790 research outputs found
Pengembangan Soal Untuk Mengukur Kemampuan Berpikir Tingkat Tinggi Pokok Bahasan Barisan Dan Deret Bilangan Di Kelas IX Akselerasi SMP Xaverius Maria Palembang
Teaching fast learning students is not enough by giving them ordinary mathematics problems. Teaching activities for fast learning students bring consequence for teacher to modify teaching activities from regular to activity that needs Higher Order Thinking skills. Therefore it is need to develop problems to measure higher order thinking skills. This study aims to (1) produce a valid and practical prototype problems to measure Higher Order Thinking skills in Number Sequences and Series for Acceleration Class Grade IX (2) see the effects of the problems to measure higher order thinking skills on students\u27 achievement in Number Sequence and Series was tried out to students of acceleration class grade IX . This study use development research that consists of analyzing, designing, evaluating, and revising. The instrument for collecting data is written test. Test is used to see students\u27 achievement in Number Sequences and Series. All data are analyzed using descriptive technique. Subjects in this research are students of Acceleration Class Grade IX of SMP Xaverius Maria Palembang. The total subject are 22 students The results of analysis are: (1) problems prototype which is developed has been valid and practical. (2) based on developing process can be obtained that problems which is developed contains potential effect to higher order thinking skills of Acceleration Class Grade IX of SMP Xaverius Maria Palembang shown by written test result score 35.59. It means that students\u27 thinking skill is good category. The final conclusion is the problems which is developed can be used to measure higher order thinking skills in Number Sequence and Serie
Pengembangan Soal Untuk Mengukur Kemampuan Berpikir Tingkat Tinggi Pokok Bahasan Barisan Dan Deret Bilangan Di Kelas IX Akselerasi SMP Xaverius Maria Palembang
Teaching fast learning students is not enough by giving them ordinary mathematics problems. Teaching activities for fast learning students bring consequence for teacher to modify teaching activities from regular to activity that needs Higher Order Thinking skills. Therefore it is need to develop problems to measure higher order thinking skills. This study aims to (1) produce a valid and practical prototype problems to measure Higher Order Thinking skills in Number Sequences and Series for Acceleration Class Grade IX (2) see the effects of the problems to measure higher order thinking skills on students' achievement in Number Sequence and Series was tried out to students of acceleration class grade IX . This study use development research that consists of analyzing, designing, evaluating, and revising. The instrument for collecting data is written test. Test is used to see students' achievement in Number Sequences and Series. All data are analyzed using descriptive technique. Subjects in this research are students of Acceleration Class Grade IX of SMP Xaverius Maria Palembang. The total subject are 22 students The results of analysis are: (1) problems prototype which is developed has been valid and practical. (2) based on developing process can be obtained that problems which is developed contains potential effect to higher order thinking skills of Acceleration Class Grade IX of SMP Xaverius Maria Palembang shown by written test result score 35.59. It means that students' thinking skill is good category. The final conclusion is the problems which is developed can be used to measure higher order thinking skills in Number Sequence and Serie
A simple expression for the ADM mass
We show by an almost elementary calculation that the ADM mass of an
asymptotically flat space can be computed as a limit involving a rate of change
of area of a closed 2-surface. The result is essentially the same as that given
by Brown and York. We will prove this result in two ways, first by direct
calculation from the original formula as given by Arnowitt, Deser and Misner
and second as a corollary of an earlier result by Brewin for the case of
simplicial spaces.Comment: 9 pages, 1 figur
Editorial
Editorial of the 2018 edition of the Journal Música em Contexto (Music in Context).Editorial de la edición de 2018 del periódico Música en Contexto.Editorial da edição de 2018 do periódico Música em Contexto
Injectivity of sections of convex harmonic mappings and convolution theorems
In the article the authors consider the class of
sense-preserving harmonic functions defined in the unit disk
and normalized so that and , where
and are analytic in the unit disk. In the first part of the article we
present two classes and of
functions from and show that if
and , then the harmonic convolution is a univalent
and close-to-convex harmonic function in the unit disk provided certain
conditions for parameters and are satisfied. In the second
part we study the harmonic sections (partial sums) where , and denote the -th partial sums of
and , respectively. We prove, among others, that if
is a univalent harmonic convex mapping,
then is univalent and close-to-convex in the disk for
, and is also convex in the disk for
and . Moreover, we show that the section of is not convex in the disk but is shown to be convex
in a smaller disk.Comment: 16 pages, 3 figures; To appear in Czechoslovak Mathematical Journa
On the particle paths and the stagnation points in small-amplitude deep-water waves
In order to obtain quite precise information about the shape of the particle
paths below small-amplitude gravity waves travelling on irrotational deep
water, analytic solutions of the nonlinear differential equation system
describing the particle motion are provided. All these solutions are not closed
curves. Some particle trajectories are peakon-like, others can be expressed
with the aid of the Jacobi elliptic functions or with the aid of the
hyperelliptic functions. Remarks on the stagnation points of the
small-amplitude irrotational deep-water waves are also made.Comment: to appear in J. Math. Fluid Mech. arXiv admin note: text overlap with
arXiv:1106.382
Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal cancer—the relationship with regulatory hypoxia-inducible factor-1α expression, tumor invasiveness, and patient prognosis
Increased glucose uptake mediated by glucose
transporters and reliance on glycolysis are common features
of malignant cells. Hypoxia-inducible factor-1α supports the
adaptation of hypoxic cells by inducing genes related to
glucose metabolism. The contribution of glucose transporter
(GLUT) and hypoxia-inducible factor-1α (HIF-1α) activity to
tumor behavior and their prognostic value in head and neck
cancers remains unclear. The aim of this study was to examine
the predictive value of GLUT1, GLUT3, and HIF-1α messenger
RNA (mRNA)/protein expression as markers of tumor
aggressiveness and prognosis in laryngeal cancer. The level of
hypoxia/metabolic marker genes was determined in 106 squamous
cell laryngeal cancer (SCC) and 73 noncancerous
matched mucosa (NCM) controls using quantitative realtime
PCR. The related protein levels were analyzed by
Western blot. Positive expression of SLC2A1, SLC2A3, and
HIF-1α genes was noted in 83.9, 82.1, and 71.7 % of SCC
specimens and in 34.4, 59.4, and 62.5 % of laryngeal cancer
samples. Higher levels of mRNA/protein for GLUT1 and
HIF-1α were noted in SCC compared to NCM (p<0.05).
SLC2A1 was found to have a positive relationship with grade,
tumor front grading (TFG) score, and depth and mode of
invasion (p<0.05). SLC2A3 was related to grade and invasion
type (p<0.05). There were also relationships of HIF-1α with
pTNM, TFG scale, invasion depth and mode, tumor recurrences,
and overall survival (p<0.05). In addition, more advanced
tumors were found to be more likely to demonstrate
positive expression of these proteins. In conclusion, the
hypoxia/metabolic markers studied could be used as molecular
markers of tumor invasiveness in laryngeal cancer.This work was supported, in part, by the statutory
fund of the Department of Cytobiochemistry, University of Łódź, Poland
(506/811), and by grant fromtheNational Science Council, Poland (N403
043 32/2326)
Ecological succession of a Jurassic shallow-water ichthyosaur fall.
After the discovery of whale fall communities in modern oceans, it has been hypothesized that during the Mesozoic the carcasses of marine reptiles created similar habitats supporting long-lived and specialized animal communities. Here, we report a fully documented ichthyosaur fall community, from a Late Jurassic shelf setting, and reconstruct the ecological succession of its micro- and macrofauna. The early 'mobile-scavenger' and 'enrichment-opportunist' stages were not succeeded by a 'sulphophilic stage' characterized by chemosynthetic molluscs, but instead the bones were colonized by microbial mats that attracted echinoids and other mat-grazing invertebrates. Abundant cemented suspension feeders indicate a well-developed 'reef stage' with prolonged exposure and colonization of the bones prior to final burial, unlike in modern whale falls where organisms such as the ubiquitous bone-eating worm Osedax rapidly destroy the skeleton. Shallow-water ichthyosaur falls thus fulfilled similar ecological roles to shallow whale falls, and did not support specialized chemosynthetic communities
Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment
Pituitary tumor transforming gene (PTTG)-binding factor (PBF or PTTG1IP) is a little characterized protooncogene that has been implicated in the etiology of breast and thyroid tumors. In this study, we created a murine transgenic model to target PBF expression to the thyroid gland (PBF-Tg mice) and found that these mice exhibited normal thyroid function, but a striking enlargement of the thyroid gland associated with hyperplastic and macrofollicular lesions. Expression of the sodium iodide symporter (NIS), a gene essential to the radioiodine ablation of thyroid hyperplasia, neoplasia, and metastasis, was also potently inhibited in PBF-Tg mice. Critically, iodide uptake was repressed in primary thyroid cultures from PBF-Tg mice, which could be rescued by PBF depletion. PBF-Tg thyroids exhibited upregulation of Akt and the TSH receptor (TSHR), each known regulators of thyrocyte proliferation, along with upregulation of the downstream proliferative marker cyclin D1. We extended and confirmed findings from the mouse model by examining PBF expression in human multinodular goiters (MNG), a hyperproliferative thyroid disorder, where PBF and TSHR was strongly upregulated relative to normal thyroid tissue. Furthermore, we showed that depleting PBF in human primary thyrocytes was sufficient to increase radioiodine uptake. Together, our findings indicate that overexpression of PBF causes thyroid cell proliferation, macrofollicular lesions, and hyperplasia, as well as repression of the critical therapeutic route for radioiodide uptake
Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia: an RCT
Contains fulltext :
86695.pdf (publisher's version ) (Open Access)Rationale Pharmacokinetics of melatonin in children might differ from that in adults.
Objectives This study aims to establish a dose–response relationship for melatonin in advancing dim light melatonin onset (DLMO), sleep onset (SO), and reducing sleep onset latency (SOL) in children between 6 and 12 years with chronic sleep onset insomnia (CSOI).
Methods The method used for this study is the randomized, placebo-controlled double-blind trial. Children with CSOI (n=72) received either melatonin 0.05, 0.1, and 0.15 mg/kg or placebo during 1 week. Sleep was assessed with log and actigraphy during this week and the week before. Outcomes were the shifts in DLMO, SO, and SOL.
Results Treatment with melatonin significantly advanced SO and DLMO by approximately 1 h and decreased SOL by 35 min. Within the three melatonin groups, effect size was not different, but the circadian time of administration (TOA) correlated significantly with treatment effect on DLMO (rs=-0.33, p=0.022) and SO (rs=-0.38, p=0.004), whereas clock TOA was correlated with SO shift (r=-0.35, p=0.006) and not with DLMO shift.
Conclusions No dose–response relationship of melatonin with SO, SOL, and DLMO is found within a dosage range of 0.05–0.15 mg/kg. The effect of exogenous melatonin on SO, SOL, and DLMO increases with an earlier circadian TOA. The soporific effects of melatonin enhance the SO shift. This study demonstrates that melatonin for treatment of CSOI in children is effective in a dosage of 0.05 mg/kg given at least 1 to 2 h before DLMO and before desired bedtime.13 p
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