Beam Dynamics Studies and Design Optimisation of New Low Energy Antiproton Facilities

Antiprotons, stored and cooled at low energies in a storage ring or at rest in traps, are highly desirable for the investigation of a large number of basic questions on fundamental interactions. This includes the static structure of antiprotonic atomic systems and the time-dependent quantum dynamics of correlated systems. The Antiproton Decelerator (AD) at CERN is currently the worlds only low energy antiproton factory dedicated to antimatter experiments. New antiproton facilities, such as the Extra Low ENergy Antiproton ring (ELENA) at CERN and the Ultra-low energy Storage Ring (USR) at FLAIR, will open unique possibilities. They will provide cooled, high quality beams of extra-low energy antiprotons at intensities exceeding those achieved presently at the AD by factors of ten to one hundred. These facilities, operating in the energy regime between 100 keV down to 20 keV, face several design and beam dynamics challenges, for example nonlinearities, space charge and scattering effects limiting beam life time. Detailed investigations into the low energy and long term beam dynamics have been carried out to address many of those challenges towards the design optimisation. Results from these studies are presented in this contribution, showing some examples for ELENA.Comment: 6 pages, 4 figures, 12th International Conference on Low Energy Antiproton Physics, LEAP 2016. Submitted to JPS Conference Proceeding

Improving the geospatial consistency of digital libraries metadata

Consistency is an essential aspect of the quality of metadata. Inconsistent metadata records are harmful: given a themed query, the set of retrieved metadata records would contain descriptions of unrelated or irrelevant resources, and may even not contain some resources considered obvious. This is even worse when the description of the location is inconsistent. Inconsistent spatial descriptions may yield invisible or hidden geographical resources that cannot be retrieved by means of spatially themed queries. Therefore, ensuring spatial consistency should be a primary goal when reusing, sharing and developing georeferenced digital collections. We present a methodology able to detect geospatial inconsistencies in metadata collections based on the combination of spatial ranking, reverse geocoding, geographic knowledge organization systems and information-retrieval techniques. This methodology has been applied to a collection of metadata records describing maps and atlases belonging to the Library of Congress. The proposed approach was able to automatically identify inconsistent metadata records (870 out of 10,575) and propose fixes to most of them (91.5%) These results support the ability of the proposed methodology to assess the impact of spatial inconsistency in the retrievability and visibility of metadata records and improve their spatial consistency

Transient Posterior Encephalopathy Induced by Chemotherapy in Children

The cases of three children, 16, 12, and 12 years of age, who suffered sudden confusional state and cortical blindness lasting 12 to 30 minutes while under treatment with high-dose methotrexate, cyclophosphamide, and dactinomycin for a lower limb osteosarcoma are reported. Transient neuropsychologic deficits arose after the acute phase of treatment: left hemispatial neglect and constructive apraxia (Patient 1); constructive apraxia (Patient 2); and constructive apraxia and alexia without aphasia (Patient 3). The three patients recovered completely from all their deficits within the time frame of 3 hours to 2 weeks. Arterial hypertension and hypomagnesemia were found during the acute phase in all patients. In Patients 2 and 3, magnetic resonance imaging revealed increased parieto-occipital T(2) signal involving gray and white matter. In Patients 1 and 2, HmPAO-SPECT revealed parieto-occipital hypoperfusion that resolved a few days later. The alterations detected by neuroimaging were concurrent with the appearance and disappearance of the clinical symptoms. Such transient acute episodes have been named occipital-parietal encephalopathy. On the basis of our clinical, laboratory, and neuroimaging findings, an explanation for the origin of this syndrome, a migrainelike mechanism, triggered by chemotherapy-induced hypomagnesemia, is proposed

Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure

The aim of this study was to investigate whether torasemide modifies collagen cross-linking in the failing human heart. We analyzed the degree of cross-linking and the expression of the enzyme lysyl oxidase, which regulates cross-linking, in the myocardium of patients with chronic heart failure at baseline and after 8 months of treatment with either torasemide or furosemide in addition to their standard heart failure therapy. Whereas lysyl oxidase protein expression was very scarce in normal hearts, it was highly expressed in failing hearts. Cross-linking was increased (P<0.001) in heart failure patients compared with normal hearts. These 2 parameters decreased (P=0.021 and P=0.034) in torasemide-treated patients and remained unchanged in furosemide-treated patients. In addition, more (P=0.009) patients showed normalization of left ventricular chamber stiffness in the torasemide subgroup than in the furosemide subgroup after treatment. Lysyl oxidase expression correlated with cross-linking (r=0.661; P<0.001), and cross-linking correlated with left ventricular chamber stiffness (r=0.452; P=0.002) in all patients. These findings show for the first time that lysyl oxidase overexpression is associated with enhanced collagen cross-linking in the failing human heart. In addition, we report that the ability of torasemide to correct both lysyl oxidase overexpression and enhanced collagen cross-linking results in normalization of left ventricular chamber stiffness in patients with heart failure. Lysyl oxidase may thus represent a target for reduction of stiff collagen and improvement of left ventricular mechanical properties in heart failure patients

The 'Second Wave' of Spanish Clinical Legal Education: Empirical, Pedagogical and Institutional Lessons for a Pilot Course and Program at the University of Granada

Spanish clinicians today benefit from the ‘first wave’ of early adopters. We also benefit from decades of clinical scholarship — most recently about the Western European and global clinical legal education movements — and empirical data on what lawyers actually do and need in practice. In this article, the authors summarize key empirical, pedagogical, and institutional lessons to ground the creation of a pilot course and program at the University of Granada

Route Towards a Label-free Optical Waveguide Sensing Platform Based on Lossy Mode Resonances

According to recent market studies of the North American company Allied Market Research, the field of photonic sensors is an emerging strategic field for the following years and it is expected to garner $18 billion by 2021. The integration of micro and nanofabrication technologies in the field of sensors has allowed the development of new technological concepts such as lab-on-a-chip, which have achieved extraordinary advances in terms of detection and applicability, for example in the field of biosensors. This continuous development has allowed that equipment consisting of many complex devices that occupied a whole room a few years ago, at present it is possible to handle them in the palm of the hand; that formerly long duration processes are carried out in a matter of milliseconds and that a technology previously dedicated solely to military or scientific uses is available to the vast majority of consumers. The adequate combination of micro and nanostructured coatings with optical fiber sensors has permitted us to develop novel sensing technologies, such as the first experimental demonstration of lossy mode resonances (LMRs) for sensing applications, with more than one hundred citations and related publications in high rank journals and top conferences. In fact, fiber optic LMR-based devices have been proven as devices with one of the highest sensitivity for refractometric applications. Refractive index sensitivity is an indirect and simple indicator of how sensitive the device is to chemical and biological species, topic where this proposal is focused. Consequently, the utilization of these devices for chemical and biosensing applications is a clear opportunity that could open novel and interesting research lines and applications as well as simplify current analytical methodologies. As a result, on the basis of our previous experience with LMR based sensors to attain very high sensitivities, the objective of this paper is presenting the route for the development of label-free optical waveguide sensing platform based on LMRs that enable to explore the limits of this technology for bio-chemosensing applications

A Cultural Comparison of the ''Dark Constellations'' in the Milky Way

Cultures around the world find meaning in the groupings of stars and features in the Milky Way. The striking appearance of our Galaxy in the night sky serves as a reference to traditional knowledge, encoding science and culture to a memory space, becoming part of their overarching cosmologies. This paper examines traditional views of the Milky Way from cultures around the world, primarily in the Southern Hemisphere. These views comprise dark constellations: familiar shapes made up of the dark dust lanes in the Milky Way, rather than the bright stars. Some of the better-known examples include the celestial emu from Aboriginal traditions of Australia, and the llama in Inca traditions of the Andes. We conduct a comparative analysis of cultural perceptions of ‘dark constellations’ in the Milky Way, examining common cultural themes and meanings at the crossroads of Indigenous Knowledge and Western science with applications to topics ranging from Indigenous Studies to psychology.Fil: Gullberg, Steven R.. Oklahoma State University; Estados UnidosFil: Hamacher, Duane. University of Melbourne; AustraliaFil: Lopez, Alejandro Martin. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto de Ciencias Antropológicas. Sección de Etnología y Etnografía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mejuto, Javier. Universidad Nacional Autónoma de Honduras; HondurasFil: Munro, Andrew M.. University of Oklahoma; Estados UnidosFil: Orchiston, Wayne. University of Southern Queensland; Australia. National Astronomical Research Institute of Thailand; Tailandi

Retrospective pathology review of captive black rhinoceros Diceros bicornis in the EAZA Ex-situ Programme (1995-2022)

The husbandry of black rhinoceros Diceros bicornis is challenging due to a number of peculiar diseases affecting this species. Causes of mortality and morbidity were evaluated from 67 necropsy reports of black rhinos deceased in the EAZA Ex-situ Programme (EEP) in 1995–2022, and the prevalence of specific diseases were compared with previous surveys in the literature. Whereas some problems described as typical, such as haemolytic anaemia, aspergillosis or specific skin diseases presented at low prevalence, signs of iron overload disorder (IOD) were close to ubiquitous across animals, and skin disease, excessive tooth wear (often linked to impaction) and gastric ulceration were particularly prevalent. While this evaluation cannot add to understanding of the aetiology of these conditions, it emphasises the need to further investigate IOD and other diseases (which will require access to routine blood samples of both healthy and diseased animals facilitated by medical training). The findings also recommend further investigation of measures to rdce stress, possibly including that triggered by conspecifics as well as humans. Species-adequate nutrition still requires proactive approaches in providing dicot-based forages without resorting to monocot (grass) products

Monitoring the influence of marine aquaculture on wild fish communities: benefits and limitations of fatty acid profiles

Fatty acids (FA) have been applied as indicators of the influence of coastal sea-cage fish farming on wild fish communities in several recent scientific publications. Due to the relatively high conservation of FA composition throughout the food web, they are useful for characterizing trophic relationships. The increasing utilization of vegetable or alternative animal oils in the production of aquafeeds results in cultivated fish exhibiting higher levels of terrestrial FAs in their tissues. As previously reported, wild fish ubiquitously aggregate around fish farms as a consequence of the introduction of new habitat and the easy availability of food—fish farms act as enhanced fish aggregation devices (FADs). The influence of food pellets on the composition of wild fish has been detected in recent studies on salmon, sea bass and sea bream aquaculture, with increased levels of linoleic acid (18:2n-6) and a low n-3/n-6 ratio as clear indicators of the consumption of food pellets from the farms. The potential ecological and physiological effects on wild fish are presently unknown. In the present article, guidelines are proposed for the investigation and use of terrestrial FAs to track the effects of coastal aquaculture on wild fish communities and local fisheries, as well as the benefits or limitations of this technique