Anti-Anti-Cartesianism: Reply to Suart Shanker

There have been many criticisms of “nativism” in “Cartesian linguistics,” attacking positions that neither Chomsky nor any well-known generative grammarian has ever thought to defend. Shanker's polemic is no exception. It involves two spurious claims: (1) Cartesian linguistics (hypothesizing universal, grammar-specific principles that structure any language acquired through usual interaction with the learner's community) vitiates understanding language structure and use; (2) nativism permits linguistic anthropology only to “validate” and “apply” (wrong-headed) generative principles. Briefly, Chomsky's (2000) outlines a language system, LS, of the human brain. LS reflexively discriminates and categorizes parts of the flux of human experience as “language,” and develops complex abilities to infer and interpret this highly structured, and structurally peculiar, type of human production. There is nothing intrinsically different about LS – concerning innateness, evolution or universality – than the visual system (VS), immune system (IS), respiratory system (RS), or any other complex biological system. Much polemic is driven by distaste for “innateness,” “genes,” and “evolution.” Historical and ideological reasons explain this aversion - some well-justified. None bear on universal grammar. Biologists believe all life consists of universal, highly structured codings of biological information (DNA, proteins, genes, cells). Still, biologists go on to explore diversity at many different levels (bacteria, species, individuals, phyla). Similarly, linguistic anthropology can use generative grammar to better comprehend the diversity of languages and the cultural worlds they describe. This includes the very issues about proper names that Shanker highlights

Reginaldo Chayax Huex (1939-2020)

Fig. 1 – Reginaldo Chayax Huex (photo David Tiago Ribeiro, San José, Petén, Guatemala, 2015) Yun Reginaldo Chayax Wex, a leader of the Itza’ people of San José Petén, Guatemala, and founder of the Bio-Itzá Forest Reserve and Language School, died from Covid-19 at the age of 81 on October 1, 2020. Married to Na’ix María Espectación Tesucún Chan, he had 10 children, 28 grandchildren, and 17 great-grandchildren. Added to the pain of his departure is the passing of his son Orlando Chayax Tesucún..

Reginaldo Chayax Huex (1939-2020)

Fig. 1 – Reginaldo Chayax Huex (foto David Tiago Ribeiro, San José, Petén, Guatemala, 2015) Don Reginaldo Chayax Huex, líder del pueblo maya itza’ de San José, Petén, Guatemala, y fundador de la Reserva forestal y de la Escuela de lengua Bio-Itzá, falleció a la edad de 81 años el 1o de octubre de 2020 a consecuencia de la Covid-19. Casado con doña María Espectación Tesucún Chan, tuvo 10 hijos, 28 nietos y 17 bisnietos. Al dolor de su partida se agrega el fallecimiento de su hijo Orlando Chay..

Modelling Human Regulatory Variation in Mouse: Finding the Function in Genome-Wide Association Studies and Whole-Genome Sequencing

An increasing body of literature from genome-wide association studies and human whole-genome sequencing highlights the identification of large numbers of candidate regulatory variants of potential therapeutic interest in numerous diseases. Our relatively poor understanding of the functions of non-coding genomic sequence, and the slow and laborious process of experimental validation of the functional significance of human regulatory variants, limits our ability to fully benefit from this information in our efforts to comprehend human disease. Humanized mouse models (HuMMs), in which human genes are introduced into the mouse, suggest an approach to this problem. In the past, HuMMs have been used successfully to study human disease variants; e.g., the complex genetic condition arising from Down syndrome, common monogenic disorders such as Huntington disease and β-thalassemia, and cancer susceptibility genes such as BRCA1. In this commentary, we highlight a novel method for high-throughput single-copy site-specific generation of HuMMs entitled High-throughput Human Genes on the X Chromosome (HuGX). This method can be applied to most human genes for which a bacterial artificial chromosome (BAC) construct can be derived and a mouse-null allele exists. This strategy comprises (1) the use of recombineering technology to create a human variant–harbouring BAC, (2) knock-in of this BAC into the mouse genome using Hprt docking technology, and (3) allele comparison by interspecies complementation. We demonstrate the throughput of the HuGX method by generating a series of seven different alleles for the human NR2E1 gene at Hprt. In future challenges, we consider the current limitations of experimental approaches and call for a concerted effort by the genetics community, for both human and mouse, to solve the challenge of the functional analysis of human regulatory variation

Women in (Dis)placement: The Field of Studies on Migrations, Social Remittances, Care and Gender in Chile

This article presents current perspectives on the gender approach to the study of migration in Chile between 1990 and 2018, contextualizing it in light of international debates in the social sciences. We will discuss how the feminization and the growth of Latin American migrations have given rise to a prolific field of research, as exemplified by studies conducted in central and northern Chile. We will show how the concepts of social remittances and caregiving permeate the Chilean debate on migrant women. We conclude with reflections on topics and perspectives to be incorporated into the Chilean research agenda on gender and migration.Se presenta un estado del arte sobre el enfoque de género en los estudios de la migración en Chile entre 1990 y 2018, contextualizándolo a la luz de debates internacionales de las ciencias sociales. Abordaremos cómo la feminización y el incremento de las migraciones latinoamericanas inauguran un prolijo campo de investigaciones, articulado a través de estudios desarrollados en el centro y en el norte de Chile. Señalaremos cómo los conceptos de remesas sociales y cuidados permean el debate chileno sobre las mujeres migrantes. Finalizamos con reflexiones sobre temas y perspectivas a ser incorporados en la agenda chilena de investigaciones sobre género y migración.The authors would like to thank the Chilean National Commission for Scientific and Technological Research (CONICYT) for funding the study that led to this article through Fondecyt Regular Project number 1160683: “Ser Mujer Mayor en Santiago. Organización social de los cuidados, feminización del envejecimiento y desigualdades acumuladas” (“Being an older woman in Santiago. Social organization of care, feminization of ageing and accumulated inequalities”), led by Herminia Gonzálvez Torralbo and Fondecyt Regular Project number 1190056: “The Boundaries of Gender Violence: Migrant Women’s Experiences in South American Border Territories” led by Menara Lube Guizardi

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Ximena Chrisagis interview for a Wright State University History Course

On February 26, 2003 Lois Foy interviewed Ximena Chrisagis, a librarian at Wright State, for a class project dealing with oral histories and capturing the history of the Miami Valley. During the interview Ximena discusses her childhood in Ohio, growing up with a disability, how she came to Dayton, and more

Lexical Categories and Root Classes in Amerindian Languages

The problem of lexical categories and root class determination is fundamental in linguistic description and theory. Research on this topic has been particularly stimulated by studies of Amerindian languages. The essays in this collection, written by specialists in languages from South, Middle and North America, provide new insights into processes, levels, functions, and the aquisition of lexical categories, from various recent theoretical perspectives. The volume also addresses recent debates about root indeterminacy. Focusing on morphosyntax, phonology, and semantics, the contributions offer invaluable material for typological generalizations and for comprehension of the nature of the mental lexicon