Historical, fictional and illustrative readings of the vivisected body 1873-1913

This thesis analyses why the practice of vivisection captured the imagination of a small section of late-Victorian society, and how these individuals articulated their concerns. By adopting an interdisciplinary approach, this study brings together the texts of both anti and pro-vivisectionists to place literary texts alongside medical textbooks and illustrations, essays and campaigning leaflets to suggest a representation of the vivisector throughout the different texts assembled. The first chapter explores the interaction, in print, between activist Frances Power Cobbe and physiologist, Elie de Cyon alongside the ways in which the antivivisectionists used images of vivisected animals, sourced from scientific manuals, to assist in constructing the movement’s identity. The second chapter analyses the lecture notes of two young medical students published as The Shambles of Science (1903) and how the authors strived to secure a literary representation for pain. These findings will then pave the way for an examination of how anti-vivisection rhetoric influenced fiction. The next chapter is concerned with the relationship between the ‘heart’ and ‘science’ and considers the more positive outcomes for those existing on the periphery of scientific experimentation. The fourth chapter examines the relationship between vivisection and hydrophobia, while simultaneously considering the implications of nurturing the young vivisector. The final chapter examines how the signature of the vivisectionist can be read through the incisions made on the surface of the opened body. By delving into these interactive, textual and imaginative bodies, this chapter explores the ways in which the vivisected body, traced by the scalpel and relayed by the instrumentation of the laboratory became a literary object

Supersymmetric dark-matter Q-balls and their interactions in matter

Supersymmetric extensions of the Standard Model contain non-topological solitons, Q-balls, which can be stable and can be a form of cosmological dark matter. Understanding the interaction of SUSY Q-balls with matter fermions is important for both astrophysical limits and laboratory searches for these dark matter candidates. We show that a baryon scattering off a baryonic SUSY Q-ball can convert into its antiparticle with a high probability, while the baryon number of the Q-ball is increased by two units. For a SUSY Q-ball interacting with matter, this process dominates over those previously discussed in the literature.Comment: 12 page

Understanding why farmers change their farming practices : the role of orienting principles in technology transfer

This report presents results from a qualitative study of sheep, beef and dairy farmers in the Temuka, Geraldine area of the South Island, New Zealand. Farmers' accounts of their farming practices, and how they decide to adopt, or not adopt, innovations are analysed to highlight the key orienting principles that guide their decision making. Farmers in each type of production have different orientations to innovation, in large part reflecting the nature of the industry in which they are located. Sheep and beef farmers emphasise profitability and the need to control risk and to farm safely. Dairy farmers emphasise increasing production, increasing efficiency and control by monitoring production. The results are important for alerting researchers and educationalists to the farmers' point of view in the development of effective extension.Funding for this research was received from the Foundation for Research, Science and Technology. The Lotteries Board supported the research by providing technical equipment. The former New Zealand Institute for Social Research and Development initiated this project and it was continued by the AERU in November, 1994

Extracellular Matrix Mineralization Promotes E11/gp38 Glycoprotein Expression and Drives Osteocytic Differentiation

Osteocytes are terminally differentiated osteoblasts which reside in a mineralized extracellular matrix (ECM). The factors that regulate this differentiation process are unknown. We have investigated whether ECM mineralization could promote osteocyte formation. To do this we have utilised MLO-A5 pre-osteocyte-like cells and western blotting and comparative RT-PCR to examine whether the expression of osteocyte-selective markers is elevated concurrently with the onset of ECM mineralization. Secondly, if mineralization of the ECM is indeed a driver of osteocyte formation, we reasoned that impairment of ECM mineralization would result in a reversible inhibition of osteocyte formation. Supplementation of MLO-A5 cell cultures with ascorbic acid and phosphate promoted progressive ECM mineralization as well as temporally associated increases in expression of the osteocyte-selective markers, E11/gp38 glycoprotein and sclerostin. Consistent with a primary role for ECM mineralization in osteocyte formation, we also found that inhibition of ECM mineralization, by omitting phosphate or adding sodium pyrophosphate, a recognized inhibitor of hydroxyapatite formation, resulted in a 15-fold decrease in mineral deposition that was closely accompanied by lower expression of E11 and other osteocyte markers such as Dmp1, Cd44 and Sost whilst expression of osteoblast markers Ocn and Col1a increased. To rule out the possibility that such restriction of ECM mineralization may produce an irreversible modification in osteoblast behaviour to limit E11 expression and osteocytogenesis, we also measured the capacity of MLO-A5 cells to re-enter the osteocyte differentiation programme. We found that the mineralisation process was re-initiated and closely allied to increased expression of E11 protein after re-administration of phosphate or omission of sodium pyrophosphate, indicating an ECM mineralization-induced restoration in osteocyte formation. These results emphasise the importance of cell-ECM interactions in regulating osteoblast behaviour and, more importantly, suggest that ECM mineralization exerts pivotal control during terminal osteoblast differentiation and acquisition of the osteocyte phenotype

A new modelling approach for piled and other ground heat exchanger applications

Pile heat exchangers have an increasing role to play in the delivery of renewable heating and cooling energy. Traditionally the thermal design of ground heat exchangers has relied upon analytical approaches which take a relatively simple approach to the inside of the heat exchanger. This approach is justified while the heat exchanger diameter remains small. However, as larger diameter piled foundations are used as heat exchangers, the transient heat transfer processes operating within the pile become more important. To increase our understanding of these processes and ultimately lead to improved thermal design approaches for pile heat exchangers it is important to examine the heat transfer within the pile in detail. To accomplish this, a new numerical approach has been implemented within the finite element software ABAQUS. Coupling of the convective heat transfer due to fluid flow within the heat transfer pipes and the heat transfer by conduction within the pile concrete is the most important facet of the model. The resulting modelling approach, which is ready to generalise to other geothermal applications and to assess thermo-mechanical couplings, has been validated against a multi-stage thermal response test carried out on a test pile in London Clay

Reading Guide 7: Intervention strategies and business case

Earthworks deteriorate over time and are additionally subject to increasingly extreme weather conditions. A range of intervention types is available to maintain the safety and serviceability of earthworks assets, and these should be selected and made as cost-effectively as possible, to maximise asset condition improvement within the available budget

Thermal Conductivity of Simulated Soils by the Needle Probe Method for Energy Foundation Applications

Soil thermal conductivity is an important parameter in the design of ground source heat pump and energy foundation systems. A laboratory method for measuring the soil thermal conductivity is the needle probe method. Earlier, analysis of the needle probe test data has been simplistic, relying heavily on human judgment and rules of thumb. This article presents an alternative method of analyzing the needle probe data with the aid of MATLAB, which is a technical programming language and computing environment. Four agar–kaolin specimens of varying densities were prepared to resemble simple soils. These were tested using the needle probe for a range of heating times and heating powers, to see what effect these parameters would have on the results. The repeatability when keeping the heating time and heating power constant was within ±2%. When the heating time and heating power were varied, the variation in results from the average for a given specimen ranged from ±4% to +10%/–8%. This range is significantly higher than the repeatability. Possible reasons for this are discussed in this article

Influences on the thermal efficiency of energy piles

Energy piles have recently emerged as a viable alternative to borehole heat exchangers, but their energy efficiency has so far seen little research. In this work, a finite element numerical model is developed for the accurate 3D analysis of transient diffusive and convective heat exchange phenomena taking place in geothermal structures. The model is validated by reproducing both the outcome of a thermal response test carried out on a test pile, and the average response of the linear heat source analytical solution. Then, the model is employed to carry out a parametric analysis to identify the key factors in maximising the pile energy efficiency. It is shown that the most influential design parameter is the number of pipes, which can be more conveniently increased, within a reasonable range, compared to increasing the pile dimensions. The influence of changing pile length, concrete conductivity, pile diameter and concrete cover are also discussed in light of their energetic implications. Counter to engineering intuition, the fluid flowrate does not emerge as important in energy efficiency, provided it is sufficient to ensure turbulent flow. The model presented in this paper can be easily adapted to the detailed study of other types of geothermal structures