Environmental Policy Update 2012: Development Strategies and Environmental Policy in East Africa

The seven chapters that comprise this report explore ways to integrate sustainability goals and objectives into Ethiopia's current development strategies

Peer review and design fiction:"Great Scott! The quotes are redacted"

In the 10 years since the term was coined 'design fiction' has become an increasingly common approach in HCI research. The practice involves working with 'diegetic prototypes', that is prototypes that need not exist in reality, but instead exist from within a 'story world'. Although fictional aspects are not unusual in HCI prototyping methods (e.g. storyboards, personas, Wizard-of-Oz), the breadth and flexibility of design fiction poses new challenges. This paper originally featured quotes from peer reviews of design fiction orientated papers that have previously been submitted to ACM SIGCHI conferences in order to highlight inherent challenges when reviewing research that may be based upon or include elements of fiction. In response to the SIGCHI Executive Committee's request to not directly quote reviewers the quotes have now been redacted. This somewhat changes the paper's tone and also makes very clear that publishing discussions relating to peer reviews (or the reviews themselves) is extremely challenging

The search for low-mass axion dark matter with ABRACADABRA-10cm

Two of the most pressing questions in physics are the microscopic nature of the dark matter that comprises 84% of the mass in the universe and the absence of a neutron electric dipole moment. These questions would be resolved by the existence of a hypothetical particle known as the quantum chromodynamics (QCD) axion. In this work, we probe the hypothesis that axions constitute dark matter, using the ABRACADABRA-10cm experiment in a broadband configuration, with world-leading sensitivity. We find no significant evidence for axions, and we present 95% upper limits on the axion-photon coupling down to the world-leading level $g_{a\gamma\gamma}<3.2 \times10^{-11}$ GeV$^{-1}$, representing one of the most sensitive searches for axions in the 0.41 - 8.27 neV mass range. Our work paves a direct path for future experiments capable of confirming or excluding the hypothesis that dark matter is a QCD axion in the mass range motivated by String Theory and Grand Unified Theories.Comment: 17 pages, 12 figure

Design and Implementation of the ABRACADABRA-10 cm Axion Dark Matter Search

The past few years have seen a renewed interest in the search for light particle dark matter. ABRACADABRA is a new experimental program to search for axion dark matter over a broad range of masses, $10^{-12}\lesssim m_a\lesssim10^{-6}$ eV. ABRACADABRA-10 cm is a small-scale prototype for a future detector that could be sensitive to QCD axion couplings. In this paper, we present the details of the design, construction, and data analysis for the first axion dark matter search with the ABRACADABRA-10 cm detector. We include a detailed discussion of the statistical techniques used to extract the limit from the first result with an emphasis on creating a robust statistical footing for interpreting those limits.Comment: 12 pages, 8 figure

Effects for Efficiency: Asymptotic Speedup with First-Class Control

We study the fundamental efficiency of delimited control. Specifically, we show that effect handlers enable an asymptotic improvement in runtime complexity for a certain class of functions. We consider the generic count problem using a pure PCF-like base language $\lambda_b$ and its extension with effect handlers $\lambda_h$. We show that $\lambda_h$ admits an asymptotically more efficient implementation of generic count than any $\lambda_b$ implementation. We also show that this efficiency gap remains when $\lambda_b$ is extended with mutable state. To our knowledge this result is the first of its kind for control operators

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Expanding modes of reflection in design futuring

Design futuring approaches, such as speculative design, design fiction and others, seek to (re)envision futures and explore alternatives. As design futuring becomes established in HCI design research, there is an opportunity to expand and develop these approaches. To that end, by reflecting on our own research and examining related work, we contribute five modes of reflection. These modes concern formgiving, temporality, researcher positionality, real-world engagement, and knowledge production. We illustrate the value of each mode through careful analysis of selected design exemplars and provide questions to interrogate the practice of design futuring. Each reflective mode offers productive resources for design practitioners and researchers to articulate their work, generate new directions for their work, and analyze their own and others’ work.

Cellular Levels and Binding of c-di-GMP Control Subcellular Localization and Activity of the Vibrio cholerae Transcriptional Regulator VpsT

The second messenger, cyclic diguanylate (c-di-GMP), regulates diverse cellular processes in bacteria. C-di-GMP is produced by diguanylate cyclases (DGCs), degraded by phosphodiesterases (PDEs), and receptors couple c-di-GMP production to cellular responses. In many bacteria, including Vibrio cholerae, multiple DGCs and PDEs contribute to c-di-GMP signaling, and it is currently unclear whether the compartmentalization of c-di-GMP signaling components is required to mediate c-di-GMP signal transduction. In this study we show that the transcriptional regulator, VpsT, requires c-di-GMP binding for subcellular localization and activity. Only the additive deletion of five DGCs markedly decreases the localization of VpsT, while single deletions of each DGC do not impact VpsT localization. Moreover, mutations in residues required for c-di-GMP binding, c-di-GMP-stabilized dimerization and DNA binding of VpsT abrogate wild type localization and activity. VpsT does not co-localize or interact with DGCs suggesting that c-di-GMP from these DGCs diffuses to VpsT, supporting a model in which c-di-GMP acts at a distance. Furthermore, VpsT localization in a heterologous host, Escherichia coli, requires a catalytically active DGC and is enhanced by the presence of VpsT-target sequences. Our data show that c-di-GMP signaling can be executed through an additive cellular c-di-GMP level from multiple DGCs affecting the localization and activity of a c-di-GMP receptor and furthers our understanding of the mechanisms of second messenger signaling