The evolution of the manosphere across the web

We present a large-scale characterization of the Manosphere, a conglomerate of Web-based misogynist movements focused on “men’s issues,” which has prospered online. Analyzing 28.8M posts from 6 forums and 51 subreddits, we paint a comprehensive picture of its evolution across the Web, showing the links between its different communities over the years. We find that milder and older communities, such as Pick Up Artists and Men’s Rights Activists, are giving way to more extreme ones like Incels and Men Going Their Own Way, with a substantial migration of active users. Moreover, our analysis suggests that these newer communities are more toxic and misogynistic than the older ones.Accepted manuscrip

Toward Optimization of Imaging System and Lymphatic Tracer for Near-Infrared Fluorescent Sentinel Lymph Node Mapping in Breast Cancer

Near-infrared (NIR) fluorescent sentinel lymph node (SLN) mapping in breast cancer requires optimized imaging systems and lymphatic tracers. A small, portable version of the FLARE imaging system, termed Mini-FLARE, was developed for capturing color video and two semi-independent channels of NIR fluorescence (700 and 800 nm) in real time. Initial optimization of lymphatic tracer dose was performed using 35-kg Yorkshire pigs and a 6-patient pilot clinical trial. More refined optimization was performed in 24 consecutive breast cancer patients. All patients received the standard of care using (99m)Technetium-nanocolloid and patent blue. In addition, 1.6 ml of indocyanine green adsorbed to human serum albumin (ICG:HSA) was injected directly after patent blue at the same location. Patients were allocated to 1 of 8 escalating ICG:HSA concentration groups from 50 to 1000 mu M. The Mini-FLARE system was positioned easily in the operating room and could be used up to 13 in. from the patient. Mini-FLARE enabled visualization of lymphatic channels and SLNs in all patients. A total of 35 SLNs (mean = 1.45, range 1-3) were detected: 35 radioactive (100%), 30 blue (86%), and 35 NIR fluorescent (100%). Contrast agent quenching at the injection site and dilution within lymphatic channels were major contributors to signal strength of the SLN. Optimal injection dose of ICG:HSA ranged between 400 and 800 mu M. No adverse reactions were observed. We describe the clinical translation of a new NIR fluorescence imaging system and define the optimal ICG:HSA dose range for SLN mapping in breast cancer.EndocrinologyOV5Oncologic ImagingImaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

SNAPSHOT USA 2019 : a coordinated national camera trap survey of the United States

This article is protected by copyright. All rights reserved.With the accelerating pace of global change, it is imperative that we obtain rapid inventories of the status and distribution of wildlife for ecological inferences and conservation planning. To address this challenge, we launched the SNAPSHOT USA project, a collaborative survey of terrestrial wildlife populations using camera traps across the United States. For our first annual survey, we compiled data across all 50 states during a 14-week period (17 August - 24 November of 2019). We sampled wildlife at 1509 camera trap sites from 110 camera trap arrays covering 12 different ecoregions across four development zones. This effort resulted in 166,036 unique detections of 83 species of mammals and 17 species of birds. All images were processed through the Smithsonian's eMammal camera trap data repository and included an expert review phase to ensure taxonomic accuracy of data, resulting in each picture being reviewed at least twice. The results represent a timely and standardized camera trap survey of the USA. All of the 2019 survey data are made available herein. We are currently repeating surveys in fall 2020, opening up the opportunity to other institutions and cooperators to expand coverage of all the urban-wild gradients and ecophysiographic regions of the country. Future data will be available as the database is updated at eMammal.si.edu/snapshot-usa, as well as future data paper submissions. These data will be useful for local and macroecological research including the examination of community assembly, effects of environmental and anthropogenic landscape variables, effects of fragmentation and extinction debt dynamics, as well as species-specific population dynamics and conservation action plans. There are no copyright restrictions; please cite this paper when using the data for publication.Publisher PDFPeer reviewe

Mammal responses to global changes in human activity vary by trophic group and landscape

Wildlife must adapt to human presence to survive in the Anthropocene, so it is critical to understand species responses to humans in different contexts. We used camera trapping as a lens to view mammal responses to changes in human activity during the COVID-19 pandemic. Across 163 species sampled in 102 projects around the world, changes in the amount and timing of animal activity varied widely. Under higher human activity, mammals were less active in undeveloped areas but unexpectedly more active in developed areas while exhibiting greater nocturnality. Carnivores were most sensitive, showing the strongest decreases in activity and greatest increases in nocturnality. Wildlife managers must consider how habituation and uneven sensitivity across species may cause fundamental differences in human–wildlife interactions along gradients of human influence.Peer reviewe

Upward Mobility: Optimizing Information to Improve Graduation Rates for America’s 407,000 Youth in Foster Care

In the United States, there are 407,000 youth in foster care. Of those, nearly 30,000 reach the age of adulthood (age 18 to 21) and are discharged—disconnected from the vital resources that stand-in for familial structures and inter-generational wealth. High school completion is a powerful and accessible avenue to achieve social mobility that is unconditional on one’s socioeconomic background or foster care status, yet literature does not exist addressing the topic of high school completion broadly for youth in foster care due to the ethical concerns of qualitative studies and lack of accessible, unified administrative data for quantitative studies. This paper attempts to fill this gap by utilizing the National Youth in Transition Database’s (NYTD) survey data and the three completed Cohorts: Cohort 2011, Cohort 2014, and Cohort 2017. Findings suggest that youth in foster care complete high school at rates far lower than their peers—this paper provides an optimistic estimate of at least 20 percentage points lower. Those who complete high school while in foster care follow similar trends to national graduation rates based on demographic characteristics, and there is evidence of a statistically significant association between all but one characteristic captured in the NYTD data and high school graduation. There is evidence that some characteristics captured in the NYTD data are significant predictors for high school graduation by age 19. However, the attempted deployment of machine learning models and evaluation of their efficacy of predicting high school graduation suggests that data collection standards, data quality, and types of data collected should be revisited by both federal and state governments.</p

Local anesthetic systemic toxicity: A narrative review for emergency clinicians

Introduction: Emergency clinicians utilize local anesthetics for a variety of procedures in the emergency depart-ment (ED) setting. Local anesthetic systemic toxicity (LAST) is a potentially deadly complication.Objective: This narrative review provides emergency clinicians with the most current evidence regarding the pathophysiology, evaluation, and management of patients with LAST.Discussion: LAST is an uncommon but potentially life-threatening complication of local anesthetic use that may be encountered in the ED. Patients at extremes of age or with organ dysfunction are at higher risk. Inadvertent intra-arterial or intravenous injection, as well as repeated doses and higher doses of local anesthetics are associ-ated with greater risk of developing LAST. Neurologic and cardiovascular manifestations can occur. Early recog-nition and intervention, including supportive care and intravenous lipid emulsion 20%, are the mainstays of treatment. Using ultrasound guidance, aspirating prior to injection, and utilizing the minimal local anesthetic dose needed are techniques that can reduce the risk of LAST.Conclusions: This focused review provides an update for the emergency clinician to manage patients with LAST. Published by Elsevier Inc

Modeling district heating and cooling systems with URBANopt, GeoJSON to Modelica Translator, and the Modelica Buildings Library

The URBANopt project has successfully leveraged OpenStudio/EnergyPlus to model buildings and electrical systems at an urban scale; however, URBANopt has lacked the ability to model district thermal energy systems until recently. This paper will present the modeling infrastructure that was developed specifically for the analysis of district heating and cooling systems, and how it is integrated into the existing URBANopt framework. The paper also discusses the development of new models added to the Modelica Buildings Library to model various district energy system components including loads, energy transfer stations (ETS), distribution networks, and central plants. The paper describes how different building loads can be modeled including time series, TEASER reduced-order models, or Spawn of EnergyPlus models. URBANopt District Energy Systems allows the user to switch between the various configurations