Condition monitoring of an advanced gas-cooled nuclear reactor core

A critical component of an advanced gas-cooled reactor station is the graphite core. As a station ages, the graphite bricks that comprise the core can distort and may eventually crack. Since the core cannot be replaced, the core integrity ultimately determines the station life. Monitoring these distortions is usually restricted to the routine outages, which occur every few years, as this is the only time that the reactor core can be accessed by external sensing equipment. This paper presents a monitoring module based on model-based techniques using measurements obtained during the refuelling process. A fault detection and isolation filter based on unknown input observer techniques is developed. The role of this filter is to estimate the friction force produced by the interaction between the wall of the fuel channel and the fuel assembly supporting brushes. This allows an estimate to be made of the shape of the graphite bricks that comprise the core and, therefore, to monitor any distortion on them

Combining DLC, Shot blasting, chemical dip and nano fullerene surface treatments to reduce wear and friction when used with bio-lubricants in automotive contacts

The interaction of three bio-lubricant base oil candidates with seventeen combinations of surface treatment was studied, comparing wear scar volumes and coefficient of friction results. Substrates were initially ground, then a combination of superfinished, Dymon-iC™ DLC, an impact technique of ultra-fine shot blasting method doped with Tin and Molybdenum Disulfide, a calcium based chemical dip containing calcium sulfate and nano fullerene, were used.DLC is well reported to reduce friction. Some reports suggest wear in coated contacts is independent of the type of lubricant used, whilst others report that bio-lubricants offer reduced friction and wear in combination with DLC. Shot blasting can also reduce wear and friction, due to the surface dimples acting as lubricant reservoirs, making hydrodynamic lubrication more likely. Previous work has also explored the performance of surface texturing in combination with coatings, some reporting higher friction when surface texturing and DLC is used. As a surface coating, fullerene has been shown to have significantly lower wear and friction than DLC coatings. The calcium based chemical treatment used has no published data.A ball on flat reciprocating wear tester was used with bio-lubricant base oil candidates, jojoba and soybean oil, with a mineral base oil used for comparison. Wear scars were analysed using a scanning electron microscope.Coefficient of friction results from testing with bio-lubricant base oil candidates’ soybean and jojoba oil were lower than tests with mineral base oil. A hybridized coating combination of superfinish, diamond like carbon and chemical dip gave the highest wear protection for tests with the mineral base oil and bio-lubricant base oil candidate soybean oil. A hybridized coating combination of superfinish, impact technique and chemical dip gave highest wear protection when tested with bio-lubricant base oil candidate jojoba oil. Results showed no overall improvement in wear protection when substrates were processed with the impact technique. Superfinishing substrates improved the performance of both the chemical dip and DLC

Class Attendance and Students’ Evaluations of Teaching: Do No-Shows Bias Course Ratings and Rankings?

Background: Many university departments use students’ evaluations of teaching (SET) to compare and rank courses. However, absenteeism from class is often nonrandom and, therefore, SET for different courses might not be comparable. Objective: The present study aims to answer two questions. Are SET positively biased due to absenteeism? Do procedures, which adjust for absenteeism, change course rankings? Research Design: The author discusses the problem from a missing data perspective and present empirical results from regression models to determine which factors are simultaneously associated with students’ class attendance and course ratings. In order to determine the extent of these biases, the author then corrects average ratings for students’ absenteeism and inspect changes in course rankings resulting from this adjustment. Subjects: The author analyzes SET data on the individual level. One or more course ratings are available for each student. Measures: Individual course ratings and absenteeism served as the key outcomes. Results: Absenteeism decreases with rising teaching quality. Furthermore, both factors are systematically related to student and course attributes. Weighting students’ ratings by actual absenteeism leads to mostly small changes in ranks, which follow a power law. Only a few, average courses are disproportionally influenced by the adjustment. Weighting by predicted absenteeism leads to very small changes in ranks. Again, average courses are more strongly affected than courses of very high or low in quality. Conclusions: No-shows bias course ratings and rankings. SET are more appropriate to identify high- and low-quality courses than to determine the exact ranks of average courses

Anti-LRP/LR specific antibody IgG1-iS18 impedes adhesion and invasion of liver cancer cells.

Two key events, namely adhesion and invasion, are pivotal to the occurrence of metastasis. Importantly, the 37 kDa/67 kDa laminin receptor (LRP/LR) has been implicated in enhancing these two events thus facilitating cancer progression. In the current study, the role of LRP/LR in the adhesion and invasion of liver cancer (HUH-7) and leukaemia (K562) cells was investigated. Flow cytometry revealed that the HUH-7 cells displayed significantly higher cell surface LRP/LR levels compared to the poorly-invasive breast cancer (MCF-7) control cells, whilst the K562 cells displayed significantly lower cell surface LRP/LR levels in comparison to the MCF-7 control cells. However, Western blotting and densitometric analysis revealed that all three tumorigenic cell lines did not differ significantly with regards to total LRP/LR levels. Furthermore, treatment of liver cancer cells with anti-LRP/LR specific antibody IgG1-iS18 (0.2 mg/ml) significantly reduced the adhesive potential of cells to laminin-1 and the invasive potential of cells through the ECM-like Matrigel, whilst leukaemia cells showed no significant differences in both instances. Additionally, Pearson's correlation coefficients suggested direct proportionality between cell surface LRP/LR levels and the adhesive and invasive potential of liver cancer and leukaemia cells. These findings suggest the potential use of anti-LRP/LR specific antibody IgG1-iS18 as an alternative therapeutic tool for metastatic liver cancer through impediment of the LRP/LR- laminin-1 interaction.National Research Foundation.NCS201

In Vitro Inhibition of Angiogenesis by Antibodies Directed against the 37kDa/67kDa Laminin Receptor

The 37kDa/67kDa laminin receptor (LRP/LR) is a central receptor mediating interactions between tumour cells and the basement membrane and is thereby a key player in adhesion and invasion, essential processes in metastatic cancer. To affect continued tumour growth, tumours induce angiogenesis for the constant delivery of nutrients and oxygen. This study aims to determine the blocking effect of the anti-LRP/LR specific antibody, W3 on the angiogenic potential of HUVE (human umbilical vein endothelial) cells. Flow cytometric analysis revealed that 97% of HUVE cells display cell surface LRP/LR. An angiogenesis assay was conducted employing HUVE cells seeded on the basement membrane reconstituent Matrigel™ supplemented with the pro-angiogenic factor vascular endothelial growth factor (VEGF). Post 18h incubation at 37°C tubular structures, namely tube lengths were assessed. Treatment of established tubular structures with 100 μg/ml anti-LRP/LR specific antibody completely blocked angiogenesis. Our findings suggest a central role of the 37kDa/67kDa LRP/LR in tube formation and recommends anti-LRP/LR specific antibodies as potential therapeutic tools for treatment of tumour angiogenesis.This work was supported by the National Research Foundation, the Republic of South Africa and the Medical Research Council, the Republic of South Africa.NCS201

Sea-ice information and forecast needs for industry maritime stakeholders

Profound changes in Arctic sea-ice, a growing desire to utilize the Arctic’s abundant natural resources, and the potential competitiveness of Arctic shipping routes, all provide for increased industry marine activity throughout the Arctic Ocean. This is anticipated to result in further challenges for maritime safety. Those operating in ice-infested waters require various types of information for sea-ice and iceberg hazards. Ice information requirements depend on regional needs and whether the stakeholder wants to avoid ice all together, operate near or in the Marginal Ice Zone, or areas within the ice pack. An insight into user needs demonstrates how multiple spatial and temporal resolutions for sea-ice information and forecasts are necessary to provide information to the marine operating community for safety, planning, and situational awareness. Although ship-operators depend on sea-ice information for tactical navigation, stakeholders working in route and capacity planning can benefit from climatological and long-range forecast information at lower spatial and temporal resolutions where the interest is focused on open-water season. The advent of the Polar Code has brought with it additional information requirements, and exposed gaps in capacity and knowledge. Thus, future satellite data sources should be at resolutions that support both tactical and planning activities

Polyhedra in loop quantum gravity

Interwiners are the building blocks of spin-network states. The space of intertwiners is the quantization of a classical symplectic manifold introduced by Kapovich and Millson. Here we show that a theorem by Minkowski allows us to interpret generic configurations in this space as bounded convex polyhedra in Euclidean space: a polyhedron is uniquely described by the areas and normals to its faces. We provide a reconstruction of the geometry of the polyhedron: we give formulas for the edge lengths, the volume and the adjacency of its faces. At the quantum level, this correspondence allows us to identify an intertwiner with the state of a quantum polyhedron, thus generalizing the notion of quantum tetrahedron familiar in the loop quantum gravity literature. Moreover, coherent intertwiners result to be peaked on the classical geometry of polyhedra. We discuss the relevance of this result for loop quantum gravity. In particular, coherent spin-network states with nodes of arbitrary valence represent a collection of semiclassical polyhedra. Furthermore, we introduce an operator that measures the volume of a quantum polyhedron and examine its relation with the standard volume operator of loop quantum gravity. We also comment on the semiclassical limit of spinfoams with non-simplicial graphs.Comment: 32 pages, many figures. v2 minor correction

Patient engagement with antibiotic messaging in secondary care: a qualitative feasibility study of the ‘review & revise’ experience

Background: We aimed to investigate and optimise the acceptability and usefulness of a patient leaflet about antibiotic prescribing decisions made during hospitalisation, and to explore individual patient experiences and preferences regarding the process of antibiotic prescription ‘review & revise’ which is a key strategy to minimise antibiotic overuse in hospitals. Methods: In this qualitative study, run within the feasibility study of a large, cluster-randomised stepped wedge trial of 36 hospital organisations, a series of semi-structured, think-aloud telephone interviews were conducted and data were analysed using thematic analysis. Fifteen adult patients who had experienced a recent acute medical hospital admission during which they had been prescribed antimicrobials and offered a patient leaflet about antibiotic prescribing were recruited to the study. Results: Participants reacted positively to the leaflet, reporting that it was both an accessible and important source of information which struck the appropriate balance between informing and reassuring. Participants all valued open communication with clinicians, and were keen to be involved in antibiotic prescribing decisions, with individuals reporting positive experiences regarding antibiotic prescription changes or stopping. Many participants had prior experience or knowledge of antibiotics and resistance, and generally welcomed efforts to reduce antibiotic usage. Overall, there was a feeling that healthcare professionals (HCPs) are trusted experts providing the most appropriate treatment for individual patient conditions. Conclusions: This study offers novel insights into how patients within secondary care are likely to respond to messages advocating a reduction in the use of antibiotics through the ‘review & revise’ approach. Due to the level of trust that patients place in their care provider, encouraging HCPs within secondary care to engage patients with greater communication and information provision could provide great advantages in the drive to reduce antibiotic use. It may also be beneficial for HCPs to view patient experiences as cumulative events that have the potential to impact future behaviour around antibiotic use. Finally, pre-testing messages about antibiotic prescribing and resistance is vital to dispelling any misconceptions either around effectiveness of treatment for patients, or perceptions of how messages may be received

Nonlinear Protein Degradation and the Function of Genetic Circuits

The functions of most genetic circuits require sufficient degrees of cooperativity in the circuit components. While mechanisms of cooperativity have been studied most extensively in the context of transcriptional initiation control, cooperativity from other processes involved in the operation of the circuits can also play important roles. In this study, we examine a simple kinetic source of cooperativity stemming from the nonlinear degradation of multimeric proteins. Ample experimental evidence suggests that protein subunits can degrade less rapidly when associated in multimeric complexes, an effect we refer to as cooperative stability. For dimeric transcription factors, this effect leads to a concentration-dependence in the degradation rate because monomers, which are predominant at low concentrations, will be more rapidly degraded. Thus cooperative stability can effectively widen the accessible range of protein levels in vivo. Through theoretical analysis of two exemplary genetic circuits in bacteria, we show that such an increased range is important for the robust operation of genetic circuits as well as their evolvability. Our calculations demonstrate that a few-fold difference between the degradation rate of monomers and dimers can already enhance the function of these circuits substantially. These results suggest that cooperative stability needs to be considered explicitly and characterized quantitatively in any systematic experimental or theoretical study of gene circuits.Comment: 42 pages, 10 figure

Application of the speed-duration relationship to normalize the intensity of high-intensity interval training

The tolerable duration of continuous high-intensity exercise is determined by the hyperbolic Speed-tolerable duration (S-tLIM) relationship. However, application of the S-tLIM relationship to normalize the intensity of High-Intensity Interval Training (HIIT) has yet to be considered, with this the aim of present study. Subjects completed a ramp-incremental test, and series of 4 constant-speed tests to determine the S-tLIM relationship. A sub-group of subjects (n = 8) then repeated 4 min bouts of exercise at the speeds predicted to induce intolerance at 4 min (WR4), 6 min (WR6) and 8 min (WR8), interspersed with bouts of 4 min recovery, to the point of exercise intolerance (fixed WR HIIT) on different days, with the aim of establishing the work rate that could be sustained for 960 s (i.e. 4×4 min). A sub-group of subjects (n = 6) also completed 4 bouts of exercise interspersed with 4 min recovery, with each bout continued to the point of exercise intolerance (maximal HIIT) to determine the appropriate protocol for maximizing the amount of high-intensity work that can be completed during 4×4 min HIIT. For fixed WR HIIT tLIM of HIIT sessions was 399±81 s for WR4, 892±181 s for WR6 and 1517±346 s for WR8, with total exercise durations all significantly different from each other (P<0.050). For maximal HIIT, there was no difference in tLIM of each of the 4 bouts (Bout 1: 229±27 s; Bout 2: 262±37 s; Bout 3: 235±49 s; Bout 4: 235±53 s; P>0.050). However, there was significantly less high-intensity work completed during bouts 2 (153.5±40. 9 m), 3 (136.9±38.9 m), and 4 (136.7±39.3 m), compared with bout 1 (264.9±58.7 m; P>0.050). These data establish that WR6 provides the appropriate work rate to normalize the intensity of HIIT between subjects. Maximal HIIT provides a protocol which allows the relative contribution of the work rate profile to physiological adaptations to be considered during alternative intensity-matched HIIT protocols