5,247 research outputs found
A Reputation Economy: Results from an Empirical Survey on Academic Data Sharing
Academic data sharing is a way for researchers to collaborate and thereby
meet the needs of an increasingly complex research landscape. It enables
researchers to verify results and to pursuit new research questions with "old"
data. It is therefore not surprising that data sharing is advocated by funding
agencies, journals, and researchers alike. We surveyed 2661 individual academic
researchers across all disciplines on their dealings with data, their
publication practices, and motives for sharing or withholding research data.
The results for 1564 valid responses show that researchers across disciplines
recognise the benefit of secondary research data for their own work and for
scientific progress as a whole-still they only practice it in moderation. An
explanation for this evidence could be an academic system that is not driven by
monetary incentives, nor the desire for scientific progress, but by individual
reputation-expressed in (high ranked journal) publications. We label this
system a Reputation Economy. This special economy explains our findings that
show that researchers have a nuanced idea how to provide adequate formal
recognition for making data available to others-namely data citations. We
conclude that data sharing will only be widely adopted among research
professionals if sharing pays in form of reputation. Thus, policy measures that
intend to foster research collaboration need to understand academia as a
reputation economy. Successful measures must value intermediate products, such
as research data, more highly than it is the case now
Neue Cyclopentadienylverbindungen des Aluminiums sowie Herstellung kupferhaltiger Aluminiumschichten mittels des MOCVD-Verfahrens
Avoiding Patterns in the Abelian Sense
We classify all 3 letter patterns that are avoidable in the abelian sense. A short list of four letter patterns for which abelian avoidance is undecided is given. Using a generalization of Zimin words we deduce some properties of ω-words avoiding these patterns.Research of both authors supported by NSERC Operating Grants.https://www.cambridge.org/core/journals/canadian-journal-of-mathematics/article/avoiding-patterns-in-the-abelian-sense/42148B0781A38A6618A537AAD7D39B8
Phase separation and rotor self-assembly in active particle suspensions
Adding a non-adsorbing polymer to passive colloids induces an attraction
between the particles via the `depletion' mechanism. High enough polymer
concentrations lead to phase separation. We combine experiments, theory and
simulations to demonstrate that using active colloids (such as motile bacteria)
dramatically changes the physics of such mixtures. First, significantly
stronger inter-particle attraction is needed to cause phase separation.
Secondly, the finite size aggregates formed at lower inter-particle attraction
show unidirectional rotation. These micro-rotors demonstrate the self assembly
of functional structures using active particles. The angular speed of the
rotating clusters scales approximately as the inverse of their size, which may
be understood theoretically by assuming that the torques exerted by the
outermost bacteria in a cluster add up randomly. Our simulations suggest that
both the suppression of phase separation and the self assembly of rotors are
generic features of aggregating swimmers, and should therefore occur in a
variety of biological and synthetic active particle systems.Comment: Main text: 6 pages, 5 figures. Supplementary information: 5 pages, 4
figures. Supplementary movies available from
httP://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1116334109/-/DCSupplementa
Case-control risk factor study of methicillin-resistant Staphylococcus pseudintermedius (MRSP) infection in dogs and cats in Germany
New media, familiar dynamics: academic hierarchies influence academics' following behaviour on Twitter
For what reasons do academics follow one another on Twitter? Robert Jäschke, Stephanie B. Linek and Christian P. Hoffmann analysed the Twitter activity of computer scientists and found that while the quality of information provided by a Twitter account is a key motive for following academic colleagues, there is also evidence of a career planning motive. As well as there being reciprocal following between users of the same academic status (except, remarkably, between PhD researchers), a form of strategic politeness can be observed whereby users follow those of higher academic status without necessarily being followed back. The emerging academic public sphere facilitated by Twitter is largely shaped by dynamics and hierarchies all too familiar to researchers struggling to plot their careers in academia
When are active Brownian particles and run-and-tumble particles equivalent? Consequences for motility-induced phase separation
Active Brownian particles (ABPs, such as self-phoretic colloids) swim at
fixed speed along a body-axis that rotates by slow angular
diffusion. Run-and-tumble particles (RTPs, such as motile bacteria) swim with
constant \u until a random tumble event suddenly decorrelates the
orientation. We show that when the motility parameters depend on density
but not on , the coarse-grained fluctuating hydrodynamics of
interacting ABPs and RTPs can be mapped onto each other and are thus strictly
equivalent. In both cases, a steeply enough decreasing causes phase
separation in dimensions , even when no attractive forces act between
the particles. This points to a generic role for motility-induced phase
separation in active matter. However, we show that the ABP/RTP equivalence does
not automatically extend to the more general case of \u-dependent motilities
Reputation instead of obligation: forging new policies to motivate academic data sharing.
Despite strong support from funding agencies and policy makers academic data sharing sees hardly any adoption among researchers. Current policies that try to foster academic data sharing fail, as they try to either motivate researchers to share for the common good or force researchers to publish their data. Instead, Dr Sascha Friesike, Benedikt Fecher, Marcel Hebing, and Stephanie Linek argue that in order to tap into the vast potential that is attributed to academic data sharing we need to forge new policies that follow the guiding principle reputation instead of obligation
It’s all about information? The Following Behaviour of Professors and PhD Students on Twitter
In this paper we investigate the role of the academic status in the following behaviour of computer scientists on Twitter. Based on a uses and gratifications perspective, we focus on the activity of a Twitter account and the reciprocity of following relationships. We propose that the account activity addresses the users' information motive only, whereas the user's academic status relates to both the information motive and community development (as in peer networking or career planning). Variables were extracted from Twitter user data. We applied a biographical approach to correctly identify the academic status (professor versus PhD student). We calculated a MANOVA on the influence of the activity of the account and the academic status (on different groups of followers) to differentiate the influence of the information motive versus the motive for community development. Results suggest that for computer scientists Twitter is mainly an information network. However, we found significant effects in the sense of career planning, that is, the accounts of professors had even in the case of low activity a relatively high number of researcher followers -- both PhD followers as well as professor followers. Additionally, there was also some weak evidence for community development gratifications in the sense of peer-networking of professors. Overall, we conclude that the academic use of Twitter is not only about information, but also about career planning and networking
Evidence for steric regulation of fibrinogen binding to staphylococcus aureus fibronectin-binding protein A (FnBPA)
Background: Staphylococcus aureus fibronectin-binding protein A (FnBPA) binds fibronectin and fibrinogen at adjacent sites.
Results: The fibrinogen-binding mechanism is similar but not identical to homologous bacterial proteins. Ternary complex formation by intact fibronectin and fibrinogen on adjacent FnBPA sites could not be demonstrated.
Conclusion: Fibrinogen-binding is sterically regulated by fibronectin binding.
Significance: Steric regulation might result in targeting of S. aureus to fibrin clots.
ABSTRACT
The adjacent fibrinogen (Fg)- and fibronectin (Fn)- binding sites on Fn-binding protein A (FnBPA), a cell-surface protein from Staphylococcus aureus, are implicated in the initiation and persistence of infection. FnBPA contains a single Fg-binding site (that also binds elastin) and multiple Fn-binding sites. Here, we solved the structure of the N2N3 domains containing the Fg-binding site of FnBPA in the apo-form and in complex with a Fg-peptide. The Fg-binding mechanism is similar to that of homologous bacterial proteins but without the requirement for “latch” strand residues. We show that the Fg- and the most N-terminal Fn-binding sites are non-overlapping but in close proximity. While Fg and a sub-domain of Fn can form a ternary complex on an FnBPA protein construct containing a Fg- and single Fn-binding site, binding of intact Fn appears to inhibit Fg binding, suggesting steric regulation. Given the concentrations of Fn and Fg in the plasma, this mechanism might result in targeting of S. aureus to fibrin-rich thrombi or elastin-rich tissues
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