590 research outputs found
Investigation of fast initialization of spacecraft bubble memory systems
Bubble domain technology offers significant improvement in reliability and functionality for spacecraft onboard memory applications. In considering potential memory systems organizations, minimization of power in high capacity bubble memory systems necessitates the activation of only the desired portions of the memory. In power strobing arbitrary memory segments, a capability of fast turn on is required. Bubble device architectures, which provide redundant loop coding in the bubble devices, limit the initialization speed. Alternate initialization techniques are investigated to overcome this design limitation. An initialization technique using a small amount of external storage is demonstrated
Bubble memory module for spacecraft application
Bubble domain technology offers an all-solid-state alternative for data storage in onboard data systems. A versatile modular bubble memory concept was developed. The key module is the bubble memory module which contains all of the storage devices and circuitry for accessing these devices. This report documents the bubble memory module design and preliminary hardware designs aimed at memory module functional demonstration with available commercial bubble devices. The system architecture provides simultaneous operation of bubble devices to attain high data rates. Banks of bubble devices are accessed by a given bubble controller to minimize controller parts. A power strobing technique is discussed which could minimize the average system power dissipation. A fast initialization method using EEPROM (electrically erasable, programmable read-only memory) devices promotes fast access. Noise and crosstalk problems and implementations to minimize these are discussed. Flight memory systems which incorporate the concepts and techniques of this work could now be developed for applications
A Keplerian Circumbinary Disk around the Protobinary System L1551 NE
We present SubMillimeter-Array observations of a Keplerian disk around the
Class I protobinary system L1551 NE in 335 GHz continuum emission and
submillimeter line emission in 13CO (J=3-2) and C18O (J=3-2) at a resolution of
~120 x 80 AU. The 335-GHz dust-continuum image shows a strong central peak
closely coincident with the binary protostars and likely corresponding to
circumstellar disks, surrounded by a ~600 x 300 AU feature elongated
approximately perpendicular to the [Fe II] jet from the southern protostellar
component suggestive of a circumbinary disk. The 13CO and C18O images confirm
that the circumbinary continuum feature is indeed a rotating disk; furthermore,
the C18O channel maps can be well modeled by a geometrically-thin disk
exhibiting Keplerian rotation. We estimate a mass for the circumbinary disk of
~0.03-0.12 Msun, compared with an enclosed mass of ~0.8 Msun that is dominated
by the protobinary system. Compared with several other Class I protostars known
to exhibit Keplerian disks, L1551 NE has the lowest bolometric temperature (~91
K), highest envelope mass (~0.39 Msun), and the lowest ratio in stellar mass to
envelope + disk + stellar mass (~0.65). L1551 NE may therefore be the youngest
protostellar object so far found to exhibit a Keplerian disk. Our observations
present firm evidence that Keplerian disks around binary protostellar systems,
``Keplerian circumbinary disks', can exist. We speculate that tidal effects
from binary companions could transport angular momenta toward the inner edge of
the circumbinary disk and create the Keplerian circumbinary disk.Comment: 27 pages, 8 figure
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A NEW DEVICE AND METHOD FOR MEASURING VOLATILE COMPOUNDS IN MONITORING WELLS
Accurate, timely measurement of chlorinated solvents and other volatile contaminants in groundwater is crucial to support responsible environmental management. Traditionally, two distinctly different paradigms have been explored to meet this need--fixed laboratory analysis and ''real-time'' sensors. While these alternatives remain important, field based and field screening tools represent a potentially useful intermediate approach that balances some of the advantages and disadvantages of the traditional ''endmember'' paradigms. The value of accurate, in-field measurements during characterization was recognized in recent sampling/decision methods, such as the TRIAD approach (ITRC, 2003). Strategies that support gathering accurate data on the timescales representative of the rate of change of the system (e.g., months to years, not seconds to minutes) is key for long-term monitoring for chlorinated solvent plumes in which attenuation based remedies are being considered. A team of researchers developed a down-well sampling device that, when used in combination with field gas analysis tools, provides data in the field. The test results indicate this tool, as configured, will provide accurate measurements (as compared with laboratory methods) at concentrations in the hundreds of ppb or higher range, but require confirmatory traditional sampling with laboratory analysis at concentrations approaching 20 ppb and less. The logistics and costs of the sampling device were somewhat complex. The results of the study, while equivocal, generally suggest that future development of this type of in-field technique may be warranted
β2M Signals Monocytes Through Non-Canonical TGFβ Receptor Signal Transduction.
Rationale: Circulating monocytes can have pro-inflammatory or pro-reparative phenotypes. The
endogenous signaling molecules and pathways that regulate monocyte polarization in vivo are poorly
understood. We have shown that platelet derived beta-2 microglobulin (β2M) and transforming growth
factor beta (TGFβ) have opposing effects on monocytes by inducing inflammatory and reparative
phenotypes respectively, but each bind and signal through the same receptor. We now define the signaling
pathways involved.
Objective: To determine the molecular mechanisms and signal transduction pathways by which β2M and
TGFβ regulate monocyte responses both in vitro and in vivo.
Methods and Results: Wild-type (WT) and platelet specific β2M knockout (Plt-β2M-/-) mice were treated
intravenously with either β2M or TGFβ to increase plasma concentrations to those in cardiovascular
diseases. Elevated plasma β2M increased pro-inflammatory monocytes, while increased plasma TGFβ
increased pro-reparative monocytes. TGFβ receptor (TGFβR) inhibition blunted monocyte responses to
both β2M and TGFβ in vivo. Using imaging flow cytometry, we found that β2M decreased monocyte
SMAD2/3 nuclear localization, while TGFβ promoted SMAD nuclear translocation, but decreased noncanonical/
inflammatory (JNK and NFκB nuclear localization). This was confirmed in vitro using both
imaging flow cytometry and immunoblots. β2M, but not TGFβ, promoted ubiquitination of SMAD3 and
SMAD4, that inhibited their nuclear trafficking. Inhibition of ubiquitin ligase activity blocked noncanonical
SMAD-independent monocyte signaling and skewed monocytes towards a pro-reparative
monocyte response.
Conclusions: Our findings indicate that elevated plasma β2M and TGFβ dichotomously polarize
monocytes. Furthermore, these immune molecules share a common receptor, but induce SMAD-dependent
canonical signaling (TGFβ) versus non-canonical SMAD-independent signaling (β2M) in a ubiquitin ligase
dependent manner. This work has broad implications as β2M is increased in several inflammatory
conditions, while TGFβ is increased in fibrotic diseases.pre-print3451 K
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Developing an MNA Modeling Tool Based on RT3D: 3 Reports
Integral to the accept of MNA and EA as part of a remediation system is documenting the sustainability of the attenuation mechanisms. As many sites are located in complex hydrogeologic settings, documentation of sustainability will require the use of complex models that have the capabilities to mathematically represent the various attenuation mechanisms. To address this need a team of researchers developed specific reaction modules for complex chlorinated solvent reactions that occur in subsurface. These reaction modules support the RT3D model
Relaxation Effects in the Transition Temperature of Superconducting HgBa2CuO4+delta
In previous studies on a number of under- and overdoped high temperature
superconductors, including YBa_{2}Cu_{3}O_{7-y} and Tl_{2}Ba_{2}CuO_{6+\delta},
the transition temperature T_c has been found to change with time in a manner
which depends on the sample's detailed temperature and pressure history. This
relaxation behavior in T_c is believed to originate from rearrangements within
the oxygen sublattice. In the present high-pressure studies on
HgBa_{2}CuO_{4+\delta} to 0.8 GPa we find clear evidence for weak relaxation
effects in strongly under- and overdoped samples () with
an activation energy . For overdoped
HgBa_{2}CuO_{4+\delta} E_{A} increases under pressure more rapidly than
previously observed for YBa_{2}Cu_{3}O_{6.41}, yielding an activation volume of
+11 \pm 5 cm^{3}; the dependence of T_c on pressure is markedly nonlinear, an
anomalous result for high-T_c superconductors in the present pressure range,
giving evidence for a change in the electronic and/or structural properties
near 0.4 GPa
INDEPENDENT REVIEW OF THE X-701B GROUNDWATER REMEDY, PORTSMOUTH, OHIO: TECHNICAL EVALUATION AND RECOMMENDATIONS
The Department of Energy Portsmouth Paducah Project Office requested assistance from Department of Energy Office of Environmental Management (EM-22) to provide independent technical experts to evaluate past and ongoing remedial activities at the Portsmouth facility that were completed to address TCE contamination associated with the X-701B groundwater plume and to make recommendations for future efforts. The Independent Technical Review team was provided with a detailed and specific charter. The charter requested that the technical team first review the past and current activities completed for the X-701B groundwater remedy for trichloroethene (TCE) in accordance with a Decision Document that was issued by Ohio EPA on December 8, 2003 and a Work Plan that was approved by Ohio EPA on September 22, 2006. The remedy for X-701B divides the activities into four phases: Phase I - Initial Source Area Treatment, Phase II - Expanded Source Area Treatment, Phase III - Evaluation and Reporting, and Phase IV - Downgradient Remediation and Confirmation of Source Area Treatment. Phase I of the remedy was completed during FY2006, and DOE has now completed six oxidant injection events within Phase II. The Independent Technical Review team was asked to evaluate Phase II activities, including soil and groundwater results, and to determine whether or not the criteria that were defined in the Work Plan for the Phase II end point had been met. The following criteria are defined in the Work Plan as an acceptable Phase II end point: (1) Groundwater samples from the identified source area monitoring wells have concentrations below the Preliminary Remediation Goal (PRG) for TCE in groundwater, or (2) The remedy is no longer effective in removing TCE mass from the source area. In addition, the charter specifies that if the Review Team determines that the Phase II endpoint has not been reached, then the team should address the following issues: (1) If additional injection events are recommended, the team should identify the type of injection and target soil horizon for these injections; (2) Consider the feasibility of declaring Technical Impracticability and proceeding with the RCRA Cap for the X-701B; and (3) Provide a summary of other cost-effective technologies that could be implemented (especially for the lower Gallia). The Independent Technical Review team focused its evaluation solely on the X-701B source zone and contaminant plume. It did not review current or planned remedial activities at other plumes, waste areas, or landfills at the Portsmouth site, nor did it attempt to integrate such activities into its recommendations for X-701B. However, the ultimate selection of a remedy for X-701B by site personnel and regulators should take into account potentially synergistic efforts at other waste areas. Assessment of remedial alternatives in the context of site-wide management practices may reveal opportunities for leveraging and savings that would not otherwise be identified. For example, the cost of source-zone excavation or construction of a permeable reactive barrier at X-701B might be substantially reduced if contaminated soil could be buried on site at an existing or planned landfill. This allowance would improve the feasibility and competitiveness of both remedies. A comprehensive examination of ongoing and future environmental activities across the Portsmouth Gaseous Diffusion Plant is necessary to optimize the selection and timing of X-701B remediation with respect to cleanup efficiency, safety, and economics. A selected group of technical experts attended the technical workshop at the Portsmouth Gaseous Diffusion Plant from November 18 through 21, 2008. During the first day of the workshop, both contractor and DOE site personnel briefed the workshop participants and took them on a tour of the X-701B site. The initial briefing was attended by representatives of Ohio EPA who participated in the discussions. On subsequent days, the team reviewed baseline data and reports, were provided additional technical information from site personnel, evaluated work plans, determined critical issues and uncertainties, and recommended alternatives. This report documents the findings and recommendations of the independent technical review team
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