929 research outputs found
The Grid[Way] Job Template Manager, a tool for parameter sweeping
Parameter sweeping is a widely used algorithmic technique in computational
science. It is specially suited for high-throughput computing since the jobs
evaluating the parameter space are loosely coupled or independent.
A tool that integrates the modeling of a parameter study with the control of
jobs in a distributed architecture is presented. The main task is to facilitate
the creation and deletion of job templates, which are the elements describing
the jobs to be run. Extra functionality relies upon the GridWay Metascheduler,
acting as the middleware layer for job submission and control. It supports
interesting features like multi-dimensional sweeping space, wildcarding of
parameters, functional evaluation of ranges, value-skipping and job template
automatic indexation.
The use of this tool increases the reliability of the parameter sweep study
thanks to the systematic bookkeping of job templates and respective job
statuses. Furthermore, it simplifies the porting of the target application to
the grid reducing the required amount of time and effort.Comment: 26 pages, 1 figure
El dictamen pericial en la formación de los alumnos de seminarios y casas de formación
Sumario: Siglas y abreviaturas. 1. Introducción. 1.1. Vocación y actualidad. 1.2. Psicología y vocación. 2. Documentos
del Concilio Vaticano II respecto a la importancia de la psicología y de los peritos en la postulación y formación de los
seminarios. 2.1. El Decreto Optatam totius y la formación integral de los futuros sacerdotes. 2.2. Perfectæ caritatis. 3.
Código de 1983. 3.1. Admisión a los candidatos al seminario e Institutos religiosos. 3.1.1. Idoneidad de quienes postulan
al seminario mayor (c. 241 § 1). 3.2. Relevancia de la opinión del perito en la recepción de las sagradas órdenes.
3.3. Salida involuntaria del Instituto religioso al expirar el plazo de los votos temporales (c. 689). 4. La Ratio Fundamentalis
Institutionis Sacerdotalis (Normas fundamentales de la formación sacerdotal), 19.III .1985. 5. La Exh. Ap. Pastores
dabo vobis. 6. La formación en los Institutos religiosos: las orientaciones Potissimum institutionis. 7. Carta respecto a los
escrutinios de idoneidad de los candidatos al sacramento del orden. 8. Otros documentos emanados por las Congregaciones
de la Curia Romana. 8.1. Discernimiento en el acceso al sacramento del orden por parte de las personas que
padecen enfermedad celíaca. 8. 2. Instrucción respecto al discernimiento vocacional al sacramento del orden en
personas con tendencias homosexuales. 8.3. La competencia psicológica en el discernimiento vocacional al sacramento
del orden. 9. La nueva Ratio Fundamentalis Institutionis Sacerdotalis, 8.XII .2016. 10. Relevancia de la opinión del
perito en la aceptación de candidatos y en el período de formación. 10.1. Necesidad de la opinión de un especialista en
los procedimientos de postulación. 10.2. Valoración del dictamen pericial por parte de los formadores. 10.3. Funciones
del perito durante la etapa de formación en el seminario. 11. Conclusión. Bibliografía. Índice de la tesis doctoral
Quantum Double Models coupled with matter: an algebraic dualisation approach
In this paper, we constructed a new generalization of a class of discrete
bidimensional models, the so called Quantum Double Models, by introduce matter
qunits to the faces of the lattice that supports these models. This new
generalization can be interpreted as the algebraic dual of a first, where we
introduce matter qunits to the vertices of this same lattice. By evaluating the
algebraic and topological orders of these new models, we prove that, as in the
first generalization, a new phenomenon of quasiparticle confinement may appear
again: this happens when the co-action homomorphism between matter and gauge
groups is non-trivial. Consequently, this homomorphism not only classifies the
different models that belong to this new class, but also suggests that they can
be interpreted as a 2-dimensional restriction of the 2-lattice gauge theories.Comment: 18 pages, 8 figures; submitted to publicatio
ArCLight - a Compact Dielectric Large-Area Photon Detector
ArCLight is a novel device for detecting scintillation light over large areas
with Photon Detection Efficiency (PDE) of the order of a few percent. Its
robust technological design allows for efficient use in large-volume particle
detectors, such as Liquid Argon Time Projection Chambers (LArTPCs) or liquid
scintillator detectors. Due to its dielectric structure it can be placed inside
volumes with high electric field. It could potentially replace vacuum
PhotoMultiplier Tubes (PMTs) in applications where high PDE is not required.
The photon detection efficiency for a 10x10cm2 detector prototype was measured
to be in the range of 0.8% to 2.2% across the active area
El desarrollo de un modelo de agricultura intensiva bajo plástico en un territorio de condiciones extremas: aproximación al estudio del caso de Daklha en el Sahara occidental
Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles
Indexación: Scopus.Acknowledgments: This work was supported by FONDECYT No. 11130701. We would also like to thank fDoTr CthLeafbr efeora vthaeil afrbeilei tayvoafiltahbeilsitoyf towfa trheer seoqfutwireadret orecqaulciureladt etothcealAcuDla(thet ttph:e/ A/dDt c(lhatbt.pw:/e/dbstc.cloabm.w/seobfst.wcoamre/-stoofotlws aarned-tools and http://teqip.jdvu.ac.in/QSAR_Tools/). SDG. Conflicts of Interest: The authors declare no conflict of interest. Conflicts of Interest: The authors declare no conflict of interest.The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there is only one drug on the market, mirabegron, approved for the treatment of OAB. In the present study, we have carried out an extensive structure-activity relationship analysis of a series of 41 aryloxypropanolamine compounds based on three-dimensional quantitative structure-activity relationship (3D-QSAR) techniques. This is the first combined comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) study in a series of selective aryloxypropanolamines displaying anti-diabetes and anti-obesity pharmacological profiles. The best CoMFA and CoMSIA models presented values of r2 ncv = 0.993 and 0.984 and values of r2 test = 0.865 and 0.918, respectively. The results obtained were subjected to extensive external validation (q2, r2, r2 m, etc.) and a final series of compounds was designed and their biological activity was predicted (best pEC50 = 8.561). © 2018 by the authors.https://www.mdpi.com/1420-3049/23/5/119
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