Reprise fragments in English and Hungarian: further evidence for an in-situ Q-equivalence approach to clausal ellipsis

Theoretical and Experimental Linguistic

A new study of the spectroscopic binary 7 Vul with a Be star primary

We confirmed the binary nature of the Be star 7~Vul, derived a~more accurate spectroscopic orbit with an orbital period of (69.4212+/-0.0034) d, and improved the knowledge of the basic physical elements of the system. Analyzing available photometry and the strength of the \ha emission, we also document the long-term spectral variations of the Be primary. In addition, we confirmed rapid light changes with a~period of 0.5592 d, which is comparable to the expected rotational period of the Be primary, but note that its amplitude and possibly its period vary with time. We were able to disentangle only the He I 6678 A line of the secondary, which could support our tentative conclusion that the secondary appears to be a hot subdwarf. A search for this object in high-dispersion far-UV spectra could provide confirmation. Probable masses of the binary components are ($6\pm1$)~Mnom \ and ($0.6\pm0.1$)~Mnom. If the presence of a hot subdwarf is firmly confirmed, 7 Vul might be identified as a rare object with a B4-B5 primary; all Be + hot subdwarf systems found so far contain B0-B3 primaries.Comment: 17 pages, 23 figures, accepted for publication in Astronomy and Astrophysic

Casimir scaling in G(2) lattice gauge theory

We computed potentials between static color sources from the six lowest representations of G(2) lattice gauge theory, in numerical simulations with the Wilson action on asymmetric lattices with nonperturbatively estimated values of the bare anisotropy. We present evidence for (approximate) Casimir scaling of the obtained intermediate string tensions. The agreement with the Casimir-scaling prediction improves by increasing the coupling beta in the weak-coupling region above the crossover observed in G(2) gauge theory. The result naturally fits into confinement models with magnetic disorder and vacuum domain structure, but may represent a challenge for other approaches.Comment: 14 pages, 12 figures (24 EPS files), RevTeX4. In v2: typos corrected, discussion of systematic errors and of smearing expanded, references added. Version to appear in Phys. Rev.

Algorithms for Jumbled Pattern Matching in Strings

The Parikh vector p(s) of a string s is defined as the vector of multiplicities of the characters. Parikh vector q occurs in s if s has a substring t with p(t)=q. We present two novel algorithms for searching for a query q in a text s. One solves the decision problem over a binary text in constant time, using a linear size index of the text. The second algorithm, for a general finite alphabet, finds all occurrences of a given Parikh vector q and has sub-linear expected time complexity; we present two variants, which both use a linear size index of the text.Comment: 18 pages, 9 figures; article accepted for publication in the International Journal of Foundations of Computer Scienc

Transposon-Based Reporter Marking Provides Functional Evidence for Intercellular Bridges in the Male Germline of Rabbits

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The creation of a multiallele knockout genotype in rabbit using crispr/cas9 and its application in translational medicine

Nonrodent animal models have recently become more valuable in preclinical studies. The limitation of nonrodent animal models is that they must demonstrate relatively reliable and predictable responses in addition to representing complex etiologies of a genetically diverse patient population. In our study, we applied CRISPR/Cas9 technology to produce transgenic rabbits. This approach can be useful for creating genetically divergent and homogeneous populations for studies in translational medicine. NADPH oxidase 4 (NOX4) is a promising therapeutic target, as it is linked to several pathologies including stroke, atherosclerosis, and lung and kidney fibrosis. NOX4 knockout (KO) rabbit lines were created in order to study the in vivo effects resulting from a lack of NOX4 protein and loss of gene function. One of the knockout founders was a germline multiallelic knockout male. Its offspring segregated into three distinct NOX4 knockout and a wild-type lines. Mosaicism is a relatively frequent phenomenon in rabbit transgenesis. Our results point to the possible application of mosaicism in preclinical studies. However, careful planning and evaluation of results are necessary. The predicted off-target sites were studied as well, and no signs of off-target events were detected. © 2020 by the authors. Licensee MDPI, Basel, Switzerland

Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant

Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone (spasticity) and related pains of different origin. In the present review, basic pharmacodynamic effects measured on whole animals, analyses of its actions on cell and tissue preparations and molecular mechanism of action on sodium and calcium channels are summarized as recently significantly new data were reported

Taming the terminological tempest in invasion science

Standardized terminology in science is important for clarity of interpretation and communication. In invasion science — a dynamic and quickly evolving discipline — the rapid proliferation of technical terminology has lacked a standardized framework for its language development. The result is a convoluted and inconsistent usage of terminology, with various discrepancies in descriptions of damages and interventions. A standardized framework is therefore needed for a clear, universally applicable, and consistent terminology to promote more effective communication across researchers, stakeholders, and policymakers. Inconsistencies in terminology stem from the exponential increase in scientific publications on the patterns and processes of biological invasions authored by experts from various disciplines and countries since the 1990s, as well as publications by legislators and policymakers focusing on practical applications, regulations, and management of resources. Aligning and standardizing terminology across stakeholders remains a prevailing challenge in invasion science. Here, we review and evaluate the multiple terms used in invasion science (e.g. 'non-native', 'alien', 'invasive' or 'invader', 'exotic', 'non-indigenous', 'naturalized, 'pest') to propose a more simplified and standardized terminology. The streamlined framework we propose and translate into 28 other languages is based on the terms (i) 'non-native', denoting species transported beyond their natural biogeographic range, (ii) 'established non-native', i.e. those non-native species that have established self-sustaining populations in their new location(s) in the wild, and (iii) 'invasive non-native' — populations of established non-native species that have recently spread or are spreading rapidly in their invaded range actively or passively with or without human mediation. We also highlight the importance of conceptualizing 'spread' for classifying invasiveness and 'impact' for management. Finally, we propose a protocol for classifying populations based on (1) dispersal mechanism, (2) species origin, (3) population status, and (4) impact. Collectively and without introducing new terminology, the framework that we present aims to facilitate effective communication and collaboration in invasion science and management of non-native species