260 research outputs found
Interaction induced mergence of Dirac points in Non-Abelian optical lattices
We study the properties of an ultracold Fermi gas loaded in a square optical
lattice and subjected to an external and classical non-Abelian gauge field. We
calculate the energy spectrum of the system and show that the Dirac points in
the energy spectrum will remain quite stable under onsite interaction of
certain strength. Once the on-site interaction grows stronger than a critical
value, the Dirac points will no longer be stable and merge into a single hybrid
point. This mergence implies a quantum phase transition from a semimetallic
phase to a band insulator. The on-site interaction between ultracold fermions
could be conveniently controlled by Feshbach resonances in current experiments.
We proposed that this remarkable interaction induced mergence of Dirac points
may be observed in the ultracold fermi gas experiments
Large Scale Structures a Gradient Lines: the case of the Trkal Flow
A specific asymptotic expansion at large Reynolds numbers (R)for the long
wavelength perturbation of a non stationary anisotropic helical solution of the
force less Navier-Stokes equations (Trkal solutions) is effectively constructed
of the Beltrami type terms through multi scaling analysis. The asymptotic
procedure is proved to be valid for one specific value of the scaling
parameter,namely for the square root of the Reynolds number (R).As a result
large scale structures arise as gradient lines of the energy determined by the
initial conditions for two anisotropic Beltrami flows of the same helicity.The
same intitial conditions determine the boundaries of the vortex-velocity tubes,
containing both streamlines and vortex linesComment: 27 pages, 2 figure
Penetration of particles through multi-barrier systems
The paper gives a theoretical justification for the effect of increasing permeability of ultra-thin membranes by altering their internal material structure, namely through the process of creating one or two energy voids within the permeable layer. An effective computing technology for solving the stationary Schrödinger equation is also described
Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations.
Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their mechanisms are poorly understood. Here, 19F NMR is used to delineate the effects of cations on functional states of the adenosine A2A GPCR. While Na+ reinforces an inactive ensemble and a partial-agonist stabilized state, Ca2+ and Mg2+ shift the equilibrium toward active states. Positive allosteric effects of divalent cations are more pronounced with agonist and a G-protein-derived peptide. In cell membranes, divalent cations enhance both the affinity and fraction of the high affinity agonist-bound state. Molecular dynamics simulations suggest high concentrations of divalent cations bridge specific extracellular acidic residues, bringing TM5 and TM6 together at the extracellular surface and allosterically driving open the G-protein-binding cleft as shown by rigidity-transmission allostery theory. An understanding of cation allostery should enable the design of allosteric agents and enhance our understanding of GPCR regulation in the cellular milieu
Numerical simulation of oil pool boundary evolution
The study of spatial distribution of hydrocarbon resources and forecasting their geographical location is of great importance for the most complete recovery of hydrocarbons from deposits. The present study gives new mathematical results in the theory of stratified fluid flow in a porous medium. This paper analyzes the evolution of oil pool boundary basing on vortex numerical model for movement of the boundary separating fluids of different densities. It presents the investigation of how the location of light fluid regarding the heavier fluid influences on the changes in the boundary between two media in case of various shifting of the well
Direct mass measurements of 19B, 22C, 29F, 31Ne, 34Na and other light exotic nuclei
We report on direct time-of-flight based mass measurements of 16 light
neutron-rich nuclei. These include the first determination of the masses of the
Borromean drip-line nuclei B, C and F as well as that of
Na. In addition, the most precise determinations to date for N
and Ne are reported. Coupled with recent interaction cross-section
measurements, the present results support the occurrence of a two-neutron halo
in C, with a dominant configuration, and a
single-neutron halo in Ne with the valence neutron occupying
predominantly the 2 orbital. Despite a very low two-neutron separation
energy the development of a halo in B is hindered by the 1
character of the valence neutrons.Comment: 5 page
Quantifying how post-transcriptional noise and gene copy number variation bias transcriptional parameter inference from mRNA distributions
Transcriptional rates are often estimated by fitting the distribution of mature mRNA numbers measured using smFISH (single molecule fluorescence in situ hybridization) with the distribution predicted by the telegraph model of gene expression, which defines two promoter states of activity and inactivity. However, fluctuations in mature mRNA numbers are strongly affected by processes downstream of transcription. In addition, the telegraph model assumes one gene copy but in experiments, cells may have two gene copies as cells replicate their genome during the cell cycle. While it is often presumed that post-transcriptional noise and gene copy number variation affect transcriptional parameter estimation, the size of the error introduced remains unclear. To address this issue, here we measure both mature and nascent mRNA distributions of GAL10 in yeast cells using smFISH and classify each cell according to its cell cycle phase. We infer transcriptional parameters from mature and nascent mRNA distributions, with and without accounting for cell cycle phase and compare the results to live-cell transcription measurements of the same gene. We find that: (i) correcting for cell cycle dynamics decreases the promoter switching rates and the initiation rate, and increases the fraction of time spent in the active state, as well as the burst size; (ii) additional correction for post-transcriptional noise leads to further increases in the burst size and to a large reduction in the errors in parameter estimation. Furthermore, we outline how to correctly adjust for measurement noise in smFISH due to uncertainty in transcription site localisation when introns cannot be labelled. Simulations with parameters estimated from nascent smFISH data, which is corrected for cell cycle phases and measurement noise, leads to autocorrelation functions that agree with those obtained from live-cell imaging
Focal Plane Detector System of SHARAQ Spectrometer
International audienceThis report describes the basic performance of the detector system installed in the final momentum-dispersive focal plane of the SHARAQ spectrometer
Bayesian Best-Arm Identification for Selecting Influenza Mitigation Strategies
Pandemic influenza has the epidemic potential to kill millions of people.
While various preventive measures exist (i.a., vaccination and school
closures), deciding on strategies that lead to their most effective and
efficient use remains challenging. To this end, individual-based
epidemiological models are essential to assist decision makers in determining
the best strategy to curb epidemic spread. However, individual-based models are
computationally intensive and it is therefore pivotal to identify the optimal
strategy using a minimal amount of model evaluations. Additionally, as
epidemiological modeling experiments need to be planned, a computational budget
needs to be specified a priori. Consequently, we present a new sampling
technique to optimize the evaluation of preventive strategies using fixed
budget best-arm identification algorithms. We use epidemiological modeling
theory to derive knowledge about the reward distribution which we exploit using
Bayesian best-arm identification algorithms (i.e., Top-two Thompson sampling
and BayesGap). We evaluate these algorithms in a realistic experimental setting
and demonstrate that it is possible to identify the optimal strategy using only
a limited number of model evaluations, i.e., 2-to-3 times faster compared to
the uniform sampling method, the predominant technique used for epidemiological
decision making in the literature. Finally, we contribute and evaluate a
statistic for Top-two Thompson sampling to inform the decision makers about the
confidence of an arm recommendation
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