De novo 2.3 Mb microdeletion of 1q32.2 involving the Van der Woude Syndrome locus

10.1186/1755-8166-6-31Molecular Cytogenetics61

Self-consistent simulation of high-brightness diode lasers with external optical feedback

This paper presents a model for simulating the impact of external optical feedback on large-optical cavity high-brightness diode lasers. The simulations are performed with our 2.5D simulation tool for high-brightness laser diodes. The external cavity is modelled using commercial coherent ray tracing software. We consider the impact of the optical feedback on the excitation of amplified spontaneous emission in the parasitic vertical modes

Design and simulation of high-speed nanophotonic electro-optic modulators

In this work, an ultracompact electro-optic modulator based on refractive index modulation by plasma dispersion effect in PhC all-optical gate (AOG) is proposed. The index modulation is achieved by applying a time-varying bias voltage across the electrical contacts of the AOG. The proposed modulator has potential for high-speed operation, with bandwidths in excess of 30GHz achievable

Superconductivity in graphene stacks: from the bilayer to graphite

We study the superconducting phase transition, both in a graphene bilayer and in graphite. For that purpose we derive the mean-field effective potential for a stack of graphene layers presenting hopping between adjacent sheets. For describing superconductivity, we assume there is an on-site attractive interaction between electrons and determine the superconducting critical temperature as a function of the chemical potential. This displays a dome-shaped curve, in agreement with previous results for two-dimensional Dirac fermions. We show that the hopping between adjacent layers increases the critical temperature for small values of the chemical potential. Finally, we consider a minimal model for graphite and show that the transition temperature is higher than that for the graphene bilayer for small values of chemical potential. This might explain why intrinsic superconductivity is observed in graphite

Adiabatic following criterion, estimation of the nonadiabatic excitation fraction and quantum jumps

An accurate theory describing adiabatic following of the dark, nonabsorbing state in the three-level system is developed. An analytical solution for the wave function of the particle experiencing Raman excitation is found as an expansion in terms of the time varying nonadiabatic perturbation parameter. The solution can be presented as a sum of adiabatic and nonadiabatic parts. Both are estimated quantitatively. It is shown that the limiting value to which the amplitude of the nonadiabatic part tends is equal to the Fourier component of the nonadiabatic perturbation parameter taken at the Rabi frequency of the Raman excitation. The time scale of the variation of both parts is found. While the adiabatic part of the solution varies slowly and follows the change of the nonadiabatic perturbation parameter, the nonadiabatic part appears almost instantly, revealing a jumpwise transition between the dark and bright states. This jump happens when the nonadiabatic perturbation parameter takes its maximum value.Comment: 33 pages, 8 figures, submitted to PRA on 28 Oct. 200

Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity

Most computational methods that infer somatic copy number alterations (SCNAs) from bulk sequencing of DNA analyse tumour samples individually. However, the sequencing of multiple tumour samples from a patient's disease is an increasingly common practice. We introduce Refphase, an algorithm that leverages this multi-sampling approach to infer haplotype-specific copy numbers through multi-sample phasing. We demonstrate Refphase's ability to infer haplotype-specific SCNAs and characterise their intra-tumour heterogeneity, to uncover previously undetected allelic imbalance in low purity samples, and to identify parallel evolution in the context of whole genome doubling in a pan-cancer cohort of 336 samples from 99 tumours

Thermal Casimir effect in ideal metal rectangular boxes

The thermal Casimir effect in ideal metal rectangular boxes is considered using the method of zeta functional regularization. The renormalization procedure is suggested which provides the finite expression for the Casimir free energy in any restricted quantization volume. This expression satisfies the classical limit at high temperature and leads to zero thermal Casimir force for systems with infinite characteristic dimensions. In the case of two parallel ideal metal planes the results, as derived previously using thermal quantum field theory in Matsubara formulation and other methods, are reproduced starting from the obtained expression. It is shown that for rectangular boxes the temperature-dependent contribution to the electromagnetic Casimir force can be both positive and negative depending on side lengths. The numerical computations of the scalar and electromagnetic Casimir free energy and force are performed for cubesComment: 10 pages, 4 figures, to appear in Europ. Phys. J.

ECOSTRESS: NASA's next generation mission to measure evapotranspiration from the International Space Station

The ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station ECOSTRESS) was launched to the International Space Station on June 29, 2018. The primary science focus of ECOSTRESS is centered on evapotranspiration (ET), which is produced as level‐3 (L3) latent heat flux (LE) data products. These data are generated from the level‐2 land surface temperature and emissivity product (L2_LSTE), in conjunction with ancillary surface and atmospheric data. Here, we provide the first validation (Stage 1, preliminary) of the global ECOSTRESS clear‐sky ET product (L3_ET_PT‐JPL, version 6.0) against LE measurements at 82 eddy covariance sites around the world. Overall, the ECOSTRESS ET product performs well against the site measurements (clear‐sky instantaneous/time of overpass: r2 = 0.88; overall bias = 8%; normalized RMSE = 6%). ET uncertainty was generally consistent across climate zones, biome types, and times of day (ECOSTRESS samples the diurnal cycle), though temperate sites are over‐represented. The 70 m high spatial resolution of ECOSTRESS improved correlations by 85%, and RMSE by 62%, relative to 1 km pixels. This paper serves as a reference for the ECOSTRESS L3 ET accuracy and Stage 1 validation status for subsequent science that follows using these data