Eficacia del programa “Mis historias bíblicas” para reducir las conductas agresivas en los niños y niñas de 5 años de la Institución Educativa Inicial N° 611 San Julián, Juliaca – 2018

El objetivo de la presente investigación fue determinar la eficacia del programa “Mis historias bíblicas” en la reducción de las conductas agresivas en los niños y niñas de 5 años de la Institución Educativa Inicial N ° 611 San Julián, Juliaca – 2018. Este estudio corresponde al tipo experimental de diseño de investigación pre- experimental; con un solo grupo, pre-test (prueba de entrada) y post-test (prueba de salida). Para la recolección de datos se utilizó la ficha de observación que contiene 3 dimensiones y 11 ítems, diseñado por Torres y Vargas (2017). La población de este estudio consta de 108 niños y niñas; como muestra se tomó en cuenta a 10 niños y 11 niñas de 5 años. El tratamiento estadístico se realizó con el programa Stadistical Package of Social Science (SPSS) 23 que nos permitió determinar la eficacia del programa “Mis historias bíblicas”; con los resultados obtenidos. Por la prueba de rangos con el signo de Wilcoxon nos revelaron que la aplicación del programa “Mis Historias bíblicas” es eficaz en la reducción de las conductas agresivas en los niños y niñas de 5 años siendo el Valor Z = -4,021 y p = 0,000 < 0,05); asimismo en cada una de las dimensiones analizadas: Agresividad verbal (valor Z -4,041 y p = 0,000); Agresividad física (valor Z -3,42 y p = 0,001) y la agresividad material (valor Z -2,963 y p = 0,003).TesisJULIACAEscuela Profesional de EducaciónTeorías, métodos, organización y planificación de la educació

Caractériser la notion de médiation en didactique des langues à l’ère du numérique : apports d’une réflexion plurielle en ingénierie(s)

L’objectif de cet article est de nourrir la réflexion sur la notion de médiation à l’ère du numérique en procédant à une triangulation d’apports issus de l’ingénierie pédagogique, de l’ingénierie de la formation et de l’ingénierie de la recherche. Il sera fait appel à des exemples issus d’un projet franco-allemand de formation de formateurs de français langue étrangère (FLE) mis en place durant l’année universitaire 2014-2015 entre les Universités de Siegen et de la Sorbonne Nouvelle et prenant la forme d’un dispositif hybride. De manière plus précise, pour rendre compte de la dimension « ingénierie de la recherche » de la notion de médiation, un état de l’art visant à identifier comment la littérature récente du domaine de la didactique des langues et des cultures et des sciences de l’éducation perçoit cette notion sera dans un premier temps dressé. La dimension « ingénierie pédagogique » de la notion de médiation sera ensuite explorée à l’aune d’une évaluation (démarche qualité) dudit dispositif de formation initiale. Dans un troisième temps, nous tâcherons de rendre compte de la dimension « ingénierie de la formation » de la notion de médiation en analysant les représentations projetées par des futur-e-s professionnel-le-s de l’enseignement du FLE quant à cette même notion. Nous terminerons cet article par une ébauche de modélisation visant à rendre compte de la manière dont ces trois niveaux d’ingénierie s’articulent, au vu des analyses proposées dans cet article.In this paper, we propose a threefold reflection on the notion of mediation in the digital age. To do so, we first present a state-of-the-art review of the notion to explore how the recent literature of the field (applied linguistics and educational sciences) perceives this notion. Then, the notion of mediation is studied from an instructional design viewpoint. To do so, particular emphasis is given to a Franco-German blended learning course dedicated to pre service language teachers (n = 54). Eventually, those pre service language teachers’ beliefs about the concept of mediation are analyzed. Cross-references and comparison of the data led to a first version of a model whose aim is to stimulate reflection on the notion of mediation in the digital era

Metaproteomic evidence of changes in protein expression following a change in electrode potential in a robust biocathode microbiome

Microorganisms that respire electrodes may be exploited for biotechnology applications if key pathways for extracellular electron transfer (EET) can be identified and manipulated through bioengineering. To determine whether expression of proposed Biocathode-MCL EET proteins are changed by modulating electrode potential without disrupting the relative distribution of microbial constituents, metaproteomic and 16S rRNA gene expression analyses were performed after switching from an optimal to suboptimal potential based on an expected decrease in electrode respiration. Five hundred and seventy-nine unique proteins were identified across both potentials, the majority of which were assigned to three previously defined Biocathode-MCL metagenomic clusters: a Marinobacter sp., a member of the family Chromatiaceae, and a Labrenzia sp. Statistical analysis of spectral counts using the Fisher's exact test identified 16 proteins associated with the optimal potential, five of which are predicted electron transfer proteins. The majority of proteins associated with the suboptimal potential were involved in protein turnover/turnover, motility, and membrane transport. Unipept and 16S rRNA gene expression analyses indicated that the taxonomic profile of the microbiome did not change after 52 hours at the suboptimal potential. These findings show that protein expression is sensitive to the electrode potential without inducing shifts in community composition, a feature that may be exploited for engineering Biocathode-MCL

Au@Nb@HₓK₁₋ₓNbO₃ nanopeapods with near-infrared active plasmonic hot-electron injection for water splitting

Full-spectrum utilization of diffusive solar energy by a photocatalyst for environmental remediation and fuel generation has long been pursued. In contrast to tremendous efforts in the UV-to-VIS light regime of the solar spectrum, the NIR and IR areas have been barely addressed although they represent about 50% of the solar flux. Here we put forward a biomimetic photocatalyst blueprint that emulates the growth pattern of a natural plant—a peapod—to address this issue. This design is exemplified via unidirectionally seeding core-shell Au@Nb nanoparticles in the cavity of semiconducting H x K1−xNbO3 nanoscrolls. The biomimicry of this nanopeapod (NPP) configuration promotes near-field plasmon–plasmon coupling between bimetallic Au@Nb nanoantennas (the peas), endowing the UV-active H x K1−xNbO3 semiconductor (the pods) with strong VIS and NIR light harvesting abilities. Moreover, the characteristic 3D metal-semiconductor junction of the Au@Nb@H x K1−xNbO3 NPPs favors the transfer of plasmonic hot carriers to trigger dye photodegradation and water photoelectrolysis as proofs-of-concept. Such broadband solar spectral response renders the Au@Nb@H x K1−xNbO3 NPPs highly promising for widespread photoactive devices

Review on Pediatric Malignant Focal Liver Lesions with Imaging Evaluation: Part II

Malignant focal liver lesions (FLLs) represent various kinds of epithelial and mesenchymal tumors. In pediatric patients, the understanding of pediatric liver diseases and associated imaging manifestations is essential for making accurate diagnosis and differential diagnosis. This paper will discuss the latest knowledge of the common pediatric malignant FLLs, including undifferentiated embryonal sarcoma, rhabdomyosarcoma, epithelioid hemangioendothelioma, angiosarcoma, and malignant rhabdoid tumor. Medical imaging features are not only helpful for clinical diagnosis, but can also be useful in the evaluation and follow-up of pre- and post-treatment. The future perspectives of contrast-enhanced ultrasound (CEUS) enhancement patterns of FLLs in pediatric patients are also mentioned

Review on Pediatric Malignant Focal Liver Lesions with Imaging Evaluation: Part I

Malignant focal liver lesions (FLLs) are commonly reported in adults but rarely seen in the pediatric population. Due to the rarity, the understanding of these diseases is still very limited. In children, most malignant FLLs are congenital. It is very important to choose appropriate imaging examination concerning various factors. This paper will outline common pediatric malignant FLLs, including hepatoblastoma, hepatocellular carcinoma, and cholangiocarcinoma and discuss them against the background of the latest knowledge on comparable/similar tumors in adults. Medical imaging features are of vital importance for the non-invasive diagnosis and follow-up of treatment of FLLs in pediatric patients. The use of CEUS in pediatric patients for characterizing those FLLs that remain indeterminate on conventional B mode ultrasounds may be an effective option in the future and has great potential to be integrated into imaging algorithms without the risk of exposure to ionizing radiation

A Previously Uncharacterized, Nonphotosynthetic Member of the Chromatiaceae Is the Primary CO_2-Fixing Constituent in a Self-Regenerating Biocathode

Biocathode extracellular electron transfer (EET) may be exploited for biotechnology applications, including microbially mediated O_2 reduction in microbial fuel cells and microbial electrosynthesis. However, biocathode mechanistic studies needed to improve or engineer functionality have been limited to a few select species that form sparse, homogeneous biofilms characterized by little or no growth. Attempts to cultivate isolates from biocathode environmental enrichments often fail due to a lack of some advantage provided by life in a consortium, highlighting the need to study and understand biocathode consortia in situ. Here, we present metagenomic and metaproteomic characterization of a previously described biocathode biofilm (+310 mV versus a standard hydrogen electrode [SHE]) enriched from seawater, reducing O_2, and presumably fixing CO_2 for biomass generation. Metagenomics identified 16 distinct cluster genomes, 15 of which could be assigned at the family or genus level and whose abundance was roughly divided between Alpha- and Gammaproteobacteria. A total of 644 proteins were identified from shotgun metaproteomics and have been deposited in the the ProteomeXchange with identifier PXD001045. Cluster genomes were used to assign the taxonomic identities of 599 proteins, with Marinobacter, Chromatiaceae, and Labrenzia the most represented. RubisCO and phosphoribulokinase, along with 9 other Calvin-Benson-Bassham cycle proteins, were identified from Chromatiaceae. In addition, proteins similar to those predicted for iron oxidation pathways of known iron-oxidizing bacteria were observed for Chromatiaceae. These findings represent the first description of putative EET and CO_2 fixation mechanisms for a self-regenerating, self-sustaining multispecies biocathode, providing potential targets for functional engineering, as well as new insights into biocathode EET pathways using proteomics

Integrating solutions to adapt cities for climate change

Record climate extremes are reducing urban liveability, compounding inequality, and threatening infrastructure. Adaptation measures that integrate technological, nature-based, and social solutions can provide multiple co-benefits to address complex socioecological issues in cities while increasing resilience to potential impacts. However, there remain many challenges to developing and implementing integrated solutions. In this Viewpoint, we consider the value of integrating across the three solution sets, the challenges and potential enablers for integrating solution sets, and present examples of challenges and adopted solutions in three cities with different urban contexts and climates (Freiburg, Germany; Durban, South Africa; and Singapore). We conclude with a discussion of research directions and provide a road map to identify the actions that enable successful implementation of integrated climate solutions. We highlight the need for more systematic research that targets enabling environments for integration; achieving integrated solutions in different contexts to avoid maladaptation; simultaneously improving liveability, sustainability, and equality; and replicating via transfer and scale-up of local solutions. Cities in systematically disadvantaged countries (sometimes referred to as the Global South) are central to future urban development and must be prioritised. Helping decision makers and communities understand the potential opportunities associated with integrated solutions for climate change will encourage urgent and deliberate strides towards adapting cities to the dynamic climate reality.Peer reviewe

Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human

Regulatory T-cells (Treg) play an essential role in the negative regulation of immune answers by developing an attenuated cytokine response that allows suppressing proliferation and effector function of T-cells (CD4+ Th). The transcription factor FoxP3 is responsible for the regulation of many genes involved in the Treg gene signature. Its ablation leads to severe immune deficiencies in human and mice. Recent developments in sequencing technologies have revolutionized the possibilities to gain insights into transcription factor binding by ChiP-seq and into transcriptome analysis by mRNA-seq. We combine FoxP3 ChiP-seq and mRNA-seq in order to understand the transcriptional differences between primary human CD4+ T helper and regulatory T-cells, as well as to study the role of FoxP3 in generating those differences. We show, that mRNA-seq allows analyzing the transcriptomal landscape of T-cells including the expression of specific splice variants at much greater depth than previous approaches, whereas 50% of transcriptional regulation events have not been described before by using diverse array technologies. We discovered splicing patterns like the expression of a kinase-dead isoform of IRAK1 upon T-cell activation. The immunoproteasome is up-regulated in both Treg and CD4+ Th cells upon activation, whereas the ‘standard’ proteasome is up-regulated in Tregs only upon activation

Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human

Regulatory T-cells (Treg) play an essential role in the negative regulation of immune answers by developing an attenuated cytokine response that allows suppressing proliferation and effector function of T-cells (CD4+ Th). The transcription factor FoxP3 is responsible for the regulation of many genes involved in the Treg gene signature. Its ablation leads to severe immune deficiencies in human and mice. Recent developments in sequencing technologies have revolutionized the possibilities to gain insights into transcription factor binding by ChiP-seq and into transcriptome analysis by mRNA-seq. We combine FoxP3 ChiP-seq and mRNA-seq in order to understand the transcriptional differences between primary human CD4+ T helper and regulatory T-cells, as well as to study the role of FoxP3 in generating those differences. We show, that mRNA-seq allows analyzing the transcriptomal landscape of T-cells including the expression of specific splice variants at much greater depth than previous approaches, whereas 50% of transcriptional regulation events have not been described before by using diverse array technologies. We discovered splicing patterns like the expression of a kinase-dead isoform of IRAK1 upon T-cell activation. The immunoproteasome is up-regulated in both Treg and CD4+ Th cells upon activation, whereas the ‘standard’ proteasome is up-regulated in Tregs only upon activation