The Interacting W3W_3 String

We present a procedure for computing gauge-invariant scattering amplitudes in the $W_3$ string, and use it to calculate three-point and four-point functions. We show that non-vanishing scattering amplitudes necessarily involve external physical states with excitations of ghosts as well as matter fields. The crossing properties of the four-point functions are studied, and it is shown that the duality of the Virasoro string amplitudes generalises in the $W_3$ string, with different sets of intermediate states being exchanged in different channels. We also exhibit a relation between the scattering amplitudes of the $W_3$ string and the fusion rules of the Ising model.Comment: (Revised version), 26 pages, Plain Tex, CTP TAMU-86/92, KUL-TF-92/4

Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation

HuR promotes myogenesis by stabilizing the MyoD, myogenin and p21 mRNAs during the fusion of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA destabilizing activity, promotes the early steps of myogenesis by reducing the expression of the cell cycle promoter nucleophosmin (NPM). Depletion of HuR stabilizes the NPM mRNA, increases NPM protein levels and inhibits myogenesis, while its overexpression elicits the opposite effects. NPM mRNA destabilization involves the association of HuR with the decay factor KSRP as well as the ribonuclease PARN and the exosome. The C terminus of HuR mediates the formation of the HuR-KSRP complex and is sufficient for maintaining a low level of the NPM mRNA as well as promoting the commitment of muscle cells to myogenesis. We therefore propose a model whereby the downregulation of the NPM mRNA, mediated by HuR, KSRP and its associated ribonucleases, is required for proper myogenesis

Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions

Therapeutic cell differentiatio

Expert consensus on the metaverse in medicine

BACKGROUND Recently, Professor Chunxue Bai and colleagues have proposed a definition of the Metaverse in Medicine as the medical Internet of Things (MIoT) facilitated using AR and/or VR glasses. METHODS A multi-disciplinary panel of doctors and IT experts from Asia, the United States, and Europe analyzed published articles regarding expert consensus on the Medical Internet of Things, with reference to study results in the field of metaverse technology. FINDINGS It is feasible to implement the three basic functions of the MIoT, namely, comprehensive per ception, reliable transmission, and intelligent processing, by applying a metaverse platform, which is composed of AR and VR glasses and the MIoT system, and integrated with the technologies of holographic construction, holographic emulation, virtuality-reality integration, and virtuality-reality interconnection. In other words, through interactions between virtual and real cloud experts and terminal doctors, we will be able to carry out medical education, science popularization, consultation, graded diagnosis and treat ment, clinical research, and even comprehensive healthcare in the metaverse. The interaction between virtual and real cloud experts and terminal users (including terminal doctors, patients, and even their family members) could also facilitate different medical services, such as disease prevention, healthcare, physical examination, diagnosis and treatment of diseases, rehabilitation, management of chronic dis eases, in-home care, first aid, outpatient attendance, consultation, etc. In addition, it is noteworthy that security is a prerequisite for the Metaverse in Medicine, and a reliable security system is the foundation to ensure the normal operation of such a platform. CONCLUSION: The application of a Cloud Plus Terminal platform could enable interaction between virtual and real cloud experts and terminal doctors, in order to realize medical education, science popularization, consultation, graded diagnosis and treatment, clinical research, and even comprehensive healthcare in the metaverse