7-(3-Nitro­phen­yl)-9,10-dihydro-7H-benzo[h]cyclo­penta­[b]quinolin-8(11H)-one

In the title compound, C22H16N2O3, the naphthalene ring, the 1,4-dihydro­pyridine ring and the cyclo­pent-2-enone ring are nearly coplanar, with the dihedral angles between the neighbouring rings being 1.93 (11) and 2.30 (9)°, respectively. The benzene ring group at position 7 and the 1,4-dihydro­pyridine ring form a dihedral angle of 78.75 (4)°. Inter­molecular N—H⋯O hydrogen bonds and C—H⋯π inter­actions stabilize the crystal packing

Research and implementation of parallel artificial bee colony algorithm based on ternary optical computer

The artificial bee colony (ABC) algorithm is a widely used algorithm in the field of function optimization problems. The traditional ABC algorithm has long search time, slow convergence speed and easy to fall into local optimum at the end of the search. In this paper, the design scheme and method of implementing parallel ABC algorithm are studied, which makes use of the characteristics of many data bits and easy expansion of data bits of the ternary optical computer (TOC). First, by analysing the traditional ABC algorithm, we can find the parallel parts and parallel design. Then the detailed algorithm implementation flow is given and the clock cycle of the algorithm is analysed. Finally, the correctness of the parallel scheme is verified by experiments. Compared with the ABC algorithm and parallel ABC algorithms based on computer (PABC), the ABC algorithm based on TOC (TOC-PABC) effectively shortens the search time, improves the optimization performance of complex multimodal function optimization problems and obtains a higher speedup

The Dynamic Model of Double Auction Market

Most financial markets operate as double auction markets in which buyers and sellers submit limit and market orders. In this case the traders have to decide firstly whether they want to submit a buy or sell order and then secondly what the limit price of this order is. In this thesis I develop further a theoretical model based on Chatterjee and Samuelson (1983) in which two traders trade with each other in a double auction market. Assuming that both traders assign a private value to the asset they are trading, which is known only to them but not their trading partner, I determine whether the traders should submit a buy or sell order and what the optimal limit price should be. I develop a single-period model in which traders only trade once and thus cannot learn each other’s private values from trading as well as a multi-period model that allows to infer to some degree the other trader’s private value from their order submission behavior. Using this theoretical model as a benchmark, I then conducted experiments with students to evaluate whether the actual behavior of students fits the theory developed. Although we find that in general the behavior of traders is consistent with the proposed theory, there are some significant differences. Most notably traders seem to underreact to differences in their own private value, i.e. do not adjust their limit price to the extend suggested by theory. I evaluate these outcomes in light of results established results in behavioral finance.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Advantages of grass-legume mixture for improvement of crop growth and reducing potential nitrogen loss in a boreal climate

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4-(4-Bromo­phen­yl)-3-methyl-1-phenyl-6,7-dihydro-1H-pyrazolo­[3,4-b]thieno[2,3-e]pyridine 5,5-dioxide

In the title compound, C21H16BrN3O2S, the pyrazole and pyridine rings are nearly coplanar, the dihedral angle between their planes being 3.17 (14)°. The 2,3-dihydro­thio­phene ring adopts an envelope conformation. The 4-bromo­phen­yl/pyridine ring and phen­yl/pyrazole rings form dihedral angles of 60.06 (9) and 33.49 (11)°, respectively. There is an intra­molecular C—H⋯N hydrogen bond. The crystal packing is stabilized by inter­molecular C—H⋯O hydrogen bonding and C—H⋯π inter­actions

Heavy Metals Migration in Soil in Tailing Dam Region of Shuikoushan, Hunan Province, China

AbstractThe nonferrous mining industry in China has been exploiting rich domestic mineral resources in order to sustain rapidly economic and social development. The paper chooses the tailing dam region as the research object in the Shuikoushan, and researches the distribution of Pb, Zn, Cu, Cd, As, Cr, which reveals heavy metal migration regularities in layers from new and old tailing dam region. In addition, this article focuses on making the research of Potential Ecological Risk Index appraisal to the heavy metal contamination level. The results showed that the concentrations of heavy metals in old tailing dam region were much higher than those of in the new tailing dam region. As well, the concentrations of most heavy metal reduced progressively with the soil depth increasing for the new tailing dam region, while the change tendency was inversely for the old one. Potential ecological risk index showed that the potential ecological risks were at low and low to moderate level in tailing dam region

The ROS/NF-κB/NR4A2 Pathway is Involved in H\u3csub\u3e2\u3c/sub\u3eO\u3csub\u3e2\u3c/sub\u3e Induced Apoptosis of Resident Cardiac Stem Cells via Autophagy

Cardiac stem cells (CSCs)-based therapy provides a promising avenue for the management of ischemic heart diseases. However, engrafted CSCs are subjected to acute cell apoptosis in the ischemic microenvironment. Here, stem cell antigen 1 positive (Sca-1+) CSCs proved to own therapy potential were cultured and treated with H2O2 to mimic the ischemia situation. As autophagy inhibitor, 3-methyladenine (3MA), inhibited H2O2-induced CSCs apoptosis, thus we demonstrated that H2O2 induced autophagy-dependent apoptosis in CSCs, and continued to find key proteins responsible for the crosstalk between autophagy and apoptosis. Nuclear Receptor Subfamily 4 Group A Member 2 (NR4A2), increased upon cardiomyocyte injury with unknown functions in CSCs, was increased by H2O2. NR4A2 siRNA attenuated H2O2 induced autophagy and apoptosis in CSCs, which suggested an important role of NR4A2 in CSCs survival in ischemia conditions. Reactive oxygen species (ROS) and NF- κB (P65) subunit were both increased by H2O2. Either the ROS scavenger, N-acetyl-lcysteine (NAC) or NF-κB signaling inhibitor, bay11-7082 could attenuate H2O2-induced autophagy and apoptosis in CSCs, which suggested they were involved in this process. Furthermore, NAC inhibited NF-κB activities, while bay11-7082 inhibited NR4A2 expression, which revealed a ROS/NF-κB/NR4A2 pathway responsible for H2O2- induced autophagy and apoptosis in CSCs. Our study supports a new clue enhancing the survival rate of CSCs in the infarcted myocardium for cell therapy in ischemic cardiomyopathy

Response of Soil Bacterial Community Diversity and Composition to Time, Fertilization, and Plant Species in a Sub-Boreal Climate

Pastures are an important part of crop and food systems in cold climates. Understanding how fertilization and plant species affect soil bacterial community diversity and composition is the key for understanding the role of soil bacteria in sustainable agriculture. To study the response of soil bacteria to different fertilization and cropping managements, a 3-year (2013-2015) field study was established. In the split-plot design, fertilizer treatment (unfertilized control, organic fertilizer, and synthetic fertilizer) was the main plot factor, and plant treatment [clear fallow, red clover (Trifolium pratense), timothy (Phleum pratense), and a mixture of red clover and timothy] was the sub-plot factor. Soil bacterial community diversity and composition, soil properties, and crop growth were investigated through two growing seasons in 2014 and 2015, with different nitrogen input levels. The community diversity measures (richness, Shannon diversity, and Shannon evenness) and composition changed over time (P<0.05) and at different time scales. The community diversity was lower in 2014 than in 2015. The temporal differences were greater than the differences between treatments. The overall correlations of Shannon diversity to soil pH, NO3-, NH4+, and surplus nitrogen were positive and that of bacterial richness to crop dry matter yield was negative (P<0.05). The major differences in diversity and community composition were found between fallow and planted treatments and between organic and synthetic fertilizer treatments. The differences between the planted plots were restricted to individual operational taxonomic units (OTUs). Soil moisture, total carbon content, and total nitrogen content correlated consistently with the community composition (P<0.05). Compared to the unfertilized control, the nitrogen fertilizer loading enhanced the temporal change of community composition in pure timothy and in the mixture more than that in red clover, which further emphasizes the complexity of interactions between fertilization and cropping treatments on soil bacteria.Peer reviewe