Correlation effects and spin dependent transport in carbon nanostructures

The impact of symmetry breaking perturbations on the spin dependent transport through carbon nanotube quantum dots in the Kondo regime is discussed.Comment: 10 pages, 6 figure

Reaching the Hard to Reach: Empowering Community Members to Think Differently and Embrace Teens with Substance Use Disorder and Mental Health Challenges During the Time of COVID

Being a teenager is hard, and COVID-19 has made these difficult years even harder. Over the past decade, U.S. teens report feeling increased pressure and stress and those working with this population see the result -- young people with mental health conditions, lack of resiliency skills and many with substance use disorder. The healthy coping mechanisms that used to contribute to mental wellness, like community connection, physical activity and the pursuit of creative outlets has been declining. These trends were happening even before COVID! Teens with mental health issues often develop substance use disorder. It has been said that the opposite of addiction is not sobriety, it is connection. As the COVID19 pandemic continues, so does the nation’s opioid epidemic. The AMA has expressed concern over the increasing number of reports from national, state and local media suggesting increases in opioid-related overdose deaths. Young people, many of whom were already challenged with mental health conditions are seeking connection and are not finding it because of the social distancing and school closures necessary because of this contagious virus. Those who specialize in behavioral health are warning that a tsunami is about to hit our country in the form of mental health needs. This surge in mental health conditions is predicted to last for years. Join us for a webinar that will shed some light on teen mental health and substance use disorders. Presenters Stephanie Briody, CEO of Behavioral Health Innovators and Michelle Muffet - Lipinski, Principal of Northshore Recovery High School will share their innovative initiatives and programs that are filling in the gaps in services for teens with mental health and substance use disorders. Learn how you can prepare for this surge in mental health challenges with examples of practices and programs that can be replicated in your community, and that provide the needed connection with teens who are hard to reach. Learning Objectives: Learn about the PASS program and RecoveryBuild Alternative Peer Groups (APG’s) and how these positive discipline interventions are working to address and treat substance use disorder and other mental health conditions. Learn about recent legislative initiatives that address mental health and substance use disorder. Learn about some virtual connection tools and games you can use to provide expressive therapy using the arts

Serendipitous Discovery of Light-Induced \u3cem\u3e(In Situ)\u3c/em\u3e Formation of An Azo-Bridged Dimeric Sulfonated Naphthol as a Potent PTP1B Inhibito

Background Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders such as hemangiomas. The PTPs are also known to be notoriously difficult targets for designing inihibitors that become viable drug leads. Therefore, the pipeline for approved drugs in this class is minimal. Furthermore, drug screening for targets like PTPs often produce false positive and false negative results. Results Studies presented herein provide important insights into: (a) how to detect such artifacts, (b) the importance of compound re-synthesis and verification, and (c) how in situ chemical reactivity of compounds, when diagnosed and characterized, can actually lead to serendipitous discovery of valuable new lead molecules. Initial docking of compounds from the National Cancer Institute (NCI), followed by experimental testing in enzyme inhibition assays, identified an inhibitor of DUSP5. Subsequent control experiments revealed that this compound demonstrated time-dependent inhibition, and also a time-dependent change in color of the inhibitor that correlated with potency of inhibition. In addition, the compound activity varied depending on vendor source. We hypothesized, and then confirmed by synthesis of the compound, that the actual inhibitor of DUSP5 was a dimeric form of the original inhibitor compound, formed upon exposure to light and oxygen. This compound has an IC50 of 36 μM for DUSP5, and is a competitive inhibitor. Testing against PTP1B, for selectivity, demonstrated the dimeric compound was actually a more potent inhibitor of PTP1B, with an IC50 of 2.1 μM. The compound, an azo-bridged dimer of sulfonated naphthol rings, resembles previously reported PTP inhibitors, but with 18-fold selectivity for PTP1B versus DUSP5. Conclusion We report the identification of a potent PTP1B inhibitor that was initially identified in a screen for DUSP5, implying common mechanism of inhibitory action for these scaffolds

Oxygen and temperature influence the distribution of deepwater Cape hake Merluccius paradoxus in the southern Benguela: a GAM analysis of a 10-year time-series

Generalised additive models (GAMs) were applied to survey data to assess the influence of dissolved oxygen, water temperature and year of sampling upon the presence/absence of small (≤15 cm TL), medium (16–34 cm TL) and large (≥35 cm TL) size classes of deepwater Cape hake Merluccius paradoxus captured off the west coast of South Africa. Data were obtained from surveys using the RV Dr Fridtjof Nansen conducted in 2003 and from 2005 to 2013 during summer (January–February). Among the variables investigated, oxygen was the most important for the small size class (juveniles), with both low and high constraints (two-sided, ‘just right’ option), whereas for the medium and large size classes the oxygen effects were one-sided (avoiding lows). This finding, in combination with other published information, suggests that the Orange Banks is a nursery ground for juvenile M. paradoxus and that the area covered by this nursery ground can vary with the optimal oxygen concentration. The temperature constraint was generally wider and weaker than that for oxygen, being two-sided for the small and medium hake and one-sided (avoiding highs) for the large hake. The medium hake displayed the greatest tolerance to the investigated variables, which resulted in the widest distribution for this size class. Temperature, oxygen and sampling year play an important role in determining the distribution of M. paradoxus, but details of the biology (life cycle) of the species, such as its pelagic–demersal transition and associated movements, are no less important.publishedVersio

Effects of 3 Topical Plant Extracts on Wound Healing in Beef Cattle

Eleven heifers of the Purunã cattle breed were used to evaluate wound healing by second intention. An experimental wound excision model in bovines was created by means of a skin punch of diameter 2cm. The animals were topically treated for 17 days with a saline control or decoctions of Schinus terebinthifolius Raddi (Aroeira mansa), Tabebuia avellanedae Lorentz ex Griseb (Ipê Roxo), and Casearia sylvestris Sw.(Guaçatonga) mixed with carboxymethyl cellulose. Centripetal retraction, clinical, and histological aspects of the wounds were observed until complete healing. Decoctions of T. avellanedae and S. terebinthifolius, but not C. sylvestris, had a beneficial effect on wound healing by second intention

Rab6 and Rab11 Regulate Chlamydia trachomatis Development and Golgin-84-Dependent Golgi Fragmentation

Many intracellular pathogens that replicate in special membrane bound compartments exploit cellular trafficking pathways by targeting small GTPases, including Rab proteins. Members of the Chlamydiaceae recruit a subset of Rab proteins to their inclusions, but the significance of these interactions is uncertain. Using RNA interference, we identified Rab6 and Rab11 as important regulators of Chlamydia infections. Depletion of either Rab6 or Rab11, but not the other Rab proteins tested, decreased the formation of infectious particles. We further examined the interplay between these Rab proteins and the Golgi matrix components golgin-84 and p115 with regard to Chlamydia-induced Golgi fragmentation. Silencing of the Rab proteins blocked Chlamydia-induced and golgin-84 knockdown-stimulated Golgi disruption, whereas Golgi fragmentation was unaffected in p115 depleted cells. Interestingly, p115-induced Golgi fragmentation could rescue Chlamydia propagation in Rab6 and Rab11 knockdown cells. Furthermore, transport of nutrients to Chlamydia, as monitored by BODIPY-Ceramide, was inhibited by Rab6 and Rab11 knockdown. Taken together, our results demonstrate that Rab6 and Rab11 are key regulators of Golgi stability and further support the notion that Chlamydia subverts Golgi structure to enhance its intracellular development

Evidence for the formation of magnetic moments in the cuprate superconductor Hg0.8_{0.8}Cu0.2_{0.2}Ba2_2Ca2_2Cu3_3O8+δ_{8+\delta} below TcT_c seen by NQR

We report pure zero field nuclear magnetic resonance (NQR) measurements on the optimally doped three layer high-$T_{c}$-compounds HgBaCaCuO and HgBaCaCuO(F) with $T_c$ 134 K. Above $T_{c}$ two Cu NQR line pairs are observed in the spectra corresponding to the two inequivalent Cu lattice sites. Below $T_{c}$ the Cu NQR spectra show additional lines leading to the extreme broadened Cu NQR spectra at 4.2 K well known for the HgBaCaCuO compounds. The spin-lattice relaxation curves follow a triple exponential function with coefficients depend onto the saturation time (number of saturation pulses), whereas the spin-spin relaxation curve is described by a single exponential function. From the spin-lattice relaxation we deduced a complete removal of the Kramers degeneracy of the Cu quadrupole indicating that the additional lines are due to a Zeemann splitting of the $^{63/65}$Cu lines due to the spontaneous formation of magnetic moments within the CuO layers. Below 140 K, the spectra are well fitted by a number of 6 $^{63/65}$Cu line pairs. From the number of the Cu lines, the position of the lines relative to each other and the complete removal of the Kramers degeneracy we deduced an orientation of the magnetic moments parallel to the symmetry axis of the electric field gradient tensor with magnitudes of the order of 1000 G. We also discuss the possible microscopic origin of the observed internal magnetic fields.Comment: 11 pages, 12 figure