Impact of working capital management on profitability for Spanish fish canning companies

Credit restrictions, such as those happening in the current context shaped by the crisis derived from COVID-19, make working capital management (WCM) a driving force behind SME performance. This paper analyses whether WCM policies affect the economic and financial profitability of Spanish companies in the fish canning industry. Spain leads the EU’s production of canned seafood and the seafood industry is a key sector for the Spanish economy. To assess the WCM-profitability relationship, we applied a dynamic panel data methodology in a sample consisting of 377 companies during the period 2010–2018. We can conclude that the economic profitability of fish canning companies is related to the collection period (Days Sales Outstanding or DSO) and the inventory conversion period (Days Inventory Outstanding or DIO). Moreover, empirical evidence reveals the existence of an optimal level of receivables that balances the benefits of increasing sales and the opportunity costs of customer funding. The findings also identify a convex relationship between investment in inventory and economic profitabilityS

The influence of sociability over non-mortgage debt

In recent years, especially after the recent economic downturn, household debt has increased in importance, due to its influence on the economy in general and on households’ wellbeing in particular. Therefore, the study of household debt turns out to be necessary in order to know what leads to its demand, and thus to avoid situations of over-indebtedness. In this regard, previous research has analysed debt decisions from different approaches, however, the effect of individuals’ sociability has been neglected in literature. To this end, the aim of this paper is to analyse the effect of sociability on the Europeans’ decision to incur non-mortgage debt. The study sample, taken from the sixth wave (year 2015) of the Survey of Health, Ageing and Retirement in Europe, consists of 68,231 people from 18 European countries and also Israel. After applying probit binomial models, empirical evidence confirms the non-negligible effect of sociability on households’ non-mortgage debts. However, this effect depends on the underlying mechanisms through which sociability operates. Thus, when the sociability variable reflects learning based on the transmission of information (or 'word of mouth'), its influence over non-mortgage debt is positive, whereas when sociability reflects learning based on observation, the effect is negativeS

Does self-control constitute a driver of millennials’ financial behaviors and attitudes?

[Abstract] Millennials are currently facing particular financial challenges that will condition the future financial well-being of the society as a whole, and the decision-making process happening in worse circumstances than those of preceding generations. However, few studies to date have deeply analyzed millennials’ financial behaviors, and particularly, how self-control operationalizes their financial choices. Using data from the 2017 Survey of Financial Competences of Spanish individuals, this paper analyzes how self-control influences different financial behaviors and attitudes and whether this effect differs between millennials and older generations. The results indicate that self-control does influence the individuals’ financial attitudes regardless of generation, whereas in the case of financial behaviors, only those millennials exhibiting the highest levels of self-control are affected by it when deciding on a saving account or a personal loan. These outcomes have numerous significant implications, in addition to providing recommendations to policy makers aimed at engaging millennials in healthier financial behaviors

Self-control and debt decisions relationship: evidence for different credit options

In recent years, households have become increasingly indebted, which constitutes a matter of concern. Based on a sample from the Spanish Survey of Financial Competences, this paper examines the relationship between self-control and consumer borrowing behaviour and, in so doing, it proposes a new multi-item scale of individual’s self-control in financial matters and considers several types of consumer debt, thus overcoming the main gaps identified in previous research. Empirical evidence reveals that, overall, self-control problems lead to more indebtedness. However, comprehensive analyses have demonstrated that the influence of self-control differs across an exhaustive range of credit options. In this regard, the lack of self-control increases the probability of taking out unsecured personal loans, loans from family or friends, and credit card use. Evidence suggests that individuals’ first impulse leads them to ask their social circle for a loan. Overall, individuals might be tempted to get indebted when they cannot make ends meet. However, this first impulse usually faces barriers from the supply perspective, so the evidence suggests that the effect of self-control on borrowing decisions might be shaped not only by the demand side of credit but also by the supply oneOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer NatureS

El género como factor determinante del emprendimiento tecnológico en sudamérica

[RESUMEN] El emprendimiento influye positivamente sobre la creación de empleo y el crecimiento económico, más aún cuando estos son llevados a cabo en sectores tecnológicos. La evidencia empírica demuestra que las mujeres se enfrentan a mayores barreras cuando de emprender se trata, pero ¿sucede lo mismo en el emprendimiento tecnológico? El presente trabajo tiene un doble objetivo: 1) analizar el efecto del factor género sobre la participación de los individuos sudamericanos en emprendimientos tecnológicos; 2) identificar en qué medida estos efectos difieren con respecto al emprendimiento en sectores convencionales. El análisis está basado en una muestra de la población sudamericana (Argentina, Brasil, Chile, Colombia, Perú, Uruguay y Venezuela) de entre 18 a 64 años, utilizando datos del Global Entrepreneurship Monitor (GEM) para el año 2011. Tras un análisis descriptivo que definió el perfil de la persona emprendedora tecnológica en Sudamérica, el análisis econométrico permitió, mediante logit, medir la probabilidad asociada al factor género sobre el emprendimiento de base tecnológica. Los resultados empíricos obtenidos revelan que el hecho de ser mujer ejerce un efecto negativo sobre la probabilidad de estar involucrada en un emprendimiento tecnológico. Sin embargo, el género tiene un efecto indiferente sobre el emprendimiento convencional. Estos resultados parecen estar indicando que en Sudamérica la participación de las mujeres en el emprendimiento tecnológico podría no haber superado las barreras sociales y personales que se les adhiere tradicionalmente, a diferencia de los que podría haber ocurrido con el emprendimiento convencional

Association between speech reception threshold in noise and multimorbidity: The UK Biobank Study

Objective. To investigate the association between hearing function, as approached with the functional auditory capacity, and multimorbidity. Study Design. Cross-sectional study. Setting. The UK Biobank was established from 2006 to 2010 in the United Kingdom. This cross-sectional analysis included 165,524 participants who provided baseline information on hearing function. Methods. Functional auditory capacity was measured with a digit triplet test. Three categories were defined according to the speech reception threshold in noise (SRTn): normal (SRTn < −5.5 dB signal-to-noise ratio [SNR]), insufficient (SRTn ≥ −5.5 to ≤ −3.5 dB SNR) and poor hearing function (SRTn > −3.5 dB SNR). To define multimorbidity, 9 chronic diseases were considered, including chronic obstructive pulmonary disease, dementia, Parkinson's disease, stroke, cancer, depression, osteoarthritis, coronary heart disease, and diabetes; multimorbidity was defined as the coexistence of 2 or more in the same individual. Analyses were conducted using logistic models adjusted for relevant confounders. Results. Among the study participants, 54.5% were women, and the mean (range) age was 56.7 (39-72) years. The prevalence of insufficient and poor hearing function and multimorbidity was 13% and 13.2%, respectively. In comparison with having a normal SRTn, the odds ratio (95% confidence interval) of multimorbidity associated with insufficient SRTn was 1.13 (1.08- 1.18), and with poor SRTn was 1.25 (1.14-1.37). Conclusion. Insufficient and poor hearing function was associated with multimorbidity. This association suggests common biological pathways for many of the considered morbiditiesThis work was supported by Instituto de Salud Carlos III through the FIS project 20/01040 (Instituto de Salud Carlos III, State Secretary of R + D + I), and co‐funded by a European Regional Development Fund, “A way of shaping Europe.” Ellen A. Struijk holds a Ramón y Cajal contract (RYC‐ 2021‐031146‐I) from the Ministry of Science, Innovation and Universities and FEDER/FS

Bruxismo de la vigilia

El bruxismo del sueño ha sido extensamente estudiado en las últimas décadas pero aún persiste una considerable controversia científica en relación al bruxismo de la vigilia. El presente trabajo de revisión se focalizó en este tema, incluyendo 45 artículos publicados entre los años 2011 al año 2020. Los consensos internacionales plantean avances en nuevas clasificaciones diagnósticas, que contemplan herramientas como cuestionarios, examen clínico, electromiografía, polisomnografía, evaluación ecológica momentánea y métodos de muestreo de experiencias. Se considera al bruxismo de la vigilia un problema comportamental, pasible de ser tratado mediante terapias comportamentales que lo controlen. La evaluación ecológica momentánea permite capturar información comportamental en tiempo real y se presenta como una herramienta valiosa para el diagnóstico y evaluación del bruxismo de la vigilia. A pesar de numerosos avances presentados en esta revisión, aún se requieren estudios que exploren esta área del conocimiento, especialmente en los mecanismos fisiopatológicos y los posibles tratamientos

Análise Epidemiológica Multicêntrica de Fraturas de Quadril no Uruguai: Importância e Planejamento de um Registro Nacional

Alexis Sosa: Clínica de Traumatología y Ortopedia del Adulto de la Facultad de Medicina de la Udelar. Correo electrónico: [email protected] ORCID: 0000-0001-7896-3921 -- Chiara Bruno: Carrera de Doctor en Medicina de la UdelaR (Curso de Metodología Científica II) [email protected] -- Verónica Fernández de la Vega: Carrera de Doctor en Medicina de la UdelaR (Curso de Metodología Científica II). [email protected] -- Deneb Mazzilli: Carrera de Doctor en Medicina de la UdelaR (Curso de Metodología Científica II) [email protected], ORCID: 0000-0002-1268-8063 -- Carolina Rey: Carrera de Doctor en Medicina de la UdelaR (Curso de Metodología Científica II) [email protected], ORCID: 0000-0002-7591-7935 -- Lucia Taibo: ORCID: Carrera de Doctor en Medicina de la UdelaR (Curso de Metodología Científica II) [email protected], 0000-0002-3330-6677 -- Martin Espiga: Clínica de Traumatología y Ortopedia del Adulto de la Facultad de Medicina de la Udelar. [email protected], ORCID: 0000-0001-5964-1927 -- Paola Filomeno: Clínica de Traumatología y Ortopedia del Adulto de la Facultad de Medicina de la Udelar. [email protected], ORCID: 0000-0003-4664-1527 -- Domingo Beltramelli: CASMU. Correo electrónico: [email protected] ORCID: 0000-0001-7165-7489 -- Rogelio Rey: Clínica de Traumatología y Ortopedia del Adulto de la Facultad de Medicina de la Udelar. [email protected], ORCID: 0000-0001-5736-3601Introducción: La incidencia de fracturas de cadera presenta un aumento dramático desde la mediana edad, constituyendo un problema de salud prevalente en adultos mayores. Se realizó una revisión bibliográfica de los registros internacionales de fracturas de cadera y un estudio epidemiológico multicéntrico para conocer la incidencia, los costos y la mortalidad de esta patología en nuestro país. Material y métodos: Se realizó una búsqueda, revisión y análisis de todos los registros internacionales de fracturas de cadera existentes en el mundo. Posteriormente, se llevó a cabo un análisis descriptivo observacional retrospectivo y multicéntrico en 4 instituciones de pacientes mayores de 50 años intervenidos quirúrgicamente con osteosíntesis por fractura de cadera en el año 2019. En los datos anonimizados se evaluaron edad, sexo, tipo de fractura, incidencia y costos. Se incluyeron y asociaron, además, datos estadísticos y económicos del Registro del Fondo Nacional de Recursos. Se utilizó el software estadístico SPSS para establecer asociaciones univariadas, bivariadas y ultivariadas. Para comparar las proporciones se empleó el test estadístico de chi cuadrado. Resultados: Se resume la revisión de registros en una tabla. El análisis multicéntrico contó con 646 pacientes con fracturas de cadera. Destacamos la alta prevalencia de esta patología en pacientes mayores de 79 años (63,1%) y en el sexo femenino (77,6%), en concordancia con los registros internacionales, con asociación significativa entre ambas variables (p < 0,0001). A diferencia de otros registros, y quizás dato erróneo, la fractura más frecuente fue la del cuello de fémur (43%). El tiempo entre la fractura y la cirugía y los días de internación fueron de 2,6 y 7,2 días, respectivamente, en la institución de asistencia más efectiva. Nuestro cálculo mostró una incidencia de fractura de cadera en Uruguay que oscila entre 235 y 391 en 100.000 habitantes mayores de 50 años. El costo calculado de la serie evaluada fue de unos U$S 2.855.320 y, en general, esta patología provoca un gasto para nuestro país que se aproxima a U$S 20.000.000 por año. Conclusión: La fractura de cadera presenta una elevada incidencia, costos y morbimortalidad en la población de adultos mayores, comparable con datos internacionales. Es necesario contar con un Registro Nacional de Fracturas de Cadera que permita conocer datos estadísticos certeros para poder establecer políticas adecuadas de prevención, tratamiento y control de gastos.Introduction: The incidence of hip fractures dramatically increases from middle age on, posing a prevalent health problem in elderly people. A literature review of the international hip fracture registers, as well as a multicenter, epidemiological study were carried out in order to assess the incidence, costs, and mortality of this pathology in our country. Material and methods: All international hip fracture registers in the world were searched, reviewed and analyzed. An observational, retrospective, multicenter descriptive analysis was then carried out in 4 healthcare centers for patents over 50 years of age who underwent surgery with osteosynthesis due to hip fracture in 2019. Age, sex, type of fracture, incidence and costs were assessed from the anonymized data. Statistical and economic data from the National Resources Fund Register were also included and associated. The SPSS statistical software was used to establish univariate, bivariate, and multivariate associations. The chi squared statistical test was used to compare proportions. Results: Review of the registers is summarized in a table. The multicenter analysis included 646 patients with hip fractures. Worth of note is the high prevalence of this pathology in patients over 79 years of age (63.1%) and females (77.6%), in line with the international registers, and a significant association between both variables (p < 0.0001). Unlike other registers, and probably due to inaccurate data, the most frequent fracture was that of femoral neck (43%). The time from fracture to surgery and inpatient days were 2.6 and 7.2 days, respectively, in the most effective health care center. Our calculation showed a hip fracture incidence in Uruguay between 235 and 391 per 100,000 inhabitants over 50 years of age. The estimated cost of the assessed series was about U$S 2,855,320, and in general this pathology generates an annual expense of about U$S 20,000,000 for our country. Conclusion: Hip fractures have high incidence, costs and mortality and morbidity in the elderly population comparable with international data. It is necessary to have a National Hip Fracture Register that provides accurate statistical data in order to establish adequate prevention, treatment and cost control policies.Introdução: A incidência de fraturas de quadril apresenta um aumento dramático a partir da meiaidade, constituindo um problema de saúde prevalente em idosos. Uma revisão bibliográfica dos Registros Internacionais de Fratura de Quadril e um estudo epidemiológico multicêntrico foram realizados para determinar a incidência, os custos e a mortalidade dessa patologia em nosso país. Material e métodos: Foi realizada uma busca, revisão e análise de todos os Registros Internacionais de fraturas de quadril existentes no mundo. Posteriormente, foi realizada uma análise observacional descritiva retrospectiva e multicêntrica, em 4 Instituições, de pacientes maiores de 50 anos, submetidos à cirurgia com osteossíntese, para fratura de quadril em 2019. Nos dados anônimos foram avaliados idade e sexo, tipo de fratura , incidência e custos. Dados estatísticos e econômicos do Registro do Fundo Nacional de Recursos também foram incluídos e associados. O software estatístico SPSS foi usado para estabelecer associações univariadas, bivariadas e multivariadas. O teste estatístico do qui quadrado foi usado para comparar as proporções. Resultados: a revisão dos registros é resumida em uma tabela. A análise multicêntrica incluiu 646 pacientes com fraturas de quadril. Destacase a alta prevalência dessa patologia em pacientes maiores de 79 anos (63,1%) e no sexo feminino (77,6%), de acordo com registros internacionais, com associação significativa entre as duas variáveis (p <0,0001). Ao contrário de outros registros, e talvez dados errôneos, a fratura mais frequente foi a do colo do fêmur (43%). O tempo decorrido entre a fratura e a cirurgia e os dias de internação foram de 2,6 e 7,2 dias, respectivamente, na instituição assistencial mais efetiva. Nosso cálculo mostrou uma incidência de fratura de quadril no Uruguai, variando entre 235 e 391 em 100.000 habitantes com mais de 50 anos de idade. O custo calculado da série avaliada foi em torno de US $2.855.320 e, em geral, essa patologia acarreta um gasto para o nosso país que é próximo a US$ 20.000.000 por ano. Conclusão: A fratura de quadril tem alta incidência, custo e morbimortalidade na população idosa, comparável a dados internacionais. É necessário um Cadastro Nacional de Fraturas de Quadril, que permita conhecer dados estatísticos precisos, para estabelecer políticas adequadas de prevenção, tratamento e ontrole de custos

Adquisición del español en niños sordos a través de la logogenia para la inclusión familiar, escolar y social

Logogenia method creates conditions to enable the process to acquire Spanish in deaf people, through their exposure to the written code, so that they can learn the language to communicate. Due to the usefullness of the logogenia, it is necessary to identify its functionality in children. The research aimed to identify if the application of logogenia allows deaf children from 5 to 8 years to activate the acquisition process of Spanish language skills early, especially in five dimensions: comprehension, expression and use of content elements, and understanding, expression and use of functional elements, grammar rules, grammatical discrimination and grammatical awareness; It also sought to identify if this activation had influence on the participation in the community. The results, through U Mann-Whitney tests, showed that the participants of the experimental group developed skills in the syntactic processes, which allowed them to activate the acquisition of the language, through the written code of Spanish. In the same way, the linguistic activation allowed an effective and efficient participation in social, family and school contexts; those aspects were not evidenced in the control group.El método de la logogenia crea condiciones para posibilitar el proceso de adquisición del español en personas sordas, a través de su exposición al código escrito, para que estas puedan comunicarse. Debido a la utilidad de la logogenia en sordos jóvenes y adultos, es pertinente identificar su funcionalidad en niños, época de la vida en la que podría tener mayor impacto. El estudio tuvo como objetivo identificar si la aplicación de la logogenia permite que los sordos de 5 a 8 años activen tempranamente el proceso de adquisición de la competencia lingüística del español, en especial en cinco dimensiones: comprensión, expresión y uso de elementos de contenido, y comprensión, expresión y uso de elementos funcionales, reglas gramaticales, discriminación de gramaticalidad y conciencia gramatical; además se buscaba identificar si esta activación tenía incidencia en la participación en la comunidad a través de la lengua escrita. Los resultados, a través de pruebas de U Mann-Whitney, mostraron que los participantes del grupo experimental que fueron sometidos a la logogenia desarrollaron habilidades en los procesos sintácticos, que les permitió activar la adquisición de la lengua, a través del código escrito del español. Asimismo, esta activación lingüística propició una efectiva y eficiente participación en los contextos sociales, familiares y escolares, aspectos no evidenciados en el grupo control

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

The current view of cancer progression highlights that cancer cells must undergo through a post-translational regulation and metabolic reprogramming to progress in an unfriendly environment. In here, the importance of neddylation modification in liver cancer was investigated. We found that hepatic neddylation was specifically enriched in liver cancer patients with bad prognosis. In addition, the treatment with the neddylation inhibitor MLN4924 in Phb1-KO mice, an animal model of hepatocellular carcinoma showing elevated neddylation, reverted the malignant phenotype. Tumor cell death in vivo translating into liver tumor regression was associated with augmented phosphatidylcholine synthesis by the PEMT pathway, known as a liver-specific tumor suppressor, and restored mitochondrial function and TCA cycle flux. Otherwise, in protumoral hepatocytes, neddylation inhibition resulted in metabolic reprogramming rendering a decrease in oxidative phosphorylation and concomitant tumor cell apoptosis. Moreover, Akt and LKB1, hallmarks of proliferative metabolism, were altered in liver cancer being new targets of neddylation. Importantly, we show that neddylation-induced metabolic reprogramming and apoptosis were dependent on LKB1 and Akt stabilization. Overall, our results implicate neddylation/signaling/metabolism, partly mediated by LKB1 and Akt, in the development of liver cancer, paving the way for novel therapeutic approaches targeting neddylation in hepatocellular carcinoma