Introducción a historia de las colecciones e historia de los museos

SIAM. Series Iberoamericanas de Museología. Año 3, Vol.

A questão tributária e a problemática da arrecadação fiscal em decorrência da mineração industrial na Amazônia

The fiscal and financing incentives concessions had been absolutely necessary concerning the development of the mining and metallurgical industry. The Federal Government considering the country importance with expressive foreign trade superávit outcome, with the aim of reducing the foreign vulnerability of the Brazilian economy resolved reward the cooperation evolving other beings of the federation in a export effort. The Kandir law promoted the dispense of the ICMS in the operations destined to foreign goods as well as services located abroad. States and municipalities have been lost parcel of income tax receipts. The municipalities had been double damaged by the ISS direct dispense and product share reduction of the product of collection of the ICMS.A concessão de incentivos fiscais e financeiros foi indispensável para o desenvolvimento da indústria mínero-metalúrgica, principalmente no Estado do Pará. O Governo Federal, ao considerar a importância para o país da obtenção de expressivos resultados superavitários no comércio exterior, com o objetivo de reduzir a vulnerabilidade externa da economia brasileira, resolveu premiar a cooperação dos demais entes da federação nesse esforço exportador. A Lei Kandir promoveu a exoneração do ICMS nas operações que destinem mercadorias para o exterior, bem como os serviços prestados a tomadores localizados no exterior. Com isso, Estados e Municípios perderam parcela da arrecadação de seus impostos. Os Municípios foram duplamente prejudicados pela exoneração direta do ISS e pela redução na partilha do produto de arrecadação do ICMS

The chemokine receptor CCR6 is an important component of the innate immune response

In our initial studies we found that naÏve CCR6-deficient (CCR6 –/– ) C57BL/6 mice possessed significantly lower number of both F4/80 + macrophages and dendritic cells (DC), but higher number of B cells in the peritoneal cavity, as compared to naÏve wild type (WT) controls. Furthermore, peritoneal macrophages isolated from CCR6 –/– mice expressed significantly lower levels of inflammatory cytokines and nitric oxide following lipopolysaccharide (LPS)stimulation, as compared to WT macrophages. In a severe experimental peritonitis model induced by cecal ligation and puncture (CLP), CCR6 –/– mice were protected when compared with WT controls. At 24 h following the induction of peritonitis, CCR6 –/– mice exhibited significantly lower levels of inflammatory cytokines/chemokines in both the peritoneal cavity and blood. Interestingly, DC recruitment into the peritoneal cavity was impaired in CCR6 –/– mice during the evolution of CLP-induced peritonitis. Peritoneal macrophages isolated from surviving CCR6 –/– mice 3 days after CLP-induced peritonitis exhibited an enhanced LPS response compared with similarly treated WT peritoneal macrophages. These data illustrate that CCR6 deficiency alters the innate response via attenuating the hyperactive local and systemic inflammatory response during CLP-induced peritonitis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/56112/1/2487_ftp.pd

Human cytomegalovirus US28 facilitates cell-to-cell viral dissemination

Human cytomegalovirus (HCMV) encodes a number of viral proteins with homology to cellular G protein-coupled receptors (GPCRs). These viral GPCRs, including US27, US28, UL33, and UL78, have been ascribed numerous functions during infection, including activating diverse cellular pathways, binding to immunomodulatory chemokines, and impacting virus dissemination. To investigate the role of US28 during virus infection, two variants of the clinical isolate TB40/E were generated: TB40/E-US28(YFP) expressing a C-terminal yellow fluorescent protein tag, and TB40/E-FLAG(YFP) in which a FLAG-YFP cassette replaces the US28 coding region. The TB40/E-US28(YFP) protein localized as large perinuclear fluorescent structures at late times post-infection in fibroblasts, endothelial, and epithelial cells. Interestingly, US28(YFP) is a non-glycosylated membrane protein throughout the course of infection. US28 appears to impact cell-to-cell spread of virus, as the ΔUS28 virus (TB40/E-FLAG(YFP)) generated a log-greater yield of extracellular progeny whose spread could be significantly neutralized in fibroblasts. Most strikingly, in epithelial cells, where dissemination of virus occurs exclusively by the cell-to-cell route, TB40/E-FLAG(YFP) (ΔUS28) displayed a significant growth defect. The data demonstrates that HCMV US28 may contribute at a late stage of the viral life cycle to cell-to-cell dissemination of virus

Obesity, diabetes and OSAS induce of sleep disorders: Exercise as therapy

Sleep is an integral part of good health. Sleep disorders and variations in sleep habits are associated with a low-grade inflammatory status, which may be either a cause or consequence of other conditions, including obesity, diabetes and cardiovascular disease. Several strategies are available to counteract these conditions including continuous positive airway pressure (CPAP), pharmacological and nutritional interventions, and even surgery. At present, our group is investigating the effect of chronic endurance exercise on sleep alterations

Increased responsiveness of murine eosinophils to MIPâ 1β (CCL4) and TCAâ 3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141970/1/jlb1019.pd

The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes

6Ckine is an unusual chemokine capable of attracting naive T lymphocytes in vitro. It has been recently reported that lack of 6Ckine expression in lymphoid organs is a prominent characteristic of mice homozygous for the paucity of lymph node T cell (plt) mutation. These mice show reduced numbers of T cells in lymph nodes, Peyer's patches, and the white pulp of the spleen. The genetic reason for the lack of 6Ckine expression in the plt mouse, however, has remained unknown. Here we demonstrate that mouse 6Ckine is encoded by two genes, one of which is expressed in lymphoid organs and is deleted in plt mice. A second 6Ckine gene is intact and expressed in the plt mouse

Desarrollo de instrumentos de laboratorio para la asignatura de Sistema de medición en el área de Sistemas de Adquisición de Datos que contribuya a la construcción de un aprendizaje significado de los estudiantes en Ingeniería Electrónica

Presenta el resultado del desarrollo de instrumentos de laboratorio para la asignatura de Sistema de medición en el área de adquisición de datos de la carrera de Ingeniería electrónica. Las guías de laboratorio están elaboradas con el propósito de ser utilizadas con las tarjetas de adquisición de datos y el Software Processing para que el estudiante tenga las herramientas necesarias para construir un aprendizaje significativo en los sistemas de adquisición de dato

Skin expression of IL-23 drives the development of psoriasis and psoriatic arthritis in mice

Psoriasis (PS) is a chronic skin inflammation. Up to 30% of the patients with PS develop psoriatic arthritis (PsA), a condition characterized by inflammatory arthritis that affects joints or entheses. Although there is mounting evidence for a critical role of interleukin-23 (IL-23) signaling in the pathogenesis of both PS and PsA, it remains unclear whether IL-23-induced skin inflammation drives joint disease. Here, we show that mice expressing increased levels of IL-23 in the skin (K23 mice) develop a PS-like disease that is characterized by acanthosis, parakeratosis, hyperkeratosis, and inflammatory infiltrates in the dermis. Skin disease preceded development of PsA, including enthesitis, dactylitis, and bone destruction. The development of enthesitis and dactylitis was not due to high circulating levels of IL-23, as transgenic animals and controls had similar levels of this cytokine in circulation. IL-22, a downstream cytokine of IL-23, was highly increased in the serum of K23 mice. Although IL-22 deficiency did not affect skin disease development, IL-22 deficiency aggravated the PsA-like disease in K23 mice. Our results demonstrate a central role for skin expressed IL-23 in the initiation of PS and on pathogenic processes leading to PsA.Fil: Chen, Lili. Icahn School of Medicine at Mount Sinai; Estados UnidosFil: Deshpande, Madhura. Icahn School of Medicine at Mount Sinai; Estados UnidosFil: Grisotto, Marcos. Icahn School of Medicine at Mount Sinai; Estados UnidosFil: Smaldini, Paola Lorena. Icahn School of Medicine at Mount Sinai; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Garcia, Roberto. Hospital for Special Surgery; Estados UnidosFil: He, Zhengxiang. Icahn School of Medicine at Mount Sinai; Estados UnidosFil: Gulko, Percio. Icahn School of Medicine at Mount Sinai; Estados UnidosFil: Lira, Sergio A.. Icahn School of Medicine at Mount Sinai; Estados UnidosFil: Furtado, Glaucia C.. Icahn School of Medicine at Mount Sinai; Estados Unido