High resolution spectroscopy of single NV defects coupled with nearby 13^{13}C nuclear spins in diamond

We report a systematic study of the hyperfine interaction between the electron spin of a single nitrogen-vacancy (NV) defect in diamond and nearby $^{13}$C nuclear spins, by using pulsed electron spin resonance spectroscopy. We isolate a set of discrete values of the hyperfine coupling strength ranging from 14 MHz to 400 kHz and corresponding to $^{13}$C nuclear spins placed at different lattice sites of the diamond matrix. For each lattice site, the hyperfine interaction is further investigated through nuclear spin polarization measurements and by studying the magnetic field dependence of the hyperfine splitting. This work provides informations that are relevant for the development of nuclear-spin based quantum register in diamond.Comment: 8 pages, 5 figure

Energy levels and decoherence properties of single electron and nuclear spins in a defect center in diamond

The coherent behavior of the single electron and single nuclear spins of a defect center in diamond and a 13C nucleus in its vicinity, respectively, are investigated. The energy levels associated with the hyperfine coupling of the electron spin of the defect center to the 13C nuclear spin are analyzed. Methods of magnetic resonance together with optical readout of single defect centers have been applied in order to observe the coherent dynamics of the electron and nuclear spins. Long coherence times, in the order of microseconds for electron spins and tens of microseconds for nuclear spins, recommend the studied system as a good experimental approach for implementing a 2-qubit gate.Comment: 4 pages, 4 figure

Genetic testing approaches for hereditary breast cancer: Perspectives from a private diagnostic laboratory

Breast cancer is highly prevalent in South Africa, and up to 10% of breast cancer cases may be hereditary. The landscape of genetic testing options for hereditary breast cancer (HBC) has changed significantly over the past decade, and healthcare providers are faced with multiple options when referring breast cancer patients for genetic testing. We have performed a retrospective study of 3 years’ worth of breast cancer genetic testing referrals to our laboratory. While Afrikaner and Ashkenazi Jewish founder screens may be appropriate as first-line tests in a limited subset of patients, we have shown that in the majority of cases it is more effective to adopt a multigene panel approach. While variants in the BRCA1 and BRCA2 genes still account for a significant proportion of cases, close to 40% of pathogenic variants were found in genes other than BRCA1 or BRCA2. There are many factors that healthcare providers should consider when requesting genetic testing for breast cancer patients and families, including family history, ancestral background, cost, medical aid scheme reimbursement and scope of testing. We summarise our findings and provide advantages and disadvantages of each approach, with the aim of assisting clinicians and genetic counsellors to make appropriate testing decisions

Continuous electroencephalographic monitoring and selective shunting reduces neurologic morbidity rates in carotid endarterectomy

Purpose:The role of continuous electroencephalographic (EEG) monitoring during carotid endarterectomy was evaluated in this retrospective review.Methods:We analyzed data from 902 consecutive carotid endarterectomy procedures performed with vein patch angioplasty. In 591 operations from 1980 to 1988 we did not use intraoperative EEG monitoring or shunting (non-EEG group). Continuous intraoperative EEG monitoring and selective shunting were used in 311 procedures from 1988 to 1994 (EEG group). The patients' mean age was higher in the EEG group (68.8 years; range, 41 to 87 years) than in the non-EEG group (66.2 years; range, 34 to 90 years; p < 0.001). There was also a significantly higher incidence of hypertension (56.2% vs 41.9%) and redo operations (5.4% vs 2.54%) in the EEG group than in the non-EEG group (p < 0.05). The operative technique was identical in both groups. We defined a significant EEG change as a greater than 50% reduction of the amplitude of the faster frequencies, a persistent increase of delta activity, or both.Results:In the EEG group, acute EEG changes occurred in 40 patients (12.8%); 31 (77.5%) unilateral and ipsilateral to the operated carotid artery, and nine (22.5%) bilateral. In five patients (12.5%) the changes correlated with an intraoperative episode of hypotension, and after normal blood pressure was restored the EEG returned to normal. In 35 procedures (87.5%) a carotid shunt was inserted. In 33 of those patients the EEG returned to baseline, in one patient there was a significant improvement, and in one patient the EEG changes persisted. Postoperative hospital strokes occurred in one patient (0.32%) in the EEG group and in 13 patients (2.19%) in the non-EEG group (p < 0.05). All strokes (n = 14) were ipsilateral to the operated carotid artery. Of the 13 strokes in the non-EEG group nine were major and four were minor. The one stroke in the EEG group was embolic in origin and occurred before carotid cross-clamping; it was associated with profound EEG changes that did not reverse after placement of a shunt. In the total group (n = 902), intraoperative EEG monitoring was inversely associated with postoperative stroke (p < 0.05).Conclusion:The overall neurologic morbidity rate was significantly lower in the EEG group than in the non-EEG group, thereby demonstrating the value of intraoperative EEG monitoring in carotid endarterectomy

The MeerKAT Fornax Survey

We present the science case and observations plan of the MeerKAT Fornax Survey, an HI and radio continuum survey of the Fornax galaxy cluster to be carried out with the SKA precursor MeerKAT. Fornax is the second most massive cluster within 20 Mpc and the largest nearby cluster in the southern hemisphere. Its low X-ray luminosity makes it representative of the environment where most galaxies live and where substantial galaxy evolution takes place. Fornax's ongoing growth makes it an excellent laboratory for studying the assembly of clusters, the physics of gas accretion and stripping in galaxies falling in the cluster, and the connection between these processes and the neutral medium in the cosmic web. We will observe a region of 12 deg$^2$ reaching a projected distance of 1.5 Mpc from the cluster centre. This will cover a wide range of environment density out to the outskirts of the cluster, where gas-rich in-falling groups are found. We will: study the HI morphology of resolved galaxies down to a column density of a few times 1e+19 cm$^{-2}$ at a resolution of 1 kpc; measure the slope of the HI mass function down to M(HI) 5e+5 M(sun); and attempt to detect HI in the cosmic web reaching a column density of 1e+18 cm$^{-2}$ at a resolution of 10 kpc.Comment: Proceedings of Science, "MeerKAT Science: On the Pathway to the SKA", Stellenbosch, 25-27 May 201

Spectral classification of emission-line galaxies from the Sloan Digital Sky Survey. II. A supplementary diagnostic for AGNs using the Dn(4000) index

In this paper we present a classification of emission-line galaxies at intermediate and high redshifts (0.52.5 for near-infrared spectra), using the Dn(4000) index as a supplementary diagnostic. Our goal is to complement the diagnostic based only on emission-line ratios from the blue part of the spectra, which suffer from some limitations for the classification of Seyfert 2 and composite galaxies. We used a sample of 89 379 galaxies with a good signal-to-noise ratio from the Sloan Digital Sky Survey (data release 7). Using the classification scheme presented in Paper I, we classified these galaxies with a diagnostic diagram involving the [Oiii]5007 /Hbeta and [Oii]3726+3729 /Hbeta emission-line ratios. Then we derived a supplementary diagnostic involving Dn(4000) to improve this classification, in the regions where objects of different types are mixed. To show the validity of our spectral classification we established success-rate and contamination charts, then we compared our results to those obtained with the reference classification that was scheme obtained also using Halpha, [Nii]6584, and [Sii]6717+6731 emission lines. We show that our supplementary classification based on the Dn(4000) index allows to separate unambiguously star-forming galaxies from Seyfert 2 in the region where they were mixed in Paper I. It also significantly reduces the region where star-forming galaxies are mixed with composites.Comment: accepted for publication in A\&A, 10 pages corrected bug in LateX file for equations 7 and

Anisotropic interactions of a single spin and dark-spin spectroscopy in diamond

The nitrogen-vacancy (N-V) center in diamond is a promising atomic-scale system for solid-state quantum information processing. Its spin-dependent photoluminescence has enabled sensitive measurements on single N-V centers, such as: electron spin resonance, Rabi oscillations, single-shot spin readout and two-qubit operations with a nearby 13C nuclear spin. Furthermore, room temperature spin coherence times as long as 58 microseconds have been reported for N-V center ensembles. Here, we have developed an angle-resolved magneto-photoluminescence microscopy apparatus to investigate the anisotropic electron spin interactions of single N-V centers at room temperature. We observe negative peaks in the photoluminescence as a function of both magnetic field magnitude and angle that are explained by coherent spin precession and anisotropic relaxation at spin level anti-crossings. In addition, precise field alignment unmasks the resonant coupling to neighboring dark nitrogen spins that are not otherwise detected by photoluminescence. The latter results demonstrate a means of investigating small numbers of dark spins via a single bright spin under ambient conditions.Comment: 13 pages, 4 figure

The star formation histories of galaxies in different stages of pre-processing in the Fornax A group

We study the recent star formation histories of ten galaxies in the Fornax A galaxy group, on the outskirts of the Fornax cluster. The group galaxies are gas-rich, and their neutral atomic hydrogen (HI) was studied in detail with observations from the MeerKAT telescope. This allowed them to be classified into different stages of pre-processing (early, ongoing, advanced). We use long-slit spectra obtained with the South African Large Telescope (SALT) to analyse stellar population indicators to constrain quenching timescales and to compare these to the HI gas content of the galaxies. The H$\alpha$ equivalent width, EW(H$\alpha$), suggest that the pre-processing stage is closely related to the recent (< 10 Myr) specific Star Formation Rate (sSFR). The early-stage galaxy (NGC 1326B) is not yet quenched in its outer parts, while the ongoing-stage galaxies mostly have a distributed population of very young stars, though less so in their outer parts. The galaxies in the advanced stage of pre-processing show very low recent sSFR in the outer parts. Our results suggest that NGC 1326B, FCC 35 and FCC 46 underwent significantly different histories from secular evolution during the last Gyr. The fact that most galaxies are on the secular evolution sequence implies that pre-processing has a negligible effect on these galaxies compared to secular evolution. We find EW(H$\alpha$) to be a useful tool for classifying the stage of pre-processing in group galaxies. The recent sSFR and HI morphology show that galaxies in the Fornax A vicinity are pre-processing from the outside in.Comment: 17 pages, accepted for publication in MNRA

Controlling the quantum dynamics of a mesoscopic spin bath in diamond

Understanding and mitigating decoherence is a key challenge for quantum science and technology. The main source of decoherence for solid-state spin systems is the uncontrolled spin bath environment. Here, we demonstrate quantum control of a mesoscopic spin bath in diamond at room temperature that is composed of electron spins of substitutional nitrogen impurities. The resulting spin bath dynamics are probed using a single nitrogen-vacancy (NV) centre electron spin as a magnetic field sensor. We exploit the spin bath control to dynamically suppress dephasing of the NV spin by the spin bath. Furthermore, by combining spin bath control with dynamical decoupling, we directly measure the coherence and temporal correlations of different groups of bath spins. These results uncover a new arena for fundamental studies on decoherence and enable novel avenues for spin-based magnetometry and quantum information processing

The negatively charged nitrogen-vacancy centre in diamond: the electronic solution

The negatively charged nitrogen-vacancy centre is a unique defect in diamond that possesses properties highly suited to many applications, including quantum information processing, quantum metrology, and biolabelling. Although the unique properties of the centre have been extensively documented and utilised, a detailed understanding of the physics of the centre has not yet been achieved. Indeed there persists a number of points of contention regarding the electronic structure of the centre, such as the ordering of the dark intermediate singlet states. Without a sound model of the centre's electronic structure, the understanding of the system's unique dynamical properties can not effectively progress. In this work, the molecular model of the defect centre is fully developed to provide a self consistent model of the complete electronic structure of the centre. The application of the model to describe the effects of electric, magnetic and strain interactions, as well as the variation of the centre's fine structure with temperature, provides an invaluable tool to those studying the centre and a means to design future empirical and ab initio studies of this important defect.Comment: 24 pages, 6 figures, 10 table