The role of answer fluency and perceptual fluency in the monitoring and control of reasoning: Reply to Alter, Oppenheimer, and Epley

In this reply, we provide an analysis of Alter et al. (2013) response to our earlier paper (Thompson et al., 2013). In that paper, we reported difficulty in replicating Alter, Oppenheimer, Epley, and Eyre’s (2007) main finding, namely that a sense of disfluency produced by making stimuli difficult to perceive, increased accuracy on a variety of reasoning tasks. Alter, Oppenheimer, and Epley (2013) argue that we misunderstood the meaning of accuracy on these tasks, a claim that we reject. We argue and provide evidence that the tasks were not too difficult for our populations (such that no amount of “metacognitive unease” would promote correct responding) and point out that in many cases performance on our tasks was well above chance or on a par with Alter et al.’s (2007) participants. Finally, we reiterate our claim that the distinction between answer fluency (the ease with which an answer comes to mind) and perceptual fluency (the ease with which a problem can be read) is genuine, and argue that Thompson et al. (2013) provided evidence that these are distinct factors that have different downstream effects on cognitive processe

Designing “little worlds” in Walnut Park: How architects adopted an ethnographic case study on living with dementia

Understanding future users is recognised to be essential in design, yet also challenging. Often architects have no direct access to the experiences of others, like people with dementia. Case studies have been suggested as an adequate format to inform designers. This paper investigates the role of an ethnographic case study about a person living with dementia, as provided to an architectural firm designing a residential care facility. Interviews with the architects and an analysis of design materials reveal how they incorporated the case study in their ongoing design. Results indicate that the case study offered insight into users’ daily life and facilitated architects’ concept development. Architects’ resulting concept proved valuable to frame design decisions, while its visualisation played a significant role in internal and external communication. The study contributes to untangling important aspects in informing architects about future users and raises questions regarding researchers’ and designers’ roles in transferring knowledge

Architects’ Attitudes Towards Users: A Spectrum of Advocating and Envisioning Future Use(rs) in Design

As designers of people’s living environments, architects are committed to deliver ‘good’ designs, but whose appreciation is considered here may differ. Perspectives range from architects themselves or their professional community over a particular client to society at large. Due to the increasing complexity of design processes, however, architects may not have direct access to users’ perspectives. This article explores what underpins architects’ constructions of the people they design for, drawing on an ethnographic study in three Belgian architecture firms. Interviews with architects shed light on their motivations and reasoning regarding responsibilities towards users. Additionally, observations of design meetings illustrate the visions in play when architects reflect-in-action about future use(rs). Results show a spectrum of attitudes, affecting how the presence of ‘the user’ is shaped in design. The insights are useful for developing strategies to support architects in accommodating, negotiating and acting more consciously on user experience in design

Distributed Entanglement

Consider three qubits A, B, and C which may be entangled with each other. We show that there is a trade-off between A's entanglement with B and its entanglement with C. This relation is expressed in terms of a measure of entanglement called the "tangle," which is related to the entanglement of formation. Specifically, we show that the tangle between A and B, plus the tangle between A and C, cannot be greater than the tangle between A and the pair BC. This inequality is as strong as it could be, in the sense that for any values of the tangles satisfying the corresponding equality, one can find a quantum state consistent with those values. Further exploration of this result leads to a definition of the "three-way tangle" of the system, which is invariant under permutations of the qubits.Comment: 13 pages LaTeX; references added, derivation of Eq. (11) simplifie

Harmonic generation in ring-shaped molecules

We study numerically the interaction between an intense circularly polarized laser field and an electron moving in a potential which has a discrete cylindrical symmetry with respect to the laser pulse propagation direction. This setup serves as a simple model, e.g., for benzene and other aromatic compounds. From general symmetry considerations, within a Floquet approach, selection rules for the harmonic generation [O. Alon Phys. Rev. Lett. 80 3743 (1998)] have been derived recently. Instead, the results we present in this paper have been obtained solving the time-dependent Schroedinger equation ab initio for realistic pulse shapes. We find a rich structure which is not always dominated by the laser harmonics.Comment: 15 pages including 7 figure

The use of bat houses as day roosts in macadamia orchards, South Africa

The loss of roost sites is one of the major drivers of the worldwide decline in bat populations and roost site preferences, either natural or artificially provided, are not well known for African bat species specifically. In this study we focus on the preference for different artificial roost sites by insectivorous bats in macadamia orchards in northern South Africa. From June 2016 to July 2017 we monitored 31 bat houses, mounted on poles in six macadamia orchards, for presence of bats or other occupants. Twenty-one multi-chambered bat houses of three different designs were erected in sets of three. Additionally, five Rocket boxes, four bat houses in sets of two (painted black and white) and one colony bat house were erected. Bats were counted and visually identified to family or species level. From December 2016 to the end of March 2017 iButtons were installed to record and analyze temperature variation within one set of three bat houses. We related the occupancy of bat houses to the different types of houses and the environmental variables: distance to water, altitude and height of the bat houses above the ground. Overall bat house occupancy was significantly higher in the central bat house, in the set of three, and the black bat house, in the set of two. Mean temperatures differed between houses in the set of three with the central bat house having a significantly higher mean temperature than the houses flanking it. Our study might confirm previous assumptions that the microclimate of bat houses appears to be an important factor influencing occupancy. In conclusion, from the different bat houses tested in this study the designs we assume the warmest and best insulated attracted the most bats. Further research is needed on the preferred microclimate of different bat species, co-habitation within bat houses and the potential importance of altitude and distance to water. Our study provided little variation in both altitude and the distance to water

Changes of bat species composition over altitudinal gradients on northern and southern aspects of the Soutpansberg mountain range, South Africa.

In order to gain insight into the pattern of bat species composition over altitude and the environmental variables driving the observed pattern, we compared data from moist southern and drier northern aspects of the Soutpansberg range in northern South Africa. Acoustical monitoring and additional capturing of bats was used for analysis of species distribution patterns and comparisons of community composition. Bat activity generally followed a linear decline with increasing altitude, possibly related to reproductive females preferring lower altitudes. Species richness followed a hump-shaped distribution on the northern aspect and across the transect, whereas a pattern of a linear decline was observed on the southern aspect. Our study strongly supports a previously published climate model for insectivorous bats which assumes that water availability linked with temperature determines the shape of altitudinal distribution in bat species. Step-wise selection from multiple regression models retained habitat type and/or measures of habitat structure in all final models, supporting several other studies in that vegetation correlated to altitude is a primary determinant of bat species distribution over altitude. This study also supports that the Soutpansberg is a biodiversity hotspot for bats and emphasises that conservation efforts should by no means ignore the lower altitudes

PET Imaging of Extracellular pH in Tumors with \u3csup\u3e64\u3c/sup\u3eCu- and \u3csup\u3e18\u3c/sup\u3eF-Labeled pHLIP Peptides: A Structure–Activity Optimization Study

pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants (Var3 and Var7) and wild-type (WT) pHLIP peptides have shown promise for in vivo imaging of breast cancer. Two positron emitting radionuclides (64Cu and 18F) were used to label the NOTA- and NO2A-derivatized Var3, Var7, and WT peptides for in vivo biodistribution studies in 4T1 orthotopic tumor-bearing BALB/c mice. All of the constructs were radiolabeled with 64Cu or [18F]-AlF in good yield. The in vivo biodistribution of the 12 constructs in 4T1 orthotopic allografted female BALB/c mice indicated that NO2A-cysVar3, radiolabeled with either 18F (4T1 uptake; 8.9 ± 1.7%ID/g at 4 h p.i.) or 64Cu (4T1 uptake; 8.2 ± 0.9%ID/g at 4 h p.i. and 19.2 ± 1.8% ID/g at 24 h p.i.), shows the most promise for clinical translation. Additional studies to investigate other tumor models (melanoma, prostate, and brain tumor models) indicated the universality of tumor targeting of these tracers. From this study, future clinical translation will focus on 18F- or 64Cu-labeled NO2A-cysVar3

Neural correlates of sexual cue reactivity in individuals with and without compulsive sexual behaviours

Although compulsive sexual behaviour (CSB) has been conceptualized as a "behavioural" addiction and common or overlapping neural circuits may govern the processing of natural and drug rewards, little is known regarding the responses to sexually explicit materials in individuals with and without CSB. Here, the processing of cues of varying sexual content was assessed in individuals with and without CSB, focusing on neural regions identified in prior studies of drug-cue reactivity. 19 CSB subjects and 19 healthy volunteers were assessed using functional MRI comparing sexually explicit videos with non-sexual exciting videos. Ratings of sexual desire and liking were obtained. Relative to healthy volunteers, CSB subjects had greater desire but similar liking scores in response to the sexually explicit videos. Exposure to sexually explicit cues in CSB compared to non-CSB subjects was associated with activation of the dorsal anterior cingulate, ventral striatum and amygdala. Functional connectivity of the dorsal anterior cingulate-ventral striatum-amygdala network was associated with subjective sexual desire (but not liking) to a greater degree in CSB relative to non-CSB subjects. The dissociation between desire or wanting and liking is consistent with theories of incentive motivation underlying CSB as in drug addictions. Neural differences in the processing of sexual-cue reactivity were identified in CSB subjects in regions previously implicated in drug-cue reactivity studies. The greater engagement of corticostriatal limbic circuitry in CSB following exposure to sexual cues suggests neural mechanisms underlying CSB and potential biological targets for interventions

RAD50 and NBS1 form a stable complex functional in DNA binding and tethering

The RAD50/MRE11/NBS1 protein complex (RMN) plays an essential role during the early steps of DNA double-strand break (DSB) repair by homologous recombination. Previous data suggest that one important role for RMN in DSB repair is to provide a link between DNA ends. The striking architecture of the complex, a globular domain from which two extended coiled coils protrude, is essential for this function. Due to its DNA-binding activity, ability to form dimers and interact with both RAD50 and NBS1, MRE11 is considered to be crucial for formation and function of RMN. Here, we show the successful expression and purification of a stable complex containing only RAD50 and NBS1 (RN). The characteristic architecture of the complex was not affected by absence of MRE11. Although MRE11 is a DNA-binding protein it was not required for DNA binding per se or DNA-tethering activity of the complex. The stoichiometry of NBS1 in RMN and RN complexes was estimated by SFM-based volume analysis. These data show that in vitro, R, M and N form a variety of stable complexes with variable subunit composition and stoichiometry, which may be physiologically relevant in different aspects of RMN function