1,033 research outputs found
Order parameter model for unstable multilane traffic flow
We discuss a phenomenological approach to the description of unstable vehicle
motion on multilane highways that explains in a simple way the observed
sequence of the phase transitions "free flow -> synchronized motion -> jam" as
well as the hysteresis in the transition "free flow synchronized motion".
We introduce a new variable called order parameter that accounts for possible
correlations in the vehicle motion at different lanes. So, it is principally
due to the "many-body" effects in the car interaction, which enables us to
regard it as an additional independent state variable of traffic flow. Basing
on the latest experimental data (cond-mat/9905216) we assume that these
correlations are due to a small group of "fast" drivers. Taking into account
the general properties of the driver behavior we write the governing equation
for the order parameter. In this context we analyze the instability of
homogeneous traffic flow manifesting itself in both of the mentioned above
phase transitions where, in addition, the transition "synchronized motion ->
jam" also exhibits a similar hysteresis. Besides, the jam is characterized by
the vehicle flows at different lanes being independent of one another. We
specify a certain simplified model in order to study the general features of
the car cluster self-formation under the phase transition "free flow
synchronized motion". In particular, we show that the main local parameters of
the developed cluster are determined by the state characteristics of vehicle
motion only.Comment: REVTeX 3.1, 10 pages with 10 PostScript figure
226 A work load study to determine the proportion of time spent on delivering rescue vs. prevention clinical care in adults with cystic fibrosis
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Kinetic and Spectroscopic Characterization of the H178A Methionyl Aminopeptidase from \u3cem\u3eEscherichia coli\u3c/em\u3e
To gain insight into the role of the strictly conserved histidine residue, H178, in the reaction mechanism of the methionyl aminopeptidase from Escherichia coli (EcMetAP-I), the H178A mutant enzyme was prepared. Metal-reconstituted H178A binds only one equivalent of Co(II) or Fe(II) tightly with affinities that are identical to the WT enzyme based on kinetic and isothermal titration calorimetry (ITC) data. Electronic absorption spectra of Co(II)-loaded H178A EcMetAP-I indicate that the active site divalent metal ion is pentacoordinate, identical to the WT enzyme. These data indicate that the metal binding site has not been affected by altering H178. The effect of altering H178 on activity is, in general, due to a decrease in kcat. The kcat value for Co(II)-loaded H178A decreased 70-fold toward MGMM and 290-fold toward MP-p-NA compared to the WT enzyme, while kcat decreased 50-fold toward MGMM for the Fe(II)-loaded H178A enzyme and 140-fold toward MP-p-NA. The Km values for MGMM remained unaffected, while those for MP-p-NA increased approximately 2-fold for Co(II)- and Fe(II)-loaded H178A. The kcat/Km values for both Co(II)- and Fe(II)-loaded H178A toward both substrates ranged from ∼50- to 580-fold reduction. The pH dependence of log Km, log kcat, and log(kcat/Km) of both WT and H178A EcMetAP-I were also obtained and are identical, within error, for H178A and WT EcMetAP-I. Therefore, H178A is catalytically important but is not required for catalysis. Assignment of one of the observed pKa values at 8.1 for WT EcMetAP-I was obtained from plots of molar absorptivity at λmax(640) vs pH for both WT and H178A EcMetAP-I. Apparent pKa values of 8.1 and 7.6 were obtained for WT and H178A EcMetAP-I, respectively, and were assigned to the deprotonation of a metal-bound water molecule. The data reported herein provide support for the key elements of the previously proposed mechanism and suggest that a similar mechanism can apply to the enzyme with a single metal in the active site
Educational Technology Research Past and Present: Balancing Rigor and Relevance to Impact School Learning
Today, the exponential growth of technology usage in education, via such applications of distance education, Internet access, simulations, and educational games, has raised substantially the focus and importance of educational technology research. In this paper, we examine the past and present research trends, with emphasis on the role and contribution of research evidence for informing instructional practices and policies to improve learning in schools. Specific topics addressed include: (a) varied conceptions of “effective” technology uses in classroom instruction as topics for research, (b) historical trends in research approaches and topics of inquiry; (c) alternative research designs for balancing internal (rigor) and external (relevance) validity; and (d) suggested directions for future research. Attention is devoted to describing varied experimental designs as options for achieving appropriate rigor and relevance of research evidence, and using mixed-methods research for investigating and understanding technology applications in complex real-life settings
Male Antarctic fur seals: neglected food competitors of bioindicator species in the context of an increasing Antarctic krill fishery.
The fishery for Antarctic krill is currently managed using a precautionary, ecosystem-based approach to limiting catch, with performance indices from a long-term monitoring program focused on several krill-dependent predators that are used to track ecosystem health. Concerns over increased fishing in concentrated areas and ongoing efforts to establish a Marine Protected Area along the Peninsula, a key fishing region, is driving the development of an adaptive management system for the fishery. The cumulative effects of fishing effort and interactions among krill-dependent predators and their performance is at present neglected in the CCAMLR Ecosystem Monitoring Program. However, we show considerable overlap between male Antarctic fur seals and the krill fishery in a complex mosaic, suggesting potential for cumulative impacts on other krill dependent predators. A holistic view is required as part of future efforts to manage the krill fishery that incorporates various sources of potential impacts on the performance of bioindicator species, including the fishery and its interactions with various krill dependent predators. © 2020, The Author(s)
Root to Kellerer
We revisit Kellerer's Theorem, that is, we show that for a family of real
probability distributions which increases in convex
order there exists a Markov martingale s.t.\ .
To establish the result, we observe that the set of martingale measures with
given marginals carries a natural compact Polish topology. Based on a
particular property of the martingale coupling associated to Root's embedding
this allows for a relatively concise proof of Kellerer's theorem.
We emphasize that many of our arguments are borrowed from Kellerer
\cite{Ke72}, Lowther \cite{Lo07}, and Hirsch-Roynette-Profeta-Yor
\cite{HiPr11,HiRo12}.Comment: 8 pages, 1 figur
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Lewy body compared with Alzheimer dementia is associated with decreased functional connectivity in resting state networks.
Resting state functional magnetic resonance imaging (fMRI) was used to measure whole brain functional connectivity within specific networks hypothesised to be more affected in dementia with Lewy bodies (DLB) (a disease characterised by prominent attentional deficits, spontaneous motor features of parkinsonism and depression) than in Alzheimer׳s disease (AD) and controls. This study involved 68 subjects (15 DLB, 13 AD and 40 controls) who were scanned using resting state BOLD (blood-oxygen-level-dependent) fMRI on a 3T MRI scanner. Functional connectivity was measured using a model-free independent component analysis approach that consisted of temporally concatenating the resting state fMRI data of all study subjects and investigating group differences using a back-reconstruction procedure. Resting state functional connectivity was affected in the default mode, salience, executive and basal ganglia networks in DLB subjects compared with AD and controls. Functional connectivity was lower in DLB compared with AD and controls in these networks, except for the basal ganglia network, where connectivity was greater in DLB. No resting state networks showed less connectivity in AD compared with DLB or controls. Our results suggest that functional connectivity of resting state networks can identify differences between DLB and AD subjects that may help to explain why DLB subjects have more frequent attentional deficits, parkinsonian symptoms, and depression than those with AD.North East Dementia and Neurodegenerative Diseases Research Network (DeNDRoN)This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.pscychresns.2014.06.00
Environmental Aging of Scotch-Weld(TradeMark) AF-555M Structural Adhesive in Composite to Composite Bonds
Fiber reinforced resin matrix composites have found increased usage in recent years. Due to the lack of service history of these relatively new material systems, their long-term aging performance is not well established. In this study, adhesive bonds were prepared by the secondary bonding of Scotch-Weld(TradeMark) AF-555M between pre-cured adherends comprised of T800H/3900-2 uni-directional laminate. The adherends were co-cured with wet peel-ply for surface preparation. Each bond-line of single-lap-shear (SLS) specimen was measured to determine thickness and inspected visually for voids. A three-year environmental aging plan for the SLS specimens at 82 C and 85% relative humidity was initiated. SLS strengths were measured for both controls and aged specimens at room temperature and 82 C. The aging results of strength retention and failure modes to date are reported
Drones and marine mammals in Svalbard, Norway
The impact of remotely piloted aircraft systems (RPAS) on
marine mammals remains poorly documented despite their
increasing use. In the high-Arctic Archipelago of Svalbard, where
marine mammals face increasing pressure from climate change
and expanding tourism, the use of RPAS remains largely
unregulated. In this study we assessed the impacts of RPAS
across a range of species to provide science-based management
advice, using a variety of aircraft sizes and approach strategies.
We explored RPAS sound levels and animal behavior prior to
and after flights. Preexperimental alertness influenced sensitivity
to disturbance notably. Harbor seals were more sensitive during
prebreeding than during molting, reacting at distances of 80 m,
whereas walruses responded at distances <50 m. Polar bears
reacted to the sound of RPAS during take-off at 300 m,
although response levels were relatively low. White whales
reacted to the sight of RPAS when flown ahead of the pod,
below 15 m. Variations in sound levels typical in overhead
descents and manual flights increased disturbance potential
more than RPAS size; preprogrammed flight paths are advised.
Our study highlights factors that can influence sensitivity to
RPAS including tidal state and swell, the presence of young individuals, ambient noise levels, and RPAS approach strategies
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