Developing an integrated approach to understanding the effects of climate change and other environmental alterations at a flyway level

The environmental consequences of global climate change are predicted to have their greatest effect at high latitudes and have great potential to impact fragile tundra ecosystems. The Arctic tundra is a vast biodiversity resource and provides breeding areas for many migratory geese. Importantly, tundra ecosystems also currently act as a global carbon “sink”, buffering carbon emissions from human activities. In January 2003, a new three year project was implemented to understand and model the interrelationships between goose population dynamics, conservation, European land use/agriculture and climate change. A range of potential future climate and land-use scenarios will be applied to the models and combined with information from field experiments on grazing and climate change in the Arctic. This paper describes the content of the research programme as well as issues in relation to engaging stakeholders with the project

Developing an integrated approach to understanding the effects of climate change and other environmental alterations at a flyway level

The environmental consequences of global climate change are predicted to have their greatest effect at high latitudes and have great potential to impact fragile tundra ecosystems. The Arctic tundra is a vast biodiversity resource and provides breeding areas for many migratory geese. Importantly, tundra ecosystems also currently act as a global carbon “sink”, buffering carbon emissions from human activities. In January 2003, a new three year project was implemented to understand and model the interrelationships between goose population dynamics, conservation, European land use/agriculture and climate change. A range of potential future climate and land-use scenarios will be applied to the models and combined with information from field experiments on grazing and climate change in the Arctic. This paper describes the content of the research programme as well as issues in relation to engaging stakeholders with the project

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Interleukin-22 (IL-22) is a critical immune defence cytokine that maintains intestinal homeostasis and promotes wound healing and tissue regeneration, which can support the growth of colorectal tumours. Mutations in the adenomatous polyposis coli gene (Apc) are a major driver of familial colorectal cancers (CRCs). How IL-22 contributes to APC-mediated tumorigenesis is poorly understood. To investigate IL-22 signalling in wild-type (WT) and APC-mutant cells, we performed RNA sequencing (RNAseq) of IL-22-treated murine small intestinal epithelial organoids. In WT epithelia, antimicrobial defence and cellular stress response pathways were most strongly induced by IL-22. Surprisingly, although IL-22 activates signal transducer and activator of transcription 3 (STAT3) in APC-mutant cells, STAT3 target genes were not induced. Our analyses revealed that ApcMin/Min cells are resistant to IL-22 due to reduced expression of the IL-22 receptor, and increased expression of inhibitors of STAT3, particularly histone deacetylases (HDACs). We further show that IL-22 increases DNA damage and genomic instability, which can accelerate cellular transition from heterozygosity (ApcMin/+) to homozygosity (ApcMin/Min) to drive tumour formation. Our data reveal an unexpected role for IL-22 in promoting early tumorigenesis while excluding a function for IL-22 in transformed epithelial cells

Late Onset Myasthenia Gravis Is Associated with HLA DRB1*15:01 in the Norwegian Population

BACKGROUND: Acquired myasthenia gravis (MG) is a rare antibody-mediated autoimmune disease caused by impaired neuromuscular transmission, leading to abnormal muscle fatigability. The aetiology is complex, including genetic risk factors of the human leukocyte antigen (HLA) complex and unknown environmental factors. Although associations between the HLA complex and MG are well established, not all involved components of the HLA predisposition to this heterogeneous disease have been revealed. Well-powered and comprehensive HLA analyses of subgroups in MG are warranted, especially in late onset MG. METHODOLOGY/PRINCIPAL FINDINGS: This case-control association study is of a large population-based Norwegian cohort of 369 MG patients and 651 healthy controls. We performed comprehensive genotyping of four classical HLA loci (HLA-A, -B, -C and -DRB1) and showed that the DRB1*15:01 allele conferred the strongest risk in late onset MG (LOMG; onset ≥ 60 years) (OR 2.38, p(c)7.4 × 10(-5)). DRB1*13:01 was found to be a protective allele for both early onset MG (EOMG) and LOMG (OR 0.31, p(c) 4.71 × 10(-4)), a finding not previously described. No significant association was found to the DRB1*07:01 allele (p(nc) = 0.18) in a subset of nonthymomatous anti-titin antibody positive LOMG as reported by others. HLA-B*08 was mapped to give the strongest contribution to EOMG, supporting previous studies. CONCLUSION: The results from this study provide important new information concerning the susceptibility of HLA alleles in Caucasian MG, with highlights on DRB1*15:01 as being a major risk allele in LOMG

Opportunities and pitfalls of using building performance simulation in explorative R&D contexts

One of the promising use cases of building performance simulation (BPS) is its role as a virtual laboratory in research and development (R&D) projects that aim to bring innovative building components from initial idea towards market introduction. By facilitating what-if explorations and whole-building insights, BPS can create complementary value, alongside actual experiments. However, explorative R&D projects tend to be rather erratic and are more ill-defined than typical BPS tasks. This raises several issues concerning application, interpretation and communication of BPS-based performance predictions in explorative contexts. The aim of this paper is to highlight opportunities and potential pitfalls of the use of BPS in this application domain. First, the characteristic properties of exploration-driven R&D projects are contrasted with more conventional BPS projects using a systematic requirements engineering approach. Then, the process and outcomes of three R&D projects of innovative façade systems are discussed. Finally, the lessons learned from these studies are presented

Assisting the development of innovative responsive façade elements using building performance simulation

Thermal mass is usually positively associated with energy efficiency and thermal comfort in buildings. However, the slow response of heavyweight constructions is not beneficial at all times, as these dynamic effects may actually also increase heating and cooling energy demand during intermittent operation or can cause unwanted discomfort. This study investigates the potential of energy simulations to support the exploration-driven development of two innovative responsive building elements: “Spong3D” and “Convective Concrete”. Both use fluid flow (Spong3D: water, Convective Concrete: air) inside the construction to reduce building energy demand by exploiting the use of natural energy sinks and sources in the ambient environment, aiming to make more intelligent use of thermal mass. During the development of these concepts, different simulation tools were used alongside experiments for e.g. materials selection, climate analysis, comfort prediction and risk assessment. By presenting the results from a series of simulation studies and by reflecting on their application, this paper shows how computational building performance analyses can play a useful role in ill-defined R&D processes

Development and prototyping of an integrated 3D-printed façade for thermal regulation in complex geometries

\u3cp\u3eCurrently, several research projects investigate Additive Manufacturing (AM) technology as a possible construction method for future buildings. AM methods have some advantages over other production processes, such as great freedom of form, shape complexity, scale, and material use. These characteristics are relevant for façade applications, which demand the integration of several functions. Given the established capacity of AM to generate complex geometries, most existing research focuses on mechanical material properties and mainly in relation to the load-bearing capacity and the construction system. The integration of additional aspects is often achieved with post processing and the use of multiple materials. Research is needed to investigate properties for insulation, thermal storage, and energy harvesting, combined in one component and one production technology. To this end. the research project SPONG3D' aimed at developing a 3D-printed façade panel that integrates insulating properties with heat storage in a complex, mono-material geometry. This paper gives an overview of the panel development process, including aspects of material selection, printing process, structural properties, energy performance, and thermal heat storage. The development process was guided by experiments and simulations and resulted in the design and manufacturing of a full-scale façade element prototype using FDM printing with PETG. The project proved the possibility of the integration of functions in 3D-printed façades, but also highlighted the limitations and the need for further developments.\u3c/p\u3

Spong3d : 3D printed facade system enabling movable fluid heat storage

Spong3D is an adaptive 3D printed facade system that integrates multiple functions to optimize thermal performances according to the different environmental conditions throughout the year. The proposed system incorporates air cavities to provide thermal insulation and a movable liquid (water plus additives) to provide heat storage where and whenever needed. The air cavities have various dimensions and are located in the inner part of the system. The movable liquid provides heat storage as it flows through channels located along the outer surfaces of the system (on the indoor and outdoor faces of the façade). Together, the composition of the channels and the cavities form a complex structure, integrating multiple functions into a singular component, which can only be produced by using an Additive Manufacturing (AM; like 3D printing) technology

A multi-scale, multi-model approach for analyzing the future dynamics of European land use

C68, R14, R15, R52,