wake cycle, with subsequent eating disorders. We proposed that more attention should be paid to the working pattern and the related health consequences

Physiological responses to arm exercise in difficult to wean patients with chronic obstructive pulmonary disease

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Peculiar acceleration

It has been proposed recently to observe the change in cosmological redshift of distant galaxies or quasars with the next generation of large telescope and ultra-stable spectrographs (the so-called Sandage-Loeb test). Here we investigate the possibility of observing the change in peculiar velocity in nearby clusters and galaxies. This ``peculiar acceleration'' could help reconstructing the gravitational potential without assuming virialization. We show that the expected effect is of the same order of magnitude of the cosmological velocity shift. Finally, we discuss how to convert the theoretical predictions into quantities directly related to observations.Comment: 9 page

Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression

open10Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and our previous work highlighted that abnormal Glu release may represent a leading mechanism for excessive synaptic Glu. We demonstrated that group I metabotropic Glu receptors (mGluR1, mGluR5) produced abnormal Glu release in SOD1G93A mouse spinal cord at a late disease stage (120 days). Here, we studied this phenomenon in pre-symptomatic (30 and 60 days) and early-symptomatic (90 days) SOD1G93A mice. The mGluR1/5 agonist (S)-3,5-Dihydroxyphenylglycine (3,5-DHPG) concentration dependently stimulated the release of [3H]d-Aspartate ([3H]d-Asp), which was comparable in 30- and 60-day-old wild type mice and SOD1G93A mice. At variance, [3H]d-Asp release was significantly augmented in 90-day-old SOD1G93A mice and both mGluR1 and mGluR5 were involved. The 3,5-DHPG-induced [3H]d-Asp release was exocytotic, being of vesicular origin and mediated by intra-terminal Ca2+ release. mGluR1 and mGluR5 expression was increased in Glu spinal cord axon terminals of 90-day-old SOD1G93A mice, but not in the whole axon terminal population. Interestingly, mGluR1 and mGluR5 were significantly augmented in total spinal cord tissue already at 60 days. Thus, function and expression of group I mGluRs are enhanced in the early-symptomatic SOD1G93A mouse spinal cord, possibly participating in excessive Glu transmission and supporting their implication in ALS. Please define all abbreviations the first time they appear in the abstract, the main text, and the first figure or table caption.openTiziana Bonifacino, Claudia Rebosio, Francesca Provenzano, Carola Torazza, Matilde Balbi, Marco Milanese, Luca Raiteri, Cesare Usai, Ernesto Fedele, Giambattista Bonanno.Bonifacino, Tiziana; Rebosio, Claudia; Provenzano, Francesca; Torazza, Carola; Balbi, Matilde; Milanese, Marco; Raiteri, Luca; Usai, Cesare; Fedele, Ernesto; Bonanno, Giambattist

Socio-Economic Regional Risk Assessment (SERRA) application to flood risk in the Vipacco Basin (north-east Italy)

According to EEA (European Environmental Agency), flood is the most dangerous natural hazard in Europe in terms of economic losses. TheKULTURisk Project (EU FP7) has developed a novel methodology for evaluating the integrated benefits of risk prevention of water related natural hazards: SERRA (i.e. Socio-Economic Regional Risk Assessment). The proposed methodology enhances the traditional flood risk assessment by integrating the missing socio-economic dimension into the established regional risk assessment. Several case studies across Europe allowed for the consolidation, validation, and refinement of SERRA. This paper presents the results of its application to assess the benefits deriving from the installation of an Early Warning System in Vipacco river basin in Friuli Venezia Giulia (Italy). Social, economic and physical data are used to assess the total expected risk for several receptors such as economic activities, cultural heritage, people, etc. The collected socio-economic data are stored in Geographic Information System (GIS) and processed according to SERRA algorithms to produce maps of various categories of costs (beyond physical-environmental damages) in order to assist the Decision Makers (DMs) in making more informative decisions. The visualization of total risk through GIS maps allows the DMs to understand the spatial distribution of social vulnerability, risk, and associated costs

Emergency endovascular treatment of cavernous internal carotid artery acute bleeding with flow diverter stent: a single-center experience

Background and objective To describe our single-center experience in the treatment of cavernous internal carotid artery (ICA) acute bleeding with flow diverter stent (FDS), as a single endovascular procedure or combined with an endoscopic endonasal approach. Methods We analyze a case series of 5 patients with cavernous ICA acute bleeding, i.e., 3 iatrogenic, 1 post-traumatic, and 1 erosive neoplastic. After an immediate nasal packing to temporarily bleeding control, patients underwent digital subtraction angiography (DSA) to identify the site of the ICA injury. A concomitant balloon occlusion test (BOT) was performed, to exclude post-occlusive ischemic neurological damage. An FDS was placed with parallel intravenous infusion of abciximab in 3 cases and tirofiban in 2 cases. In two patients, an innovative "sandwich technique" combining the endovascular reconstruction with an extracranial intrasphenoidal cavernous ICA resurfacing with autologous flaps or grafts by endoscopic endonasal approach was performed. Results No patient had periprocedural ischemic-hemorrhagic complications. All patients had a regular clinical evolution, without general complications or new onset of focal neurological deficits. No further bleeding occurred in 3 patients, while 2 cases experienced a mild rebleeding in a period ranging from 5 to 15 days after the endovascular procedure. In these two cases, we proceeded with an endoscopic endonasal procedure to resurface the exposed ICA wall in the sphenoid sinus. Conclusions Although the treatment of choice for cavernous ICA acute bleeding remains the occlusion of the injured vessel, in cases of poor hemodynamic compensation at the BTO, the endovascular FDS emergency placement can be effective. A combined endoscopic endonasal technique to support the extracranial side of the vessel using autologous flaps or grafts can be performed to prevent the risk of rebleeding

Risk of latent tuberculosis infection among healthcare workers in Italy: a retrospective study with Quantiferon Test

OBJECTIVE. The latent tuberculosis infection (LTBI) is a state of persistent immune response to stimulation by Mycobacterium Tuberculosis antigens without clinical manifestation: the healthcare workers (HCWs) have a higher exposure risk so prevention is an important challenge for occupational medicine. The aim of our study is to evaluate the prevalence of LTBI among HCWs of the Foundation Policlinic “Tor Vergata”. METHODS. This is a retrospective study conducted by analyzing the clinical records of 825 HCWs of the PTV, from January 1st to December 31th 2016. To evaluate the TB infection we used the Quantiferon TB Gold interferon-gamma release assay. RESULTS. Our study underline the low prevalence of LTBI in the Italian healthcare workers. CONCLUSION. Although the LTBI status is not contagious, the diagnosis and the safety strategies require specific clinical and preventive considerations

Comer o no comer : Modernidad artística brasileña y emergencia latinoamericana

La metáfora antropofágica nos permite leer las búsquedas estéticas y políticas del propio Movimiento Antropofágico pero también del Muralismo Mexicano, el Creacionismo chileno, el Martinfierrismo rioplatense u otras experiencias más allá de la pertenencia a un movimiento particular. En este capítulo, nos centraremos en el proceso brasileño y en el valor de esta metáfora desde la cual leer la tensión arcaico –moderno/cosmopolitismo– nacional; como así también para pensar la relación entre lo real y lo fantástico o maravilloso.Facultad de Arte