Quantum confinement in PbI2 nanodisks prepared with cucurbit[7]uril

This work presents an alternative route for the preparation of heavy metal iodide nanoparticles, particularly lead iodide nanodisks (ca. 50-340 × 7 Å, diameter × thickness), using the macrocycle cucurbit[7]uril as a synthetic template and stabilizing agent. These nanoparticles exhibit an optical-gap blue shift consistent with their small size and 1D quantum confinement. Their thicknesses are compatible with an exfoliated single layer of lead iodide, indicating that cucurbit[7]uril, preventing the stacking and formation of tactoids, thus limiting nanoparticles growth in the z direction. The structure, morphology and properties of these disks were analyzed by X-ray powder diffractometry (XRD), UV-Visible spectroscopy, atomic force microscopy (AFM), scanning electron microscopy with analysis of energy dispersive X-ray fluorescence (SEM-EDS) and high resolution transmission electron microscopy (HRTEM).Este trabalho apresenta uma rota alternativa para a preparação de nanodiscos de iodeto de chumbo (ca. 50-340 × 7Å, diâmetro × espessura) utilizando o macrocíclico cucurbit[7]urila como molde de síntese e agente estabilizante. Estas nanopartículas apresentam um deslocamento para o azul de gap óptico consistente com seu tamanho reduzido e confinamento quântico 1D. Suas espessuras são compatíveis com a de uma camada de iodeto de chumbo esfoliado, indicando que cucurbit[7]urila impede a formação de estruturas lamelares e limita o crescimento das nanopartículas. A estrutura, a morfologia e as propriedades destes discos foram verificadas por difratometria de raios X em pó (XRD), espectroscopia no UV-Visível, microscopia de força atômica (AFM), microscopia eletrônica de varredura com análise de fluorescência de raios X por dispersão de energia (SEM-EDS) e microscopia eletrônica de transmissão de alta resolução (HRTEM).Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

Synthesis, antimalarial activity in vitro, and docking studies of novel neolignan derivatives

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESThe absence of effective vaccines against malaria and the difficulties associated with controlling mosquito vectors have left chemotherapy as the primary control measure against malaria. However, the emergence and spread of parasite resistance to conventi903464472CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESSEM INFORMAÇÃOSEM INFORMAÇÃOSEM INFORMAÇÃOThe authors thank Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES (CAPES) for financial suppor

Antinociceptive activity of acetylbergenin in mice

Endopleura uchi (Huber) Cuatrec. (Humiriaceae), a Brazilian Amazon plant, is used in folk medicine for the treatment of arthritis. Bergenin, one of the chemical constituents of E. uchi, has several biological activities, including anti-inflammatory properties. Acetylbergenin was obtained from acetylation of bergenin to investigate the antinociceptive effect assessed in models of nociception in mice. This compound dosed at 1, 5, 10, 15 and 25 mg/kg in the writhing test reduced the abdominal constrictions in a significant manner, in 28.2 %, 52.7 %, 61.1 %, 68.3 % and 95.0 %, respectively with ED50 of 6.8 mg/kg. Acetylbergenin in the hot plate test was assayed at 6.8 mg/kg producing no alterations in the latency time when compared to the control. It was tested at 6.8 mg/kg in the formalin test inhibiting significantly the second phase of the algic stimulous, in 88.3 %. These results suggest that acetylbergenin has analgesic activity, probably of peripheral origin. The mechanism involved is not completely understood, however, the results suggest that the opioid system must be involved in the antinociceptive action.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Synthesis, characterization and in vitro anticancer activity of Novel 8,4’ : oxyneolignan analogues

Neolignans are a class of natural products with a wide range of biological effects. These substances are of great synthetic and biological interest, especially in searching for novel anticancer agents. In this paper, we report the synthesis of a new subclass of 8,4’-oxyneolignan analogues (β-ketoethers and β-ketoesters) and their cell viability assay on twenty four different cancer cells, among leukemias and carcinomas. Three compounds inhibited the growth of most human cancer cells. 2-Oxo-2-phenylethyl(2E)-3-[4-(2-oxo-2-phenylethoxy) phenyl]prop-2-enoate showed an antiproliferative activity superior to doxorubicin for U-87, U-138 MG and H1299 cell types and (E)-2-oxo-2-phenylethyl 3-(3-methoxy-4-(2-oxo-2-phenylethoxy)phenyl)acrylate was found to be very selective, demonstrating a growth inhibition of 92.0% against KG-1 cells. Furthermore, 1-oxo-1-phenylpropan-2-yl cinnamate exhibited significant inhibition activity in a range of 52.2 to 91.2% against twelve kinds of leukemia cell lines, revealing excellent results and very comparable to the reference drug

Structure-Activity Relationship of Compounds which are Anti-Schistosomiasis Active

The molecular orbital method AM1 was employed to calculate a set of molecular descriptors for twenty synthetic neolignan derivatives with anti-schistosomiasis activity. The pattern recognition method (principal component analysis PCA and cluster analysis CA and discriminant analysis methods) have been employed to obtain the relationship between the molecular descriptors and biological activity. The set of molecules was classified into two groups according to their degree of biological activity. These results allow us to rationally project new compounds, potential candidates for synthesis and biological evaluation