Evidence that the degree of band 3 phosphorylation modulates human erythrocytes nitric oxide efflux – in vitro model of hyperfibrinogenemia

© 2011 – IOS Press and the authors. All rights reservedRecent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO) modulation. In the present pioneer in-vitro study, whole blood samples were harvested from healthy subjects and aliquots were incubated in the absence (control aliquots) and presence of fibrinogen at different degrees of band 3 phosphorylation, and the levels of NO, nitrite, nitrate and S-nitroglutathione (GSNO) were determined. Hyperfibrinogenemia interferes with erythrocyte NO mobilization without changing its efflux in a way that seems to be dependent of the degree of band 3 phosphorylation. In presence of higher fibrinogen concentrations the NO efflux is reinforced when band 3 is phosphorylated (p < 0.001). Higher levels of nitrite, nitrate and GSNO were documented (p < 0.05). However, the mechanisms by which fibrinogen signalling modulates erythrocyte function remain to be clarified and are currently under study. These conditions may be considered an approach to be followed in blood storage for transfusions.This study was supported by grants from the FCT - Fundação para a Ciência e a Tecnologia (project reference PTDC/SAU-OSM/73449/2006

The Evolution of Web Search User Interfaces -- An Archaeological Analysis of Google Search Engine Result Pages

Web search engines have marked everyone's life by transforming how one searches and accesses information. Search engines give special attention to the user interface, especially search engine result pages (SERP). The well-known ''10 blue links'' list has evolved into richer interfaces, often personalized to the search query, the user, and other aspects. More than 20 years later, the literature has not adequately portrayed this development. We present a study on the evolution of SERP interfaces during the last two decades using Google Search as a case study. We used the most searched queries by year to extract a sample of SERP from the Internet Archive. Using this dataset, we analyzed how SERP evolved in content, layout, design (e.g., color scheme, text styling, graphics), navigation, and file size. We have also analyzed the user interface design patterns associated with SERP elements. We found that SERP are becoming more diverse in terms of elements, aggregating content from different verticals and including more features that provide direct answers. This systematic analysis portrays evolution trends in search engine user interfaces and, more generally, web design. We expect this work will trigger other, more specific studies that can take advantage of our dataset.Comment: 10 pages, Full Paper of CHIIR 202

Produção de mudas de palma-forrageira utilizando fragmentos de cladódios.

A palma (Opuntia ficus-indica L.) é uma das principais alternativas para alimentação de caprinos, ovinos e bovinos no Semiárido brasileiro. Contudo, o ataque da cochonilhado-carmim (Dactylopius opuntiae Cockerel) erradicou grande parte da área plantada, já que a maioria das variedades cultivadas são suscetíveis à praga. Três novas variedades resistentes à praga foram identificadas: Orelha-de-elefante mexicana, Miúda ou Doce e a variedade Mão-de-moça (clones IPA-Sertânea e PALMEPA-PB1). Contudo, a disponibilidade de material propagativo (cladódios ou raquetes) ainda é baixa, aumentando o preço da palma-semente. Assim, desenvolveu-se uma metodologia utilizando-se fragmentos (pedaços) de raquetes para a obtenção de novas mudas

Intangibles as innovative drivers for competitive businesses

This paper aims to identify the impact of intangible resources as drivers of firms’ performance and profitability, in the major technological firms in the world. Using information from the major technological firms for a four years economic period, a set of intellectual capital proxies were identified and regressed against the major performance and profitability indicators. The regression model embodies a set of knowledge-based resources intangible (e.g. goodwill, licenses and patents, software and R&D, and advertising expenses) and human capital proxies, aiming to identify potential disaggregated effects of intangibles those key performance indicators. Broadly, results suggest the existence of effective isolated effect for some variables, in particular for intangibles recognized in the financial reporting. Furthermore, this research also suggests that the capitalization of intangible resources can be associated with region and corresponding accounting standards used in the preparation of the financial reporting.info:eu-repo/semantics/acceptedVersio

Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease

Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by expansion of the polyglutamine domain of the ataxin-3 (ATX3) protein. MJD/SCA3 is the most frequent autosomal dominant ataxi4912FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO2007/57559-9; 2013/07559-3sem informaçã

Vanishing Viscosity Limits and Boundary Layers for Circularly Symmetric 2D Flows

We continue the work of Lopes Filho, Mazzucato and Nussenzveig Lopes [LMN], on the vanishing viscosity limit of circularly symmetric viscous flow in a disk with rotating boundary, shown there to converge to the inviscid limit in $L^2$-norm as long as the prescribed angular velocity $\alpha(t)$ of the boundary has bounded total variation. Here we establish convergence in stronger $L^2$ and $L^p$-Sobolev spaces, allow for more singular angular velocities $\alpha$, and address the issue of analyzing the behavior of the boundary layer. This includes an analysis of concentration of vorticity in the vanishing viscosity limit. We also consider such flows on an annulus, whose two boundary components rotate independently. [LMN] Lopes Filho, M. C., Mazzucato, A. L. and Nussenzveig Lopes, H. J., Vanishing viscosity limit for incompressible flow inside a rotating circle, preprint 2006