Effect of Socio-Demographics, Health-Related Problems, and Family Structure on Chronic Absenteeism Among Children

Purpose/Background: From 5 to 7.5 million school children are chronically absent, defined as missing ≥15 days of school within a year. Students miss schools due to various reasons such as health, socioeconomic status, and environmental factors. We examined child’s health and behavior, family structure, and socio-demographics to understand chronic absenteeism. Materials & Methods: The population included children ages 6 to 17 years from the Medical Expenditure Panel Survey (MEPS) years 2008-2013. Multivariable logistic regressions were used to identify the risk factors of chronic absenteeism, adjusting for the complex sampling design. Results: Among socio-demographic variables, age ≥14 years, race/ethnicity, lower-income family, public health insurance, US-born, and speaking English at home were associated with chronic absenteeism. Asians, Mexican Hispanics, and blacks have lower chronic absenteeism than whites. Among health-related variables, children using an inhaler for asthma, having behavioral problems, and less healthy than other children were more likely to be chronically absent. Among family variables, a smaller family size was a risk factor for chronic absenteeism. Discussion/Conclusion: Asthma and behavioral problems were highly associated with chronic absenteeism. The identification of children at risk for chronic absenteeism will help the educational professionals identify the barriers to academic achievements and develop integrated educational interventions and policies to support disadvantaged children

Japans Energy Policy under Abe: Liberalization of the Energy Market and Nuclear U-turn

The purpose of this paper is to analyze the direction and background of energy policy under the Abe administration, which has achieved a long-term hold on power by prioritizing reconstruction of the Japanese economy. Japan encountered an opportunity to conduct a major shift in energy policy through the Fukushima nuclear accident that occurred following the 2011 Great East Japan Earthquake. However, the Democratic Party of Japan, then the ruling party, failed politically, allowing Abe and the Liberal Democratic Party to regain power, and Japans energy policy has since been characterized by liberalization of the energy market and a return to pre-Fukushima nuclear policy. It may be difficult to understand why the Abe administration decided on such a nuclear U-turn. It can be concluded that this reflects concerns regarding damage to energy and environmental security, political pressure from nuclear host communities, and international apprehension over Japans accumulating stockpile of plutonium. Liberalization of the energy market is leading to fierce competition among large corporations, and the Japanese energy market is expected to become more dependent on gas and nuclear power for the time being. The paper concludes by discussing the implications of these developments for South Korea, which is aiming for energy policy transition under Moon Jae-ins leadership

Healthcare Database and Research at Biostatistics Core Facility of John A. Burns School of Medicine

The Department of Quantitative Health Science at John A. Burns School of Medicine operates a Biostatistics Core Facility, which employs extensive healthcare databases to advance health-related research and enhance our understanding of healthcare. The Core Facility is dedicated to offering biostatistical research assistance to basic science, clinical, and translational researchers. Its expertise lies in the areas of study design, data management and analysis, grant proposal development, methodology research, and education in biostatistics and related fields

Three Initiatives for Community-Based Art Education Practices

Copyright holder is the National Art Education Association. All rights reserved.According to Lawton (2010), art educators should be concerned with teaching their students to make critical connections between the classroom and the outside world. one effective way to make these critical connections is to provide students with the opportunity to engage in community-based art endeavors (Bolin, 2000; Gude, 2007). In this article, three university art educators discuss engaging preservice art teachers in community arts events. The first author reviews a collaborative mural project as a meaning-making process that fostered a constructive partnership between the university and the local public school and promoted preservice art teachers’ positive attitudes toward community service-learning art projects. The second author examines the Pecan Festival as a community service-learning activity for preservice art teachers. She emphasizes the importance of studying the local community and environment while connecting the art education course curriculum to a community art event. The third author reflects on the significant benefits preservice art teachers achieved through community involvement and outreach with the Youth Art Festival

Knowledge and Attitudes of Guam Residents Towards Cancer Clinical Trial Participation

Purpose/Background: Currently there are no cancer clinical trials conducted in Guam, but interest is growing. Limited information exists on the knowledge and attitudes of Guam’s population towards cancer clinical research, yet cancer is the second highest cause of death in Guam and among the CHamoru people, Guam’s indigenous population. CHamoru people suffer the highest rates of cancer mortality compared to other ethnic groups in Guam. The purpose of this study was to determine differences in knowledge and attitudes towards cancer clinical trials participation, and attitudes towards traditional medicine. Materials & Methods: A telephone survey instrument was designed, pilot-tested, IRB-approved, and implemented using a third-party marketing company. Questions were adapted from existing surveys and new questions were developed to address unique, Guam-specific interests. Recruited subjects were Guam residents adults 18 years of age and older with telephone service. Guam residents were called from October 6 to 10, 2018 to assess levels of knowledge and attitudes towards cancer clinical trials and the attitudes towards using traditional medicine to treat cancer. Descriptive statistics were computed for demographic variables by response category. Univariate logistic regression was conducted to investigate the bivariate association between a survey question and demographic variables. Odds ratios (ORs) and associated 95% confidence intervals (CIs) were calculated. Multivariable logistic regression model was developed for each question, adjusting for important covariates. Hosmer-Lemeshow tests and c-statistics were used to evaluate goodness of fit. Results: The survey respondents’ (n=152) demographic data closely reflected the US Census ethnicity data for Guam: CHamoru (47.0%), Filipino (26.5%), Caucasian (11.3%) and Other (15.2%). Fifty-three percent understood the term “clinical trial”; 73.7% would be willing to participate if they had cancer, and 59.9% believed they would receive good quality treatment from a clinical trial offered in Guam. Approximately 56.0% thought they would have to pay out-of-pocket expenses; and 67.0% disagreed or were not sure that clinical trial sponsors pay for the study drug while other costs are billed to the insurance company. Physician ethnicity was not important to 100% of Caucasians, but was important to at least 30.0% of non-Caucasians; family support was very important to 94.7% of respondents, while religious community support was important to 55.4%. Approximately 65.1% did not believe that people participating in clinical trials were treated like ‘guinea pigs’. Having college education (OR = 3.26; 95% CI: 1.53 – 6.98) and knowing English language well (OR=5.86; 95% CI: 1.21 – 28.38) were significantly associated with higher aggregated knowledge about clinical trials. Although the majority (67.2%) would seek traditional healing practices if diagnosed with cancer, most (84.9%) did not think a suruhano (CHamoru traditional healer) could treat cancer, and 94.7% did not believe cancer was caused by taotaomo’na (ancient spirits). Discussion/Conclusion: Knowledge and attitudes towards cancer clinical trials and the use of traditional medicine to treat cancer were significantly associated with key demographic variables including ethnicity, income, employment status, place of birth and insurance type. Knowledge about cancer clinical trials was as expected: more participants who are Caucasian, have a higher level of education, were born in U.S., are employed, have a higher income, private insurance, self-report that they speak English well, and do not follow religion, were more aware of what a clinical trial is than the other respondents. Though knowledge about cancer clinical trials is limited, attitudes towards participation in cancer clinical trials offered in Guam were largely positive

Exposure to Secondhand Smoke and the Development of Childhood Caries: NHANES (2011-2012)

Dental caries continue to plague young children worldwide with numerous adverse effects including pain, poor growth and development, decreased quality of life as well as the potential for the development of life threatening secondary infections. Factors associated with the development of childhood caries are complex as they relate to social, economic and/or cultural behaviors. Recent evidence has linked secondhand smoke to the development of childhood dental caries. The purpose of the study is to re-examine the association between the frequency and extent of exposure to secondhand smoke with the development of childhood caries in the United States. Cross-sectional data of 1,511 children age 4 to 11 years from the U.S. National Health and Nutrition Examination Survey (NHANES) (2011-2012) were analyzed. Results indicate that children living in a home where one or more cigarettes were smoked inside per day were 1.59 times more likely to have caries compared to those who were not exposed to smoke inside the home (95% CI=1.02-2.47, p=0.041). Those children without insurance were also at highest risk for dental caries. However those with Medicare/Medicaid, despite having government mandated dental coverage, were also significantly affected and 1.67 times more likely to have dental caries compared to those with private insurance (95% CI=1.08-2.58, p=0.021). Creative approaches to improving health outcomes of families should include education about the adverse effects of ETS exposure, providing families with low or no cost community smoking cessation programs and reducing barriers to accessing preventive dental services for both children and their families

Structure-function relationships of wheat flavone O-methyltransferase: Homology modeling and site-directed mutagenesis

<p>Abstract</p> <p>Background</p> <p>Wheat (<it>Triticum aestivum </it>L.) <it>O</it>-methyltransferase (TaOMT2) catalyzes the sequential methylation of the flavone, tricetin, to its 3'-methyl- (selgin), 3',5'-dimethyl- (tricin) and 3',4',5'-trimethyl ether derivatives. Tricin, a potential multifunctional nutraceutical, is the major enzyme reaction product. These successive methylations raised the question as to whether they take place in one, or different active sites. We constructed a 3-D model of this protein using the crystal structure of the highly homologous <it>Medicago sativa </it>caffeic acid/5-hydroxyferulic acid <it>O</it>-methyltransferase (MsCOMT) as a template with the aim of proposing a mechanism for multiple methyl transfer reactions in wheat.</p> <p>Results</p> <p>This model revealed unique structural features of TaOMT2 which permit the stepwise methylation of tricetin. Substrate binding is mediated by an extensive network of H-bonds and van der Waals interactions. Mutational analysis of structurally guided active site residues identified those involved in binding and catalysis. The partly buried tricetin active site, as well as proximity and orientation effects ensured sequential methylation of the substrate within the same pocket. Stepwise methylation of tricetin involves deprotonation of its hydroxyl groups by a His262-Asp263 pair followed by nucleophilic attack of SAM-methyl groups. We also demonstrate that Val309, which is conserved in a number of graminaceous flavone OMTs, defines the preference of TaOMT2 for tricetin as the substrate.</p> <p>Conclusions</p> <p>We propose a mechanism for the sequential methylation of tricetin, and discuss the potential application of TaOMT2 to increase the production of tricin as a nutraceutical. The single amino acid residue in TaOMT2, Val309, determines its preference for tricetin as the substrate, and may define the evolutionary differences between the two closely related proteins, COMT and flavone OMT.</p

Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo

Nutrient deprivation strategies have been proposed as an adjuvant therapy for cancer cells due to their increased metabolic demand. We examined the specific inhibitory effects of amino acid deprivation on the metastatic phenotypes of the human triple-negative breast cancer (TNBC) cell lines MDA-MB-231 and Hs 578T, as well as the orthotopic 4T1 mouse TNBC tumor model. Among the 10 essential amino acids tested, methionine deprivation elicited the strongest inhibitory effects on the migration and invasion of these cancer cells. Methionine deprivation reduced the phosphorylation of focal adhesion kinase, as well as the activity and mRNA expression of matrix metalloproteinases MMP-2 and MMP-9, two major markers of metastasis, while increasing the mRNA expression of tissue inhibitor of metalloproteinase 1 in MDA-MB-231 cells. Furthermore, methionine restriction downregulated the metastasis-related factor urokinase plasminogen activatior and upregulated plasminogen activator inhibitor 1 mRNA expression. Animals on the methionine-deprived diet showed lower lung metastasis rates compared to mice on the control diet. Taken together, these results suggest that methionine restriction could provide a potential nutritional strategy for more effective cancer therapy

Design of a dye-doped liquid crystal cell with a constant transmittance-difference contour map

Thus far, the trial-and-error method has been used to find the condition for a dye-doped liquid crystal cell with desired performances. In this paper, we report a systematic design process to find the condition for the desired performances without trial-and-error process