1,285 research outputs found
Modeling Uric Acid Kidney Stones Disease in D. melanogaster using RNAi and Dietary Modulation
In humans, the major predictor for gout and forming uric acid kidney stones is elevated uric acid in the serum and urine respectively. It is known that uric acid is an end metabolite of purine degradation in humans, but in other species from D. melanogaster to lower apes, uric acid can be further metabolized by urate oxidase into readily excreted allantoin. We hypothesize that if urate oxidase enzyme activity and dietary purine are both critical in uric acid kidney stone formation, then urate oxidase knockdown in combination with dietary purine supplementation will increase uric acid and induce uric acid kidney stone formation in D. melanogaster. Initially, we confirmed urate oxidase knockdown and then elevation of uric acid as a consequence. We then confirmed uric acid kidney stones formed as a consequence of urate oxidase knocked down and a high purine diet. Next, we tested compounds used to treat gout or uric acid kidney stones in humans using our model. We found that allopurinol and potassium citrate reduced uric acid kidney stone formation in our model. We then tested whether compounds predicted to reduce uric acid and uric acid kidney stones in humans, but not currently used as treatments, can reduce uric acid kidney stone formation in our model. We found that methotrexate, hydrochlorothiazide, and l-lysine were effective at reducing uric acid kidney stone formation. Lastly, we ran a medium throughput screen of 117 natural compounds for inhibitors of uric acid kidney stone formation using our model and found seven inhibitors
T-Duality For String in Horava-Lifshitz Gravity
We continue our study of the Lorentz breaking string theories. These theories
are defined as string theory with modified Hamiltonian constraint which breaks
the Lorentz symmetry of target space-time. We analyze properties of this theory
in the target space-time that possesses isometry along one direction. We also
derive the T-duality rules for Lorentz breaking string theories and show that
they are the same as that of Buscher's T-duality for the relativistic strings.Comment: 17 pages, references adde
PCN70 Chemotherapy Treatment Patterns, Health Care Costs, and Mortality of Lung Cancer Patients in Taiwan – A Longitudinal Study Between 2000 and 2008
Qualitätsmanagementsysteme und ihre Anwendung auf Serviceeinrichtungen der WGL
"Der Arbeitsbericht gibt einen Überblick über häufig verwendete Begriffe und Konzepte im Bereich von Qualitätsmanagementsystemen. Neben der Normenfamilie ISO 9000 - 9004 sowie Total Quality Management (TQM) werden spezielle Maßnahmen wie Benchmarking und Re-Engineering angesprochen sowie Probleme der Anwendung dieser Systeme im Bereich von Forschungs- und Serviceeinrichtungen diskutiert. Auf die Evaluation und die geplanten Maßnahmen zur Qualitätssicherung im Rahmen der Institute der Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz (WGL) und die Besonderheiten von Serviceeinrichtungen wird eingegangen." (Autorenreferat
Light-like noncommutativity and duality from open strings/branes
In this paper we perform some non-trivial tests for the recently obtained
open membrane/D-brane metrics and `generalized' noncommutativity parameters
using Dp/NS5/M5-branes which have been deformed by light-like fields. The
results obtained give further evidence that these open membrane/D-brane metrics
and `generalized' noncommutativity parameters are correct. Further, we use the
open brane data and supergravity duals to obtain more information about
non-gravitational theories with light-like noncommutativity, or `generalized'
light-like noncommutativity. In particular, we investigate various duality
relations (strong coupling limits). In the light-like case we also comment on
the relation between open membrane data (open membrane metric etc.) in six
dimensions and open string data in five dimensions. Finally, we investigate the
strong coupling limit (high energy limit) of five dimensional NCYM with
\Theta^{12}=\Theta^{34}. In particular, we find that this NCYM theory can be UV
completed by a DLCQ compactification of M-theory.Comment: 24 pages, Latex. v2:Comments and references added. v3:Version
published in JHE
Epitaxial growth and electrical-transport properties of Ti7Si2C5 thin films synthesized by reactive sputter-deposition
The Lemaitre Model and the Generalisation of the Cosmic Mass
We consider the spherically symmetric metric with a comoving perfect fluid
and non-zero pressure -- the Lemaitre metric -- and present it in the form of a
calculational algorithm. We use it to review the definition of mass, and to
look at the apparent horizon relations on the observer's past null cone. We
show that the introduction of pressure makes it difficult to separate the mass
from other physical parameters in an invariant way. Under the usual mass
definition, the apparent horizon relation, that relates the diameter distance
to the cosmic mass, remains the same as in the Lemaitre-Tolman case.Comment: latex, 16 pages, Revision has minor changes due to referee's
comments
Protons in near earth orbit
The proton spectrum in the kinetic energy range 0.1 to 200 GeV was measured
by the Alpha Magnetic Spectrometer (AMS) during space shuttle flight STS-91 at
an altitude of 380 km. Above the geomagnetic cutoff the observed spectrum is
parameterized by a power law. Below the geomagnetic cutoff a substantial second
spectrum was observed concentrated at equatorial latitudes with a flux ~ 70
m^-2 sec^-1 sr^-1. Most of these second spectrum protons follow a complicated
trajectory and originate from a restricted geographic region.Comment: 19 pages, Latex, 7 .eps figure
Search for antihelium in cosmic rays
The Alpha Magnetic Spectrometer (AMS) was flown on the space shuttle
Discovery during flight STS-91 in a 51.7 degree orbit at altitudes between 320
and 390 km. A total of 2.86 * 10^6 helium nuclei were observed in the rigidity
range 1 to 140 GV. No antihelium nuclei were detected at any rigidity. An upper
limit on the flux ratio of antihelium to helium of < 1.1 * 10^-6 is obtained.Comment: 18 pages, Latex, 9 .eps figure
A Study of Cosmic Ray Secondaries Induced by the Mir Space Station Using AMS-01
The Alpha Magnetic Spectrometer (AMS-02) is a high energy particle physics
experiment that will study cosmic rays in the to range and will be installed on the International Space Station
(ISS) for at least 3 years. A first version of AMS-02, AMS-01, flew aboard the
space shuttle \emph{Discovery} from June 2 to June 12, 1998, and collected
cosmic ray triggers. Part of the \emph{Mir} space station was within the
AMS-01 field of view during the four day \emph{Mir} docking phase of this
flight. We have reconstructed an image of this part of the \emph{Mir} space
station using secondary and emissions from primary cosmic rays
interacting with \emph{Mir}. This is the first time this reconstruction was
performed in AMS-01, and it is important for understanding potential
backgrounds during the 3 year AMS-02 mission.Comment: To be submitted to NIM B Added material requested by referee. Minor
stylistic and grammer change
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