Automated Detection of Joint Attention and Mutual Gaze in Free Play Parent-Child Interactions

Observing a child’s interaction with their parents can provide us with important information about the child’s cognitive development. Nonverbal cues such as joint attention and mutual gaze can indicate a child’s engagement, and have diagnostic value. Since manual coding of gaze events during child-parent interactions is time-consuming and error-prone, there is a need for automatic assessment tools, capable of working with camera recordings without specialized eye-tracking equipment. There are few studies in this setting, and accessing naturalistic parent-child videos is difficult. In this paper, we investigate the feasibility of detecting joint attention and mutual gaze in videos. We test approach on challenging data of a child and a parent engaged in free play. By combining multiple off-the-shelf approaches, we manage to create a system that does not require much labeling and is flexible to use for view-independent interaction analysis

Cavity Design and Optimization for Organic Microcavity OLEDs

We report on detailed simulations of the emission from microcavity OLEDs consisting of widely used organic materials, n,N'-di(naphthalene-1-yl)-N,N'-diphenyl-benzidine (NPB) as a hole transport layer and tris (8-hydroxyquinoline) (Alq3) as emitting and electron transporting layer. The thick silver film was considered as a top mirror, while silver or copper films on quartz substrate were considered as bottom mirrors. The electroluminescence emission spectra, electric field distribution inside the device, carrier density and recombination rate were calculated as a function of the position of the emission layer, i.e. interface between NPB and Alq3. In order to achieve optimum emission from a microcavity OLED, it is necessary to align the position of the recombination region with the antinode of the standing wave inside the cavity. Once the optimum structure has been determined, the microcavity OLED devices were fabricated and characterized. The experimental results have been compared to the simulations and the influence of the emission region width and position on the performance of microcavity OLEDs was discussed

Farnesoid X receptor and bile acids regulate vitamin A storage

The nuclear receptor Farnesoid X Receptor (FXR) is activated by bile acids and controls multiple metabolic processes, including bile acid, lipid, carbohydrate, amino acid and energy metabolism. Vitamin A is needed for proper metabolic and immune control and requires bile acids for efficient intestinal absorption and storage in the liver. Here, we analyzed whether FXR regulates vitamin A metabolism. Compared to control animals, FXR-null mice showed strongly reduced (>90%) hepatic levels of retinol and retinyl palmitate and a significant reduction in lecithin retinol acyltransferase (LRAT), the enzyme responsible for hepatic vitamin A storage. Hepatic reintroduction of FXR in FXR-null mice induced vitamin A storage in the liver. Hepatic vitamin A levels were normal in intestine-specific FXR-null mice. Obeticholic acid (OCA, 3 weeks) treatment rapidly reduced (>60%) hepatic retinyl palmitate levels in mice, concurrent with strongly increased retinol levels (>5-fold). Similar, but milder effects were observed in cholic acid (12 weeks)-treated mice. OCA did not change hepatic LRAT protein levels, but strongly reduced all enzymes involved in hepatic retinyl ester hydrolysis, involving mostly post-transcriptional mechanisms. In conclusion, vitamin A metabolism in the mouse liver heavily depends on the FXR and FXR-targeted therapies may be prone to cause vitamin A-related pathologies

Analysis of a large-scale weighted network of one-to-one human communication

We construct a connected network of 3.9 million nodes from mobile phone call records, which can be regarded as a proxy for the underlying human communication network at the societal level. We assign two weights on each edge to reflect the strength of social interaction, which are the aggregate call duration and the cumulative number of calls placed between the individuals over a period of 18 weeks. We present a detailed analysis of this weighted network by examining its degree, strength, and weight distributions, as well as its topological assortativity and weighted assortativity, clustering and weighted clustering, together with correlations between these quantities. We give an account of motif intensity and coherence distributions and compare them to a randomized reference system. We also use the concept of link overlap to measure the number of common neighbors any two adjacent nodes have, which serves as a useful local measure for identifying the interconnectedness of communities. We report a positive correlation between the overlap and weight of a link, thus providing strong quantitative evidence for the weak ties hypothesis, a central concept in social network analysis. The percolation properties of the network are found to depend on the type and order of removed links, and they can help understand how the local structure of the network manifests itself at the global level. We hope that our results will contribute to modeling weighted large-scale social networks, and believe that the systematic approach followed here can be adopted to study other weighted networks.Comment: 25 pages, 17 figures, 2 table

Measurement of finite-frequency current statistics in a single-electron transistor

Electron transport in nano-scale structures is strongly influenced by the Coulomb interaction which gives rise to correlations in the stream of charges and leaves clear fingerprints in the fluctuations of the electrical current. A complete understanding of the underlying physical processes requires measurements of the electrical fluctuations on all time and frequency scales, but experiments have so far been restricted to fixed frequency ranges as broadband detection of current fluctuations is an inherently difficult experimental procedure. Here we demonstrate that the electrical fluctuations in a single electron transistor (SET) can be accurately measured on all relevant frequencies using a nearby quantum point contact for on-chip real-time detection of the current pulses in the SET. We have directly measured the frequency-dependent current statistics and hereby fully characterized the fundamental tunneling processes in the SET. Our experiment paves the way for future investigations of interaction and coherence induced correlation effects in quantum transport.Comment: 7 pages, 3 figures, published in Nature Communications (open access

The Scalable Modeling of Multi-layer Embedded Capacitor based on LTCC Substrate

Abstract Low temperature co-fired ceramic (LTCC) technology is the preferred platform for integrating multi-layer capacitors due to excellent high frequency performance and low-loss dielectric properties. This letter describes a novel approach to perform modeling of multi-layer capacitors in LTCC technology. This hybrid approach combines both analytical modeling and numerical modeling to provide a scalable circuit model predicting the self-resonance frequency of the multiple dielectric and electrode layers. Good correlation between the simulation results and network analyzer measurements has been also achieved. Introduction Recently, as an alternative solution for the low cost and highly integrated system with multiple functionalities, System-on-Package (SoP) technology has emerged [1] [2]. The SoP brings multiple semiconductor dies of various semiconductor processes and materials, and passive devices such as termination resistors, decoupling capacitors, inductors, waveguide, filters, and antennas into a threedimensional package, to create highly integrated products with optimized cost, size and performance. Markets for the SoP solution include wireless communication, networking, computing, and sensor and storage system applications. To integrate these multiple dies and passive devices into a tiny 3-D SoP, adoption of high-density multilayer substrate design is a common approach to mount the multiple dies on a substrate with the embedded passives, which are laterally or vertically integrated onto the package substrate. Low temperature cofired ceramic (LTCC) technology is the preferred platform for integrating multi-layer passives due to excellent high frequency performance and low-loss dielectric properties In this paper, we propose a scalable modeling method for multi-layer embedded capacitor. Even if many papers have published to accurately model capacitors and their model are quite accurate, none of them has considered the scalability of the model for the multi-layer capacito

The phylogenetically-related pattern recognition receptors EFR and XA21 recruit similar immune signaling components in monocots and dicots

During plant immunity, surface-localized pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs). The transfer of PRRs between plant species is a promising strategy for engineering broad-spectrum disease resistance. Thus, there is a great interest in understanding the mechanisms of PRR-mediated resistance across different plant species. Two well-characterized plant PRRs are the leucine-rich repeat receptor kinases (LRR-RKs) EFR and XA21 from Arabidopsis thaliana (Arabidopsis) and rice, respectively. Interestingly, despite being evolutionary distant, EFR and XA21 are phylogenetically closely related and are both members of the sub-family XII of LRR-RKs that contains numerous potential PRRs. Here, we compared the ability of these related PRRs to engage immune signaling across the monocots-dicots taxonomic divide. Using chimera between Arabidopsis EFR and rice XA21, we show that the kinase domain of the rice XA21 is functional in triggering elf18-induced signaling and quantitative immunity to the bacteria Pseudomonas syringae pv. tomato (Pto) DC3000 and Agrobacterium tumefaciens in Arabidopsis. Furthermore, the EFR:XA21 chimera associates dynamically in a ligand-dependent manner with known components of the EFR complex. Conversely, EFR associates with Arabidopsis orthologues of rice XA21-interacting proteins, which appear to be involved in EFR-mediated signaling and immunity in Arabidopsis. Our work indicates the overall functional conservation of immune components acting downstream of distinct LRR-RK-type PRRs between monocots and dicots

Self-guided laser wakefield acceleration beyond 1 GeV using ionization-induced injection

WOS:000281452000007 (Nº de Acesso Web of Science)The concepts of matched-beam, self-guided laser propagation and ionization-induced injection have been combined to accelerate electrons up to 1.45 GeV energy in a laser wakefield accelerator. From the spatial and spectral content of the laser light exiting the plasma, we infer that the 60 fs, 110 TW laser pulse is guided and excites a wake over the entire 1.3 cm length of the gas cell at densities below 1.5×1018cm-3. High-energy electrons are observed only when small (3%) amounts of CO2 gas are added to the He gas. Computer simulations confirm that it is the K-shell electrons of oxygen that are ionized and injected into the wake and accelerated to beyond 1 GeV energy

Multivariate analysis of associations between clinical sequencing and outcome in glioblastoma

BACKGROUND: Many factors impact survival in patients with glioblastoma, including age, Karnofsky Performance Status, postoperative chemoradiation, METHODS: We utilized a widely available diagnostic platform (FoundationOne CDx) to perform high-throughput next-generation sequencing on 185 patients with newly diagnosed glioblastoma in our tertiary care center. We performed multivariate analysis to control for clinical parameters with known impact on survival to elucidate the independent prognostic value of prevalent mutant genes and the independent impact of gross total resection. RESULTS: When controlling for factors with known prognostic significance including CONCLUSIONS: This study verifies the independent prognostic value of several mutant genes in glioblastoma. Six commonly found mutant genes were associated with improved survival when gross total resection was achieved. Thus, even when accounting for known predictors of survival and multiple mutant gene comparisons, extent of resection continues to be strongly associated with survival

Mechanical properties of freely suspended atomically thin dielectric layers of mica

We have studied the elastic deformation of freely suspended atomically thin sheets of muscovite mica, a widely used electrical insulator in its bulk form. Using an atomic force microscope, we carried out bending test experiments to determine the Young's modulus and the initial pre-tension of mica nanosheets with thicknesses ranging from 14 layers down to just one bilayer. We found that their Young's modulus is high (190 GPa), in agreement with the bulk value, which indicates that the exfoliation procedure employed to fabricate these nanolayers does not introduce a noticeable amount of defects. Additionally, ultrathin mica shows low pre-strain and can withstand reversible deformations up to tens of nanometers without breaking. The low pre-tension and high Young's modulus and breaking force found in these ultrathin mica layers demonstrates their prospective use as a complement for graphene in applications requiring flexible insulating materials or as reinforcement in nanocomposites.Comment: 9 pages, 5 figures, selected as cover of Nano Research, Volume 5, Number 8 (2012