2,046 research outputs found
Response to Cult of the "I"
Purpose: The purpose of this paper is to respond to an earlier article in the Journal of Documentation: The Cult of the βIβ. / Design/methodology/approach: The method is a form of critical response. / Findings: Numerous problems regarding the The Cult of the βIβ article are discussed. / Originality/value: This paper puts forward views about the iSchools Movement
Gaussian bosonic synergy: quantum communication via realistic channels of zero quantum capacity
As with classical information, error-correcting codes enable reliable
transmission of quantum information through noisy or lossy channels. In
contrast to the classical theory, imperfect quantum channels exhibit a strong
kind of synergy: there exist pairs of discrete memoryless quantum channels,
each of zero quantum capacity, which acquire positive quantum capacity when
used together. Here we show that this "superactivation" phenomenon also occurs
in the more realistic setting of optical channels with attenuation and Gaussian
noise. This paves the way for its experimental realization and application in
real-world communications systems.Comment: 5 pages, 4 figures, one appendi
Quantum internet using code division multiple access
A crucial open problem in large-scale quantum networks is how to efficiently
transmit quantum data among many pairs of users via a common data-transmission
medium. We propose a solution by developing a quantum code division multiple
access (q-CDMA) approach in which quantum information is chaotically encoded to
spread its spectral content, and then decoded via chaos synchronization to
separate different sender-receiver pairs. In comparison to other existing
approaches, such as frequency division multiple access (FDMA), the proposed
q-CDMA can greatly increase the information rates per channel used, especially
for very noisy quantum channels.Comment: 29 pages, 6 figure
PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin
Neuroendocrine tumors (NETs) are often diagnosed from the metastases of an unknown primary tumor. Specific immunohistochemical (IHC) markers indicating the location of a primary tumor are needed. The proprotein convertase subtilisin/kexin type 2 (PCSK2) is found in normal neural and neuroendocrine cells, and known to express in NETs. We investigated the tissue microarray (TMA) of 86 primary tumors from 13 different organs and 9 metastatic NETs, including primary tumor-metastasis pairs, for PCSK2 expression with polymer-based IHC. PCSK2 was strongly positive in all small intestine and appendiceal NETs, the so-called midgut NETs, in most pheochromocytomas and paragangliomas, and in some of the typical and atypical pulmonary carcinoid tumors. NETs showing strong positivity were re-evaluated in larger tumor cohorts confirming the primary observation. In the metastases, the expression of PCSK2 mirrored that of the corresponding primary tumors. We found negative or weak staining in NETs from the thymus, gastric mucosa, pancreas, rectum, thyroid, and parathyroid. PCSK2 expression did not correlate with Ki-67 in well-differentiated NETs. Our data suggest that PCSK2 positivity can indicate the location of the primary tumor. Thus, PCSK2 could function in the IHC panel determined from screening metastatic NET biopsies of unknown primary origins.Peer reviewe
Nonlocal observables and lightcone-averaging in relativistic thermodynamics
The unification of relativity and thermodynamics has been a subject of
considerable debate over the last 100 years. The reasons for this are twofold:
(i) Thermodynamic variables are nonlocal quantities and, thus, single out a
preferred class of hyperplanes in spacetime. (ii) There exist different,
seemingly equally plausible ways of defining heat and work in relativistic
systems. These ambiguities led, for example, to various proposals for the
Lorentz transformation law of temperature. Traditional 'isochronous'
formulations of relativistic thermodynamics are neither theoretically
satisfactory nor experimentally feasible. Here, we demonstrate how these
deficiencies can be resolved by defining thermodynamic quantities with respect
to the backward-lightcone of an observation event. This approach yields novel,
testable predictions and allows for a straightforward-extension of
thermodynamics to General Relativity. Our theoretical considerations are
illustrated through three-dimensional relativistic many-body simulations.Comment: typos in Eqs. (12) and (14) corrected, minor additions in the tex
Integrated information increases with fitness in the evolution of animats
One of the hallmarks of biological organisms is their ability to integrate
disparate information sources to optimize their behavior in complex
environments. How this capability can be quantified and related to the
functional complexity of an organism remains a challenging problem, in
particular since organismal functional complexity is not well-defined. We
present here several candidate measures that quantify information and
integration, and study their dependence on fitness as an artificial agent
("animat") evolves over thousands of generations to solve a navigation task in
a simple, simulated environment. We compare the ability of these measures to
predict high fitness with more conventional information-theoretic processing
measures. As the animat adapts by increasing its "fit" to the world,
information integration and processing increase commensurately along the
evolutionary line of descent. We suggest that the correlation of fitness with
information integration and with processing measures implies that high fitness
requires both information processing as well as integration, but that
information integration may be a better measure when the task requires memory.
A correlation of measures of information integration (but also information
processing) and fitness strongly suggests that these measures reflect the
functional complexity of the animat, and that such measures can be used to
quantify functional complexity even in the absence of fitness data.Comment: 27 pages, 8 figures, one supplementary figure. Three supplementary
video files available on request. Version commensurate with published text in
PLoS Comput. Bio
Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)
This article introduces the new 5-level EQ-5D (EQ-5D-5L) health status measure. EQ-5D currently measures health using three levels of severity in five dimensions. A EuroQol Group task force was established to find ways of improving the instrument's sensitivity and reducing ceiling effects by increasing the number of severity levels. The study was performed in the United Kingdom and Spain. Severity labels for 5 levels in each dimension were identified using response scaling. Focus groups were used to investigate the face and content validity of the new versions, including hypothetical health states generated from those versions. Selecting labels at approximately the 25th, 50th, and 75th centiles produced two alternative 5-level versions. Focus group work showed a slight preference for the wording 'slight-moderate-severe' problems, with anchors of 'no problems' and 'unable to do' in the EQ-5D functional dimensions. Similar wording was used in the Pain/Discomfort and Anxiety/Depression dimensions. Hypothetical health states were well understood though participants stressed the need for the internal coherence of health states. A 5-level version of the EQ-5D has been developed by the EuroQol Group. Further testing is required to determine whether the new version improves sensitivity and reduces ceiling effects
Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events
Peer reviewedPublisher PD
Ultrafast optical control of entanglement between two quantum dot spins
The interaction between two quantum bits enables entanglement, the
two-particle correlations that are at the heart of quantum information science.
In semiconductor quantum dots much work has focused on demonstrating single
spin qubit control using optical techniques. However, optical control of
entanglement of two spin qubits remains a major challenge for scaling from a
single qubit to a full-fledged quantum information platform. Here, we combine
advances in vertically-stacked quantum dots with ultrafast laser techniques to
achieve optical control of the entangled state of two electron spins. Each
electron is in a separate InAs quantum dot, and the spins interact through
tunneling, where the tunneling rate determines how rapidly entangling
operations can be performed. The two-qubit gate speeds achieved here are over
an order of magnitude faster than in other systems. These results demonstrate
the viability and advantages of optically controlled quantum dot spins for
multi-qubit systems.Comment: 24 pages, 5 figure
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