Qualities of professionalism sought by employers: Exploring, validating, and incentivizing them in business undergraduates: Working paper Series--12-08

What do employers of business-school graduates seek in job candidates? The basic technical knowledge that an accredited degree indicates, and some amount of appropriate work experience, are prerequisites for interviews. But job candidates are then distinguished by various "soft" qualities that can't easily be bulleted on resumes or readily validated by employers. This paper begins with an exploration of framework for these qualities, considered here aspects of professionalism, which is developed from a series of surveys to refine and categorize relevant descriptors. We report the confirmatory findings from a focus group of partners, HR managers, and recruiters from accounting firms - a field which is particularly sensitive to professionalism since new associates have extensive client contact. Then, one business school's novel approach for raising the level of professionalism in undergraduate business students is introduced. The paper includes discussion of the importance and limitations of this topic, and concludes with possible directions for further research

The Role of Typeface and Product Context in Influencing B2C E-Commerce Trust

Lack of user trust in B2C e-commerce websites remains a major hindrance to its continued expansion. This initial study examines the role of website typography and product context in influencing user perceptions of trust in a B2C e-commerce website. Users perceive typefaces to possess human qualities; hence the typeface used to present text-material in a website could shape user perceptions towards that website, including those of trust. This paper presents an experimental model that addresses the impact of typeface as well as its interaction with product context in influencing user perceptions of trust

Coronal and heliospheric magnetic flux circulation and its relation to open solar flux evolution

Solar cycle 24 is notable for three features that can be found in previous cycles but which have been unusually prominent: (1) sunspot activity was considerably greater in the northern/southern hemisphere during the rising/declining phase; (2) accumulation of Open Solar Flux (OSF) during the rising phase was modest, but rapid in the early declining phase; (3) the Heliospheric Current Sheet (HCS) tilt showed large fluctuations. We show these features had a major influence on the progression of the cycle. All flux emergence causes a rise then a fall in OSF, but only OSF with footpoints in opposing hemispheres progresses the solar cycle via the evolution of the polar fields. Emergence in one hemisphere, or symmetric emergence without some form of footpoint exchange across the heliographic equator, causes poleward-migrating fields of both polarities in one or both (respectively) hemispheres which temporarily enhance OSF but do not advance the polar field cycle. The heliospheric field observed near Mercury and Earth reflects the asymmetries in emergence. Using magnetograms, we find evidence that the poleward magnetic flux transport (of both polarities) is modulated by the HCS tilt, revealing an effect on OSF loss rate. The declining phase rise in OSF was caused by strong emergence in the southern hemisphere with an anomalously low HCS tilt. This implies the recent fall in the southern polar field will be sustained and that the peak OSF has limited implications for the polar field at the next sunspot minimum and hence for the amplitude of cycle 25

Chem-prep PZT95/5 for neutron generator applications : the effect of pore former type and density on the depoling behavior of chemically prepared PZT 95/5 ceramics.

The hydrostatically induced ferroelectric(FE)-to-antiferroelectric(AFE) phase transformation for chemically prepared niobium modified PZT 95/5 ceramics was studied as a function of density and pore former type (Lucite or Avicel). Special attention was placed on the effect of different pore formers on the charge release behavior associated with the FE-to-AFE phase transformation. Within the same density range (7.26 g/cm3 to 7.44 g/cm3), results showed that ceramics prepared with Lucite pore former exhibit a higher bulk modulus and a sharper polarization release behavior than those prepared with Avicel. In addition, the average transformation pressure was 10.7% greater and the amount of polarization released was 2.1% higher for ceramics with Lucite pore former. The increased transformation pressure was attributed to the increase of bulk modulus associated with Lucite pore former. Data indicated that a minimum volumetric transformational strain of -0.42% was required to trigger the hydrostatically induced FE-to-AFE phase transformation. This work has important implications for increasing the high temperature charge output for neutron generator power supply units

Exile Vol. XVII No. 1

FICTION The Backyard Burial by Heather Johnson 9-11 French Persuasion by John Benes 18-22 In His Time by Keith Mcwalter 27-37 Time Ticking Off, Not Stopping by Holly Battles 39-40 ARTWORK by Roxy Sisson 13 by Bill Lutz 16 by Carol Belfatto 17 by Ned Bittinger 23 by Gail Lutsch 41 by Diane Ulmer 43 PHOTOGRAPHY by Tim Heth 3, 4, 5, 7, 9, 12, 15, 22, 38, 40, 44 by Rip Odell 15 by Maggie Hernandez 26, 42 POETRY For G. S. & A. B. T. by Paul Holbrook 2 Picture Writer by Julie Lockwood 6 Youth by Rufus Hurst 6 Today I Watched Flies Without Wings by Alice Merrill 6 Room 102 by Alice Merrill 6 The Flick by Debby Snyder 8 For P. E. H. by Timothy Cope 12 In Memory of Gertrude Stein by Michael Daugherty 14 Apogee Analogy by Paul Holbrook 15 First Impressions by Austin Hartman, Jr. 16 Count Jack Playing Peasant by Alice Merrill 24 Cherokee Arrowsmith by R. Crozier 24 road runs down valley by Fred Hoppe 25 Singularity by M. J. Wallace 25 Love\u27s Labour Lost by Tina Ostergard 25 Gnome by Cary Spear 25 Design and Layout: Keith McWalter 1 EXILE is the literary magazine of Denison University. It is entirely student-run and student edited, and receives operating funds from the Denison Campus Government Association. Submissions are edited anonymously and final actions are made independently by each staff. Printed by Ace News, Heath, Ohio.

Student Composers Concert

Kennesaw State University School of Music presents the 2013 Student Composers Concert featuring Premieres of Newly Composed Works.https://digitalcommons.kennesaw.edu/musicprograms/1348/thumbnail.jp

Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Coronaviruses (CoVs) have emerged from animal reservoirs to cause severe and lethal disease in humans, but there are currently no FDA-approved antivirals to treat the infections. One class of antiviral compounds, nucleoside analogues, mimics naturally occurring nucleosides to inhibit viral replication. While these compounds have been successful therapeutics for several viral infections, mutagenic nucleoside analogues, such as ribavirin and 5-fluorouracil, have been ineffective at inhibiting CoVs. This has been attributed to the proofreading activity of the viral 3′-5′ exoribonuclease (ExoN). β-d-N4-Hydroxycytidine (NHC) (EIDD-1931; Emory Institute for Drug Development) has recently been reported to inhibit multiple viruses. Here, we demonstrate that NHC inhibits both murine hepatitis virus (MHV) (50% effective concentration [EC50] = 0.17 μM) and Middle East respiratory syndrome CoV (MERS-CoV) (EC50 = 0.56 μM) with minimal cytotoxicity. NHC inhibited MHV lacking ExoN proofreading activity similarly to wild-type (WT) MHV, suggesting an ability to evade or overcome ExoN activity. NHC inhibited MHV only when added early during infection, decreased viral specific infectivity, and increased the number and proportion of G:A and C:U transition mutations present after a single infection. Low-level NHC resistance was difficult to achieve and was associated with multiple transition mutations across the genome in both MHV and MERS-CoV. These results point to a virus-mutagenic mechanism of NHC inhibition in CoVs and indicate a high genetic barrier to NHC resistance. Together, the data support further development of NHC for treatment of CoVs and suggest a novel mechanism of NHC interaction with the CoV replication complex that may shed light on critical aspects of replication. IMPORTANCE The emergence of coronaviruses (CoVs) into human populations from animal reservoirs has demonstrated their epidemic capability, pandemic potential, and ability to cause severe disease. However, no antivirals have been approved to treat these infections. Here, we demonstrate the potent antiviral activity of a broad-spectrum ribonucleoside analogue, β-d-N4-hydroxycytidine (NHC), against two divergent CoVs. Viral proofreading activity does not markedly impact sensitivity to NHC inhibition, suggesting a novel interaction between a nucleoside analogue inhibitor and the CoV replicase. Further, passage in the presence of NHC generates only low-level resistance, likely due to the accumulation of multiple potentially deleterious transition mutations. Together, these data support a mutagenic mechanism of inhibition by NHC and further support the development of NHC for treatment of CoV infections

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species

Cdc42 regulates cardiac function in mice and flies downstream of a conserved Tinman/Nkx2-5–miR-1 signaling network