15 research outputs found

    Conservation policies informed by food system feedbacks can avoid unintended consequences

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    Understanding the feedbacks between food systems and conservation policies can help avoid unintended environmental consequences. Using a survey-based choice experiment and economic modelling, we quantify the potential impact of tourists’ responses to a shift in offshore fish supply after the designation of a large-scale marine protected area in Palau. We find that this conservation policy may increase offshore fish prices and tourists’ consumption of reef fish, thereby further endangering local reef ecosystems. However, if tourists are offered a sustainable offshore choice, their demand for fish could be kept at current levels, and environmental impacts from increased reef fish consumption would be avoided

    Mks6 mutations reveal tissue- and cell type-specific roles for the cilia transition zone

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    The transition zone (TZ) is a domain at the base of the cilium that is involved in maintaining ciliary compartment-specific sensory and signaling activity by regulating cilia protein composition. Mutations in TZ proteins result in cilia dysfunction, often causing pleiotropic effects observed in a group of human diseases classified as ciliopathies. The purpose of this study is to describe the importance of the TZ component Meckel-GrĂŒber syndrome 6 (Mks6) in several organ systems and tissues regarding ciliogenesis and cilia maintenance using congenital and conditional mutant mouse models. Similar to MKS, congenital loss of Mks6 is embryonic lethal, displaying cilia loss and altered cytoskeletal microtubule modifications but only in specific cell types. Conditional Mks6 mutants have a variable cystic kidney phenotype along with severe retinal degeneration with mislocalization of phototransduction cascade proteins. However, other phenotypes, such as anosmia and obesity, which are typically associated with cilia and TZ dysfunction, were not evident. These data indicate that despite Mks6 being a core TZ component, it has tissue- or cell type-specific functions important for cilia formation and cilia sensory and signaling activities

    Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections

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