Recent geophysical survey of English monastic sites

Geophysical survey can provide additional detail even from well understood monastic sites. Extended landscape survey in rural settings can reveal wider semi-industrial monastic activity. Vehicle towed ground penetrating radar used to complement earth resistance and magnetic survey

Fore! GPR survey of the Belhus Tudor water gardens

Covid-19 restrictions allowed unique access to this site on a temporarily closed golf course. Vehicle towed ground penetrating radar survey provided rapid coverage of the site. Geophysical survey helped support local volunteer research groups. Significant remains survive despite demolition of the Tudor mansion and landscaping for the golf-course. Detailed topographic data was generated from UAV based photography through Structure from Motion

The impact of cyberstalking: the lived experience - a thematic analysis.

Cyberstalking (CS) can have major psychosocial impacts on individuals. Victims report a number of serious consequences of victimization such as increased suicidal ideation, fear, anger, depression, and post traumatic stress disorder (PTSD) symptomology. Research is largely limited to quantitative outcome research. This study examines the diversity of experiences reported by people who define themselves as having been cyberstalked. Thematic analysis was used to explore 100 CS victim narratives, gathered by means of an online survey questionnaire designed to capture structured text responses. Five emergent themes were evident in the data: control and intimidation; determined offender; development of harassment; negative consequences; and lack of support. Findings identify similarities and differences to traditional stalking, along with the necessity of support for victims and illustration of the negative impacts this form of harassment produces

VLA/Realfast Detection of a Burst from FRB 180916.J0158+65 and Tests for Periodic Activity

We report on the detection of a burst from FRB 180916 by realfast/Very Large Array and present software for interpreting fast radio bursts (FRB) periodicity. We demonstrate a range of periodicity analyses with bursts from FRB 180916, FRB 121102 and FRB 180814. Our results for FRB 180916 and FRB 121102 are consistent with published results. For FRB 180814, we did not detect any significant periodic episodes. The realfast-detected and other high-frequency bursts for FRB 180916 tend to lie at the beginning of the activity window, indicating a possible phase-frequency relation. The python package frbpa can be used to reproduce and expand on this analysis to test models for repeating FRBs

VLA/Realfast Detection of a Burst from FRB180916.J0158+65 and Tests for Periodic Activity

We report on the detection of a burst from FRB180916 by realfast/VLA and present software for interpreting fast radio bursts (FRB) periodicity. We demonstrate a range of periodicity analyses with bursts from FRB180916, FRB121102 and FRB180814. Our results for FRB180916 and FRB121102 are consistent with published results. For FRB180814, we did not detect any significant periodic episodes. The realfast-detected and other high-frequency bursts for FRB180916 tend to lie at the beginning of the activity window, indicating a possible phase-frequency relation. The python package $\texttt{frbpa}$ can be used to reproduce and expand on this analysis to test models for repeating FRBs.Comment: Published in Research Notes of the AA

Entamoeba histolytica Phagocytosis of Human Erythrocytes Involves PATMK, a Member of the Transmembrane Kinase Family

Entamoeba histolytica is the cause of amebic colitis and liver abscess. This parasite induces apoptosis in host cells and utilizes exposed ligands such as phosphatidylserine to ingest the apoptotic corpses and invade deeper into host tissue. The purpose of this work was to identify amebic proteins involved in the recognition and ingestion of dead cells. A member of the transmembrane kinase family, phagosome-associated TMK96 (PATMK), was identified in a proteomic screen for early phagosomal proteins. Anti-peptide affinity-purified antibody produced against PATMK demonstrated that it was a type I integral membrane protein that was expressed on the trophozoite surface, and that co-localized with human erythrocytes at the site of contact. The role of PATMK in erythrophagocytosis in vitro was demonstrated by: (i) incubation of ameba with anti-PATMK antibodies; (ii) PATMK mRNA knock-down using a novel shRNA expression system; and (iii) expression of a carboxy-truncation of PATMK (PATMKΔ932). Expression of the carboxy-truncation of PATMKΔ932 also caused a specific reduction in the ability of E. histolytica to establish infection in the intestinal model of amebiasis, however these amebae retained the ability to cause hepatic abscesses when directly injected in the liver. In conclusion, PATMK was identified as a member of the TMK family that participates in erythrophagocytosis and is uniquely required for intestinal infection

Advances in archaeomagnetic dating in Britain: New data, new approaches and a new calibration curve

yesArchaeomagnetic dating offers a valuable chronological tool for archaeological investigations, particularly for dating fired material. The method depends on the establishment of a dated record of secular variation of the Earth's magnetic field and this paper presents new and updated archaeomagnetic directional data from the UK and geomagnetic secular variation curves arising from them. The data are taken from publications from the 1950's to the present day; 422 dated entries derived from existing archaeo and geomagnetic databases are re-evaluated and 487 new directions added, resulting in 909 entries with corresponding dates, the largest collection of dated archaeomagnetic directions from a single country. An approach to improving the largest source of uncertainty, the independent dating, is proposed and applied to the British Iron Age, resulting in 145 directions from currently available databases being updated with revised ages and/or uncertainties, and a large scale reassessment of age assignments prior to inclusion into the Magnetic Moments of the Past and GEOMAGIA50 databases. From the significantly improved dataset a new archaeomagnetic dating curve for the UK is derived through the development of a temporally continuous geomagnetic field model, and is compared with previous UK archaeomagnetic dating curves and global field models. The new model, ARCH-UK.1 allows model predictions for any location in the UK with associated uncertainties. It is shown to improve precision and accuracy in archaeomagnetic dating, and to provide new insight into past geomagnetic field changes.Arts and Humanities Research Counci

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

Objectives:&nbsp;Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD)&mdash;a widely used mouse model of prediabetes. Methods:&nbsp;We fed female mice expressing the Ca2+&nbsp;indicator GCaMP3 specifically in alpha-cells an HFD or control (CTL) diet. We then conducted&nbsp;in&nbsp;vivo&nbsp;phenotyping of these mice, as well as experiments on isolated (ex&nbsp;vivo) islets and in the&nbsp;in situ&nbsp;perfused pancreas. Results:&nbsp;In&nbsp;vivo,&nbsp;HFD-fed mice exhibited increased fed plasma glucagon levels and a reduced response to elevations in plasma glucose. Glucagon secretion from isolated islets and in the perfused mouse pancreas was elevated under both hypo- and hyperglycaemic conditions. In mice fed a CTL diet, increasing glucose reduced intracellular Ca2+&nbsp;([Ca2+]i) (oscillation frequency and amplitude). This effect was also observed in HFD mice; however, both the frequency and amplitude of the [Ca2+]i&nbsp;oscillations were higher than those in CTL alpha-cells. Given that alpha-cells are under strong paracrine control from neighbouring somatostatin-secreting delta-cells, we hypothesised that this elevation of alpha-cell output was due to a lack of somatostatin (SST) secretion. Indeed, SST secretion in isolated islets from HFD mice was reduced but exogenous SST also failed to suppress glucagon secretion and [Ca2+]i&nbsp;activity from HFD alpha-cells, in contrast to observations in CTL mice. Conclusions:&nbsp;These findings suggest that reduced delta-cell function, combined with intrinsic changes in alpha-cell sensitivity to somatostatin, accounts for the hyperglucagonaemia in mice fed an HFD.</p

A Distant Fast Radio Burst Associated with Its Host Galaxy by the Very Large Array

We present the discovery and subarcsecond localization of a new fast radio burst (FRB) by the Karl G. Jansky Very Large Array (VLA) and realfast search system. The FRB was discovered on 2019 June 14 with a dispersion measure of 959 pc cm⁻³. This is the highest DM of any localized FRB and its measured burst fluence of 0.6 Jy ms is less than nearly all other FRBs. The source is not detected to repeat in 15 hr of VLA observing and 153 hr of CHIME/FRB observing. We describe a suite of statistical and data quality tests we used to verify the significance of the event and its localization precision. Follow-up optical/infrared photometry with Keck and Gemini associate the FRB with a pair of galaxies with r ∼ 23 mag. The false-alarm rate for radio transients of this significance that are associated with a host galaxy is roughly 3×10⁻⁴ hr⁻¹. The two putative host galaxies have similar photometric redshifts of z_(phot) ∼ 0.6, but different colors and stellar masses. Comparing the host distance to that implied by the dispersion measure suggests a modest (~ 50 pc/cm⁻³) electron column density associated with the FRB environment or host galaxy/galaxies