115 research outputs found
Simultaneous fMRI–PET of the opioidergic pain system in human brain
MRI and PET provide complementary information for studying brain function. While the potential use of simultaneous MRI/PET for clinical diagnostic and disease staging has been demonstrated recently; the biological relevance of concurrent functional MRI-PET brain imaging to dissect neurochemically distinct components of the blood oxygenation level dependent (BOLD) fMRI signal has not yet been shown. We obtained sixteen fMRI-PET data sets from eight healthy volunteers. Each subject participated in randomized order in a pain scan and a control (nonpainful pressure) scan on the same day. Dynamic PET data were acquired with an opioid radioligand, [(11)C]Diprenorphine, to detect endogenous opioid releases in response to pain. BOLD fMRI data were collected at the same time to capture hemodynamic responses. In this simultaneous human fMRI-PET imaging study, we show co-localized responses in thalamus and striatum related to pain processing, while modality specific brain networks were also found. Co-localized fMRI and PET signal changes in the thalamus were positively correlated suggesting pain-induced changes in opioid neurotransmission contribute a significant component of the fMRI signal change in this region. Simultaneous fMRI-PET provides unique opportunities allowing us to relate specific neurochemical events to functional hemodynamic activation and to investigate the impacts of neurotransmission on neurovascular coupling of the human brain in vivo
Contribution a l'analyse theorique et experimental du role et des modalites d'intervention des neurones dopaminergiques mesencephaliques dans les relations cerveau-comportement
SIGLEINIST TD 19865 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
Striatal dopaminergic responses observed in latent inhibition are dependent on the hippocampal ventral subicular region
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Postnatal tetrodotoxin inactivation of the ventral subiculum abolished latent inhibition responses in the core part of the nucleus accumbens in adult rats.
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Postnatal functional blockade of the ventral subiculum abolishes latent inhibition responses in the shell part of the nucleus accumbens in adult rats.
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Neonatal functional inactivation of the prefrontal cortex results in an increased dopaminergic response in the core part of the nucleus accumbens to D-amphetamine treatment in adult rats.
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Disruption of latent inhibition- related dopaminergic responses monitored in the core part of the nucleus accumbens in adult rats following a transient neonatal inactivation of the ventral subiculum.
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