Un caso de síndrome de mano ajena fronto-calloso

Setenes Jornades de Foment de la Investigació de la FCHS (Any 2001-2002)Diferentes estudios teóricos (Feinberg, y cols., 1992; Baynes y cols. 1997; Doody y Jankovic 1992) han mostrado que el síndrome de la mano ajena (Brion y Jedynak 1972) puede tener dos manifestaciones que son: mano ajena con afectación callosa y mano ajena de afectación fronto-callosa. Este estudio presenta el caso de una mujer de 63 años relacionado con este último síndrome. Ingresada por torpeza en miembros inferiores, alteración del habla, hemiparesia derecha y cefalea. Las técnicas de neuroimagen mostraron signos indirectos de infarto en la arteria cerebral anterior izquierda que afectaban al área motora suplementaria y el cuerpo calloso. Las pruebas neuropsicológicas evaluaron funciones de atención, lenguaje, memoria, gnosias, praxias y funciones ejecutivas. Los resultados de las pruebas indicaron déficits en distintas funciones cognitivas superiores entre las que destacaba el síndrome de utilización compulsiva de objetos. Para profundizar en el análisis de este síndrome se planteó un estudio Resonancia Magnética Funcional del que se desprende que el área premotora contralateral es la responsable de los movimientos de la mano ajena

On generic singularities of intersections of ellipsoids: the octahedron

The goal of this work is to study the smoothings of singular coaxial intersections of ellipsoids (where coaxial includes concentric) with generic singularities, with special attention to the three-dimensional case

On generic singularities of intersections of ellipsoids: the octahedron

The goal of this work is to study the smoothings of singular coaxial intersections of ellipsoids (where coaxial includes concentric) with generic singularities, with special attention to the 3-dimensional case

Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis

Peritoneal dialysis (PD) is a form of renal replacement therapy whose repeated use can alter dialytic function through induction of epithelial-mesenchymal transition (EMT) and fibrosis, eventually leading to PD discontinuation. The peritoneum from Cav1-/- mice showed increased EMT, thickness and fibrosis. Exposure of Cav1-/- mice to PD fluids further increased peritoneal membrane thickness, altered permeability and increased the number of FSP-1/cytokeratin-positive cells invading the sub-mesothelial stroma. High-throughput quantitative proteomics revealed increased abundance of collagens, FN and laminin, as well as proteins related to TGF- activity in matrices derived from Cav1-/- cells. Lack of Cav1 was associated with hyperactivation of a MEK-ERK1/2-Snail-1 pathway that regulated the Smad2-3/Smad1-5-8 balance. Pharmacological blockade of MEK rescued E-cadherin and ZO-1 inter-cellular junction localization, reduced fibrosis and restored peritoneal function in Cav1-/- mice. Moreover, treatment of human PD-patient-derived MCs with drugs increasing Cav1 levels, as well as ectopic Cav1 expression, induced reacquisition of epithelial features. This study demonstrates a pivotal role of Cav1 in the balance of epithelial versus mesenchymal state and suggests targets for the prevention of fibrosis during PD

Trabajadores pobres y pobreza en el trabajo: concepto y evolución de la pobreza en la oculación: el impacto de las últimas reformas legales

Secretaría de Estado de Investigación, Desarrollo e InnovaciónFondo Europeo de Desarrollo Regional (FEDER) de la Unión Europe

Aprendizaje autónomo del Laboratorio de Química Inorgánica mediante el uso de TICs

Se ha creado un Entorno Virtual de Enseñanza y Aprendizaje (EVEA) circunscrito a la realización de prácticas en el Laboratorio de Química Inorgánica orientado a incrementar el grado de interacción entre el alumno con algún tipo de dificultad auditiva o dificultad idiomática y el profesor o el resto de sus compañeros mediante el uso conjunto del material elaborado y el uso de sistemas basados en redes sociales, mensajerías

Methodological quality checklist for studies based on observational methodology (MQCOM)

Background: No existing instrument addresses the minimum number of items that guarantee methodological quality in studies based on observational methodology. Consequently, professionals who are not experts in observational methodology do not have a basic framework to guide their practice in this type of study. This study developed a checklist to measure the minimum number of items for methodological quality that studies based on observational methodology should consider and provided evidence of their validity based on test content and intercoder reliability. Method: Fifty-four judges with at least 1 year of experience in observational methodology and research based on this methodology evaluated the items of the developed checklist in terms of relevance, usefulness, and feasibility. Items were selected if they obtained at least .5 in the Osterlind indexes of the three aspects evaluated. Two coders applied the selected items to a random selection of articles that used observational methodology to investigate soccer, and intercoder reliability was examined using Cohen's kappa (κ) coeffi cients. Results: The fi nal checklist included 16 items grouped into 11 criteria/dimensions, with adequate reliability coeffi cients. Conclusions: This study developed a useful instrument for non-expert professionals to enhance the methodological quality of studies based on observational methodology

Multifactorial Etiology of Anemia in Celiac Disease and Effect of Gluten-Free Diet: A Comprehensive Review

Celiac disease (CD) is a multisystemic disorder with di erent clinical expressions, from malabsorption with diarrhea, anemia, and nutritional compromise to extraintestinal manifestations. Anemia might be the only clinical expression of the disease, and iron deficiency anemia is considered one of the most frequent extraintestinal clinical manifestations of CD. Therefore, CD should be suspected in the presence of anemia without a known etiology. Assessment of tissue anti-transglutaminase and anti-endomysial antibodies are indicated in these cases and, if positive, digestive endoscopy and intestinal biopsy should be performed. Anemia in CD has a multifactorial pathogenesis and, although it is frequently a consequence of iron deficiency, it can be caused by deficiencies of folate or vitamin B12, or by blood loss or by its association with inflammatory bowel disease (IBD) or other associated diseases. The association between CD and IBD should be considered during anemia treatment in patients with IBD, because the similarity of symptoms could delay the diagnosis. Vitamin B12 deficiency is common in CD and may be responsible for anemia and peripheral myeloneuropathy. Folate deficiency is a well-known cause of anemia in adults, but there is little information in children with CD; it is still unknown if anemia is a symptom of the most typical CD in adult patients either by predisposition due to the fact of age or because biochemical and clinical manifestations take longer to appear

Autonomic nervous system measurement in hyperbaric environments using ECG and PPG signals

The main aim of this work was to characterise the Autonomic Nervous System (ANS) response in hyper- baric environments using electrocardiogram (ECG) and pulse- photoplethysmogram (PPG) signals. To that end, 26 subjects were introduced into a hyperbaric chamber and five stages with different atmospheric pressures (1 atm; descent to 3 and 5 atm; ascent to 3 and 1 atm) were recorded. Respiratory information was extracted from the ECG and PPG signals and a combined respiratory rate was studied. This information was also used to analyse Heart Rate Variability (HRV) and Pulse Rate Variability (PRV). The database was cleaned by eliminating those cases where the respiratory rate dropped into the low frequency band (LF: 0.04-0.15 Hz) and those in which there was a discrepancy between the respiratory rates estimated using the ECG and PPG signals. Classical temporal and frequency indices were calculated in such cases. The ECG results showed a time-related depen- dency, with the heart rate and sympathetic markers (normalised power in LF and LF/HF ratio) decreasing as more time was spent inside the hyperbaric environment. A dependency between the atmospheric pressure and the parasympathetic response, as reflected in the high frequency band power (HF: 0.15-0.40 Hz), was also found, with power increasing with atmospheric pressure. The combined respiratory rate also reached a maximum in the deepest stage, thus highlighting a significant difference between this stage and the first one. The PPG data gave similar findings and also allowed the oxygen saturation to be computed, therefore we propose the use of this signal for future studies in hyperbaric environments

Analysis of the mood of students in different degrees of Health Sciences

[EN] The mood of students has an impact on the teaching-learning process by influencing motivation, memory and the ability to develop cognitive resources; therefore, mental health should be considered in the educational process. The main objective of this study is to evaluate the state of mind of our students, as well as to know the student diversity and their emotional maturity. The results derived could be the starting point for designing teaching methodologies that are better suited to each stage of their education according to their state of mind. To this end, we have resorted to the analysis of the Profile of Mood States (POMS) in undergraduate students of Health Sciences, from three Spanish universities. We analysed the results by degree and gender, finding that the degrees in Medicine and Pharmacy showed a worse mood compared to those in Nursing and Physiotherapy. The evolution was similar in men and women.[ES] El estado de ánimo del estudiantado repercute en los procesos de enseñanza-aprendizaje al incidir sobre la motivación, la memoria y la capacidad para desarrollar recursos cognitivos, por tanto, la salud mental debe ser considerado un factor a tener en cuenta en el proceso educativo. El objetivo principal de este estudio es evaluar el estado anímico de nuestro estudiantado, así como conocer la diversidad del alumnado y su madurez emocional. Los resultados derivados podrían ser el punto de partida para diseñar metodologías docentes que encajen mejor en cada momento de su formación en función de su estado de ánimo. Para lograr este fin, hemos recurrido al análisis del Perfil de los Estados de Ánimo (Profile of Mood States, POMS) en alumnado de grados de Ciencias de la Salud, perteneciente a tres universidades españolas. Hemos analizado los resultados por grados y por género, encontrando que los grados de Medicina y Farmacia presentaban un peor estado de ánimo comparado con los de Enfermería y Fisioterapia. La evolución fue similar en hombres y mujeres.San-Miguel, T.; Mauricio, MD.; González-Santos, Á.; Ortiz-Comino, L.; Postigo-Martín, P.; López-Garzón, M.; Lozano-Lozano, M.... (2022). Análisis del estado de ánimo del alumnado en diferentes grados de Ciencias de la Salud. Editorial Universitat Politècnica de València. 983-993. https://doi.org/10.4995/INRED2022.2022.1586498399