The infection of primary avian tracheal epithelial cells with infectious bronchitis virus

Here we introduce a culture system for the isolation, passaging and amplification of avian tracheal epithelial (ATE) cells. The ATE medium, which contains chicken embryo extract and fetal bovine serum, supports the growth of ciliated cells, goblet cells and basal cells from chicken tracheas on fibronectin- or matrigel-coated dishes. Non-epithelial cells make up less than 10% of the total population. We further show that ATE cells support the replication and spread of infectious bronchitis virus (IBV). Interestingly, immunocytostaining revealed that basal cells are resistant to IBV infection. We also demonstrate that glycosaminoglycan had no effect on infection of the cells by IBV. Taken together, these findings suggest that primary ATE cells provide a novel cell culture system for the amplification of IBV and the in vitro characterization of viral cytopathogenesis

Supersymmetric CP Violation in B→Xsl+l−B \to X_s l^+ l^- in Minimal Supergravity Model

Direct CP asymmetries and the CP violating normal polarization of lepton in inclusive decay B \to X_s l^+ l^- are investigated in minimal supergravity model with CP violating phases. The contributions coming from exchanging neutral Higgs bosons are included. It is shown that the direct CP violation in branching ratio, A_{CP}^1, is of {\cal{O}}(10^{-3}) for l=e, \mu, \tau. The CP violating normal polarization for l=\mu can reach 0.5 percent when tan\beta is large (say, 36). For l=\tau and in the case of large \tan\beta, the direct CP violation in backward-forward asymmetry, A_{CP}^2, can reach one percent, the normal polarization of \tau can be as large as a few percent, and both are sensitive to the two CP violating phases, \phi_\mu and \phi_{A_0}, and consequently it could be possible to observe them (in particular, the normal polarization of \tau) in the future B factories.Comment: 14 pages, latex, 5 figure

Lepton Mixing Matrix in Standard Model Extended by One Sterile Neutrino

We consider the simplest extension of the standard electroweak model by one sterile neutrino that allows for neutrino masses and mixing. We find that its leptonic sector contains much less free physical parameters than previously realized. In addition to the two neutrino masses, the lepton mixing matrix in charged current interactions involves (n-1) free physical mixing angles for n generations. The mixing matrix in neutral current interactions of neutrinos is completely fixed by the two masses. Both interactions conserve CP. We illustrate the phenomenological implications of the model by vacuum neutrino oscillations, tritium beta decay and neutrinoless double beta decay. It turns out that, due to the revealed specific structure in its mixing matrix, the model with any n generations cannot accommodate simultaneously the data by KamLAND, K2K and CHOOZ.Comment: 14 pages, no figures; version 2: (1) added a short paragraph at the end of subsec 2.2 to record the counting of physical parameters for any numbers of generations and sterile neutrinos for completeness; (2) added a note in ref list, item [18] to quote and comment on an earlier work; (3) added the second paper to ref list, item [17]; (4) fixed typo

Non-Commutativity and Unitarity Violation in Gauge Boson Scattering

We examine the unitarity properties of spontaneously broken non-commutative gauge theories. We find that the symmetry breaking mechanism in the non-commutative Standard Model of Chaichian et al. leads to an unavoidable violation of tree-level unitarity in gauge boson scattering at high energies. We then study a variety of simplified spontaneously broken non-commutative theories and isolate the source of this unitarity violation. Given the group theoretic restrictions endemic to non-commutative model building, we conclude that it is difficult to build a non-commutative Standard Model under the Weyl-Moyal approach that preserves unitarity.Comment: 31 page

Nonsteroidal Anti-inflammatory Drugs and Change in Mammographic Density: A Cohort Study Using Pharmacy Records on Over 29,000 Postmenopausal Women

Background: Use of nonsteroidal anti-inflammatory drugs (NSAID) has been associated with a decrease in breast cancer risk, but it is unknown if they also reduce mammographic density, a strong intermediate marker of breast cancer risk. Methods: We investigated NSAID use and mammographic density in 29,284 postmenopausal women who had two screening mammograms at Group Health in Seattle. We used pharmacy records to classify women as NSAID nonusers, continuers, initiators, or discontinuers based on use between the two mammograms and nine separate prescription and nonprescription NSAID classes. Using unordered polytomous logistic regression methods, we modeled the odds ratio (OR) of staying not dense, decreasing density, or increasing density relative to remaining dense based on Breast Imaging Reporting Data System classification of density. Results: There was no association with density change from initiation or continuation of NSAIDs. However, both initiators and continuers of any NSAIDs were more likely to stay not dense than stay dense [OR, 1.12; 95% confidence interval (95% CI), 1.04-1.20; OR, 1.25; 95% CI, 1.05-1.49, respectively]. This association with staying not dense for initiators and continuers of any NSAID use was observed primarily among women ages <65 years at first mammogram (OR, 1.24; 95% CI, 1.12-1.36; OR, 1.48; 95% CI, 1.14-1.93, respectively). Conclusions: Initiation of NSAID use did not reduce mammographic density over the short term. Continuers of NSAID use were more likely to stay not dense compared with nonusers, suggesting that it is plausible that longer-term use of NSAIDs may be needed to reduce density. (Cancer Epidemiol Biomarkers Prev 2008;17(5):1088–95

An approximation algorithm for the solution of the nonlinear Lane-Emden type equations arising in astrophysics using Hermite functions collocation method

In this paper we propose a collocation method for solving some well-known classes of Lane-Emden type equations which are nonlinear ordinary differential equations on the semi-infinite domain. They are categorized as singular initial value problems. The proposed approach is based on a Hermite function collocation (HFC) method. To illustrate the reliability of the method, some special cases of the equations are solved as test examples. The new method reduces the solution of a problem to the solution of a system of algebraic equations. Hermite functions have prefect properties that make them useful to achieve this goal. We compare the present work with some well-known results and show that the new method is efficient and applicable.Comment: 34 pages, 13 figures, Published in "Computer Physics Communications

Gauge Theories on a 2+2 Anisotropic Lattice

The implementation of gauge theories on a four-dimensional anisotropic lattice with two distinct lattice spacings is discussed, with special attention to the case where two axes are finely and two axes are coarsely discretized. Feynman rules for the Wilson gauge action are derived and the renormalizability of the theory and the recovery of the continuum limit are analyzed. The calculation of the gluon propagator and the restoration of Lorentz invariance in on-shell states is presented to one-loop order in lattice perturbation theory for $SU(N_c)$ on both 2+2 and 3+1 lattices.Comment: 27 pages, uses feynmf. Font compatibility adjuste

Discerning Noncommutative Extra Dimensions

Experimental limits on the violation of four-dimensional Lorentz invariance imply that noncommutativity among ordinary spacetime dimensions must be small. Noncommutativity among extra, compactified spatial dimensions, however, is far less constrained and may have discernable collider signatures. Here we study the experimental consequences of noncommutative QED in six dimensions, with noncommutativity restricted to a TeV-scale bulk. Assuming the orbifold T^2/Z_2, we construct the effective four-dimensional theory and study interactions unique to the noncommutative case. New vertices involving the Kaluza-Klein (KK) excitations of the photon yield order 100% corrections to the pair production and to the decays of some of the lighter modes. We show that these effects are difficult to resolve at the LHC, but are likely within the reach of a future Very Large Hadron Collider (VLHC).Comment: 20 pages LaTeX, 8 eps figures (minor revisions, version to appear in Phys. Rev. D

Phenomenology of Particle Production and Propagation in String-Motivated Canonical Noncommutative Spacetime

We outline a phenomenological programme for the search of effects induced by (string-motivated) canonical noncommutative spacetime. The tests we propose are based, in analogy with a corresponding programme developed over the last few years for the study of Lie-algebra noncommutative spacetimes, on the role of the noncommutativity parameters in the $E(p)$ dispersion relation. We focus on the role of deformed dispersion relations in particle-production collision processes, where the noncommutativity parameters would affect the threshold equation, and in the dispersion of gamma rays observed from distant astrophysical sources. We emphasize that the studies here proposed have the advantage of involving particles of relatively high energies, and may therefore be less sensitive to "contamination" (through IR/UV mixing) from the UV sector of the theory. We also explore the possibility that the relevant deformation of the dispersion relations could be responsible for the experimentally-observed violations of the GZK cutoff for cosmic rays and could have a role in the observation of hard photons from distant astrophysical sources.Comment: With respect to the experimental information available at the time of writing version 1 of this manuscript (hep-th/0109191v1) the situation has evolved significantly. Our remarks on the benefits of high-energy observations found additional encouragement from the results reported in hep-th/020925

Measurements of the observed cross sections for exclusive light hadron production in e^+e^- annihilation at \sqrt{s}= 3.773 and 3.650 GeV

By analyzing the data sets of 17.3 pb$^{-1}$ taken at $\sqrt{s}=3.773$ GeV and 6.5 pb$^{-1}$ taken at $\sqrt{s}=3.650$ GeV with the BESII detector at the BEPC collider, we have measured the observed cross sections for 12 exclusive light hadron final states produced in $e^+e^-$ annihilation at the two energy points. We have also set the upper limits on the observed cross sections and the branching fractions for $\psi(3770)$ decay to these final states at 90% C.L.Comment: 8 pages, 5 figur