Capturing what and why in healthcare innovation

Funding: Dr Davis’ time was funded from a collaborative project between University of Dundee; Tayside Academic Health Sciences Partnership; Medtronic; Scottish Enterprise; National Centre for Universities and Business.Understandings of innovation usually encompass multiple overlapping aspects, putting innovation terminology at risk of vagueness and overuse. However, innovation concepts are expected to remain powerful and useful in healthcare beyond the pandemic and into the future, so clarity will be helpful for effective leadership. To disentangle and disambiguate meanings within innovation, we offer a framework that captures and simplifies foundational substance within innovation concepts. Our method is an overview review of innovation literature from the 5 years preceding COVID-19. 51 sources were sampled and analysed for explicit definitions of healthcare innovation. Drawing on broad themes suggested from previous reviews, and gathering specific themes emergent from this literary dataset, we focused on categorising the nature of innovations (the what) and reasons given for them (the why). We identified 4 categories of what (ideas, artefacts, practice/process and structure) and 10 categories of why (economic value, practical value, experience, resource use, equity/accessibility, sustainability, behaviour change, specific-problem solving, self-justifying renewal and improved health). These categories reflect contrasting priorities and values, but do not substantially interfere or occlude each other. They can freely be additively combined to create composite definitions. This conceptual scheme affords insight and clarity for creating precise meanings, and making critical sense of imprecision, around innovation. Improved communication and clear shared understandings around innovative intentions, policies and practices cannot but improve the chances of enhanced outcomes. The all-inclusive character of this scheme leaves space for considering the limits of innovation, and notwithstanding well-established critiques, provides a basis for clarity in ongoing usage.PostprintPeer reviewe

The Violent Youth of Bright and Massive Cluster Galaxies and their Maturation over 7 Billion Years

In this study we investigate the formation and evolution mechanisms of the brightest cluster galaxies (BCGs) over cosmic time. At high redshift ($z\sim0.9$), we selected BCGs and most massive cluster galaxies (MMCGs) from the Cl1604 supercluster and compared them to low-redshift ($z\sim0.1$) counterparts drawn from the MCXC meta-catalog, supplemented by SDSS imaging and spectroscopy. We observed striking differences in the morphological, color, spectral, and stellar mass properties of the BCGs/MMCGs in the two samples. High-redshift BCGs/MMCGs were, in many cases, star-forming, late-type galaxies, with blue broadband colors, properties largely absent amongst the low-redshift BCGs/MMCGs. The stellar mass of BCGs was found to increase by an average factor of $2.51\pm0.71$ from $z\sim0.9$ to $z\sim0.1$. Through this and other comparisons we conclude that a combination of major merging (mainly wet or mixed) and \emph{in situ} star formation are the main mechanisms which build stellar mass in BCGs/MMCGs. The stellar mass growth of the BCGs/MMCGs also appears to grow in lockstep with both the stellar baryonic and total mass of the cluster. Additionally, BCGs/MMCGs were found to grow in size, on average, a factor of $\sim3$, while their average S\'ersic index increased by $\sim$0.45 from $z\sim0.9$ to $z\sim0.1$, also supporting a scenario involving major merging, though some adiabatic expansion is required. These observational results are compared to both models and simulations to further explore the implications on processes which shape and evolve BCGs/MMCGs over the past $\sim$7 Gyr.Comment: Accepted for publication in MNRA

The Origin of [O II] Emission in Recently Quenched Active Galaxy Nucleus Hosts

We have employed emission-line diagnostics derived from DEIMOS and NIRSPEC spectroscopy to determine the origin of the [O II] emission line observed in six active galactic nucleus (AGN) hosts at z ~ 0.9. These galaxies are a subsample of AGN hosts detected in the Cl1604 supercluster that exhibit strong Balmer absorption lines in their spectra and appear to be in a post-starburst or post-quenched phase, if not for their [O II] emission. Examining the flux ratio of the [N II] to Hα lines, we find that in five of the six hosts the dominant source of ionizing flux is AGN continuum emission. Furthermore, we find that four of the six galaxies have over twice the [O II] line luminosity that could be generated by star formation alone given their Hα line luminosities. This strongly suggests that AGN-excited narrow-line emission is contaminating the [O II] line flux. A comparison of star formation rates calculated from extinction-corrected [O II] and Hα line luminosities indicates that the former yields a five-fold overestimate of the current activity in these galaxies. Our findings reveal the [O II] line to be a poor indicator of star formation activity in a majority of these moderate-luminosity Seyferts. This result bolsters our previous findings that an increased fraction of AGN at high redshifts is hosted by galaxies in a post-starburst phase. The relatively high fraction of AGN hosts in the Cl1604 supercluster that show signs of recently truncated star formation activity may suggest that AGN feedback plays an increasingly important role in suppressing ongoing activity in large-scale structures at high redshift

Galaxy Groups Associated with Gravitational Lenses and H_0 from B1608+656

Compact groups of galaxies recently have been discovered in association with several strong gravitational lens systems. These groups provide additional convergence to the lensing potential and thus affect the value of H_0 derived from the systems. Lens system time delays are now being measured with uncertainties of only a few percent or better. Additionally, vast improvements are being made in incorporating observational constraints such as Einstein ring structures and stellar velocity dispersions into the lens models. These advances are reducing the uncertainties on H_0 to levels at which the the effects of associated galaxy groups may contribute significantly to the overall error budget. We describe a dedicated multiwavelength program, using Keck, HST, and Chandra, to find such groups and measure their properties. We present, as a case study, results obtained from observations of the CLASS lens system B1608+656 and discuss the implications for the value of H_0 derived from this system.Comment: To appear in Proceedings of IAU Symposium 225: Impact of Gravitational Lensing on Cosmology, 6 pages, 2 figure

Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation

Acknowledgments: We thank Dr. Robert Barkley and Charis Uhlson for mass spectrometry analysis. Funding: This work was supported by grants from the National Institutes of Health HL34303 (to C.C.L., R.C.M. and D.L.B), DK54741 (to J.V.B.), GM5322 (to D.L.W.) and the Wellcome Trust (to N.A.R.G. and G.D.B.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Application of nanoparticulate conducting polyaniline in nanofilm biosensor technology

This biosensor uses a novel aqueous-based nanoparticulate polyaniline (PANI), synthesised using dodecylbenzenesulphonic acid (DBSA) and aniline as starting material. These polymer nanoparticles have been electrodeposited on to the surface of carbon electrodes resulting in conductive nano-films, which were examined by electrochemistry, scanning electron microscopy (SEM), atomic force microscopy (AFM), profilometry and spectroelectrochemistry. Biomolecules were then electrostatically adsorbed onto this surface and physical techniques have shown that the nanofilm possesses properties which allow for uniform adsorption of protein to take place. This effective biosensor format has been characterised using a horseradish peroxidase (HRP) and H2O2 format. This sensor exhibits higher signal/noise (S/N) ratios and quicker response times than previous PANI biosensor formats developed by our group, due to its nanofilm characteristic

The Properties of Radio Galaxies and the Effect of Environment in Large Scale Structures at z∼1z\sim1

In this study we investigate 89 radio galaxies that are spectroscopically-confirmed to be members of five large scale structures in the redshift range of $0.65 \le z \le 0.96$. Based on a two-stage classification scheme, the radio galaxies are classified into three sub-classes: active galactic nucleus (AGN), hybrid, and star-forming galaxy (SFG). We study the properties of the three radio sub-classes and their global and local environmental preferences. We find AGN hosts are the most massive population and exhibit quiescence in their star-formation activity. The SFG population has a comparable stellar mass to those hosting a radio AGN but are unequivocally powered by star formation. Hybrids, though selected as an intermediate population in our classification scheme, were found in almost all analyses to be a unique type of radio galaxies rather than a mixture of AGN and SFGs. They are dominated by a high-excitation radio galaxy (HERG) population. We discuss environmental effects and scenarios for each sub-class. AGN tend to be preferentially located in locally dense environments and in the cores of clusters/groups, with these preferences persisting when comparing to galaxies of similar colour and stellar mass, suggesting that their activity may be ignited in the cluster/group virialized core regions. Conversely, SFGs exhibit a strong preference for intermediate-density global environments, suggesting that dusty starbursting activity in LSSs is largely driven by galaxy-galaxy interactions and merging.Comment: 28 pages, 10 figures, accepted to MNRA

Conformal Motions and the Duistermaat-Heckman Integration Formula

We derive a geometric integration formula for the partition function of a classical dynamical system and use it to show that corrections to the WKB approximation vanish for any Hamiltonian which generates conformal motions of some Riemannian geometry on the phase space. This generalizes previous cases where the Hamiltonian was taken as an isometry generator. We show that this conformal symmetry is similar to the usual formulations of the Duistermaat-Heckman integration formula in terms of a supersymmetric Ward identity for the dynamical system. We present an explicit example of a localizable Hamiltonian system in this context and use it to demonstrate how the dynamics of such systems differ from previous examples of the Duistermaat-Heckman theorem.Comment: 13 pages LaTeX, run twice. Uses epsf.tex, 2 postscript files read directly into LaTeX file from director