The ALPINE-ALMA [C II] survey. Luminosity function of serendipitous [C II] line emitters at z \ensuremath∼ 5

We present the first [CII] 158 $\mu$m luminosity function (LF) at $z\sim 5$ from a sample of serendipitous lines detected in the ALMA Large Program to INvestigate [CII] at Early times (ALPINE). A search performed over the 118 ALPINE pointings revealed several serendipitous lines. Based on their fidelity, we selected 14 lines for the final catalog. According to the redshift of their counterparts, we identified 8 out of 14 detections as [CII] lines at $z\sim 5$, and two as CO transitions at lower redshifts. The remaining 4 lines have an elusive identification in the available catalogs and we considered them as [CII] candidates. We used the 8 confirmed [CII] and the 4 [CII] candidates to build one of the first [CII] LFs at $z\sim 5$. We found that 11 out of these 12 sources have a redshift very similar to that of the ALPINE target in the same pointing, suggesting the presence of overdensities around the targets. Therefore, we split the sample in two (a "clustered" and "field" sub-sample) according to their redshift separation and built two separate LFs. Our estimates suggest that there could be an evolution of the [CII] LF between $z \sim 5$ and $z \sim 0$. By converting the [CII] luminosity to star formation rate we evaluated the cosmic star formation rate density (SFRD) at $z\sim 5$. The clustered sample results in a SFRD $\sim 10$ times higher than previous measurements from UV-selected galaxies. On the other hand, from the field sample (likely representing the average galaxy population) we derived a SFRD $\sim 1.6$ higher compared to current estimates from UV surveys but compatible within the errors. Because of the large uncertainties, observations of larger samples are necessary to better constrain the SFRD at $z\sim 5$. This study represents one of the first efforts aimed at characterizing the demography of [CII] emitters at $z\sim 5$ using a mm-selection of galaxies.Comment: 19 pages, 12 figures; submitted to Astronomy & Astrophysic

Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status