How Do You Handle It? An Investigation of Facebook Affordances and Envy

Facebook and other social network sites (SNSs) provide over one billion users with affordances not realized in traditional interpersonal interactions. With a single online post (a comment, a picture, a like, a tag, a status update, etc.), SNS users across the planet can instantly share personal information with their entire network of friends. Some of these posts stimulate feelings of envy on the part of the reader, though the envious feelings (and the reactions to envy) may be different than those felt by individuals who learn of enviable news through traditional ( real world ) interactions. Under certain conditions, envious feelings experienced while visiting a SNS have been shown to be linked to depression and a lower sense of wellbeing. Our research reviews relevant literature on envy and social media affordances and builds a theory which relates the impact of SNS affordances to envious feelings. We present propositions to guide future research efforts that may seek to investigate the direct causes, moderators, and dispositional and situational factors that lead to feelings of SNS envy and its outcomes

A State-of-the-Science Review of Arsenic's Effects on Glucose Homeostasis in Experimental Models.

BackgroundThe prevalence of type 2 diabetes (T2D) has more than doubled since 1980. Poor nutrition, sedentary lifestyle, and obesity are among the primary risk factors. While an estimated 70% of cases are attributed to excess adiposity, there is an increased interest in understanding the contribution of environmental agents to diabetes causation and severity. Arsenic is one of these environmental chemicals, with multiple epidemiology studies supporting its association with T2D. Despite extensive research, the molecular mechanism by which arsenic exerts its diabetogenic effects remains unclear.ObjectivesWe conducted a literature search focused on arsenite exposure in vivo and in vitro, using relevant end points to elucidate potential mechanisms of oral arsenic exposure and diabetes development.MethodsWe explored experimental results for potential mechanisms and elucidated the distinct effects that occur at high vs. low exposure. We also performed network analyses relying on publicly available data, which supported our key findings.ResultsWhile several mechanisms may be involved, our findings support that arsenite has effects on whole-body glucose homeostasis, insulin-stimulated glucose uptake, glucose-stimulated insulin secretion, hepatic glucose metabolism, and both adipose and pancreatic β-cell dysfunction.DiscussionThis review applies state-of-the-science approaches to identify the current knowledge gaps in our understanding of arsenite on diabetes development. https://doi.org/10.1289/EHP4517

Dietary Fat Alters Body Composition, Mammary Development, and Cytochrome P450 Induction after Maternal TCDD Exposure in DBA/2J Mice with Low-Responsive Aryl Hydrocarbon Receptors

BackgroundIncreased fat intake is associated with obesity and may make obese individuals uniquely susceptible to the effects of lipophilic aryl hydrocarbon receptor (AHR) ligands.ObjectivesWe investigated the consequences of high-fat diet (HFD) and AHR ligands on body composition, mammary development, and hepatic P450 expression.MethodsPregnant C57BL/6J (B6) and DBA/2J (D2) dams, respectively expressing high- or low-responsive AHR, were dosed at mid-gestation with TCDD. At parturition, mice were placed on an HFD or a low-fat diet (LFD). Body fat of progeny was measured before dosing with 7,12-dimethylbenz[a]anthracene (DMBA). Fasting blood glucose was measured, and liver and mammary glands were analyzed.ResultsMaternal TCDD exposure resulted in reduced litter size in D2 mice and, on HFD, reduced postpartum survival in B6 mice. In D2 mice, HFD increased body mass and fat in off-spring, induced precocious mammary gland development, and increased AHR expression compared with mice given an LFD. Maternal TCDD exposure increased hepatic Cyp1a1 and Cyp1b1 expression in offspring on both diets, but DMBA depressed Cyp1b1 expression only in mice fed an HFD. In D2 progeny, TCDD exposure decreased mammary terminal end bud size, and DMBA exposure decreased the number of terminal end buds. Only in D2 progeny fed HFD did perinatal TCDD increase blood glucose and the size of mammary fat pads, while decreasing both branch elongation and the number of terminal end buds.ConclusionsWe conclude that despite having a low-responsive AHR, D2 progeny fed a diet similar to that consumed by most people are susceptible to TCDD and DMBA exposure effects blood glucose levels, mammary differentiation, and hepatic Cyp1 expression

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Explorations, Vol. 2, No. 1

Cover: The painting reproduced on the cover is a 22” by 30” acrylic on paper entitled Passage-10, by James Linehan, Assistant Professor of Art at the University of Maine at Orono, where he teaches painting. ©James Linehan, 1985. Articles include: Polyunsaturated Fats: are they killing us? by Linda J. Kling Where are the Dreamers: aspirations of Maine\u27s rural high school students, by Robert A. Cobb, Walter G. McIntire, and Philip A. Pratt Elsewhere in Education: a research sampler \u22Physical Education and Handicapped Children, Stephen A. Butterfield School Climate and Teacher Efficacy, Theodore Coadarci The Principal Principle, Gordon A. Donaldson, Jr. Assessing Leadership, Ronald L. Sparkes Malnutrition in Maine, by Richard A. Cook Hypertension: aging and intellect, by Merrill F. Elias and Michael Robbins From Campus to Public Schools A Ceiling on Shelter, by Peggy K. Schomaker From the Dispatch Case: Control of Cell Growth at the Level of the Genetic Code, by R.D. Blake In the Spring issue of EXPLORATIONS: The sure but silent force in American foreign policy in post World War II Japan—Harry F. Ker

Maternal Dioxin Exposure Combined with a Diet High in Fat Increases Mammary Cancer Incidence in Mice

BackgroundRESULTS from previous studies have suggested that breast cancer risk correlates with total lifetime exposure to estrogens and that early-life 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure or diets high in fat can also increase cancer risk.ObjectivesBecause both TCDD and diet affect the estrogen pathway, we examined how TCDD and a high-fat diet (HFD) interact to alter breast cancer susceptibility.MethodsWe exposed pregnant female FVB/NJ mice (12.5 days postcoitus) to 1 microg/kg TCDD or vehicle; at parturition, the dams were randomly assigned to a low-fat diet (LFD) or a high-fat diet (HFD). Female offspring were maintained on the same diets after weaning and were exposed to 7,12-dimethylbenz[a]anthracene on postnatal days (PNDs) 35, 49, and 63 to initiate mammary tumors. A second cohort of females was treated identically until PND35 or PND49, when mammary gland morphology was examined, or PND50, when mammary gland mRNA was analyzed.ResultsWe found that maternal TCDD exposure doubled mammary tumor incidence only in mice fed the HFD. Among HFD-fed mice, maternal TCDD exposure caused rapid mammary development with increased Cyp1b1 (cytochrome P450 1B1) expression and decreased Comt (catechol-O-methyltransferase) expression in mammary tissue. Maternal TCDD exposure also increased mammary tumor Cyp1b1 expression.ConclusionsOur data suggest that the HFD increases sensitivity to maternal TCDD exposure, resulting in increased breast cancer incidence, by changing metabolism capability. These results provide a mechanism to explain epidemiological data linking early-life TCDD exposure and diets high in fat to increased risk for breast cancer in humans

Attitudes, beliefs and normative influences linked to transactional sex: Insights from LINEA formative research in Brazil, Tanzania and Uganda

This brief provides an overview of research conducted by the Learning Initiative on Norms Exploitation and Abuse (LINEA) on transactional sex from 2014-2017 in Brazil, Tanzania and Uganda. Through in-depth interviews (IDIs) and focus group discussions (FGDs) with adolescent girls and young women (AGYW) aged 14-24, adolescent boys and young men aged 14-24, as well as adult women and men from the same communities, we explored participants’ attitudes, beliefs and normative influences linked to transactional sex. In alignment with LINEA’s aims we gained critical insights into: 1) individuals’ motivations for engaging in transactional sex and their perceptions of the risks and benefits of this practice; 2) community perceptions on the extent to which transactional sex is considered to be exploitative; and 3) normative influences underpinning the behaviou

Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5

Meningiomas are a diverse group of tumors with a broad spectrum of histologic features. There are over 12 variants of meningioma, whose genetic features are just beginning to be described. Angiomatous meningioma is a World Health Organization (WHO) meningioma variant with a predominance of blood vessels. They are uncommon and confirming the histopathologic classification can be challenging. Given a lack of biomarkers that define the angiomatous subtype and limited understanding of the genetic changes underlying its tumorigenesis, we compared the genomic characteristics of angiomatous meningioma to more common meningioma subtypes. While typical grade I meningiomas demonstrate monosomy of chromosome 22 or lack copy number aberrations, 13 of 14 cases of angiomatous meningioma demonstrated a distinct copy number profile – polysomies of at least one chromosome, but often of many, especially in chromosomes 5, 13, and 20. WHO grade II atypical meningiomas with angiomatous features have both polysomies and genetic aberrations characteristic of other atypical meningiomas. Sequencing of over 560 cancer-relevant genes in 16 cases of angiomatous meningioma showed that these tumors lack common mutations found in other variants of meningioma. Our study demonstrates that angiomatous meningiomas have distinct genomic features that may be clinically useful for their diagnosis

The Influence of Secondhand Smoke Exposure on Birth Outcomes in Jordan

This study investigates how secondhand smoke (SHS) exposure influences neonatal birth weight in Jordan, a country with high smoking prevalence. The findings revealed that as the average number of SHS exposure hours per week increased in the second trimester, the neonatal birth weight decreased while holding all covariates constant. Women who reported a higher average number of SHS exposure hours per week from work in the second trimester, home in the third trimester, and outside in the third trimester were at greater risk for having a low birth weight neonate than women who reported a lower average number of SHS exposure hours