738 research outputs found

    Evaluating the Effectiveness of a ‘Real‐World’ Shared Reading Intervention for Preschool Children and Their Families: A Randomised Controlled Trial

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    Background Shared reading interventions can impact positively on preschool children's language development and on their caregiver's attitudes/behaviours towards reading. However, a number of barriers may discourage families from engaging with these interventions, particularly families from lower socio‐economic status (SES) backgrounds. We investigated how families from such backgrounds responded to an intervention designed explicitly to overcome these barriers. Methods In a preregistered cluster randomised controlled trial, 85 lower SES families and their 3‐year‐old to 4‐year‐old children from 10 different preschools were randomly allocated to take part in The Reader's Shared Reading programme (intervention) or an existing ‘Story Time’ group at a library (control) once a week for 8 weeks. Three outcome measures were assessed at baseline and post intervention: (1) attendance, (2) enjoyment of the reading groups and (3) caregivers' knowledge of, attitudes and behaviours towards reading. A fourth − children's vocabulary – was assessed at baseline and 4 weeks post intervention. Results Families were significantly more likely to attend the intervention group and rated it more favourably, compared with the control group. However, there were no significant effects on caregivers' knowledge, attitudes and behaviours or on children's language. Conclusion The intervention was only successful in engaging families from disadvantaged backgrounds in shared reading. Implications for the use, duration and intensity of shared reading interventions are discussed

    Children’s engagement and caregivers’ use of language-boosting strategies during shared book reading: A mixed methods approach

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    For shared book reading to be effective for language development, the adult and child need to be highly engaged. The current paper adopted a mixed-methods approach to investigate caregiver’s language-boosting behaviours and children’s engagement during shared book reading. The results revealed there were more instances of joint attention and caregiver’s use of prompts during moments of higher engagement. However, instances of most language-boosting behaviours were similar across episodes of higher and lower engagement. Qualitative analysis assessing the link between children’s engagement and caregiver’s use of speech acts, revealed that speech acts do seem to contribute to high engagement, in combination with other aspects of the interaction

    Fate Of Abstracts Published In The Proceedings Of The First Annual Perinatal Society Of Australia And New Zealand Congress In 1997

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    Objectives: To examine the fate of research presented at the first annual Perinatal Society of Australia and New Zealand (PSANZ) Congress in 1997, by determining: the rate of publication in peer-reviewed biomedical journals; publication rate by discipline; journals in which work was published; concordance for aims, conclusions, authors and number of study subjects; and time from presentation to publication. Methods: A MEDLINE search was conducted for any publication in a peer-reviewed journal resulting from a publishable abstract from the proceedings of the first annual PSANZ Congress in 1997. Searching was completed 42 months postcongress. The concordance of aims, conclusions, authors and number of subjects between abstract and published paper was determined. Results: There were 172 publishable abstracts in the proceedings of the PSANZ Congress in 1997, and 78 (45%) were published as 83 articles. Basic sciences had the highest publication rate (67%) and midwifery the lowest (20%). Articles were published in 41 journals, with one-third of the articles in three paediatric journals. There was a match with aims in 75%, and with conclusions in 65%. There were 47/77 with the same number of subjects, 20/77 with more and 10/77 with fewer. There were 22 articles with one author added, 12 had more than one author added, 11 had one author removed and five had more than one author removed. Median time-to-publication was 18 months (interquartile range 9-26 months). Conclusions: A publication rate of 45% is comparable to other conferences. Basic science and neonatology had the highest publication rates. There were considerable differences between abstract and published article in terms of aims, conclusions, number of subjects and authors

    Three-year-olds’ comprehension of contrastive and descriptive adjectives: Evidence for contrastive inference

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    Combining information from adjectives with the nouns they modify is essential for comprehension. Previous research suggests that preschoolers do not always integrate adjectives and nouns, and may instead over-rely on noun information when processing referring expressions (Fernald, Thorpe, & Marchman, 2010; Thorpe, Baumgartner, & Fernald, 2006). This disjointed processing has implications for pragmatics, apparently preventing under-fives from making contrastive inferences (Huang & Snedeker, 2013). Using a novel experimental design that allows preschoolers time to demonstrate their abilities in adjective-noun integration and in contrastive inference, two visual world experiments investigate how English-speaking three-year-olds (N = 73, Mage = 44 months) process size adjectives across syntactic (prenominal; postnominal) and pragmatic (descriptive; contrastive) contexts. We show that preschoolers are able to integrate adjectives and nouns to resolve reference accurately by the end of the referring expression, in a variety of pragmatic and syntactic contexts and in the presence of multiple distractors. We reveal for the first time that they can contrastively infer, given a slowed speed of presentation and visually salient size contrasts. Our findings provide evidence for a continuity in the development of pragmatic skills, which do not appear to be linked to children's language proficiency or speed of processing

    Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen

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    Polyomaviruses such as BK virus and JC virus have been linked to several diseases, but treatments that thwart their propagation are limited in part because of slow growth and cumbersome culturing conditions. In contrast, the replication of one member of this family, Simian Virus 40 (SV40), is robust and has been well-characterized. SV40 replication requires two domains within the viral-encoded large tumor antigen (TAg): The ATPase domain and the N-terminal J domain, which stimulates the ATPase activity of the Hsp70 chaperone. To assess whether inhibitors of polyomavirus replication could be identified, we examined a recently described library of small molecules, some of which inhibit chaperone function. One compound, MAL2-11B, inhibited both TAg's endogenous ATPase activity and the TAg-mediated activation of Hsp70. MAL2-11B also reduced SV40 propagation in plaque assays and compromised DNA replication in cell culture and in vitro. Furthermore, the compound significantly reduced the growth of BK virus in a human kidney cell line. These data indicate that pharmacological inhibition of TAg's chaperone and ATPase activities may provide a route to combat polyomavirus-mediated disease. © 2009 Elsevier B.V. All rights reserved
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