Key Issues in Understanding the Economic and Health Security of Current and Future Generations of Seniors

Examines key issues seniors face in ensuring economic and health security and the role that Medicare, Medicaid, and Social Security play in ensuring seniors' financial security, including concerns about medical debt and disparities by race/ethnicity

Social media shopping and the elaboration likelihood model of persuasion

Social media is a quickly growing industry with a wide variety of possibilities available to all kinds of users. Whether it be personal use or for a business, social media can help form people and companies in many ways. When it comes to shopping online, social media is a new path that many businesses are learning how to use. Businesses are choosing to promote and sell their products through platforms like Instagram due to their vast pool of users. The key to using Instagram to sell products is to effectively persuade a user to make the purchase. In order for this to happen, the findings from The Elaboration Likelihood Model of Persuasion (ELM) can be used as a guide to understanding how users analyze different messages and are motivated towards a call to action. After reviewing the two options available to business to sell products through Instagram, an overview of The Elaboration Likelihood Model of Persuasion will also be provided. In addition, this report will cover an example of prior research done on The Elaboration Likelihood of Persuasion, the integration of social media shopping and ELM and the managerial application of it

Do psychological factors influence magistrates' behaviour towards mentally disordered defendants?: An empirical study

The aim of this study was to assess magistrates' knowledge of, and attitudes relating to, mentally disordered defendants / offenders and the effects upon 'disposal' [decision making]. Method: A combined quantitative and qualitative empirical study supported by a literature review was chosen. The research instrument used was a questionnaire distributed to a combined local and national sample of magistrates. The knowledge, attitudes and decisions of the whole sample were analysed and comparisons made according to gender, professional experience and length of service. No effort was made to control the three ' grouping' variables gender, professional experience and length of service. The possible influence of these three 'grouping' variables were considered and analysed. The significance of the 'grouping' variables upon knowledge and attitude were statistically analysed using the Mann Whitney U-test, Kruskal Wallis Test and chi-square test. Qualitative data was used to support the statistical analysis. Results: The level of magistrates' knowledge of the procedure for disposal of mentally disordered defendants/offenders was low. Professional experience did not indicate improved knowledge. Magistrates 'knowledge of other agencies' responsibilities and policies with regard to the mentally disordered defendant were demonstrated to be seriously deficient. Magistrates were shown to have negative attitudes towards mental disorder but a more positive attitude towards the history of mental disorder when considering the disposal of defendants/offenders. Female magistrates and longer serving magistrates were significantly inclined to a more positive attitude towards mentally disordered defendants, giving greater weight to the issue of mental disorder. Magistrates showed variable estimates of the importance of mental disorder in criminal behaviour. Magistrates find facilities and options for the handling and 'disposal' of the mentally disordered in the Magistrates' Court extremely deficient,limited and frustrating. Conclusion: The research has shown that there is in general, poor knowledge and understanding of the main issues associated with mentally disordered defendants/offenders. The study has also demonstrated that these deficiencies adversely affect magistrates' decision making 'disposal', in respect of mentally disordered defendants/offenders. The study has shown that in order to reduce the number of mentally disordered remanded to prison and thus adhere to policy outlined in Home Office circulars 66/90 and 12/95, it is necessary to take steps to improve the knowledge and understanding of the issues related to the mentally disordered defendant/mentally disordered offender for all magistrates

Macrocephaly and developmental delay caused by missense variants in RAB5C

Rab GTPases are important regulators of intracellular vesicular trafficking. RAB5C is a member of the Rab GTPase family that plays an important role in the endocytic pathway, membrane protein recycling and signaling. Here we report on 12 individuals with nine different heterozygous de novo variants in RAB5C. All but one patient with missense variants (n = 9) exhibited macrocephaly, combined with mild-to-moderate developmental delay. Patients with loss of function variants (n = 2) had an apparently more severe clinical phenotype with refractory epilepsy and intellectual disability but a normal head circumference. Four missense variants were investigated experimentally. In vitro biochemical studies revealed that all four variants were damaging, resulting in increased nucleotide exchange rate, attenuated responsivity to guanine exchange factors and heterogeneous effects on interactions with effector proteins. Studies in C. elegans confirmed that all four variants were damaging in vivo and showed defects in endocytic pathway function. The variant heterozygotes displayed phenotypes that were not observed in null heterozygotes, with two shown to be through a dominant negative mechanism. Expression of the human RAB5C variants in zebrafish embryos resulted in defective development, further underscoring the damaging effects of the RAB5C variants. Our combined bioinformatic, in vitro and in vivo experimental studies and clinical data support the association of RAB5C missense variants with a neurodevelopmental disorder characterized by macrocephaly and mild-to-moderate developmental delay through disruption of the endocytic pathway

Fear-Potentiated Startle Response Is Unrelated to Social or Emotional Functioning in Adolescents With Autism Spectrum Disorders: Startle response in adolescents with ASD

It has been suggested that atypical amygdala function contributes to the social impairments characteristic of autism spectrum disorders (ASDs). Previous research has demonstrated that adolescents and adults with ASD generate normal response during a fear-potentiated startle paradigm, suggesting this aspect of amygdala function is intact and may not account for the social dysfunction associated with the condition. The amygdala also plays a crucial role in the expression of anxiety and may contribute to high rates of reported anxiety in individuals with ASD. The present study partially replicates prior work by examining the fear-potentiated startle response in adolescents with ASD, and extends this to investigate the relationship between startle response and anxiety. Eyeblink magnitude and latency (electromyographic activity; EMG) were collected from 20 adolescents with ASD and 19 typically developing (TD) age-matched adolescents during a fear-potentiated startle paradigm. Parent report and self-report of anxiety and additional psychiatric symptoms were collected. Parental reports indicated higher rates of associated psychopathology in adolescents with ASD compared with TD adolescents. Consistent with previous results, both groups showed normal potentiated startle response, and no group differences in EMG were found. Symptoms of anxiety and level of social impairment were unrelated to startle response. These findings held for all levels of anxiety, suggesting that within the context of the fear-potentiated startle paradigm, amygdala response is not associated with degree of atypical social or emotional functioning in ASD

Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis

Accumulating evidence supports the use of higher doses of rifampicin for tuberculosis (TB) treatment. Rifampicin is a potent inducer of metabolic enzymes and drug transporters, resulting in clinically relevant drug interactions. To assess the drug interaction potential of higher doses of rifampicin, we compared the effect of high-dose rifampicin (40 mg/kg daily, RIF40) and standard-dose rifampicin (10 mg/kg daily, RIF10) on the activities of major cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp). In this open-label, single-arm, two-period, fixed-order phenotyping cocktail study, adult participants with pulmonary TB received RIF10 (days 1-15), followed by RIF40 (days 16-30). A single dose of selective substrates (probe drugs) was administered orally on days 15 and 30: caffeine (CYP1A2), tolbutamide (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), midazolam (CYP3A), and digoxin (P-gp). Intensive pharmacokinetic blood sampling was performed over 24 hours after probe drug intake. In all, 25 participants completed the study. Geometric mean ratios (90% confidence interval) of the total exposure (area under the concentration versus time curve, RIF40 versus RIF10) for each of the probe drugs were as follows: caffeine, 105% (96%-115%); tolbutamide, 80% (74%-86%); omeprazole, 55% (47%-65%); dextromethorphan, 77% (68%-86%); midazolam, 62% (49%-78%), and 117% (105%-130%) for digoxin. In summary, high-dose rifampicin resulted in no additional effect on CYP1A2, mild additional induction of CYP2C9, CYP2C19, CYP2D6, and CYP3A, and marginal inhibition of P-gp. Existing recommendations on managing drug interactions with rifampicin can remain unchanged for the majority of co-administered drugs when using high-dose rifampicin. Clinical Trials registration number NCT04525235.</p

The relationship between early neural responses to emotional faces at age 3 and later autism and anxiety symptoms in adolescents with autism

Both autism spectrum (ASD) and anxiety disorders are associated with atypical neural and attentional responses to emotional faces, differing in affective face processing from typically developing peers. Within a longitudinal study of children with ASD (23 male, 3 female), we hypothesized that early ERPs to emotional faces would predict concurrent and later ASD and anxiety symptoms. Greater response amplitude to fearful faces corresponded to greater social communication difficulties at age 3, and less improvement by age 14. Faster ERPs to neutral faces predicted greater ASD symptom improvement over time, lower ASD severity in adolescence, and lower anxiety in adolescence. Early individual differences in processing of emotional stimuli likely reflect a unique predictive contribution from social brain circuitry early in life

The impact of precarious employment on mental health: The case of Italy

Although there has been a sizeable empirical literature measuring the effect of job precariousness on the mental health of workers the debate is still open, and understanding the true nature of such relationship has important policy implications. In this paper, we investigate the impact of precarious employment on mental health using a unique, very large data set that matches information on job contracts for over 2.7 million employees in Italy followed over the years 2007e2011, with their psychotropic medication prescription. We examine the causal effects of temporary contracts, their duration and the number of contract changes during the year on the probability of having one or more prescriptions for medication to treat mental health problems. To this end, we estimate a dynamic Probit model, and deal with the potential endogeneity of regressors by adopting an instrumental variables approach. As instruments, we use firm-level probabilities of being a temporary worker as well as other firm-level variables that do not depend on the mental illness status of the workers. Our results show that the probability of psychotropic medication prescription is higher for workers under temporary job contracts. More days of work under temporary contract as well as frequent changes in temporary contract significantly increase the probability of developing mental health problems that need to be medically treated. We also find that moving from permanent to temporary employment increases mental illness; symmetrically, although with a smaller effect in absolute value, moving from temporary to permanent employment tends to reduce it. Policy interventions aimed at increasing the flexibility of the labour market through an increase of temporary contracts should also take into account the social and economic cost of these reforms, in terms of psychological wellbeing of employees

Fertile Prototaxites taiti: a basal ascomycete with inoperculate, polysporous asci lacking croziers

The affinities of Prototaxites have been debated ever since its fossils, some attaining tree-trunk proportions, were discovered in Canadian Lower Devonian rocks in 1859. Putative assignations include conifers, red and brown algae, liverworts and fungi (some lichenised). Detailed anatomical investigation led to the reconstruction of the type species, P. logani, as a giant sporophore (basidioma) of an agaricomycete (= holobasidiomycete), but evidence for its reproduction remained elusive. Tissues associated with P. taiti in the Rhynie chert plus charcoalified fragments from southern Britain are investigated here to describe the reproductive characters and hence affinities of Prototaxites. Thin sections and peels (Pragian Rhynie chert, Aberdeenshire) were examined using light and confocal microscopy; Přídolí and Lochkovian charcoalified samples (Welsh Borderland) were liberated from the rock and examined with scanning electron microscopy. Prototaxites taiti possessed a superficial hymenium comprising an epihymenial layer, delicate septate paraphyses, inoperculate polysporic asci lacking croziers and a subhymenial layer composed predominantly of thin-walled hyphae and occasional larger hyphae. Prototaxites taiti combines features of extant Taphrinomycotina (Neolectomycetes lacking croziers) and Pezizomycotina (epihymenial layer secreted by paraphyses) but is not an ancestor of the latter. Brief consideration is given to its nutrition and potential position in the phylogeny of the Ascomycota

Report of the Topical Group on Dark Energy and Cosmic Acceleration: Complementarity of Probes and New Facilities for Snowmass 2021

The mechanism(s) driving the early- and late-time accelerated expansion of the Universe represent one of the most compelling mysteries in fundamental physics today. The path to understanding the causes of early- and late-time acceleration depends on fully leveraging ongoing surveys, developing and demonstrating new technologies, and constructing and operating new instruments. This report presents a multi-faceted vision for the cosmic survey program in the 2030s and beyond that derives from these considerations. Cosmic surveys address a wide range of fundamental physics questions, and are thus a unique and powerful component of the HEP experimental portfolio.Comment: Submitted to the Proceedings of the US Community Study on the Future of Particle Physics (Snowmass 2021); Topical Group Report for CF06 (Cosmic Frontier Topical Group on Dark Energy and Cosmic Acceleration: Complementarity of Probes and New Facilitie